GB1056291A - Improved process for preparing sodium warfarin - Google Patents
Improved process for preparing sodium warfarinInfo
- Publication number
- GB1056291A GB1056291A GB115/64A GB11564A GB1056291A GB 1056291 A GB1056291 A GB 1056291A GB 115/64 A GB115/64 A GB 115/64A GB 11564 A GB11564 A GB 11564A GB 1056291 A GB1056291 A GB 1056291A
- Authority
- GB
- United Kingdom
- Prior art keywords
- warfarin
- sodium warfarin
- improved process
- sodium
- ethanol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- KYITYFHKDODNCQ-UHFFFAOYSA-M sodium;2-oxo-3-(3-oxo-1-phenylbutyl)chromen-4-olate Chemical compound [Na+].[O-]C=1C2=CC=CC=C2OC(=O)C=1C(CC(=O)C)C1=CC=CC=C1 KYITYFHKDODNCQ-UHFFFAOYSA-M 0.000 title abstract 5
- 238000004519 manufacturing process Methods 0.000 title 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 4
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 abstract 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
- 238000001035 drying Methods 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- 238000001816 cooling Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- OGHBATFHNDZKSO-UHFFFAOYSA-N propan-2-olate Chemical compound CC(C)[O-] OGHBATFHNDZKSO-UHFFFAOYSA-N 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- PJVWKTKQMONHTI-UHFFFAOYSA-N warfarin Chemical compound OC=1C2=CC=CC=C2OC(=O)C=1C(CC(=O)C)C1=CC=CC=C1 PJVWKTKQMONHTI-UHFFFAOYSA-N 0.000 abstract 1
- 229960005080 warfarin Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/42—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4
- C07D311/44—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 with one hydrogen atom in position 3
- C07D311/46—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 with one hydrogen atom in position 3 unsubstituted in the carbocyclic ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA875556 | 1963-05-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1056291A true GB1056291A (en) | 1967-01-25 |
Family
ID=4141722
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB115/64A Expired GB1056291A (en) | 1963-05-14 | 1964-01-01 | Improved process for preparing sodium warfarin |
Country Status (3)
| Country | Link |
|---|---|
| BE (1) | BE644186A (uk) |
| FR (1) | FR1397213A (uk) |
| GB (1) | GB1056291A (uk) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1089992A4 (en) * | 1995-12-28 | 2001-04-11 | Hoechst Celanese Corp | SYNTHESIS BASED ON 2-HYDROXY ACETOPHENONE |
| US6673944B2 (en) * | 2001-02-28 | 2004-01-06 | Taro Pharmaceutical Industries, Ltd. | Preparation of warfarin sodium from warfarin acid |
| WO2011145007A1 (en) * | 2010-05-20 | 2011-11-24 | Alembic Pharmaceuticals Limited | A process for the preparation of amorphous warfarin sodium |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL157555A0 (en) * | 2001-02-28 | 2004-03-28 | Taro Pharmaceuticals Usa Inc | Process for purification of warfarin acid, warfarin alkali metal salts and corresponding clathrates |
| US6512005B2 (en) | 2001-02-28 | 2003-01-28 | Taro Pharmaceutical Industries, Ltd. | Process for synthesis of pure warfarin acid, warfarin alkali metal salts and corresponding clathrates |
| US6610862B2 (en) | 2001-02-28 | 2003-08-26 | Taro Pharmaceutical Industries Ltd. | Preparation of warfarin sodium from warfarin sodium-2-propanol clathrate by solvent expulsion |
-
1963
- 1963-12-30 FR FR958840A patent/FR1397213A/fr not_active Expired
-
1964
- 1964-01-01 GB GB115/64A patent/GB1056291A/en not_active Expired
- 1964-02-21 BE BE644186D patent/BE644186A/xx unknown
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1089992A4 (en) * | 1995-12-28 | 2001-04-11 | Hoechst Celanese Corp | SYNTHESIS BASED ON 2-HYDROXY ACETOPHENONE |
| US6673944B2 (en) * | 2001-02-28 | 2004-01-06 | Taro Pharmaceutical Industries, Ltd. | Preparation of warfarin sodium from warfarin acid |
| WO2011145007A1 (en) * | 2010-05-20 | 2011-11-24 | Alembic Pharmaceuticals Limited | A process for the preparation of amorphous warfarin sodium |
Also Published As
| Publication number | Publication date |
|---|---|
| BE644186A (uk) | 1964-08-21 |
| FR1397213A (fr) | 1965-04-30 |
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