HK1187341A1 - Guanidine compound - Google Patents
Guanidine compoundInfo
- Publication number
- HK1187341A1 HK1187341A1 HK14100309.0A HK14100309A HK1187341A1 HK 1187341 A1 HK1187341 A1 HK 1187341A1 HK 14100309 A HK14100309 A HK 14100309A HK 1187341 A1 HK1187341 A1 HK 1187341A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- guanidine compound
- guanidine
- compound
- Prior art date
Links
- -1 Guanidine compound Chemical class 0.000 title 1
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 title 1
- ZRALSGWEFCBTJO-UHFFFAOYSA-N anhydrous guanidine Natural products NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 title 1
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 title 1
Classifications
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- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
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- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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KR102297433B1 (ko) * | 2013-07-30 | 2021-09-02 | 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 | Rsv 항바이러스 화합물로서의, 치환형 피리딘-피페라지닐 유사체 |
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WO2015189534A1 (en) | 2014-06-12 | 2015-12-17 | Proximagen Limited | Vap-1 inhibitors for treating muscular dystrophy |
CN107207483B (zh) | 2014-08-29 | 2020-10-30 | Tes制药有限责任公司 | α-氨基-β-羧基粘康酸半醛脱羧酶抑制剂 |
JP6809464B2 (ja) * | 2015-08-06 | 2021-01-06 | 宇部興産株式会社 | 置換グアニジン誘導体 |
AU2016366635A1 (en) | 2015-12-07 | 2018-06-21 | Benevolentai Cambridge Limited | VAP-1 inhibitors for treating pain |
US10336729B2 (en) | 2016-03-03 | 2019-07-02 | Boehringer Ingelheim International Gmbh | 4-cyano-benzyl carbamimidoylcarbamate derivatives and their use as AOC3 inhibitors |
US10730850B2 (en) | 2016-03-03 | 2020-08-04 | Boehringer Ingelheim International Gmbh | Pyridinylmethyl carbamimidoylcarbamate derivatives and their use as AOC3 inhibitors |
SG11201809687TA (en) * | 2016-05-12 | 2018-11-29 | Boehringer Ingelheim Int | Pyridinyl derivatives, pharmaceutical compositions and uses thereof as aoc3 inhibitors |
WO2018027892A1 (en) | 2016-08-12 | 2018-02-15 | Eli Lilly And Company | Amino pyrimidine ssao inhibitors |
WO2018078360A1 (en) * | 2016-10-26 | 2018-05-03 | E-Therapeutics Plc | Modulators of hedgehog (hh) signalling pathway |
CN110114350B (zh) | 2016-12-28 | 2022-03-04 | 宇部兴产株式会社 | 取代胍化合物 |
WO2018148856A1 (en) | 2017-02-14 | 2018-08-23 | Eli Lilly And Company | Diazaspirodecanyl-pyrimidine compounds useful as ssao inhibitors |
CN106866575A (zh) * | 2017-03-21 | 2017-06-20 | 苏州汉德创宏生化科技有限公司 | 2‑(1‑哌啶基)‑5‑溴噻唑的合成方法 |
EP3774742A1 (en) | 2018-04-06 | 2021-02-17 | H. Lundbeck A/S | Process for the preparation of 2,2-dimethylpiperazine |
CA3114208A1 (en) | 2018-09-28 | 2020-04-02 | Acucela Inc. | Inhibitors of vap-1 |
BR112021005920A2 (pt) * | 2018-09-28 | 2021-06-29 | Acucela Inc. | inibidores de vap-1 |
CN112789277B (zh) * | 2018-10-22 | 2022-11-04 | 广东东阳光药业有限公司 | 胍类衍生物及其用途 |
CA3112510A1 (en) | 2018-10-29 | 2020-05-07 | Boehringer Ingelheim International Gmbh | Pyridinyl sulfonamide derivatives, pharmaceutical compositions and uses thereof |
JP7425793B2 (ja) * | 2018-10-29 | 2024-01-31 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ピリジニルスルホンアミド誘導体、医薬組成物およびそれらの使用 |
CN111196806B (zh) * | 2018-11-20 | 2024-04-26 | 广东东阳光药业股份有限公司 | 胍类衍生物及其用途 |
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