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HK1162501A1 - Process for producing phenyl-substituted heterocyclic derivative through coupling using transition metal catalyst - Google Patents

Process for producing phenyl-substituted heterocyclic derivative through coupling using transition metal catalyst

Info

Publication number
HK1162501A1
HK1162501A1 HK12102980.4A HK12102980A HK1162501A1 HK 1162501 A1 HK1162501 A1 HK 1162501A1 HK 12102980 A HK12102980 A HK 12102980A HK 1162501 A1 HK1162501 A1 HK 1162501A1
Authority
HK
Hong Kong
Prior art keywords
coupling
transition metal
metal catalyst
substituted heterocyclic
heterocyclic derivative
Prior art date
Application number
HK12102980.4A
Other languages
English (en)
Chinese (zh)
Inventor
Masato Komiyama
Naoki Yajima
Masayuki Kurokawa
Original Assignee
Teijin Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teijin Pharma Ltd filed Critical Teijin Pharma Ltd
Publication of HK1162501A1 publication Critical patent/HK1162501A1/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42Oxazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/4261,3-Thiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/06Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/30Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
HK12102980.4A 2009-02-27 2012-03-26 Process for producing phenyl-substituted heterocyclic derivative through coupling using transition metal catalyst HK1162501A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2009046003 2009-02-27
JP2009153770 2009-06-29
PCT/JP2010/053043 WO2010098428A1 (ja) 2009-02-27 2010-02-26 遷移金属触媒を用いたカップリング法によるフェニル置換複素環誘導体の製造法

Publications (1)

Publication Number Publication Date
HK1162501A1 true HK1162501A1 (en) 2012-08-31

Family

ID=42665632

Family Applications (1)

Application Number Title Priority Date Filing Date
HK12102980.4A HK1162501A1 (en) 2009-02-27 2012-03-26 Process for producing phenyl-substituted heterocyclic derivative through coupling using transition metal catalyst

Country Status (19)

Country Link
US (1) US8952174B2 (xx)
EP (2) EP2754658A1 (xx)
JP (1) JP5312570B2 (xx)
KR (1) KR101639834B1 (xx)
CN (1) CN102333765B (xx)
AU (1) AU2010218748B2 (xx)
BR (1) BRPI1008308B8 (xx)
CA (1) CA2752485C (xx)
DK (1) DK2404908T3 (xx)
ES (1) ES2459722T3 (xx)
HK (1) HK1162501A1 (xx)
IL (1) IL214302A (xx)
MX (1) MX2011008348A (xx)
PL (1) PL2404908T3 (xx)
PT (1) PT2404908E (xx)
RU (1) RU2510393C9 (xx)
SG (1) SG173884A1 (xx)
TW (1) TWI466874B (xx)
WO (1) WO2010098428A1 (xx)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG187843A1 (en) * 2010-08-27 2013-03-28 Teijin Pharma Ltd Method for producing phenyl-substituted heterocyclic derivative by means of coupling method using a palladium compound
CN102234253B (zh) * 2011-06-02 2013-07-03 重庆莱美药业股份有限公司 一种制备非布索坦中间体的方法
CN103910694B (zh) * 2012-12-29 2016-08-24 广东东阳光药业有限公司 一种2-芳基腈噻唑衍生物的制备方法
RU2016148736A (ru) * 2014-05-13 2018-06-14 Тейдзин Фарма Лимитед Новые кристаллические полиморфы производного пиридина и способ их получения
JP2018052878A (ja) * 2016-09-29 2018-04-05 第一三共株式会社 ピリジン化合物
CN110066258A (zh) * 2018-01-23 2019-07-30 湘北威尔曼制药股份有限公司 噻唑-5-甲酸衍生物及其制备方法与应用
CN109293597B (zh) * 2018-10-29 2022-05-10 安徽省庆云医药股份有限公司 一种非布索坦的制备方法

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US4346094A (en) 1980-09-22 1982-08-24 Eli Lilly And Company 3-Aryl-5-isothiazolecarboxylic acids and related compounds used to lower uric acid levels
US4495195A (en) 1982-11-01 1985-01-22 Eli Lilly And Company Xanthine oxidase inhibiting 3(5)-phenyl-substituted-5(3)-pyrazole-carboxylic acid derivatives, compositions, and methods of use
JP2591632B2 (ja) 1987-12-18 1997-03-19 株式会社トプコン 真空吸引装置
ATE142494T1 (de) 1990-11-30 1996-09-15 Teijin Ltd 2-arylthiazolderivat sowie dieses enthaltendes arzneimittel
JP3399559B2 (ja) 1992-08-12 2003-04-21 帝人株式会社 2−フェニル複素環式化合物
JP3113110B2 (ja) 1993-01-19 2000-11-27 帝人株式会社 イソキサゾールおよびイソチアゾール誘導体
JP3169735B2 (ja) 1993-04-08 2001-05-28 帝人株式会社 (アルコキシシアノフェニル)チアゾール誘導体の製造方法
JP2706037B2 (ja) 1993-04-13 1998-01-28 帝人株式会社 シアノ化合物およびその製造方法
JP2834971B2 (ja) 1993-05-25 1998-12-14 帝人株式会社 2−(4−アルコキシ−3−シアノフェニル)チアゾール誘導体の製造法およびその新規製造中間体
ID21775A (id) 1996-10-25 1999-07-22 Yoshitomi Pharmaceutical Senyawa-senyawa 1-fenilpirazol dan penggunaan farmasinya
JPH10139770A (ja) 1996-11-08 1998-05-26 Teijin Ltd 2−(3−シアノフェニル)チアゾール誘導体の製造法
JPH10310578A (ja) 1996-11-13 1998-11-24 Yoshitomi Pharmaceut Ind Ltd 3−フェニルピラゾール化合物
JP3440196B2 (ja) 1997-08-13 2003-08-25 帝人株式会社 チオベンズアミド誘導体の製造方法
CN1406127A (zh) 2000-02-23 2003-03-26 奥尔顿有限公司 噻唑鎓类化合物和与蛋白老化有关的疾病的治疗
WO2002051849A1 (fr) 2000-12-26 2002-07-04 Daiichi Pharmaceutical Co., Ltd. Inhibiteurs cdk4
TWI314928B (en) * 2002-02-28 2009-09-21 Novartis A 5-phenylthiazole derivatives and use as pi3 kinase inhibitors
CN101723891A (zh) * 2003-02-10 2010-06-09 沃泰克斯药物股份有限公司 通过使n-芳基氨基甲酸酯与卤代杂芳基反应制备n-杂芳基-n-芳基胺的方法和类似方法
AU2004272599A1 (en) 2003-09-06 2005-03-24 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
EP3219709B1 (en) 2004-01-30 2020-03-18 Vertex Pharmaceuticals Incorporated Intermediate compound of modulators of atp-binding cassette transporters
ATE440820T1 (de) 2004-08-27 2009-09-15 Astellas Pharma Inc 2-phenylpyridinderivat
ES2355068T3 (es) 2005-10-07 2011-03-22 Astellas Pharma Inc. Derivado del ácido triarilcarboxílico.
CA2643272A1 (en) 2006-02-24 2007-08-30 Astellas Pharma Inc. Gent for treating or preventing digestive ulcer
JP2012096999A (ja) 2009-02-27 2012-05-24 Nagoya Univ ニッケル触媒を用いたカップリング法によるフェニル置換複素環誘導体の製造法
SG187843A1 (en) 2010-08-27 2013-03-28 Teijin Pharma Ltd Method for producing phenyl-substituted heterocyclic derivative by means of coupling method using a palladium compound

Also Published As

Publication number Publication date
ES2459722T3 (es) 2014-05-12
CA2752485A1 (en) 2010-09-02
MX2011008348A (es) 2011-09-01
EP2754658A1 (en) 2014-07-16
BRPI1008308B8 (pt) 2021-05-25
JP5312570B2 (ja) 2013-10-09
WO2010098428A1 (ja) 2010-09-02
RU2510393C2 (ru) 2014-03-27
KR101639834B1 (ko) 2016-07-14
CA2752485C (en) 2017-01-03
US20110313169A1 (en) 2011-12-22
EP2404908B1 (en) 2014-04-09
CN102333765A (zh) 2012-01-25
PL2404908T3 (pl) 2014-12-31
TW201041859A (en) 2010-12-01
IL214302A0 (en) 2011-09-27
PT2404908E (pt) 2014-06-23
RU2510393C9 (ru) 2014-08-27
US8952174B2 (en) 2015-02-10
TWI466874B (zh) 2015-01-01
KR20110120896A (ko) 2011-11-04
SG173884A1 (en) 2011-10-28
EP2404908A1 (en) 2012-01-11
RU2011139307A (ru) 2013-04-10
CN102333765B (zh) 2015-01-14
EP2404908A4 (en) 2012-08-15
IL214302A (en) 2014-09-30
DK2404908T3 (da) 2014-04-28
JPWO2010098428A1 (ja) 2012-09-06
BRPI1008308A2 (pt) 2016-02-23
BRPI1008308B1 (pt) 2020-03-31
AU2010218748A1 (en) 2011-08-11
AU2010218748B2 (en) 2015-03-26

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