HRP20070117T8 - Heterocyclic oxime derivatives, process for their preparation and use thereof in the treatment of type ii diabetes - Google Patents

Heterocyclic oxime derivatives, process for their preparation and use thereof in the treatment of type ii diabetes

Info

Publication number: HRP20070117T8
Authority: HR; Croatia
Prior art keywords: group; straight; branched; whether identical; different
Prior art date: 2003-07-28

Application number

HR20070117T

Other languages

English (en)

Croatian (hr)

Inventor

Leclerc V�ronique

Pailloux Sylvie

Carato Pascal

Introvigne Carine

Lebegue Nicolas

Berthelot Pascal

Dacquet Catherine

Albert Boutin Jean

Henri Caignard Daniel

Renard Pierre

Original Assignee

Les Laboratoires Servier

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-07-28

Filing date

2007-03-20

Publication date

2007-07-31

2007-03-20 Application filed by Les Laboratoires Servier filed Critical Les Laboratoires Servier

2007-04-30 Publication of HRP20070117T3 publication Critical patent/HRP20070117T3/xx

2007-07-31 Publication of HRP20070117T8 publication Critical patent/HRP20070117T8/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/26—Oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/04—Drugs for disorders of the urinary system for urolithiasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/12—Radicals substituted by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Physical Education & Sports Medicine (AREA)
Endocrinology (AREA)
Orthopedic Medicine & Surgery (AREA)
Urology & Nephrology (AREA)
Neurology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Biomedical Technology (AREA)
Epidemiology (AREA)
Rheumatology (AREA)
Neurosurgery (AREA)
Vascular Medicine (AREA)
Emergency Medicine (AREA)
Dermatology (AREA)
Ophthalmology & Optometry (AREA)
Child & Adolescent Psychology (AREA)
Reproductive Health (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyridine Compounds (AREA)

HR20070117T 2003-07-28 2007-03-20 Heterocyclic oxime derivatives, process for their preparation and use thereof in the treatment of type ii diabetes HRP20070117T8 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR0309214A FR2858321B1 (fr)	2003-07-28	2003-07-28	Nouveaux derives d'oximes heterocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number	Publication Date
HRP20070117T3 HRP20070117T3 (en)	2007-04-30
HRP20070117T8 true HRP20070117T8 (en)	2007-07-31

Family

ID=33523001

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR20070117T HRP20070117T8 (en)	2003-07-28	2007-03-20	Heterocyclic oxime derivatives, process for their preparation and use thereof in the treatment of type ii diabetes

Country Status (31)

Country	Link
US (1)	US7071221B2 (xx)
EP (1)	EP1502590B1 (xx)
JP (1)	JP4406331B2 (xx)
KR (1)	KR100677013B1 (xx)
CN (1)	CN100497323C (xx)
AR (1)	AR045125A1 (xx)
AT (1)	ATE348612T1 (xx)
AU (1)	AU2004203454B2 (xx)
BR (1)	BRPI0403028A (xx)
CA (1)	CA2475137C (xx)
CY (1)	CY1106336T1 (xx)
DE (1)	DE602004003751T2 (xx)
DK (1)	DK1502590T3 (xx)
EA (1)	EA007718B1 (xx)
EG (1)	EG24967A (xx)
ES (1)	ES2279310T3 (xx)
FR (1)	FR2858321B1 (xx)
GE (1)	GEP20063896B (xx)
HK (1)	HK1071748A1 (xx)
HR (1)	HRP20070117T8 (xx)
MA (1)	MA27104A1 (xx)
MX (1)	MXPA04007257A (xx)
MY (1)	MY139278A (xx)
NO (1)	NO327257B1 (xx)
NZ (1)	NZ534334A (xx)
PL (1)	PL1502590T3 (xx)
PT (1)	PT1502590E (xx)
SG (1)	SG109010A1 (xx)
SI (1)	SI1502590T1 (xx)
UA (1)	UA80814C2 (xx)
ZA (1)	ZA200405893B (xx)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2009516730A (ja) *	2005-11-23	2009-04-23	アストラゼネカアクチボラグ	Ｌ−アラニン誘導体
FR2894965B1 (fr) *	2005-12-20	2008-01-25	Servier Lab	Nouveaux derives d'oximes heterocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2898125B1 (fr) *	2006-03-06	2008-06-13	Servier Lab	Nouveaux derives heterocycliques cycloalkyles, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP2049490A1 (en) *	2006-06-09	2009-04-22	Astra Zeneca AB	N-(benzoyl)-o- [2- (pyridin- 2 -ylamino) ethyl]-l-tyrosine derivatives and related compounds as a5b1 antagonists for the treatment of solid tumors
FR2903404B1 (fr) *	2006-07-10	2008-08-22	Servier Lab	Nouveaux derives tetracycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
WO2008093065A1 (en) *	2007-01-29	2008-08-07	Astrazeneca Ab	L-ALANINE DERIVATIVES AS α5βL ANTAGONISTS
WO2008125811A1 (en) *	2007-04-11	2008-10-23	Astrazeneca Ab	N-[HETEROARYLCARBONYL]-S-THIENYL-L-ALANINE DERIVATIVES AS α5β1 ANTAGONISTS
EP2691396B1 (en)	2011-03-30	2016-08-10	Brown University	Enopeptins, uses thereof, and methods of synthesis thereto
WO2016037072A2 (en) *	2014-09-04	2016-03-10	Brown University	Enopeptin analogas and methods of use thereof
CN104788436B (zh) *	2015-03-13	2018-05-01	三峡大学	四氢苯并呋喃-4-酮肟基三唑药物，制备方法及其应用
CN104725367B (zh) *	2015-03-13	2017-06-23	三峡大学	四氢苯并噻唑‑7‑酮肟药物，制备方法及其应用
EP3509590A4 (en)	2016-09-07	2020-12-02	Pliant Therapeutics, Inc.	N-ACYL AMINO ACID COMPOUNDS AND METHOD OF USING

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US32769A (en) *		1861-07-09		Beehive
US4228292A (en) *	1978-07-20	1980-10-14	Monsanto Company	N-Substituted benzothiazolines and benzoxazolines and their use as herbicides and plant growth regulants
DE3064910D1 (en) *	1979-06-12	1983-10-27	Fujisawa Pharmaceutical Co	2-oxo-benzothiazoline, benzoxazoline or indoline derivatives, their preparation, and pharmaceutical compositions comprising such derivatives
JP3081245B2 (ja) *	1993-09-15	2000-08-28	三共株式会社	Ｎｉｄｄｍの発症を阻止又は遅延するためのチアゾリジンジオン類の用途
SK111195A3 (en) *	1994-09-13	1997-06-04	Sandoz Technology Ltd	Bicyclic ethers substituted with oxazole and thiazole, process for producing thereof and pharmaceutical composition containing same
FR2804431A1 (fr) *	2000-02-02	2001-08-03	Adir	Nouveaux derives heterocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CZ20023562A3 (cs) *	2000-04-28	2003-03-12	Sankyo Company, Limited	PPAR gama modulátory
FR2830012B1 (fr) *	2001-09-21	2003-10-31	Servier Lab	Nouveaux derives heterocycliques, leur procede de preparation et les compositions pharamaceutiques qui les contiennent

2003
- 2003-07-28 FR FR0309214A patent/FR2858321B1/fr not_active Expired - Fee Related
2004
- 2004-07-20 CA CA2475137A patent/CA2475137C/fr not_active Expired - Fee Related
- 2004-07-21 SG SG200404504A patent/SG109010A1/en unknown
- 2004-07-23 ZA ZA200405893A patent/ZA200405893B/xx unknown
- 2004-07-26 MY MYPI20042999A patent/MY139278A/en unknown
- 2004-07-27 DE DE602004003751T patent/DE602004003751T2/de not_active Expired - Lifetime
- 2004-07-27 AT AT04291901T patent/ATE348612T1/de active
- 2004-07-27 NZ NZ534334A patent/NZ534334A/en not_active IP Right Cessation
- 2004-07-27 ES ES04291901T patent/ES2279310T3/es not_active Expired - Lifetime
- 2004-07-27 PT PT04291901T patent/PT1502590E/pt unknown
- 2004-07-27 EP EP04291901A patent/EP1502590B1/fr not_active Expired - Lifetime
- 2004-07-27 PL PL04291901T patent/PL1502590T3/pl unknown
- 2004-07-27 DK DK04291901T patent/DK1502590T3/da active
- 2004-07-27 GE GE5664A patent/GEP20063896B/en unknown
- 2004-07-27 UA UA20040706233A patent/UA80814C2/xx unknown
- 2004-07-27 BR BR0403028-1A patent/BRPI0403028A/pt not_active IP Right Cessation
- 2004-07-27 EA EA200400867A patent/EA007718B1/ru not_active IP Right Cessation
- 2004-07-27 NO NO20043188A patent/NO327257B1/no not_active IP Right Cessation
- 2004-07-27 AR ARP040102657A patent/AR045125A1/es unknown
- 2004-07-27 MX MXPA04007257A patent/MXPA04007257A/es active IP Right Grant
- 2004-07-27 SI SI200430167T patent/SI1502590T1/sl unknown
- 2004-07-27 MA MA27805A patent/MA27104A1/fr unknown
- 2004-07-28 EG EG2004070320A patent/EG24967A/xx active
- 2004-07-28 KR KR1020040059237A patent/KR100677013B1/ko not_active IP Right Cessation
- 2004-07-28 AU AU2004203454A patent/AU2004203454B2/en not_active Ceased
- 2004-07-28 CN CNB2004100711283A patent/CN100497323C/zh not_active Expired - Fee Related
- 2004-07-28 JP JP2004219545A patent/JP4406331B2/ja not_active Expired - Fee Related
- 2004-07-29 US US10/902,345 patent/US7071221B2/en not_active Expired - Fee Related
2005
- 2005-05-30 HK HK05104493.9A patent/HK1071748A1/xx not_active IP Right Cessation
2007
- 2007-02-22 CY CY20071100250T patent/CY1106336T1/el unknown
- 2007-03-20 HR HR20070117T patent/HRP20070117T8/xx unknown

Also Published As

Publication number	Publication date
CN1590379A (zh)	2005-03-09
US20050026973A1 (en)	2005-02-03
JP4406331B2 (ja)	2010-01-27
ES2279310T3 (es)	2007-08-16
EA200400867A2 (ru)	2005-02-24
GEP20063896B (en)	2006-08-10
FR2858321B1 (fr)	2006-01-20
PL1502590T3 (pl)	2007-04-30
NZ534334A (en)	2005-12-23
NO327257B1 (no)	2009-05-25
JP2005047919A (ja)	2005-02-24
FR2858321A1 (fr)	2005-02-04
MA27104A1 (fr)	2004-12-20
DE602004003751D1 (de)	2007-02-01
DK1502590T3 (da)	2007-04-10
EP1502590B1 (fr)	2006-12-20
ATE348612T1 (de)	2007-01-15
BRPI0403028A (pt)	2005-06-14
AR045125A1 (es)	2005-10-19
CN100497323C (zh)	2009-06-10
US7071221B2 (en)	2006-07-04
HRP20070117T3 (en)	2007-04-30
AU2004203454A1 (en)	2005-02-17
EA200400867A3 (ru)	2005-04-28
AU2004203454B2 (en)	2010-05-27
SG109010A1 (en)	2005-02-28
DE602004003751T2 (de)	2007-10-18
EA007718B1 (ru)	2006-12-29
EP1502590A1 (fr)	2005-02-02
CA2475137A1 (fr)	2005-01-28
NO20043188L (no)	2005-01-31
PT1502590E (pt)	2007-02-28
UA80814C2 (en)	2007-11-12
KR20050013514A (ko)	2005-02-04
KR100677013B1 (ko)	2007-01-31
ZA200405893B (en)	2005-01-24
HK1071748A1 (en)	2005-07-29
CY1106336T1 (el)	2011-10-12
EG24967A (en)	2011-03-13
MY139278A (en)	2009-09-30
CA2475137C (fr)	2010-04-06
SI1502590T1 (sl)	2007-04-30
MXPA04007257A (es)	2005-03-31

Publication	Publication Date	Title
HRP20070117T3 (en)	2007-04-30	Heterocyclic oxime derivatives, process for their preparation and use thereof in the treatment of type ii diabetes
NO975987L (no)	1998-02-19	4-Fenylaminotiazol-derivater, fremgangsmåte for fremstilling av disse og farmasöytiske blandinger inneholdende nevnte derivater
TW200745117A (en)	2007-12-16	Macrocylic inhibitors of hepatitis C virus
IL161559A0 (en)	2004-09-27	Dibenzylamine derivatives and pharmaceutical compositions containing the same
WO2009016841A1 (ja)	2009-02-05	オキソピラジン誘導体及び除草剤
TW200745118A (en)	2007-12-16	Macrocylic inhibitors of hepatitis C virus
NO990227L (no)	1995-03-02	Heterocykliske forbindelser som farmas°ytika
DE60026509D1 (de)	2006-05-04	Chinolinderivate als mek enzym-inhibitoren
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