HK1215300A1 - 用於整合的樣品製備、反應和檢測的器械和方法 - Google Patents
用於整合的樣品製備、反應和檢測的器械和方法Info
- Publication number
- HK1215300A1 HK1215300A1 HK16103176.2A HK16103176A HK1215300A1 HK 1215300 A1 HK1215300 A1 HK 1215300A1 HK 16103176 A HK16103176 A HK 16103176A HK 1215300 A1 HK1215300 A1 HK 1215300A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- reaction
- detection
- methods
- sample preparation
- integrated sample
- Prior art date
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L7/00—Heating or cooling apparatus; Heat insulating devices
- B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M1/00—Apparatus for enzymology or microbiology
- C12M1/24—Apparatus for enzymology or microbiology tube or bottle type
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/60—Pump mixers, i.e. mixing within a pump
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
- B01F31/65—Mixers with shaking, oscillating, or vibrating mechanisms the materials to be mixed being directly submitted to a pulsating movement, e.g. by means of an oscillating piston or air column
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/71—Feed mechanisms
- B01F35/712—Feed mechanisms for feeding fluids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/71—Feed mechanisms
- B01F35/715—Feeding the components in several steps, e.g. successive steps
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/71—Feed mechanisms
- B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
- B01F35/7174—Feed mechanisms characterised by the means for feeding the components to the mixer using pistons, plungers or syringes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/52—Containers specially adapted for storing or dispensing a reagent
- B01L3/523—Containers specially adapted for storing or dispensing a reagent with means for closing or opening
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M1/00—Apparatus for enzymology or microbiology
- C12M1/36—Apparatus for enzymology or microbiology including condition or time responsive control, e.g. automatically controlled fermentors
- C12M1/38—Temperature-responsive control
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/686—Polymerase chain reaction [PCR]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/38—Diluting, dispersing or mixing samples
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
- B01F2101/23—Mixing of laboratory samples e.g. in preparation of analysing or testing properties of materials
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/025—Align devices or objects to ensure defined positions relative to each other
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/028—Modular arrangements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/16—Reagents, handling or storing thereof
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/04—Closures and closing means
- B01L2300/041—Connecting closures to device or container
- B01L2300/042—Caps; Plugs
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/04—Closures and closing means
- B01L2300/041—Connecting closures to device or container
- B01L2300/044—Connecting closures to device or container pierceable, e.g. films, membranes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
- B01L2300/0654—Lenses; Optical fibres
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0672—Integrated piercing tool
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0829—Multi-well plates; Microtitration plates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/087—Multiple sequential chambers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
- B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/043—Moving fluids with specific forces or mechanical means specific forces magnetic forces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0478—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure pistons
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0481—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0622—Valves, specific forms thereof distribution valves, valves having multiple inlets and/or outlets, e.g. metering valves, multi-way valves
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0633—Valves, specific forms thereof with moving parts
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0633—Valves, specific forms thereof with moving parts
- B01L2400/0644—Valves, specific forms thereof with moving parts rotary valves
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0677—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers
- B01L2400/0683—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers mechanically breaking a wall or membrane within a channel or chamber
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
- B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
- B01L3/50851—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates specially adapted for heating or cooling samples
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/52—Containers specially adapted for storing or dispensing a reagent
- B01L3/527—Containers specially adapted for storing or dispensing a reagent for a plurality of reagents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L7/00—Heating or cooling apparatus; Heat insulating devices
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
- G01N2035/0401—Sample carriers, cuvettes or reaction vessels
- G01N2035/0429—Sample carriers adapted for special purposes
- G01N2035/0436—Sample carriers adapted for special purposes with pre-packaged reagents, i.e. test-packs
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1079—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices with means for piercing stoppers or septums
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/11—Automated chemical analysis
- Y10T436/117497—Automated chemical analysis with a continuously flowing sample or carrier stream
- Y10T436/118339—Automated chemical analysis with a continuously flowing sample or carrier stream with formation of a segmented stream
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
- Y10T436/255—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.] including use of a solid sorbent, semipermeable membrane, or liquid extraction
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Clinical Laboratory Science (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Hematology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Sustainable Development (AREA)
- Dispersion Chemistry (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30728110P | 2010-02-23 | 2010-02-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1215300A1 true HK1215300A1 (zh) | 2016-08-19 |
Family
ID=44507176
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK14100274.1A HK1187364A1 (zh) | 2010-02-23 | 2014-01-10 | 用於整合的樣品製備、反應和檢測的器械和方法 |
HK16103176.2A HK1215300A1 (zh) | 2010-02-23 | 2016-03-18 | 用於整合的樣品製備、反應和檢測的器械和方法 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK14100274.1A HK1187364A1 (zh) | 2010-02-23 | 2014-01-10 | 用於整合的樣品製備、反應和檢測的器械和方法 |
Country Status (10)
Country | Link |
---|---|
US (5) | US8372340B2 (zh) |
EP (4) | EP4043546A1 (zh) |
JP (3) | JP6154137B2 (zh) |
KR (4) | KR102004319B1 (zh) |
CN (2) | CN103221529B (zh) |
AU (1) | AU2011220873B2 (zh) |
BR (1) | BR112012021202B1 (zh) |
CA (3) | CA2977845C (zh) |
HK (2) | HK1187364A1 (zh) |
WO (1) | WO2011106384A1 (zh) |
Families Citing this family (113)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7754148B2 (en) | 2006-12-27 | 2010-07-13 | Progentech Limited | Instrument for cassette for sample preparation |
US7727473B2 (en) | 2005-10-19 | 2010-06-01 | Progentech Limited | Cassette for sample preparation |
KR102004319B1 (ko) | 2010-02-23 | 2019-07-26 | 루미넥스 코포레이션 | 일체화된 샘플 제조, 반응 및 검출을 위한 장치 및 방법 |
US20110312587A1 (en) * | 2010-06-17 | 2011-12-22 | Geneasys Pty Ltd | Loc for detection of hybridization of nucleic acid sequences with primer-linked stem-and-loop probes |
CN103725591A (zh) * | 2010-07-23 | 2014-04-16 | 贝克曼考尔特公司 | 盒装载单元 |
EP2672250B1 (en) | 2011-02-04 | 2020-09-02 | Universal Bio Research Co., Ltd. | A measurement device and a corresponding measurement method |
CN107338189B (zh) | 2011-05-04 | 2021-02-02 | 卢米耐克斯公司 | 用于集成的样品制备、反应和检测的设备与方法 |
US8586387B2 (en) * | 2011-08-30 | 2013-11-19 | Supernova Diagnostics, Inc. | Methods of triggering activation of encapsulated signal-generating substances and apparatus utilising activated signal-generating substances |
US9632102B2 (en) | 2011-09-25 | 2017-04-25 | Theranos, Inc. | Systems and methods for multi-purpose analysis |
US8475739B2 (en) | 2011-09-25 | 2013-07-02 | Theranos, Inc. | Systems and methods for fluid handling |
US9664702B2 (en) | 2011-09-25 | 2017-05-30 | Theranos, Inc. | Fluid handling apparatus and configurations |
US20140170735A1 (en) | 2011-09-25 | 2014-06-19 | Elizabeth A. Holmes | Systems and methods for multi-analysis |
US10012664B2 (en) | 2011-09-25 | 2018-07-03 | Theranos Ip Company, Llc | Systems and methods for fluid and component handling |
US9810704B2 (en) | 2013-02-18 | 2017-11-07 | Theranos, Inc. | Systems and methods for multi-analysis |
WO2014017187A1 (ja) * | 2012-07-25 | 2014-01-30 | ソニー株式会社 | 核酸増幅反応用試料の調製方法及び核酸増幅反応用試料の調製装置 |
AU2013202808B2 (en) | 2012-07-31 | 2014-11-13 | Gen-Probe Incorporated | System and method for performing multiplex thermal melt analysis |
TWI528823B (zh) * | 2012-08-28 | 2016-04-01 | 緯創資通股份有限公司 | 影像資訊顯示裝置與應用於其上之影像資訊顯示與調整方法 |
CN105748108B (zh) * | 2012-10-24 | 2019-04-05 | 艾博生物医药(杭州)有限公司 | 一种装置 |
US20140322706A1 (en) | 2012-10-24 | 2014-10-30 | Jon Faiz Kayyem | Integrated multipelx target analysis |
CN103776660B (zh) | 2012-10-24 | 2016-03-09 | 艾博生物医药(杭州)有限公司 | 一种装置 |
EP2912432B1 (en) | 2012-10-24 | 2018-07-04 | Genmark Diagnostics Inc. | Integrated multiplex target analysis |
US9347056B2 (en) * | 2012-10-26 | 2016-05-24 | Seiko Epson Corporation | Nucleic acid extraction device, and nucleic acid extraction method, nucleic acid extraction kit, and nucleic acid extraction apparatus, each using the same |
CN105263627B (zh) | 2013-01-18 | 2019-05-21 | 生米公司 | 分析设备 |
US9481903B2 (en) | 2013-03-13 | 2016-11-01 | Roche Molecular Systems, Inc. | Systems and methods for detection of cells using engineered transduction particles |
CN105229465A (zh) | 2013-03-15 | 2016-01-06 | 赛拉诺斯股份有限公司 | 用于样品制备的装置、系统和方法 |
US9359632B2 (en) | 2013-03-15 | 2016-06-07 | Theranos, Inc. | Devices, systems and methods for sample preparation |
JP6351702B2 (ja) | 2013-03-15 | 2018-07-04 | ジェンマーク ダイアグノスティクス, インコーポレイテッド | 変形可能流体容器を操作するためのシステム、方法、および装置 |
USD881409S1 (en) | 2013-10-24 | 2020-04-14 | Genmark Diagnostics, Inc. | Biochip cartridge |
US9498778B2 (en) | 2014-11-11 | 2016-11-22 | Genmark Diagnostics, Inc. | Instrument for processing cartridge for performing assays in a closed sample preparation and reaction system |
US9540675B2 (en) * | 2013-10-29 | 2017-01-10 | GeneWeave Biosciences, Inc. | Reagent cartridge and methods for detection of cells |
GB201401584D0 (en) * | 2014-01-29 | 2014-03-19 | Bg Res Ltd | Intelligent detection of biological entities |
US10195610B2 (en) | 2014-03-10 | 2019-02-05 | Click Diagnostics, Inc. | Cartridge-based thermocycler |
CN204727866U (zh) * | 2014-03-31 | 2015-10-28 | 博奥生物集团有限公司 | 一种集核酸扩增和微阵列检测于一体的微流控装置 |
US9827567B2 (en) | 2014-04-22 | 2017-11-28 | Nanosphere, Inc. | Diagnostic cartridges having flexible seals |
EP3134553B1 (en) | 2014-04-24 | 2019-08-21 | Lucira Health, Inc. | Colorimetric detection of nucleic acid amplification |
JP6602796B2 (ja) | 2014-06-16 | 2019-11-06 | ライフ テクノロジーズ コーポレーション | 試薬混合器及び流体制御機器 |
EP3207472B1 (en) * | 2014-10-16 | 2024-11-27 | Cepheid | Biosecurity screening system and method |
US10005080B2 (en) | 2014-11-11 | 2018-06-26 | Genmark Diagnostics, Inc. | Instrument and cartridge for performing assays in a closed sample preparation and reaction system employing electrowetting fluid manipulation |
US9598722B2 (en) | 2014-11-11 | 2017-03-21 | Genmark Diagnostics, Inc. | Cartridge for performing assays in a closed sample preparation and reaction system |
WO2016109691A1 (en) | 2014-12-31 | 2016-07-07 | Boris Andreyev | Devices and methods for molecular diagnostic testing |
WO2016197123A2 (en) * | 2015-06-05 | 2016-12-08 | Douglas Scientific, LLC | Sample processing devices, and methods of use thereof |
US11260386B2 (en) * | 2015-06-05 | 2022-03-01 | The Emerther Company | Component of a device, a device, and a method for purifying and testing biomolecules from biological samples |
JP6925986B2 (ja) * | 2015-07-13 | 2021-08-25 | フィリップ・モーリス・プロダクツ・ソシエテ・アノニム | エアロゾル形成組成物の製造 |
US9568429B1 (en) * | 2015-07-25 | 2017-02-14 | Stem Arts Projects, Llc | Wavelength scanning apparatus and method of use thereof |
US10351893B2 (en) | 2015-10-05 | 2019-07-16 | GeneWeave Biosciences, Inc. | Reagent cartridge for detection of cells |
US9513220B1 (en) | 2015-12-29 | 2016-12-06 | International Business Machines Corporation | On-chip molecule fluorescence detection |
WO2017123970A1 (en) | 2016-01-13 | 2017-07-20 | ProteinSimple | Systems and methods for capillary electrophoresis, isoelectric point, and molecular weight analysis |
CA3214851A1 (en) | 2016-03-14 | 2017-09-21 | Lucira Health, Inc. | Devices and methods for biological assay sample preparation and delivery |
JP6891191B2 (ja) | 2016-03-14 | 2021-06-18 | ルシラ ヘルス インコーポレイテッド | 光学的性質を改変するための装置および方法 |
EP4477316A3 (en) | 2016-03-14 | 2025-02-19 | Pfizer Inc. | Selectively vented biological assay devices and associated methods |
CA3240706A1 (en) | 2016-03-14 | 2017-09-21 | Pfizer Inc. | Systems and methods for performing biological assays |
US20200408687A1 (en) * | 2016-03-25 | 2020-12-31 | The General Hospital Corporation | Polarization-Based Fluorescent Nucleic Acid Detection |
JP6982338B2 (ja) * | 2016-04-20 | 2021-12-17 | Blue Industries株式会社 | 遺伝子解析用前処理キット、核酸分析用チップ、解析システム、生体物質分析用チップ |
WO2017185067A1 (en) | 2016-04-22 | 2017-10-26 | Click Diagnostics, Inc. | Printed circuit board heater for an amplification module |
WO2017197040A1 (en) | 2016-05-11 | 2017-11-16 | Click Diagnostics, Inc. | Devices and methods for nucleic acid extraction |
JP2017225366A (ja) * | 2016-06-21 | 2017-12-28 | 大研医器株式会社 | 遺伝子検査装置 |
USD800331S1 (en) | 2016-06-29 | 2017-10-17 | Click Diagnostics, Inc. | Molecular diagnostic device |
EP3478857A1 (en) | 2016-06-29 | 2019-05-08 | Click Diagnostics, Inc. | Devices and methods for the detection of molecules using a flow cell |
USD800914S1 (en) | 2016-06-30 | 2017-10-24 | Click Diagnostics, Inc. | Status indicator for molecular diagnostic device |
USD800913S1 (en) | 2016-06-30 | 2017-10-24 | Click Diagnostics, Inc. | Detection window for molecular diagnostic device |
US11156298B2 (en) | 2016-08-11 | 2021-10-26 | Pall Corporation | Front-loading valve assembly for manifold for processing fluid sample |
CN107964507B (zh) | 2016-10-18 | 2022-09-27 | 财团法人工业技术研究院 | 热对流聚合酶连锁反应装置及其光学检测方法 |
NL2017705B1 (en) | 2016-11-02 | 2018-05-18 | Lumicks Tech B V | Method and system for studying biological cells |
PL235210B1 (pl) | 2016-12-21 | 2020-06-15 | Genomtec Spolka Akcyjna | Sposób detekcji materiału genetycznego w próbce biologicznej oraz urządzenie do jego realizacji |
GB201704747D0 (en) | 2017-01-05 | 2017-05-10 | Illumina Inc | Reagent mixing system and methods |
US10471425B2 (en) * | 2017-02-16 | 2019-11-12 | International Business Machines Corporation | Automated machine for sorting of biological fluids |
US11080848B2 (en) | 2017-04-06 | 2021-08-03 | Lucira Health, Inc. | Image-based disease diagnostics using a mobile device |
CN110573884B (zh) * | 2017-04-28 | 2023-04-28 | 以兹迪亚技术公司 | 使用大磁性颗粒复合物的自动免疫分析装置和方法 |
US11077444B2 (en) | 2017-05-23 | 2021-08-03 | Roche Molecular Systems, Inc. | Packaging for a molecular diagnostic cartridge |
DE102017005835B4 (de) * | 2017-06-20 | 2020-04-02 | Diehl Metering Gmbh | Vorrichtung zur mobilen Bestimmung einer Eigenschaft einer flüssigen, festen oder gasförmigen Probe |
AU2018319625B2 (en) * | 2017-08-24 | 2023-02-16 | Innatoss Laboratories B.V. | Liquid handling system and method |
US10549275B2 (en) | 2017-09-14 | 2020-02-04 | Lucira Health, Inc. | Multiplexed biological assay device with electronic readout |
CN111344552B (zh) | 2017-09-14 | 2021-10-08 | 卢西拉健康公司 | 具有电子读出的复用生物测定装置 |
CN111356768A (zh) * | 2017-09-15 | 2020-06-30 | 生米公司 | 用于自动化样品处理的方法和系统 |
CN107523487B (zh) * | 2017-09-18 | 2024-03-19 | 星源智(珠海)生物科技有限公司 | 一种集成化管状反应装置 |
CN116785253A (zh) * | 2017-09-29 | 2023-09-22 | 加利福尼亚大学董事会 | 单分散乳液的制备方法 |
WO2019094784A1 (en) | 2017-11-09 | 2019-05-16 | Click Diagnostics, Inc. | Portable molecular diagnostic device and methods for the detection of target viruses |
CN111712581A (zh) | 2017-12-15 | 2020-09-25 | 生米公司 | 用于分析样品的便携式装置和方法 |
CN107868752B (zh) * | 2017-12-19 | 2024-01-05 | 广东顺德墨赛生物科技有限公司 | 夹具 |
GB2572408B8 (en) * | 2018-03-29 | 2022-06-22 | Univ Heriot Watt | Fluidic device |
CN108456640A (zh) * | 2018-05-24 | 2018-08-28 | 南京岚煜生物科技有限公司 | 用于全自动核酸提取扩增诊断一体机的pcr模块 |
CN110699432A (zh) * | 2018-07-10 | 2020-01-17 | Tdk株式会社 | 采用恒温扩增技术检测核酸的装置与方法 |
US11459604B2 (en) | 2018-07-12 | 2022-10-04 | Luminex Corporation | Systems and methods for performing variable sample preparation and analysis processes |
CN108795699B (zh) * | 2018-07-19 | 2023-12-26 | 嘉兴医脉赛科技有限公司 | 封闭式磁珠纯化仪 |
US12163918B1 (en) | 2018-08-23 | 2024-12-10 | ProteinSimple | Compositions and methods for protein electrophoresis |
CN108865658B (zh) * | 2018-08-27 | 2023-12-08 | 苏州绘真医学检验有限公司 | 一种管式血浆游离核酸提取方法及系统 |
AU2019337088A1 (en) | 2018-09-03 | 2021-05-06 | Visby Medical, Inc. | Devices and methods for antibiotic susceptibility testing |
CN109030368B (zh) * | 2018-09-08 | 2023-06-23 | 重庆科技学院 | 一种与比色皿联用的微流控芯片使用方法 |
KR101996617B1 (ko) * | 2018-10-11 | 2019-07-04 | 주식회사 엘지화학 | 일체형 카트리지 |
DE102018130082B4 (de) * | 2018-11-28 | 2024-04-18 | Bundesrepublik Deutschland, vertreten durch das Bundesministerium für Gesundheit, dieses vertreten durch das Robert-Koch-Institut, vertreten durch seinen Präsidenten | Probenreaktionsgefäß und dessen Verwendung |
USD910200S1 (en) | 2018-12-21 | 2021-02-09 | Lucira Health, Inc. | Test tube |
EP3942281A4 (en) | 2019-03-21 | 2022-11-16 | Biomeme, Inc. | MULTIFUNCTIONAL ANALYTICAL DEVICES |
KR102281116B1 (ko) * | 2019-06-28 | 2021-07-27 | 주식회사 엘지화학 | 일체형 카트리지 |
CN112301097B (zh) * | 2019-07-26 | 2022-10-21 | 申翌生物科技(杭州)有限公司 | 样本裂解和pcr反应组合物 |
EP3995563A4 (en) * | 2019-07-01 | 2022-10-05 | Shenyi Biotech (Hangzhou) Co., Ltd. | NEW METHOD FOR PERFORMING A PCR REACTION USING A COMPLETE PCR REACTION SYSTEM |
WO2021101334A1 (en) * | 2019-11-22 | 2021-05-27 | Seegene, Inc. | Sample holder transferring apparatus used for thermal cycler |
KR102440141B1 (ko) * | 2019-12-31 | 2022-09-05 | 프리시젼바이오 주식회사 | 체외 진단용 시료 용액 가열 장치 |
EP4085149A4 (en) | 2020-01-03 | 2024-03-06 | Visby Medical, Inc. | Devices and methods for antibiotic susceptibility testing |
CN111235639B (zh) * | 2020-03-06 | 2021-04-20 | 通用生物系统(安徽)有限公司 | 一种噬菌体抗体洗脱装置 |
USD953561S1 (en) | 2020-05-05 | 2022-05-31 | Lucira Health, Inc. | Diagnostic device with LED display |
USD962470S1 (en) | 2020-06-03 | 2022-08-30 | Lucira Health, Inc. | Assay device with LCD display |
EP4213989A4 (en) | 2020-09-18 | 2025-01-15 | Biomeme Inc | PORTABLE DEVICES AND METHODS FOR SAMPLE ANALYSIS |
CN112322473B (zh) * | 2020-11-11 | 2021-07-20 | 苏州雅睿生物技术有限公司 | 一步法poct即时核酸检测装置 |
US20230398534A1 (en) * | 2020-11-19 | 2023-12-14 | Qstag Co., Ltd. | Diagnostic cartridge capable of automatic solution supply and multiple detection |
KR102568065B1 (ko) * | 2020-11-19 | 2023-08-18 | 주식회사 큐에스택 | 자동 용액 공급 진단 스트립 |
KR102591005B1 (ko) * | 2020-11-19 | 2023-10-18 | 주식회사 큐에스택 | 용액 공급장치를 이용한 진단 스트립 |
CN112844151B (zh) * | 2020-11-26 | 2022-12-20 | 上海金诺奥美生物科技有限公司 | 一种核酸提取设备及基于偏心振荡的混匀装置 |
CN114965263A (zh) * | 2021-02-24 | 2022-08-30 | 上海思路迪生物医学科技有限公司 | 一种集成式qpcr荧光检测系统及方法 |
KR102629738B1 (ko) * | 2021-08-12 | 2024-01-29 | 퓨쳐이엔지 주식회사 | 벌크로 시약 분주되는 핵산추출장치 |
USD1055307S1 (en) | 2021-08-13 | 2024-12-24 | Visby Medical, Inc. | Molecular diagnostic device |
KR102653571B1 (ko) * | 2021-12-20 | 2024-04-02 | 주식회사 큐에스택 | 진단 스트립 |
CN115678764B (zh) * | 2022-11-07 | 2023-09-08 | 苏州思迈德生物科技有限公司 | 一种快速分子诊断的微流控芯片 |
KR102759203B1 (ko) * | 2023-10-26 | 2025-01-24 | 김현철 | 핵산의 추출 및 증폭장치 |
Family Cites Families (230)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2940448A (en) | 1957-04-29 | 1960-06-14 | Jr Norman B Furlong | Disposable blood-gas analyzer |
SE327840B (zh) | 1968-01-25 | 1970-08-31 | Atuokemi Ab | |
US3802782A (en) | 1970-08-19 | 1974-04-09 | Rohe Scientific Corp | Chemical analyzer performing sequential analysis of samples |
US4004150A (en) | 1975-05-01 | 1977-01-18 | Samuel Natelson | Analytical multiple component readout system |
FR2368709A1 (fr) | 1976-10-19 | 1978-05-19 | Pasteur Institut | Photometre automatique |
US4201578A (en) * | 1977-11-03 | 1980-05-06 | Eastman Kodak Company | Blocked competing developers for color transfer |
US4448534A (en) | 1978-03-30 | 1984-05-15 | American Hospital Corporation | Antibiotic susceptibility testing |
FI63296C (fi) | 1980-07-11 | 1983-05-10 | Eflab Oy | Fotometer |
JPS5848836A (ja) | 1981-09-18 | 1983-03-22 | Toa Medical Electronics Co Ltd | 光学式自動分析測定装置 |
US4626684A (en) | 1983-07-13 | 1986-12-02 | Landa Isaac J | Rapid and automatic fluorescence immunoassay analyzer for multiple micro-samples |
US5500188A (en) | 1984-03-01 | 1996-03-19 | Molecular Devices Corporation | Device for photoresponsive detection and discrimination |
DE3441179C2 (de) | 1984-11-10 | 1987-02-26 | Dynatech Deutschland GmbH, 7306 Denkendorf | Temperiereinrichtung für Mikro-Küvettenanordnungen, insbesondere für Mikrotitrationsplatten |
US5333675C1 (en) | 1986-02-25 | 2001-05-01 | Perkin Elmer Corp | Apparatus and method for performing automated amplification of nucleic acid sequences and assays using heating and cooling steps |
US5656493A (en) | 1985-03-28 | 1997-08-12 | The Perkin-Elmer Corporation | System for automated performance of the polymerase chain reaction |
GB8607975D0 (en) | 1986-04-01 | 1986-05-08 | Fisons Plc | Devices |
US6645758B1 (en) | 1989-02-03 | 2003-11-11 | Johnson & Johnson Clinical Diagnostics, Inc. | Containment cuvette for PCR and method of use |
US5229297A (en) | 1989-02-03 | 1993-07-20 | Eastman Kodak Company | Containment cuvette for PCR and method of use |
DK374889D0 (da) | 1989-07-28 | 1989-07-28 | Koege Kemisk Vaerk | Fremgangsmaade til procesovervaagning |
JPH06100538B2 (ja) | 1989-08-02 | 1994-12-12 | 株式会社日立製作所 | 原子吸光分光光度計 |
US5283624A (en) | 1989-10-18 | 1994-02-01 | Hitachi, Ltd. | Multi-element simultaneous analysis atomic absorption spectroscopy photometer and multi-element simultaneous analytic method |
ES2141088T3 (es) | 1990-02-16 | 2000-03-16 | Hoffmann La Roche | Mejoras en la especificidad y conveniencia de la reaccion en cadena de la polimerasa. |
US5073029A (en) | 1990-02-16 | 1991-12-17 | Eqm Research, Inc. | Multisource device for photometric analysis and associated chromogens |
US5139745A (en) | 1990-03-30 | 1992-08-18 | Block Medical, Inc. | Luminometer |
JPH0678978B2 (ja) | 1990-05-25 | 1994-10-05 | スズキ株式会社 | 凝集パターン検出装置 |
US6787338B2 (en) | 1990-06-04 | 2004-09-07 | The University Of Utah | Method for rapid thermal cycling of biological samples |
US5935522A (en) | 1990-06-04 | 1999-08-10 | University Of Utah Research Foundation | On-line DNA analysis system with rapid thermal cycling |
US5541072A (en) | 1994-04-18 | 1996-07-30 | Immunivest Corporation | Method for magnetic separation featuring magnetic particles in a multi-phase system |
US5188455A (en) | 1990-11-13 | 1993-02-23 | The Pennsylvania Research Corporation | Apparatus for remote mixing of fluids |
KR100236506B1 (ko) | 1990-11-29 | 2000-01-15 | 퍼킨-엘머시터스인스트루먼츠 | 폴리머라제 연쇄 반응 수행 장치 |
US5242837A (en) | 1990-12-24 | 1993-09-07 | Slovacek Rudolf E | Method for the rapid detection of analytes involving specific binding reactions and the use of light attenuating magnetic particles |
US5994056A (en) | 1991-05-02 | 1999-11-30 | Roche Molecular Systems, Inc. | Homogeneous methods for nucleic acid amplification and detection |
CA2069537A1 (en) | 1991-06-07 | 1992-12-08 | Thomas A. Cook | Multiple output referencing system for evanescent wave sensor |
DE4123817C2 (de) | 1991-07-18 | 1994-06-09 | Berthold Lab Prof Dr | Strahlungsmeßgerät, insbesondere zur Messung der Lumineszenz |
JPH05157684A (ja) | 1991-12-02 | 1993-06-25 | Seikagaku Kogyo Co Ltd | 吸光光度計 |
US5348853A (en) | 1991-12-16 | 1994-09-20 | Biotronics Corporation | Method for reducing non-specific priming in DNA amplification |
US5242660A (en) | 1992-02-28 | 1993-09-07 | Paul Hsei | Sample preparation device |
EP1130117A3 (en) | 1992-04-06 | 2003-12-03 | Abbott Laboratories | Method and device for detection of nucleic acid using total internal reflectance |
US5639423A (en) | 1992-08-31 | 1997-06-17 | The Regents Of The University Of Calfornia | Microfabricated reactor |
US5897783A (en) | 1992-09-24 | 1999-04-27 | Amersham International Plc | Magnetic separation method |
US5538849A (en) | 1992-12-29 | 1996-07-23 | Toyo Boseki Kabushiki Kaisha | Apparatus for automated assay of DNA probe and method for assaying nucleic acid in sample |
IL108497A0 (en) | 1993-02-01 | 1994-05-30 | Seq Ltd | Methods and apparatus for dna sequencing |
US5494646A (en) | 1993-04-14 | 1996-02-27 | Seymour; Eugene H. | Sampling device and sample adequacy system |
US5861124A (en) | 1993-07-15 | 1999-01-19 | Hamamatsu Photonics Kk | Method and apparatus for detecting denaturation of nucleic acid |
GB9314991D0 (en) | 1993-07-20 | 1993-09-01 | Sandoz Ltd | Mechanical device |
ATE208658T1 (de) | 1993-07-28 | 2001-11-15 | Pe Corp Ny | Vorrichtung und verfahren zur nukleinsäurevervielfältigung |
US5436718A (en) | 1993-07-30 | 1995-07-25 | Biolumin Corporation | Mutli-functional photometer with movable linkage for routing optical fibers |
US5397709A (en) | 1993-08-27 | 1995-03-14 | Becton Dickinson And Company | System for detecting bacterial growth in a plurality of culture vials |
JP3326708B2 (ja) | 1993-08-31 | 2002-09-24 | 日水製薬株式会社 | 光学的測定装置およびその方法 |
CA2130013C (en) | 1993-09-10 | 1999-03-30 | Rolf Moser | Apparatus for automatic performance of temperature cycles |
US5525300A (en) | 1993-10-20 | 1996-06-11 | Stratagene | Thermal cycler including a temperature gradient block |
US5415839A (en) | 1993-10-21 | 1995-05-16 | Abbott Laboratories | Apparatus and method for amplifying and detecting target nucleic acids |
US5645801A (en) | 1993-10-21 | 1997-07-08 | Abbott Laboratories | Device and method for amplifying and detecting target nucleic acids |
US5503805A (en) | 1993-11-02 | 1996-04-02 | Affymax Technologies N.V. | Apparatus and method for parallel coupling reactions |
US5580523A (en) | 1994-04-01 | 1996-12-03 | Bard; Allen J. | Integrated chemical synthesizers |
ATE198511T1 (de) | 1994-04-29 | 2001-01-15 | Perkin Elmer Corp | Verfahren und vorrichtung zur echtzeiterfassung der produkte von nukleinsäureamplifikation |
SE9401594D0 (sv) | 1994-05-06 | 1994-05-06 | Pharmacia Lkb Biotech | Method of nucleic acid transfer |
US5511558A (en) | 1994-06-06 | 1996-04-30 | Becton, Dickinson And Company | Blood collection assembly having additive dispensing means and method for sample collection using same |
US5976896A (en) | 1994-06-06 | 1999-11-02 | Idexx Laboratories, Inc. | Immunoassays in capillary tubes |
DE4420732A1 (de) | 1994-06-15 | 1995-12-21 | Boehringer Mannheim Gmbh | Vorrichtung zur Behandlung von Nukleinsäuren aus einer Probe |
US5837144A (en) | 1994-06-16 | 1998-11-17 | Boehringer Mannheim Gmbh | Method of magnetically separating liquid components |
US5508197A (en) | 1994-07-25 | 1996-04-16 | The Regents, University Of California | High-speed thermal cycling system and method of use |
US5627041A (en) | 1994-09-02 | 1997-05-06 | Biometric Imaging, Inc. | Disposable cartridge for an assay of a biological sample |
US5705628A (en) | 1994-09-20 | 1998-01-06 | Whitehead Institute For Biomedical Research | DNA purification and isolation using magnetic particles |
US5576197A (en) | 1995-04-07 | 1996-11-19 | Molecular Bio-Products | Polymerase chain reaction container and methods of using the same |
US5578818A (en) | 1995-05-10 | 1996-11-26 | Molecular Dynamics | LED point scanning system |
US5589136A (en) | 1995-06-20 | 1996-12-31 | Regents Of The University Of California | Silicon-based sleeve devices for chemical reactions |
US6143247A (en) | 1996-12-20 | 2000-11-07 | Gamera Bioscience Inc. | Affinity binding-based system for detecting particulates in a fluid |
US20020022261A1 (en) | 1995-06-29 | 2002-02-21 | Anderson Rolfe C. | Miniaturized genetic analysis systems and methods |
US5856174A (en) * | 1995-06-29 | 1999-01-05 | Affymetrix, Inc. | Integrated nucleic acid diagnostic device |
US5686300A (en) | 1995-09-11 | 1997-11-11 | Becton Dickinson And Company | Fluorescence detector |
US5639668A (en) | 1995-09-14 | 1997-06-17 | Boehringer Mannheim Corporation | Optical apparatus for performing an immunoassay |
US6004512A (en) | 1995-12-08 | 1999-12-21 | Mj Research | Sample cartridge slide block |
US5657118A (en) | 1996-01-23 | 1997-08-12 | Lee; John T. S. | Device and method for detection/measurement of light |
US5661301A (en) | 1996-02-07 | 1997-08-26 | The Penn State Research Foundation | Spectroscopy and mapping of atoms, molecules and surface features via difference frequency generation with a scanning tunneling microscope or related instruments |
US5863801A (en) | 1996-06-14 | 1999-01-26 | Sarnoff Corporation | Automated nucleic acid isolation |
US6074827A (en) | 1996-07-30 | 2000-06-13 | Aclara Biosciences, Inc. | Microfluidic method for nucleic acid purification and processing |
US5882903A (en) | 1996-11-01 | 1999-03-16 | Sarnoff Corporation | Assay system and method for conducting assays |
US5825478A (en) | 1996-11-15 | 1998-10-20 | Wilcox; Steven | Multifunctional photometer apparatus |
US6027945A (en) | 1997-01-21 | 2000-02-22 | Promega Corporation | Methods of isolating biological target materials using silica magnetic particles |
DE19707226A1 (de) | 1997-02-24 | 1998-08-27 | Bodenseewerk Perkin Elmer Co | Lichtabtastvorrichtung |
WO1998038487A2 (en) | 1997-02-28 | 1998-09-03 | Cepheid | Heat exchanging, optically interrogated chemical reaction assembly |
US6074868A (en) | 1997-03-03 | 2000-06-13 | Regents Of The University Of Minnesota | Alumina plate method and device for controlling temperature |
US6143496A (en) | 1997-04-17 | 2000-11-07 | Cytonix Corporation | Method of sampling, amplifying and quantifying segment of nucleic acid, polymerase chain reaction assembly having nanoliter-sized sample chambers, and method of filling assembly |
US6429007B1 (en) | 1997-05-02 | 2002-08-06 | BIOMéRIEUX, INC. | Nucleic acid amplification reaction station for disposable test devices |
US5989499A (en) | 1997-05-02 | 1999-11-23 | Biomerieux, Inc. | Dual chamber disposable reaction vessel for amplification reactions |
US5904899A (en) | 1997-05-15 | 1999-05-18 | Tosoh Corporation | Assaying apparatus and a vessel holder device in use with the assaying apparatus |
WO1998053301A2 (en) | 1997-05-23 | 1998-11-26 | Becton Dickinson And Company | Automated microbiological testing apparatus and methods therefor |
SE9702005D0 (sv) * | 1997-05-28 | 1997-05-28 | Alphahelix Ab | New reaction vessel and method for its use |
US6071748A (en) | 1997-07-16 | 2000-06-06 | Ljl Biosystems, Inc. | Light detection device |
US6043506A (en) | 1997-08-13 | 2000-03-28 | Bio-Rad Laboratories, Inc. | Multi parameter scanner |
US6061128A (en) | 1997-09-04 | 2000-05-09 | Avocet Medical, Inc. | Verification device for optical clinical assay systems |
US6597450B1 (en) | 1997-09-15 | 2003-07-22 | Becton, Dickinson And Company | Automated Optical Reader for Nucleic Acid Assays |
US6222619B1 (en) | 1997-09-18 | 2001-04-24 | University Of Utah Research Foundation | Diagnostic device and method |
US6982431B2 (en) | 1998-08-31 | 2006-01-03 | Molecular Devices Corporation | Sample analysis systems |
US6297018B1 (en) | 1998-04-17 | 2001-10-02 | Ljl Biosystems, Inc. | Methods and apparatus for detecting nucleic acid polymorphisms |
ATE400358T1 (de) | 1997-12-24 | 2008-07-15 | Cepheid | Vorrichtung und verfahren zur lyse |
US6050719A (en) | 1998-01-30 | 2000-04-18 | Affymetrix, Inc. | Rotational mixing method using a cartridge having a narrow interior |
JP3551293B2 (ja) | 1998-02-02 | 2004-08-04 | 東洋紡績株式会社 | 核酸抽出装置 |
FI102906B1 (fi) | 1998-02-23 | 1999-03-15 | Bio Nobile Oy | Menetelmä ja väline aineen siirtämiseksi |
US6369893B1 (en) | 1998-05-19 | 2002-04-09 | Cepheid | Multi-channel optical detection system |
JP3813730B2 (ja) | 1998-03-19 | 2006-08-23 | 浜松ホトニクス株式会社 | 蛍光測定装置 |
US7078224B1 (en) | 1999-05-14 | 2006-07-18 | Promega Corporation | Cell concentration and lysate clearance using paramagnetic particles |
US6057163A (en) | 1998-04-28 | 2000-05-02 | Turner Designs | Luminescence and fluorescence quantitation system |
ATE423622T1 (de) | 1998-05-01 | 2009-03-15 | Gen Probe Inc | Automatisches isolierungs- und amplifizierungsverfahren für eine zielnukleinsäuresequenz |
US7498164B2 (en) | 1998-05-16 | 2009-03-03 | Applied Biosystems, Llc | Instrument for monitoring nucleic acid sequence amplification reaction |
US6818437B1 (en) | 1998-05-16 | 2004-11-16 | Applera Corporation | Instrument for monitoring polymerase chain reaction of DNA |
CA2320296A1 (en) | 1998-05-18 | 1999-11-25 | University Of Washington | Liquid analysis cartridge |
US6232608B1 (en) | 1998-08-18 | 2001-05-15 | Molecular Devices Corporation | Optimization systems in a scanning fluorometer |
US6492162B1 (en) | 1998-10-27 | 2002-12-10 | Hitachi, Ltd. | Apparatus for the recovery of nucleic acids |
US6569631B1 (en) | 1998-11-12 | 2003-05-27 | 3-Dimensional Pharmaceuticals, Inc. | Microplate thermal shift assay for ligand development using 5-(4″dimethylaminophenyl)-2-(4′-phenyl)oxazole derivative fluorescent dyes |
US6431476B1 (en) | 1999-12-21 | 2002-08-13 | Cepheid | Apparatus and method for rapid ultrasonic disruption of cells or viruses |
US6838680B2 (en) | 1999-05-12 | 2005-01-04 | Aclara Biosciences, Inc. | Multiplexed fluorescent detection in microfluidic devices |
US7423750B2 (en) | 2001-11-29 | 2008-09-09 | Applera Corporation | Configurations, systems, and methods for optical scanning with at least one first relative angular motion and at least one second angular motion or at least one linear motion |
US7387891B2 (en) | 1999-05-17 | 2008-06-17 | Applera Corporation | Optical instrument including excitation source |
US6818185B1 (en) | 1999-05-28 | 2004-11-16 | Cepheid | Cartridge for conducting a chemical reaction |
JP4495866B2 (ja) * | 1999-05-28 | 2010-07-07 | セフィード | 化学反応を制御するためのカートリッジ |
DE60022025T2 (de) * | 1999-05-28 | 2006-06-29 | Cepheid, Sunnyvale | Anlage zum brechen von zellen |
US8815521B2 (en) | 2000-05-30 | 2014-08-26 | Cepheid | Apparatus and method for cell disruption |
US20040200909A1 (en) * | 1999-05-28 | 2004-10-14 | Cepheid | Apparatus and method for cell disruption |
US6706519B1 (en) | 1999-06-22 | 2004-03-16 | Tecan Trading Ag | Devices and methods for the performance of miniaturized in vitro amplification assays |
US6353475B1 (en) | 1999-07-12 | 2002-03-05 | Caliper Technologies Corp. | Light source power modulation for use with chemical and biochemical analysis |
ES2315238T3 (es) | 1999-07-19 | 2009-04-01 | Biomerieux B.V. | Metodo para mezclar particulas magneticas con un fluido. |
US6657169B2 (en) | 1999-07-30 | 2003-12-02 | Stratagene | Apparatus for thermally cycling samples of biological material with substantial temperature uniformity |
US7708945B1 (en) | 1999-08-13 | 2010-05-04 | Bayer Technology Services Gmbh | Device and method for determining multiple analytes |
JP4045475B2 (ja) | 1999-09-06 | 2008-02-13 | 東洋紡績株式会社 | 核酸・蛋白質精製装置 |
JP3551860B2 (ja) | 1999-10-05 | 2004-08-11 | 株式会社日立製作所 | Dna検査方法及びdna検査装置 |
US6699713B2 (en) | 2000-01-04 | 2004-03-02 | The Regents Of The University Of California | Polymerase chain reaction system |
US6358387B1 (en) | 2000-03-27 | 2002-03-19 | Caliper Technologies Corporation | Ultra high throughput microfluidic analytical systems and methods |
US6783934B1 (en) | 2000-05-01 | 2004-08-31 | Cepheid, Inc. | Methods for quantitative analysis of nucleic acid amplification reaction |
GB0010910D0 (en) | 2000-05-05 | 2000-06-28 | Jones Osborn | Analytical method and apparatus |
US6690467B1 (en) | 2000-05-05 | 2004-02-10 | Pe Corporation | Optical system and method for optically analyzing light from a sample |
US6672458B2 (en) | 2000-05-19 | 2004-01-06 | Becton, Dickinson And Company | System and method for manipulating magnetically responsive particles fluid samples to collect DNA or RNA from a sample |
US6520197B2 (en) | 2000-06-02 | 2003-02-18 | The Regents Of The University Of California | Continuous laminar fluid mixing in micro-electromechanical systems |
US6511277B1 (en) | 2000-07-10 | 2003-01-28 | Affymetrix, Inc. | Cartridge loader and methods |
US7027683B2 (en) | 2000-08-15 | 2006-04-11 | Nanostream, Inc. | Optical devices with fluidic systems |
US6545758B1 (en) | 2000-08-17 | 2003-04-08 | Perry Sandstrom | Microarray detector and synthesizer |
US8048386B2 (en) | 2002-02-25 | 2011-11-01 | Cepheid | Fluid processing and control |
US7142296B2 (en) | 2000-10-30 | 2006-11-28 | Sru Biosystems, Inc. | Method and apparatus for detecting biomolecular interactions |
US8097471B2 (en) | 2000-11-10 | 2012-01-17 | 3M Innovative Properties Company | Sample processing devices |
DK1354192T3 (da) * | 2001-01-26 | 2011-12-12 | Qiagen Sciences Llc | Flerkanalkasette til bioseparation |
US6576459B2 (en) | 2001-03-23 | 2003-06-10 | The Regents Of The University Of California | Sample preparation and detection device for infectious agents |
GB0110476D0 (en) | 2001-04-30 | 2001-06-20 | Secr Defence | Reagent delivery system |
US6955589B2 (en) | 2001-05-22 | 2005-10-18 | Qed Technologies, Inc. | Delivery system for magnetorheological fluid |
WO2003002959A1 (en) | 2001-06-15 | 2003-01-09 | Mj Research, Inc. | Controller for a fluorometer |
US20030073110A1 (en) | 2001-07-03 | 2003-04-17 | Masaharu Aritomi | Method for isolating nucleic acid and a cartridge for chemical reaction and for nucleic acid isolation |
EP1419374A2 (de) | 2001-08-21 | 2004-05-19 | Bestmann, Lukas | Thermo-optisches analysesystem für biochemische reaktionen |
JP4558995B2 (ja) | 2001-09-12 | 2010-10-06 | ベックマン コールター, インコーポレイテッド | 移送ユニットおよびその移送ユニットを備える自動分析装置 |
JP5193408B2 (ja) | 2001-09-13 | 2013-05-08 | ベックマン コールター, インコーポレイテッド | 自動分析装置 |
US7459302B2 (en) | 2001-10-02 | 2008-12-02 | Stratagene California | Side-wall heater for thermocycler device |
US6739531B2 (en) | 2001-10-04 | 2004-05-25 | Cepheid | Apparatus and method for rapid disruption of cells or viruses |
US7344894B2 (en) | 2001-10-16 | 2008-03-18 | Agilent Technologies, Inc. | Thermal regulation of fluidic samples within a diagnostic cartridge |
IL161395A0 (en) | 2001-10-19 | 2004-09-27 | Monogen Inc | Filtration system and method for obtaining a cytology layer |
KR100445560B1 (ko) | 2001-10-31 | 2004-08-21 | (주)바이오넥스 | 핵산 또는 생물학적 물질을 분리하기 위한 키트의 제조방법과, 그 방법에 의해 제조된 키트와, 그 키트를사용하는 장치 |
JP2003139783A (ja) * | 2001-11-01 | 2003-05-14 | Fuji Photo Film Co Ltd | 生化学解析システムおよびそれに用いる生化学解析用ユニットハンドリングデバイス |
IL146404A0 (en) | 2001-11-08 | 2002-07-25 | E Afikin Computerized Dairy Ma | Spectroscopic fluid analyzer |
JP2005511066A (ja) | 2001-12-07 | 2005-04-28 | ダイアックス、コープ | 磁気応答性粒子を洗浄する方法及び装置 |
US7622083B2 (en) | 2002-01-28 | 2009-11-24 | Biocal Technology, Inc. | Multi-capillary electrophoresis cartridge interface mechanism |
US7373253B2 (en) | 2002-02-12 | 2008-05-13 | Idaho Technology | Multi-test analysis of real-time nucleic acid amplification |
US20030203491A1 (en) | 2002-04-26 | 2003-10-30 | Andrevski Zygmunt M. | Gravitational flow purification system |
CA2483445C (en) | 2002-04-26 | 2011-04-19 | Abbott Laboratories | Structure and method for handling magnetic particles in biological assays |
AU2003232168A1 (en) | 2002-06-11 | 2003-12-22 | Chempaq A/S | Lysing reagent, cartridge and automatic electronic cell counter for simultaneous enumeration of different types of white blood cells |
US20040126783A1 (en) | 2002-07-10 | 2004-07-01 | Massachusetts Institute Of Technology | Apparatus and method for isolating a nucleic acid from a sample |
WO2004029195A2 (en) | 2002-09-24 | 2004-04-08 | U.S. Government As Represented By The Secretary Of The Army | Portable thermocycler |
US6730883B2 (en) | 2002-10-02 | 2004-05-04 | Stratagene | Flexible heating cover assembly for thermal cycling of samples of biological material |
GB0227765D0 (en) | 2002-11-28 | 2003-01-08 | Secr Defence | Apparatus for processing a fluid sample |
US20060094108A1 (en) | 2002-12-20 | 2006-05-04 | Karl Yoder | Thermal cycler for microfluidic array assays |
EP1608952B1 (en) | 2002-12-20 | 2016-08-10 | Life Technologies Corporation | Assay apparatus and method using microfluidic arrays |
US7584019B2 (en) | 2003-12-15 | 2009-09-01 | Dako Denmark A/S | Systems and methods for the automated pre-treatment and processing of biological samples |
KR100483684B1 (ko) | 2003-01-29 | 2005-04-18 | (주)바이오넥스 | 핵산 또는 다양한 생물학적 물질을 분리 및 정제하기 위한키트와, 이러한 키트를 이용하여 생물학적 물질의 분리또는 정제 작업을 자동화하기 위한 시스템 |
WO2004080597A2 (en) * | 2003-02-05 | 2004-09-23 | Iquum, Inc. | Sample processing tubule |
WO2004087950A2 (en) | 2003-04-04 | 2004-10-14 | Roche Diagnostics Gmbh | Improved system for multi color real time pcr |
KR100528561B1 (ko) | 2003-04-21 | 2005-11-16 | 엘지전자 주식회사 | 전자기력 구동 유량 제어 밸브 및 그의 제조방법과 이를이용한 열 교환 장치 |
DE10319045A1 (de) | 2003-04-25 | 2004-12-09 | november Aktiengesellschaft Gesellschaft für Molekulare Medizin | Vorrichtung und Verfahren zur Aufbereitung Biopolymerhaltiger Flüssigkeiten |
TW579430B (en) | 2003-05-02 | 2004-03-11 | Dr Chip Biotechnology Inc | Automatic micro-fluid hybridization chip platform |
US7148043B2 (en) | 2003-05-08 | 2006-12-12 | Bio-Rad Laboratories, Inc. | Systems and methods for fluorescence detection with a movable detection module |
WO2005010147A2 (en) | 2003-06-13 | 2005-02-03 | The General Hospital Corporation | Device and method for contacting pocoliter volumes of fluids |
US7731906B2 (en) | 2003-07-31 | 2010-06-08 | Handylab, Inc. | Processing particle-containing samples |
EP1510577A1 (en) | 2003-08-29 | 2005-03-02 | Qiagen GmbH | Method for magnetic bead isolation of nucleic acids |
GB0323043D0 (en) | 2003-09-24 | 2003-11-05 | Lux Biotechnology Ltd | Biochip |
US7387485B2 (en) * | 2003-09-29 | 2008-06-17 | Quantum Corporation | Cartridge transport assembly |
US7394547B2 (en) | 2003-11-06 | 2008-07-01 | Fortebio, Inc. | Fiber-optic assay apparatus based on phase-shift interferometry |
WO2005069737A2 (en) | 2004-01-27 | 2005-08-04 | Ramot At Tel Aviv University Ltd. | Method and system for detecting analytes |
US20060257991A1 (en) | 2004-02-27 | 2006-11-16 | Mcdevitt John T | Integration of fluids and reagents into self-contained cartridges containing particle-based sensor elements and membrane-based sensor elements |
US7223949B2 (en) | 2004-04-21 | 2007-05-29 | Beckman Coulter, Inc. | Analysis apparatus having improved temperature control unit |
US20050244837A1 (en) | 2004-04-28 | 2005-11-03 | Cepheid | Method and device for sample preparation control |
ES2572382T3 (es) * | 2004-05-03 | 2016-05-31 | Handylab Inc | Un dispositivo microfluídico para el procesamiento de muestras que contienen polinucleótidos |
US7294466B2 (en) | 2004-05-07 | 2007-11-13 | Cepheid | Multiplexed detection of biological agents |
JP2008505346A (ja) | 2004-06-07 | 2008-02-21 | アイキューム, インク. | サンプルマルチ処理 |
US7585663B2 (en) | 2004-08-26 | 2009-09-08 | Applied Biosystems, Llc | Thermal device, system, and method, for fluid processing device |
KR101214780B1 (ko) | 2004-09-15 | 2012-12-21 | 인터젠엑스 인크. | 미세유동 장치 |
JP4999103B2 (ja) | 2004-10-27 | 2012-08-15 | セフィード | 閉鎖系の多段階核酸増幅反応 |
US20060165558A1 (en) | 2004-12-21 | 2006-07-27 | Thomas Witty | Cartridge for diagnostic assays |
US8883487B2 (en) * | 2004-12-23 | 2014-11-11 | Abbott Point Of Care Inc. | Molecular diagnostics system and methods |
US7699979B2 (en) | 2005-01-07 | 2010-04-20 | Board Of Trustees Of The University Of Arkansas | Separation system and efficient capture of contaminants using magnetic nanoparticles |
WO2006085443A1 (ja) | 2005-02-10 | 2006-08-17 | Matsushita Electric Industrial Co., Ltd. | 流体チップ、それを用いた流体移動制御方法、および化学反応装置 |
US20090215124A1 (en) * | 2005-02-15 | 2009-08-27 | Weidong Cao | Nucleic acid isolation methods and materials and devices thereof |
CA2871777C (en) | 2005-03-10 | 2015-07-28 | Matthew J. Hayes | System and methods for detecting multiple optical signals |
US7507575B2 (en) | 2005-04-01 | 2009-03-24 | 3M Innovative Properties Company | Multiplex fluorescence detection device having removable optical modules |
WO2006122312A2 (en) | 2005-05-11 | 2006-11-16 | The Trustees Of The University Of Pennsylvania | Methods of testing using a microfluidic cassette |
US20070036026A1 (en) | 2005-05-16 | 2007-02-15 | Laibinis Paul E | Magnetic Particle Systems and Methods |
AR054363A1 (es) * | 2005-05-23 | 2007-06-20 | Astrazeneca Ab | Compuestos que exhiben actividad moduladora en el receptor 5-hidroxi-triptamina 6 |
US20070125942A1 (en) | 2005-07-06 | 2007-06-07 | The Regents Of The University Of California | Apparatuses, systems and methods for isolating and separating biological materials |
JP2007043998A (ja) * | 2005-08-11 | 2007-02-22 | Tosoh Corp | 改良されたマイクロ流体チップ |
US20070054293A1 (en) | 2005-08-30 | 2007-03-08 | California Institute Of Technology | Microfluidic chaotic mixing systems and methods |
JP4682008B2 (ja) | 2005-10-04 | 2011-05-11 | キヤノン株式会社 | 生化学処理装置、これに用いる容器および検査装置 |
US7754148B2 (en) | 2006-12-27 | 2010-07-13 | Progentech Limited | Instrument for cassette for sample preparation |
US7727473B2 (en) | 2005-10-19 | 2010-06-01 | Progentech Limited | Cassette for sample preparation |
US8337755B2 (en) | 2006-03-13 | 2012-12-25 | Veridex, Llc | Operator independent programmable sample preparation and analysis system |
US7892493B2 (en) | 2006-05-01 | 2011-02-22 | Koninklijke Philips Electronics N.V. | Fluid sample transport device with reduced dead volume for processing, controlling and/or detecting a fluid sample |
US8232091B2 (en) | 2006-05-17 | 2012-07-31 | California Institute Of Technology | Thermal cycling system |
WO2007139746A1 (en) | 2006-05-22 | 2007-12-06 | Biovest International Inc. | Rotary actuator valve for a cell culture system |
WO2007149696A1 (en) | 2006-06-23 | 2007-12-27 | Applera Corporation | Systems and methods for cooling in biological analysis instruments |
US7888107B2 (en) | 2006-07-24 | 2011-02-15 | Nanosphere, Inc. | System using self-contained processing module for detecting nucleic acids |
GB0618966D0 (en) * | 2006-09-26 | 2006-11-08 | Iti Scotland Ltd | Cartridge system |
WO2008055257A2 (en) | 2006-11-02 | 2008-05-08 | Vectrant Technologies Inc. | Cartridge for conducting diagnostic assays |
EP3604553A3 (en) | 2006-11-03 | 2020-04-29 | Siemens Healthcare Diagnostics Inc. | Random access system for polymerase chain reaction testing |
WO2008101196A1 (en) * | 2007-02-15 | 2008-08-21 | Osmetech Molecular Diagnostics | Fluidics devices |
WO2008109878A2 (en) | 2007-03-07 | 2008-09-12 | California Institute Of Technology | Testing device |
JP2008263959A (ja) | 2007-03-23 | 2008-11-06 | Toshiba Corp | 核酸検出カセット及び核酸検出装置 |
CN101078028B (zh) * | 2007-03-30 | 2011-08-31 | 东华大学 | 一种两次bio-bar-code核酸检测技术 |
WO2009002447A1 (en) | 2007-06-21 | 2008-12-31 | Gen-Probe Incorporated | Instrument and receptacles for use in performing processes |
EP2214824A4 (en) | 2007-11-28 | 2015-08-19 | Smart Tube Inc | DEVICES, SYSTEMS AND METHODS FOR DETECTING, STIMULATING, STABILIZING AND ANALYZING A BIOLOGICAL SAMPLE |
US9409166B2 (en) | 2007-12-10 | 2016-08-09 | The Trustees Of The University Of Pennsylvania | Integrated PCR reactor for cell lysis, nucleic acid isolation and purification, and nucleic acid amplication related applications |
US20090186344A1 (en) | 2008-01-23 | 2009-07-23 | Caliper Life Sciences, Inc. | Devices and methods for detecting and quantitating nucleic acids using size separation of amplicons |
CN102149812A (zh) * | 2008-02-21 | 2011-08-10 | 埃凡特拉生物科技公司 | 基于液体流经阵列的分析 |
EP3453767A1 (en) | 2009-05-14 | 2019-03-13 | Icubate, Inc. | Apparatus for performing amplicon rescue multiplex pcr |
KR20120030130A (ko) | 2009-06-02 | 2012-03-27 | 인터젠엑스 인크. | 다이아프램 밸브를 포함하는 유체 장치 |
CN101586162B (zh) * | 2009-06-10 | 2011-02-09 | 戴立忠 | 一种提取靶核酸并进行pcr扩增检测的方法 |
KR102004319B1 (ko) | 2010-02-23 | 2019-07-26 | 루미넥스 코포레이션 | 일체화된 샘플 제조, 반응 및 검출을 위한 장치 및 방법 |
CN107338189B (zh) | 2011-05-04 | 2021-02-02 | 卢米耐克斯公司 | 用于集成的样品制备、反应和检测的设备与方法 |
-
2011
- 2011-02-23 KR KR1020187021258A patent/KR102004319B1/ko active Active
- 2011-02-23 EP EP22165886.7A patent/EP4043546A1/en not_active Withdrawn
- 2011-02-23 KR KR1020167019724A patent/KR20160088958A/ko not_active Ceased
- 2011-02-23 JP JP2012555102A patent/JP6154137B2/ja not_active Expired - Fee Related
- 2011-02-23 CA CA2977845A patent/CA2977845C/en active Active
- 2011-02-23 KR KR1020127024721A patent/KR101643196B1/ko active Active
- 2011-02-23 BR BR112012021202A patent/BR112012021202B1/pt not_active IP Right Cessation
- 2011-02-23 US US13/033,129 patent/US8372340B2/en not_active Expired - Fee Related
- 2011-02-23 KR KR1020177017626A patent/KR101882940B1/ko active Active
- 2011-02-23 CN CN201180018623.6A patent/CN103221529B/zh not_active Expired - Fee Related
- 2011-02-23 EP EP16194999.5A patent/EP3150690B1/en active Active
- 2011-02-23 EP EP11747970.9A patent/EP2539426B1/en not_active Not-in-force
- 2011-02-23 CA CA2796586A patent/CA2796586C/en active Active
- 2011-02-23 WO PCT/US2011/025871 patent/WO2011106384A1/en active Application Filing
- 2011-02-23 AU AU2011220873A patent/AU2011220873B2/en not_active Ceased
- 2011-02-23 EP EP16194996.1A patent/EP3150689B1/en active Active
- 2011-02-23 CN CN201510346632.8A patent/CN105004596B/zh not_active Expired - Fee Related
- 2011-02-23 CA CA3084515A patent/CA3084515C/en active Active
-
2013
- 2013-02-05 US US13/759,557 patent/US9074250B2/en active Active
-
2014
- 2014-01-10 HK HK14100274.1A patent/HK1187364A1/zh not_active IP Right Cessation
-
2015
- 2015-05-28 US US14/723,586 patent/US9539577B2/en not_active Expired - Fee Related
-
2016
- 2016-03-09 JP JP2016045496A patent/JP6285478B2/ja not_active Expired - Fee Related
- 2016-03-18 HK HK16103176.2A patent/HK1215300A1/zh not_active IP Right Cessation
- 2016-12-01 US US15/366,186 patent/US10040071B2/en active Active
-
2017
- 2017-08-14 JP JP2017156352A patent/JP6576988B2/ja active Active
-
2018
- 2018-07-11 US US16/032,183 patent/US10646875B2/en not_active Expired - Fee Related
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HK1244835A1 (zh) | 用於集成的樣品製備、反應和檢測的設備與方法 | |
HK1215300A1 (zh) | 用於整合的樣品製備、反應和檢測的器械和方法 | |
HK1198705A1 (zh) | 用於檢測分析物的裝置和方法 | |
IL208921A0 (en) | Pointer, position detection apparatus and position detection method | |
HK1243375A1 (zh) | 樣本分析系統 | |
EP2634570A4 (en) | ANALYSIS DEVICE | |
ZA201204038B (en) | Systems and methods for preparing samples for chemical analysis | |
EP2631336A4 (en) | DNA LIBRARY AND METHOD FOR PREPARING THE SAME, METHOD AND DEVICE FOR DETECTING SNP | |
GB2483077A8 (en) | Sample testing apparatus and method | |
IL221375A0 (en) | Assay card for sample acquisition, treatment and reaction | |
HK1179493A1 (zh) | 測試分析物的方法和系統 | |
IL220583A0 (en) | Apparatus for detecting chemical substances | |
PL2630466T3 (pl) | Urządzenie do pobierania próbki i sposób pobierania próbki | |
EP2727647A4 (en) | CHEMICAL REACTION DEVICE AND CHEMICAL REACTION PROCESS | |
EP2818866A4 (en) | NOVEL METHOD FOR THE ANTIGEN DETECTION AND DEVICE THEREFOR | |
IL225188A0 (en) | Method and device for matching discrimination | |
ZA201202094B (en) | Sample collection apparatus | |
EP2672270A4 (en) | Specimen analysis system, specimen analysis device, and specimen analysis method | |
EP2540224A4 (en) | ANALYSIS DEVICE, ANALYSIS PROCEDURE AND ANALYSIS SYSTEM | |
EP2630616A4 (en) | Method and apparatus for providing hand detection | |
EP2579024A4 (en) | DEVICE FOR DETECTING BIOMOLECULES AND PROCESS FOR DETECTING BIOMOLECULES | |
GB201004121D0 (en) | Detector device, inspection apparatus and method | |
EP2567215A4 (en) | ANALYSIS AGENTS AND METHOD THEREFOR | |
GB201019488D0 (en) | Blood analysis apparatus and method | |
GB201419816D0 (en) | Methods, packaging and apparatus for collection of biological samples |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20240225 |