HK1099286A1 - 5,7-diaminopyrazolo [4,3-d] pyrimidines with pde-5 inhibiting activity - Google Patents

5,7-diaminopyrazolo [4,3-d] pyrimidines with pde-5 inhibiting activity

Info

Publication number: HK1099286A1
Authority: HK; Hong Kong
Prior art keywords: diaminopyrazolo; pde; pyrimidines; inhibiting activity; inhibiting
Prior art date: 2003-11-24

Application number

HK07105414.0A

Other languages

English (en)

Inventor

Andrew Simon Bell

David Graham Brown

Kevin Neil Dack

David Nathan Abraham Fox

Ian Roger Marsh

Andrew Ian Morrell

Michael John Palmer

Carol Ann Winslow

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-11-24

Filing date

2007-05-22

Publication date

2007-08-10

2007-05-22 Application filed by Pfizer filed Critical Pfizer

2007-08-10 Publication of HK1099286A1 publication Critical patent/HK1099286A1/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pulmonology (AREA)
Diabetes (AREA)
Neurosurgery (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Hematology (AREA)
Obesity (AREA)
Vascular Medicine (AREA)
Hospice & Palliative Care (AREA)
Dermatology (AREA)
Immunology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Child & Adolescent Psychology (AREA)
Gynecology & Obstetrics (AREA)
Pregnancy & Childbirth (AREA)
Emergency Medicine (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

HK07105414.0A 2003-11-24 2007-05-22 5,7-diaminopyrazolo [4,3-d] pyrimidines with pde-5 inhibiting activity HK1099286A1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB0327319.0A GB0327319D0 (en)	2003-11-24	2003-11-24	Novel pharmaceuticals
PCT/IB2004/003747 WO2005049616A1 (en)	2003-11-24	2004-11-12	5,7-DIAMINOPYRAZOLO [4,3-d] PYRIMIDINES WITH PDE-5 INHIBITING ACTIVITY

Publications (1)

Publication Number	Publication Date
HK1099286A1 true HK1099286A1 (en)	2007-08-10

Family

ID=29764364

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
HK07105414.0A HK1099286A1 (en)	2003-11-24	2007-05-22	5,7-diaminopyrazolo [4,3-d] pyrimidines with pde-5 inhibiting activity
HK09107080.7A HK1128917A1 (en)	2003-11-24	2009-08-03	5,7-diaminopyrazolo [4,3-d] pyrimidines with pde-5 inhibiting activity

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
HK09107080.7A HK1128917A1 (en)	2003-11-24	2009-08-03	5,7-diaminopyrazolo [4,3-d] pyrimidines with pde-5 inhibiting activity

Country Status (44)

Country	Link
EP (1)	EP1689751B1 (ru)
JP (1)	JP4056015B2 (ru)
KR (2)	KR100893999B1 (ru)
CN (4)	CN1882591B (ru)
AP (1)	AP2227A (ru)
AR (1)	AR046711A1 (ru)
AT (1)	ATE485297T1 (ru)
AU (1)	AU2004290643B2 (ru)
BR (1)	BRPI0416869A (ru)
CA (1)	CA2546987C (ru)
CR (1)	CR8416A (ru)
CY (1)	CY1110933T1 (ru)
DE (1)	DE602004029705D1 (ru)
DK (1)	DK1689751T3 (ru)
EA (1)	EA011772B1 (ru)
EC (1)	ECSP066580A (ru)
ES (1)	ES2351622T3 (ru)
GB (1)	GB0327319D0 (ru)
GE (1)	GEP20084528B (ru)
HK (2)	HK1099286A1 (ru)
HR (1)	HRP20100651T1 (ru)
IL (1)	IL175433A (ru)
IS (1)	IS8406A (ru)
MA (1)	MA28172A1 (ru)
ME (1)	ME01216B (ru)
MX (1)	MXPA06005914A (ru)
MY (1)	MY140872A (ru)
NL (1)	NL1027568C2 (ru)
NO (1)	NO336526B1 (ru)
NZ (1)	NZ548097A (ru)
OA (1)	OA13289A (ru)
PA (1)	PA8617701A1 (ru)
PE (1)	PE20051061A1 (ru)
PL (1)	PL1689751T3 (ru)
PT (1)	PT1689751E (ru)
RS (1)	RS51556B (ru)
SG (1)	SG133614A1 (ru)
SI (1)	SI1689751T1 (ru)
TN (1)	TNSN06154A1 (ru)
TW (1)	TWI265031B (ru)
UA (1)	UA81994C2 (ru)
UY (1)	UY28625A1 (ru)
WO (1)	WO2005049616A1 (ru)
ZA (1)	ZA200602899B (ru)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2006034341A2 (en)	2004-09-20	2006-03-30	Xenon Pharmaceuticals Inc.	Pyridazine derivatives for inhibiting human stearoyl-coa-desaturase
AU2005286728A1 (en)	2004-09-20	2006-03-30	Xenon Pharmaceuticals Inc.	Heterocyclic derivatives and their use as mediators of stearoyl-CoA desaturase
WO2006034441A1 (en)	2004-09-20	2006-03-30	Xenon Pharmaceuticals Inc.	Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
US7919496B2 (en)	2004-09-20	2011-04-05	Xenon Pharmaceuticals Inc.	Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-CoA desaturase enzymes
US7767677B2 (en)	2004-09-20	2010-08-03	Xenon Pharmaceuticals Inc.	Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors
EP1799667B1 (en)	2004-09-20	2013-03-20	Xenon Pharmaceuticals Inc.	Heterocyclic derivatives and their use as therapeutic agents
JP4958785B2 (ja)	2004-09-20	2012-06-20	ゼノン・ファーマシューティカルズ・インコーポレイテッド	複素環誘導体およびステアロイル−ＣｏＡデサチュラーゼインヒビターとしてのそれらの使用
EP1809632A2 (en) *	2004-10-28	2007-07-25	Pharmacia & Upjohn Company LLC	Pyrazolo[4,3-d]pyrimidine derivatives useful as pde-5 inhibitors
ATE493413T1 (de) *	2005-05-12	2011-01-15	Pfizer	Wasserfreie kristalline formen von n-ä1,2- ethoxyethyl)-5-(n-ethyl-n-methylaminoü-7-(4- methylpyridin-2-yl-aminoü-1h-pyrazoloä4,3-
EP2029138A1 (en)	2005-06-03	2009-03-04	Xenon Pharmaceuticals Inc.	Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors
NL1029244C2 (nl) *	2005-06-10	2006-12-12	Ronald Silfried Marlin	Middel ter vergroting van het mannelijk geslachtsorgaan.
DE102005050377A1 (de) *	2005-10-21	2007-04-26	Bayer Healthcare Ag	Heterocyclische Verbindungen und ihre Verwendung
NL2000291C2 (nl) *	2005-11-10	2009-02-17	Pfizer Prod Inc	1-(1-(2-ethoxyethyl)-3-ethyl-7-(4-methylpyridin-2-ylamino)-1H- pyrazool(4,3-d)pyrimidine-5-yl)piperidine-4-carbonzuur en zouten daarvan.
EP1960372B1 (en)	2005-12-15	2015-12-09	Rigel Pharmaceuticals, Inc.	Kinase inhibitors and their uses
EP1820502A1 (en) *	2006-02-10	2007-08-22	Laboratorios Del Dr. Esteve, S.A.	Active substance combination comprising azolylcarbinol compounds
WO2007113243A2 (en) *	2006-03-31	2007-10-11	Investigación Y Clínica Andrológicas S.L.	Use of pde 5 inhibitors for the treatment of overactive bladder
WO2008132589A1 (en) *	2007-05-01	2008-11-06	Pfizer Limited	Combinations comprising pregabalin
WO2009050554A2 (en) *	2007-10-19	2009-04-23	Pfizer Inc.	Treatment of central nervous system disorders
DE102008063992A1 (de) *	2008-12-19	2010-09-02	Lerner, Zinoviy, Dipl.-Ing.	Neue aliphatisch substituierte Pyrazolopyridine und ihre Verwendung
CA2830027C (en)	2011-03-31	2016-04-26	Pfizer Inc.	Novel bicyclic pyridinones
WO2012172449A1 (en)	2011-06-13	2012-12-20	Pfizer Inc.	Lactams as beta secretase inhibitors
WO2013030713A1 (en)	2011-08-31	2013-03-07	Pfizer Inc.	Hexahydropyrano [3,4-d][1,3] thiazin-2-amine compounds
EP2852597B1 (en)	2012-05-04	2016-06-08	Pfizer Inc	Heterocyclic substituted hexahydropyrano [3,4-d][1,3]thiazin-2-amine compounds as inhibitors of app, bace1 and bace 2.
EP2897964A1 (en)	2012-09-20	2015-07-29	Pfizer Inc.	Alkyl-substituted hexahydropyrano [3,4-d][1,3]thiazin-2-amine compounds
UA110688C2 (uk)	2012-09-21	2016-01-25	Пфайзер Інк.	Біциклічні піридинони
WO2014091352A1 (en)	2012-12-11	2014-06-19	Pfizer Inc.	Hexahydropyrano [3,4-d][1,3]thiazin-2-amine compounds as inhibitors of bace1
CA2893333C (en)	2012-12-19	2017-10-24	Pfizer Inc.	Carbocyclic-and heterocyclic-substituted hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
WO2014125394A1 (en)	2013-02-13	2014-08-21	Pfizer Inc.	HETEROARYL-SUBSTITUTED HEXAHYDROPYRANO [3,4-d][1,3] THIAZIN-2-AMINE COMPOUNDS
US9233981B1 (en)	2013-02-15	2016-01-12	Pfizer Inc.	Substituted phenyl hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
KR20150119370A (ko)	2013-02-19	2015-10-23	화이자 인코포레이티드	Cns 장애 및 다른 장애의 치료를 위한 pde4 동종효소의 억제제로서의 아자벤즈이미다졸 화합물
CA2925743C (en)	2013-10-04	2018-03-06	Pfizer Inc.	Novel bicyclic pyridinones as gamma-secretase modulators
CA2934391A1 (en) *	2013-12-20	2015-06-25	Bayer Pharma Aktiengesellschaft	Glucose transport inhibitors
JP6643247B2 (ja)	2014-04-01	2020-02-12	ファイザー・インク	ガンマセクレターゼモジュレーターとしてのクロメンおよび１，１ａ，２，７Ｂ−テトラヒドロシクロプロパ［Ｃ］クロメンピリドピラジンジオン
MX364519B (es) *	2014-04-04	2019-04-30	H Lundbeck As	Quinazolin-thf-aminas halogenadas como inhibidores de pde1.
EA030085B1 (ru)	2014-04-10	2018-06-29	Пфайзер Инк.	2-АМИНО-6-МЕТИЛ-4,4a,5,6-ТЕТРАГИДРОПИРАНО[3,4-d][1,3]ТИАЗИН-8a(8H)-ИЛ-1,3-ТИАЗОЛ-4-ИЛ АМИДЫ
EP3172210B1 (en)	2014-07-24	2020-01-15	Pfizer Inc	Pyrazolopyrimidine compounds
CR20170035A (es)	2014-08-06	2017-04-28	Pfizer	Compuestos de imidazopiridazina
AU2015359624B2 (en) *	2014-12-08	2020-01-02	Janssen Sciences Ireland Uc	Piperidine substituted pyrazolo[1,5-a]pyrimidine derivatives with inhibitory activity on the replication of the respiratory syncytial virus (RSV)
AU2016214102B2 (en)	2015-02-03	2018-09-27	Pfizer Inc.	Novel cyclopropabenzofuranyl pyridopyrazinediones
DK3766885T3 (da)	2015-06-17	2022-08-01	Pfizer	Tricykliske forbindelser og deres anvendelse som phoshodiesteraseinhibitorer
EP3353174A1 (en)	2015-09-24	2018-08-01	Pfizer Inc	N-[2-(3-amino-2,5-dimethyl-1,1-dioxido-5,6-dihydro-2h-1,2,4-thiadiazin-5-yl)-1,3-thiazol-4-yl]amides useful as bace inhibitors
AU2016325665A1 (en)	2015-09-24	2018-03-08	Pfizer Inc.	N-[2-(2-amino-6,6-disubstituted-4, 4a, 5, 6-tetrahydropyrano [3,4-d][1,3] thiazin-8a (8h)-yl) -1, 3-thiazol-4-yl] amides
JP2018531924A (ja)	2015-09-24	2018-11-01	ファイザー・インク	テトラヒドロピラノ［３，４−ｄ］［１，３］オキサジン誘導体、およびｂａｃｅ阻害剤としてのその使用
PL3419979T3 (pl)	2016-02-23	2020-06-29	Pfizer Inc.	Związki 6,7-dihydro-5h-pirazolo[5,1-b][1,3]oksazyno-2- karboksyamidowe
EP3478679B1 (en)	2016-07-01	2021-04-21	Pfizer Inc.	5,7-dihydro-pyrrolo-pyridine derivatives for treating neurological and neurodegenerative diseases
ES2937236T3 (es)	2017-06-22	2023-03-27	Pfizer	Derivados de dihidro-pirrolo-piridina
AR115015A1 (es)	2018-03-23	2020-11-18	Pfizer	Derivados de azaespiro piperazina
US11786528B2 (en)	2018-06-04	2023-10-17	Exscientia Ltd.	Pyrazolopyrimidine compounds as adenosine receptor antagonists
EP3840755A4 (en) *	2018-08-24	2022-04-20	Terns, Inc.	THYROID HORMONE RECEPTOR BETA AGONIST COMPOUNDS
WO2022182658A1 (en)	2021-02-23	2022-09-01	Hoth Therapeutics, Inc.	Use of aprepitant for treating alzheimer's disease
WO2024118524A1 (en)	2022-11-28	2024-06-06	Cerevel Therapeutics, Llc	Azaindole compounds and their use as phosphodiesterase inhibitors

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW444018B (en) *	1992-12-17	2001-07-01	Pfizer	Pyrazolopyrimidines
PT1123296E (pt) *	1998-10-23	2003-12-31	Pfizer	Inibidores de cgmp pdes derivados da pirazolopirimidinona para tratamento da disfuncao sexual
GB9823102D0 (en) *	1998-10-23	1998-12-16	Pfizer Ltd	Pharmaceutically active compounds
DE10031236A1 (de) *	2000-06-27	2002-01-10	Qiagen Gmbh	Verwendung von Carbonsäuren und anderen Additiven in Kombination mit kationischen Verbindungen zur Stabilisierung von Nukleinsäuren in biologischen Materialien
DE10031584A1 (de) *	2000-06-29	2002-01-10	Merck Patent Gmbh	5-Aminoalkyl-pyrazolo[4,3-d]pyrimidine
DE60237425D1 (de) *	2002-03-28	2010-10-07	Univerzita Palackeho V Olomouc	PyrazoloÄ4,3-dÜpyrimidine, Verfahren zu ihrer Herstellung und therapeutische Anwendung
JP4015176B2 (ja) *	2003-04-29	2007-11-28	ファイザー・インク	高血圧症の治療に有用な５，７−ジアミノピラゾロ４，３−ジピリミジン類

2003
- 2003-11-24 GB GBGB0327319.0A patent/GB0327319D0/en not_active Ceased
2004
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Also Published As

Publication number	Publication date
MY140872A (en)	2010-01-29
NL1027568A1 (nl)	2005-05-26
CN101362764B (zh)	2011-04-20
PA8617701A1 (es)	2005-08-04
WO2005049616A1 (en)	2005-06-02
EA011772B1 (ru)	2009-06-30
CN101362765B (zh)	2011-02-02
MXPA06005914A (es)	2006-06-27
UY28625A1 (es)	2005-06-30
WO2005049616A8 (en)	2006-06-01
CN101362765A (zh)	2009-02-11
MA28172A1 (fr)	2006-09-01
NL1027568C2 (nl)	2005-11-30
NZ548097A (en)	2008-12-24
EA200600677A1 (ru)	2006-12-29
CN1882591B (zh)	2011-08-10
KR20070026334A (ko)	2007-03-08
TWI265031B (en)	2006-11-01
NO336526B1 (no)	2015-09-21
KR100848216B1 (ko)	2008-07-24
SG133614A1 (en)	2007-07-30
CY1110933T1 (el)	2015-06-10
HK1128917A1 (en)	2009-11-13
CN1882591A (zh)	2006-12-20
HRP20100651T1 (hr)	2011-01-31
GEP20084528B (en)	2008-11-10
OA13289A (en)	2007-01-31
IS8406A (is)	2006-04-10
DE602004029705D1 (de)	2010-12-02
ZA200602899B (en)	2007-07-25
CN101362764A (zh)	2009-02-11
CA2546987C (en)	2009-05-12
GB0327319D0 (en)	2003-12-24
KR100893999B1 (ko)	2009-04-20
JP2007512314A (ja)	2007-05-17
AP2227A (en)	2011-03-29
CR8416A (es)	2006-11-15
CN101647802A (zh)	2010-02-17
AU2004290643A1 (en)	2005-06-02
ATE485297T1 (de)	2010-11-15
JP4056015B2 (ja)	2008-03-05
EP1689751A1 (en)	2006-08-16
AR046711A1 (es)	2005-12-21
AP2006003591A0 (en)	2006-04-30
EP1689751B1 (en)	2010-10-20
RS51556B (en)	2011-06-30
PT1689751E (pt)	2010-11-29
UA81994C2 (en)	2008-02-25
KR20080052666A (ko)	2008-06-11
IL175433A0 (en)	2006-09-05
CA2546987A1 (en)	2005-06-02
TW200520758A (en)	2005-07-01
AU2004290643B2 (en)	2008-08-07
NO20062950L (no)	2006-08-23
DK1689751T3 (da)	2011-01-17
IL175433A (en)	2011-08-31
ECSP066580A (es)	2006-12-20
SI1689751T1 (sl)	2011-01-31
BRPI0416869A (pt)	2007-03-27
PL1689751T3 (pl)	2011-03-31
TNSN06154A1 (fr)	2007-11-15
ME01216B (me)	2013-03-20
PE20051061A1 (es)	2005-12-12
ES2351622T3 (es)	2011-02-08

Publication	Publication Date	Title
IL175433A0 (en)	2006-09-05	5,7 diaminopyrazolo [4,3-d] pyrimidines with pde-5 inhibiting activity
IL182099A0 (en)	2007-07-24	Piperidinylamino-thieno[2,3-d] pyrimidine compounds
EP1599482A4 (en)	2008-10-01	PYRAZOLO1,5-A PYRIMIDINE DERIVATIVES
PL376916A1 (pl)	2006-01-09	Pochodne pirymido [4,5-d] pirymidyny o działaniu przeciwrakowym
HK1086012A1 (en)	2006-09-08	8-substitued-6,7,8,9-tetrahydropyrimidoÄ1,2-aÜ pyrimidin-4-one derivatives
TWI365189B (en)	2012-06-01	Novel pyrrolo[3,2-d]pyrimidin-4-one derivatives
EG24843A (en)	2010-10-13	Herbicidal pyrimidines
HK1088893A1 (en)	2006-11-17	Substituted 8-perfluoroalkyl-6,7,8,9-tetrahydropyrimidoÄ1,2-aÜ pyrimidin-4-one derivatives
IL159832A0 (en)	2004-06-20	4-amino-6-phenyl-pyrrolo[2,3-d] pyrimidine derivatives
EP1653969A4 (en)	2006-12-20	PYRROLO 1,2-B PYRIDAZINE DERIVATIVES
HK1091488A1 (en)	2007-01-19	Pyrimidine derivatives
ZA200604960B (en)	2007-11-28	Substituted 8'-pyri(mi)dinyl-dihydrospiro-[cycloalkylamine]-pyrimido[1,2-A]pyrimidin-6-onederivatives
AP2002002543A0 (en)	2002-06-30	Pyrrolo Ä2,3-dÜ pyrimidine compounds
IL172098A0 (en)	2009-02-11	Triazolopyrimidines
PL358551A1 (en)	2004-08-09	5-aminoalkyl-pyrazolo[4,3-d]pyrimidines
PL372989A1 (en)	2005-08-08	Triazolopyrimidines
AP2157A (en)	2010-09-13	2-substituted pyrimidines.
ZA200510276B (en)	2007-03-28	Triazolopyrimidines
MXPA03004498A (es)	2003-09-05	Uso de pirazolo (4,3-d)pirimidinas.
TWI372760B (en)	2012-09-21	A pyrazolo[1,5-a]pyrimidine compound
MXPA03004907A (es)	2003-09-05	Uso de pirazolo (4,3-d) pirimidinas.
GB0323137D0 (en)	2003-11-05	2,4,6- Trisubstituted pyrimidines and their different uses
IL172845A0 (en)	2006-06-11	2-substituted pyrimidines
IL173347A0 (en)	2006-06-11	7-SUBSTITUTED 3-NITRO-PYRAZOLO[1,5-a] PYRIMIDINES
TJ431B (en)	2007-06-05	2-Brom-7-methil-5-oxo-5h-1,3,4-thyodyazol-(3,2-a)pyrimidin, has antibacterial activity

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Date	Code	Title	Description
2019-06-21	PC	Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)	Effective date: 20181112