HK1154868A1 - Cholest-4-en-3-one oxime derivatives, pharmaceutical compositions containing same, and preparation method -4--3- - Google Patents

Cholest-4-en-3-one oxime derivatives, pharmaceutical compositions containing same, and preparation method -4--3-

Info

Publication number: HK1154868A1
Authority: HK; Hong Kong
Prior art keywords: cholest; preparation; pharmaceutical compositions; compositions containing; containing same
Prior art date: 2008-07-30

Application number

HK11109140.7A

Other languages

English (en)

Chinese (zh)

Inventor

Rebecca Pruss

Abdesslame Nazih

Corinne Chaimbault

Cyrille Drouot

Original Assignee

Trophos

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-07-30

Filing date

2011-08-30

Publication date

2012-05-04

2011-08-30 Application filed by Trophos filed Critical Trophos

2012-05-04 Publication of HK1154868A1 publication Critical patent/HK1154868A1/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
- C07J41/0016—Oximes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Immunology (AREA)
Physical Education & Sports Medicine (AREA)
Communicable Diseases (AREA)
Virology (AREA)
Oncology (AREA)
Cardiology (AREA)
Hospice & Palliative Care (AREA)
Hematology (AREA)
Diabetes (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Urology & Nephrology (AREA)
Orthopedic Medicine & Surgery (AREA)
Obesity (AREA)
Psychology (AREA)
Tropical Medicine & Parasitology (AREA)
Ophthalmology & Optometry (AREA)
Psychiatry (AREA)
Gastroenterology & Hepatology (AREA)
AIDS & HIV (AREA)
Molecular Biology (AREA)

HK11109140.7A 2008-07-30 2011-08-30 Cholest-4-en-3-one oxime derivatives, pharmaceutical compositions containing same, and preparation method -4--3- HK1154868A1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR0804338A FR2934596B1 (fr)	2008-07-30	2008-07-30	Nouveaux derives de l'oxime de cholest-4-en-3-one, compositions pharmaceutiques les renfermant, et procede de preparation
PCT/FR2009/000944 WO2010012904A2 (fr)	2008-07-30	2009-07-29	Nouveaux dérivés de l'oxime de cholest-4-èn-3-one, compositions pharmaceutiques les renfermant, et procédé de préparation

Publications (1)

Publication Number	Publication Date
HK1154868A1 true HK1154868A1 (en)	2012-05-04

Family

ID=40506441

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HK11109140.7A HK1154868A1 (en)	2008-07-30	2011-08-30	Cholest-4-en-3-one oxime derivatives, pharmaceutical compositions containing same, and preparation method -4--3-

Country Status (12)

Country	Link
US (1)	US9447140B2 (xx)
EP (1)	EP2307438B1 (xx)
JP (2)	JP5872897B2 (xx)
CN (1)	CN102083849B (xx)
AU (1)	AU2009275790B2 (xx)
BR (1)	BRPI0915120A2 (xx)
CA (1)	CA2725791C (xx)
FR (1)	FR2934596B1 (xx)
HK (1)	HK1154868A1 (xx)
IL (1)	IL210951B (xx)
RU (1)	RU2496784C2 (xx)
WO (1)	WO2010012904A2 (xx)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2874923B1 (fr) *	2004-09-07	2006-10-27	Trophos Sa	Application a titre de medicaments de derives du 3, 5-seco-4-nor-cholestane, compositions pharmaceutiques les renfermant, nouveaux derives et leur procede de preparation
FR2919180B1 (fr) *	2007-07-25	2009-11-27	Trophos	Utilisation d'au moins un derive oxime de la cholest-4-en-3-one comme antioxydants
FR2934596B1 (fr) *	2008-07-30	2015-04-10	Trophos	Nouveaux derives de l'oxime de cholest-4-en-3-one, compositions pharmaceutiques les renfermant, et procede de preparation
FR2979239A1 (fr)	2011-08-25	2013-03-01	Trophos	Liposome comprenant au moins un derive de cholesterol
CN102633852B (zh) *	2012-03-29	2014-06-11	南昌大学	亚胺类豆甾醇衍生物及其在抗癌药物中的应用
TWI638815B (zh)	2013-02-15	2018-10-21	英商葛蘭素史克智慧財產發展有限公司	作為激酶抑制劑之雜環醯胺類（一）
CN105441391A (zh) *	2015-12-10	2016-03-30	湖南中医药大学	一种糖尿病并发抑郁症的细胞模型及建立方法和应用
US11951092B2 (en) *	2017-06-02	2024-04-09	Fujifilm Toyama Chemical Co., Ltd.	Agent for preventing or treating brain atrophy
NZ759647A (en)	2017-06-02	2022-02-25	Fujifilm Toyama Chemical Co Ltd	Agent for preventing or treating spinocerebellar ataxia
WO2018221728A1 (ja)	2017-06-02	2018-12-06	富山化学工業株式会社	アルツハイマー型認知症予防または治療剤
JP7256118B2 (ja)	2017-06-02	2023-04-11	富士フイルム富山化学株式会社	アミロイドβ蛋白質量減少剤
US11548878B2 (en)	2017-10-30	2023-01-10	Fujifilm Toyama Chemical Co., Ltd.	Emopamil binding protein binding agent and use thereof
WO2019188491A1 (ja) *	2018-03-29	2019-10-03	森永乳業株式会社	抗老化用組成物
GB201820887D0 (en) *	2018-12-20	2019-02-06	Nzp Uk Ltd	Compounds
CN113855684B (zh) *	2021-11-25	2023-02-24	南京市儿童医院	奥利索西在制备用于减轻或改善顺铂诱导的急性肾损伤的药物中的用途
WO2023245086A1 (en) *	2022-06-15	2023-12-21	Navrogen, Inc.	Humoral immune activators for the treatment of humoral immunosuppressed pathologies, cancer and infectious disease and humoral immune suppressors for the treatment of inflammatory diseases
CN117018000B (zh) *	2023-08-29	2025-01-28	东莞市东南部中心医院(东莞市东南部中医医疗服务中心)	4-胆甾烯-3-酮在制备预防或治疗炎症性肠病药物中的应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3257384A (en) *	1963-01-04	1966-06-21	Upjohn Co	Derivatives of 25-azacholesterol and 22-oxa-25-azacholesterol
US3296253A (en) *	1964-03-19	1967-01-03	Merck & Co Inc	Pyrazoles of 21-alkyl steroids of the pregnane series
JP4970932B2 (ja) *	2003-03-11	2012-07-11	トロフォ	コレスト−４−エン−３−オンの誘導体の医薬としての使用、これらを含む医薬組成物、新規誘導体及びそれらの製造方法
FR2894968B1 (fr) *	2005-12-20	2008-02-22	Trophos Sa	Nouveaux derives de l'oxime de cholest-4-en-3-one, compositions pharmaceutiques les renfermant, et procede de preparation
FR2934596B1 (fr) *	2008-07-30	2015-04-10	Trophos	Nouveaux derives de l'oxime de cholest-4-en-3-one, compositions pharmaceutiques les renfermant, et procede de preparation

2008
- 2008-07-30 FR FR0804338A patent/FR2934596B1/fr not_active Expired - Fee Related
2009
- 2009-07-29 CA CA2725791A patent/CA2725791C/fr not_active Expired - Fee Related
- 2009-07-29 BR BRPI0915120A patent/BRPI0915120A2/pt not_active IP Right Cessation
- 2009-07-29 US US13/056,867 patent/US9447140B2/en not_active Expired - Fee Related
- 2009-07-29 WO PCT/FR2009/000944 patent/WO2010012904A2/fr active Application Filing
- 2009-07-29 CN CN200980126355.2A patent/CN102083849B/zh not_active Expired - Fee Related
- 2009-07-29 JP JP2011520549A patent/JP5872897B2/ja not_active Expired - Fee Related
- 2009-07-29 RU RU2011106948/04A patent/RU2496784C2/ru not_active IP Right Cessation
- 2009-07-29 EP EP09784316.3A patent/EP2307438B1/fr not_active Not-in-force
- 2009-07-29 AU AU2009275790A patent/AU2009275790B2/en not_active Ceased
2011
- 2011-01-30 IL IL210951A patent/IL210951B/en active IP Right Grant
- 2011-08-30 HK HK11109140.7A patent/HK1154868A1/xx not_active IP Right Cessation
2015
- 2015-06-09 JP JP2015116450A patent/JP2015205899A/ja active Pending

Also Published As

Publication number	Publication date
FR2934596A1 (fr)	2010-02-05
CA2725791C (fr)	2017-02-28
BRPI0915120A2 (pt)	2016-07-26
IL210951B (en)	2018-05-31
CN102083849A (zh)	2011-06-01
RU2496784C2 (ru)	2013-10-27
RU2011106948A (ru)	2012-09-10
WO2010012904A2 (fr)	2010-02-04
EP2307438B1 (fr)	2018-03-07
AU2009275790A1 (en)	2010-02-04
WO2010012904A3 (fr)	2010-04-22
US9447140B2 (en)	2016-09-20
CA2725791A1 (fr)	2010-02-04
AU2009275790B2 (en)	2014-10-09
JP5872897B2 (ja)	2016-03-01
JP2015205899A (ja)	2015-11-19
US20110224180A1 (en)	2011-09-15
FR2934596B1 (fr)	2015-04-10
JP2011529478A (ja)	2011-12-08
CN102083849B (zh)	2015-07-22
EP2307438A2 (fr)	2011-04-13
IL210951A0 (en)	2011-04-28

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Legal Events

Date	Code	Title	Description
2021-03-19	PC	Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)	Effective date: 20200803