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EA201391315A1 - Гуанидиновое соединение - Google Patents

Гуанидиновое соединение

Info

Publication number
EA201391315A1
EA201391315A1 EA201391315A EA201391315A EA201391315A1 EA 201391315 A1 EA201391315 A1 EA 201391315A1 EA 201391315 A EA201391315 A EA 201391315A EA 201391315 A EA201391315 A EA 201391315A EA 201391315 A1 EA201391315 A1 EA 201391315A1
Authority
EA
Eurasian Patent Office
Prior art keywords
vap
pharmaceutical composition
compound
prevention
treatment
Prior art date
Application number
EA201391315A
Other languages
English (en)
Other versions
EA024102B1 (ru
Inventor
Коусеи Йосихара
Дайсуке Судзуки
Сусуму Ямаки
Хиройоси Ямада
Хисаси Михара
Норио Секи
Original Assignee
Астеллас Фарма Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Астеллас Фарма Инк. filed Critical Астеллас Фарма Инк.
Publication of EA201391315A1 publication Critical patent/EA201391315A1/ru
Publication of EA024102B1 publication Critical patent/EA024102B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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Abstract

Изобретение относится к соединению, пригодному в качестве активного ингредиента фармацевтической композиции, в частности фармацевтической композиции для предотвращения и/или лечения связанных с VAP-1 заболеваний. Авторы изобретения провели интенсивные исследования соединения с ингибирующей VAP-1 активностью и в результате выявили, что соединение или его соль по настоящему изобретению демонстрируют превосходную ингибирующую VAP-1 активность и пригодны для предотвращения и/или лечения связанных с VAP-1-заболеваний, в частности диабетической нефропатии или диабетического отека желтого пятна, таким образом осуществляя настоящее изобретение. Кроме того, изобретение относится к фармацевтической композиции, в частности фармацевтической композиции для предотвращения и/или лечения связанных с VAP-1-заболеваний, содержащей соединение или его соль по настоящему изобретению и эксципиент.
EA201391315A 2011-03-15 2012-03-13 Гуанидиновые соединения, полезные для предотвращения и/или лечения диабетической нефропатии или диабетического отека желтого пятна EA024102B1 (ru)

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EA201500448A EA025839B1 (ru) 2011-03-15 2012-03-13 Гуанидиновые соединения, полезные для предотвращения и/или лечения диабетической нефропатии или диабетического отека желтого пятна

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