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MX2011008348A - Proceso para producir derivado heterociclico sustituido con fenilo a traves de acoplamiento usando catalizador de metal de transicion. - Google Patents

Proceso para producir derivado heterociclico sustituido con fenilo a traves de acoplamiento usando catalizador de metal de transicion.

Info

Publication number
MX2011008348A
MX2011008348A MX2011008348A MX2011008348A MX2011008348A MX 2011008348 A MX2011008348 A MX 2011008348A MX 2011008348 A MX2011008348 A MX 2011008348A MX 2011008348 A MX2011008348 A MX 2011008348A MX 2011008348 A MX2011008348 A MX 2011008348A
Authority
MX
Mexico
Prior art keywords
coupling
transition metal
metal catalyst
substituted heterocyclic
heterocyclic derivative
Prior art date
Application number
MX2011008348A
Other languages
English (en)
Inventor
Naoki Yajima
Masato Komiyama
Masayuki Kurokawa
Original Assignee
Teijin Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teijin Pharma Ltd filed Critical Teijin Pharma Ltd
Publication of MX2011008348A publication Critical patent/MX2011008348A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Un proceso para producir eficientemente, a través de pocos pasos, ya sea un inhibidor de xantina oxidasa, que sea un agente terapéutico para hiperuricemia, o un intermediario del mismo. El proceso es un proceso novedoso de acoplamiento que comprende someter un compuesto representado por la fórmula (1) a reacción de acoplamiento con un compuesto representado por la fórmula (2) en presencia de un compuesto de metal de transición para así obtener un compuesto representado por la fórmula (3).
MX2011008348A 2009-02-27 2010-02-26 Proceso para producir derivado heterociclico sustituido con fenilo a traves de acoplamiento usando catalizador de metal de transicion. MX2011008348A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2009046003 2009-02-27
JP2009153770 2009-06-29
PCT/JP2010/053043 WO2010098428A1 (ja) 2009-02-27 2010-02-26 遷移金属触媒を用いたカップリング法によるフェニル置換複素環誘導体の製造法

Publications (1)

Publication Number Publication Date
MX2011008348A true MX2011008348A (es) 2011-09-01

Family

ID=42665632

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2011008348A MX2011008348A (es) 2009-02-27 2010-02-26 Proceso para producir derivado heterociclico sustituido con fenilo a traves de acoplamiento usando catalizador de metal de transicion.

Country Status (18)

Country Link
US (1) US8952174B2 (es)
EP (2) EP2754658A1 (es)
JP (1) JP5312570B2 (es)
KR (1) KR101639834B1 (es)
CN (1) CN102333765B (es)
AU (1) AU2010218748B2 (es)
BR (1) BRPI1008308B8 (es)
CA (1) CA2752485C (es)
DK (1) DK2404908T3 (es)
ES (1) ES2459722T3 (es)
IL (1) IL214302A (es)
MX (1) MX2011008348A (es)
PL (1) PL2404908T3 (es)
PT (1) PT2404908E (es)
RU (1) RU2510393C9 (es)
SG (1) SG173884A1 (es)
TW (1) TWI466874B (es)
WO (1) WO2010098428A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2610248T (pt) * 2010-08-27 2016-08-23 Teijin Pharma Ltd Método para produção de derivado heterocíclico substituído por fenilo por meio de método de acoplamento usando um composto de paládio
CN102234253B (zh) * 2011-06-02 2013-07-03 重庆莱美药业股份有限公司 一种制备非布索坦中间体的方法
CN103910694B (zh) * 2012-12-29 2016-08-24 广东东阳光药业有限公司 一种2-芳基腈噻唑衍生物的制备方法
RU2016148736A (ru) * 2014-05-13 2018-06-14 Тейдзин Фарма Лимитед Новые кристаллические полиморфы производного пиридина и способ их получения
JP2018052878A (ja) * 2016-09-29 2018-04-05 第一三共株式会社 ピリジン化合物
CN110066258A (zh) * 2018-01-23 2019-07-30 湘北威尔曼制药股份有限公司 噻唑-5-甲酸衍生物及其制备方法与应用
CN109293597B (zh) * 2018-10-29 2022-05-10 安徽省庆云医药股份有限公司 一种非布索坦的制备方法

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US4495195A (en) 1982-11-01 1985-01-22 Eli Lilly And Company Xanthine oxidase inhibiting 3(5)-phenyl-substituted-5(3)-pyrazole-carboxylic acid derivatives, compositions, and methods of use
JP2591632B2 (ja) 1987-12-18 1997-03-19 株式会社トプコン 真空吸引装置
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JP3113110B2 (ja) 1993-01-19 2000-11-27 帝人株式会社 イソキサゾールおよびイソチアゾール誘導体
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JPWO2002051849A1 (ja) 2000-12-26 2004-04-22 第一製薬株式会社 Ｃｄｋ４活性阻害剤
PE20030968A1 (es) * 2002-02-28 2004-01-12 Novartis Ag Derivados de 5-feniltiazol como inhibidores de cinasas
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PT2610248T (pt) * 2010-08-27 2016-08-23 Teijin Pharma Ltd Método para produção de derivado heterocíclico substituído por fenilo por meio de método de acoplamento usando um composto de paládio

Also Published As

Publication number Publication date
RU2510393C9 (ru) 2014-08-27
PT2404908E (pt) 2014-06-23
CN102333765B (zh) 2015-01-14
US20110313169A1 (en) 2011-12-22
RU2510393C2 (ru) 2014-03-27
BRPI1008308A2 (pt) 2016-02-23
KR20110120896A (ko) 2011-11-04
AU2010218748B2 (en) 2015-03-26
TWI466874B (zh) 2015-01-01
EP2404908A1 (en) 2012-01-11
KR101639834B1 (ko) 2016-07-14
CA2752485C (en) 2017-01-03
CA2752485A1 (en) 2010-09-02
IL214302A (en) 2014-09-30
JP5312570B2 (ja) 2013-10-09
IL214302A0 (en) 2011-09-27
SG173884A1 (en) 2011-10-28
JPWO2010098428A1 (ja) 2012-09-06
AU2010218748A1 (en) 2011-08-11
BRPI1008308B1 (pt) 2020-03-31
BRPI1008308B8 (pt) 2021-05-25
RU2011139307A (ru) 2013-04-10
US8952174B2 (en) 2015-02-10
TW201041859A (en) 2010-12-01
EP2754658A1 (en) 2014-07-16
EP2404908B1 (en) 2014-04-09
DK2404908T3 (da) 2014-04-28
WO2010098428A1 (ja) 2010-09-02
ES2459722T3 (es) 2014-05-12
HK1162501A1 (en) 2012-08-31
PL2404908T3 (pl) 2014-12-31
CN102333765A (zh) 2012-01-25
EP2404908A4 (en) 2012-08-15

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