GB796512A - Process for recovering an antibiotic nystatin - Google Patents
Process for recovering an antibiotic nystatinInfo
- Publication number
- GB796512A GB796512A GB31091/55A GB3109155A GB796512A GB 796512 A GB796512 A GB 796512A GB 31091/55 A GB31091/55 A GB 31091/55A GB 3109155 A GB3109155 A GB 3109155A GB 796512 A GB796512 A GB 796512A
- Authority
- GB
- United Kingdom
- Prior art keywords
- solvent
- recovering
- broth
- nystatia
- adjust
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/465—Streptomyces
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Nystatin is recovered from an aqueous streptomyces noursei fermentation broth by adding to the whole broth a water-miscible organic solvent which is isopropanol, n-propanol, ethanol, methanol, or acetone, filtering the resulting mixture, removing the water-miscible solvent from the filtrate and recovering the resulting nystatia precipitate. After adding the solvent to the broth, it is preferred to adjust the pH to 4 to 6 and especially 4.5 to 5.5 by acids such as phosphoric to assist the solubilization of the nystatia in the aqueous solvent and then to adjust the pH to 6.5 to 7.5 and especially 7 by means of alkali such as sodium hydroxide in order to precipitate impurities which are filtered off. It is preferred to remove the solvent under vacuum at a temperature of up to substantially 30 DEG C. Specification 714,189 is referred to.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US796512XA | 1954-11-04 | 1954-11-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB796512A true GB796512A (en) | 1958-06-11 |
Family
ID=22151916
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB31091/55A Expired GB796512A (en) | 1954-11-04 | 1955-10-31 | Process for recovering an antibiotic nystatin |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB796512A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103755758A (en) * | 2014-01-21 | 2014-04-30 | 北京安汀医药生物科技有限公司 | Preparation method of nystatin |
-
1955
- 1955-10-31 GB GB31091/55A patent/GB796512A/en not_active Expired
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103755758A (en) * | 2014-01-21 | 2014-04-30 | 北京安汀医药生物科技有限公司 | Preparation method of nystatin |
| CN103755758B (en) * | 2014-01-21 | 2016-04-27 | 北京安汀医药生物科技有限公司 | A kind of preparation method of nystatin |
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