FR16C0026I2 - Souches de virus herpetique pour therapie genique - Google Patents
Souches de virus herpetique pour therapie geniqueInfo
- Publication number
- FR16C0026I2 FR16C0026I2 FR16C0026C FR16C0026C FR16C0026I2 FR 16C0026 I2 FR16C0026 I2 FR 16C0026I2 FR 16C0026 C FR16C0026 C FR 16C0026C FR 16C0026 C FR16C0026 C FR 16C0026C FR 16C0026 I2 FR16C0026 I2 FR 16C0026I2
- Authority
- FR
- France
- Prior art keywords
- hsv1
- strain
- hsv
- gene therapy
- virus strains
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/76—Viruses; Subviral particles; Bacteriophages
- A61K35/763—Herpes virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
- C12N15/869—Herpesviral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55516—Proteins; Peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55522—Cytokines; Lymphokines; Interferons
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16021—Viruses as such, e.g. new isolates, mutants or their genomic sequences
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16033—Use of viral protein as therapeutic agent other than vaccine, e.g. apoptosis inducing or anti-inflammatory
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
- C12N2710/16632—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
- C12N2710/16641—Use of virus, viral particle or viral elements as a vector
- C12N2710/16643—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Biotechnology (AREA)
- Virology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Mycology (AREA)
- Oncology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Communicable Diseases (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0001475A GB0001475D0 (en) | 2000-01-21 | 2000-01-21 | Virus strains |
GB0002854A GB0002854D0 (en) | 2000-02-08 | 2000-02-08 | Virus strains |
GB0100288A GB0100288D0 (en) | 2001-01-05 | 2001-01-05 | Virus strains |
GB0100430A GB0100430D0 (en) | 2001-01-06 | 2001-01-06 | Virus strains |
PCT/GB2001/000225 WO2001053505A2 (fr) | 2000-01-21 | 2001-01-22 | Souches de virus herpetique |
Publications (2)
Publication Number | Publication Date |
---|---|
FR16C0026I1 FR16C0026I1 (fr) | 2016-07-22 |
FR16C0026I2 true FR16C0026I2 (fr) | 2018-04-27 |
Family
ID=27447756
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR16C0026C Active FR16C0026I2 (fr) | 2000-01-21 | 2016-06-15 | Souches de virus herpetique pour therapie genique |
Country Status (22)
Country | Link |
---|---|
US (12) | US7223593B2 (fr) |
EP (4) | EP1252322B2 (fr) |
JP (6) | JP4921669B2 (fr) |
KR (2) | KR100802403B1 (fr) |
CN (2) | CN1418255A (fr) |
AT (2) | ATE282708T1 (fr) |
AU (2) | AU2695101A (fr) |
BE (1) | BE2016C033I2 (fr) |
BR (3) | BRPI0107737B8 (fr) |
CA (2) | CA2398343A1 (fr) |
CY (2) | CY2016020I2 (fr) |
DE (2) | DE60107203T3 (fr) |
DK (2) | DK1252323T3 (fr) |
ES (2) | ES2254359T3 (fr) |
FR (1) | FR16C0026I2 (fr) |
GB (2) | GB2375113B (fr) |
HK (2) | HK1047451B (fr) |
IL (4) | IL150678A0 (fr) |
LU (2) | LU93101I2 (fr) |
NL (2) | NL300821I2 (fr) |
PT (1) | PT1252322E (fr) |
WO (2) | WO2001053505A2 (fr) |
Families Citing this family (181)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AUPQ425699A0 (en) | 1999-11-25 | 1999-12-23 | University Of Newcastle Research Associates Limited, The | A method of treating a malignancy in a subject and a pharmaceutical composition for use in same |
CA2398343A1 (fr) * | 2000-01-21 | 2001-07-26 | Biovex Limited | Souches virales pour le traitement oncolytique du cancer |
EP1381280B1 (fr) | 2001-03-27 | 2011-05-11 | Catherex, Inc. | Vecteurs viraux et utilisation de ces derniers dans des methodes therapeutiques |
GB0203285D0 (en) | 2002-02-12 | 2002-03-27 | Brown Susanne M | An herpes simplex virus complex |
JP2004099584A (ja) * | 2002-05-02 | 2004-04-02 | Keio Gijuku | Hsvを用いた抗腫瘍剤 |
AU2002953436A0 (en) | 2002-12-18 | 2003-01-09 | The University Of Newcastle Research Associates Limited | A method of treating a malignancy in a subject via direct picornaviral-mediated oncolysis |
GB0317511D0 (en) | 2003-07-25 | 2003-08-27 | Biovex Ltd | Viral vectors |
GB0326798D0 (en) * | 2003-11-17 | 2003-12-24 | Crusade Lab Ltd | Methods for generating mutant virus |
US7897146B2 (en) | 2003-11-17 | 2011-03-01 | Crusade Laboratories Limited | Treatment using herpes simplex virus |
WO2005049846A2 (fr) * | 2003-11-17 | 2005-06-02 | Crusade Laboratories Limited | Virus mutants |
AU2005228788B2 (en) * | 2004-03-31 | 2010-12-02 | Tomoki Todo | Anticancer activity enhancer of viral therapy and method of cancer prevention or treatment |
CA2561714A1 (fr) * | 2004-04-08 | 2005-10-27 | Sangamo Biosciences, Inc. | Procedes et compositions permettant de traiter les troubles neuropathiques et neurodegeneratifs |
US9273326B2 (en) * | 2004-04-30 | 2016-03-01 | The Brigham And Women's Hospital, Inc. | Tetracycline-regulated gene expression in HSV-1 vectors |
ES2564823T3 (es) * | 2005-05-27 | 2016-03-29 | Ospedale San Raffaele S.R.L. | Vector génico que comprende miARN |
US20080008686A1 (en) * | 2006-07-10 | 2008-01-10 | The Brigham And Women's Hospital, Inc. | Tetracycline repressor regulated oncolytic viruses |
US8450106B2 (en) * | 2007-10-17 | 2013-05-28 | The Ohio State University Research Foundation | Oncolytic virus |
US8313896B2 (en) * | 2008-04-04 | 2012-11-20 | The General Hospital Corporation | Oncolytic herpes simplex virus immunotherapy in the treatment of brain cancer |
CA2689707A1 (fr) | 2009-11-16 | 2011-05-16 | Jean-Simon Diallo | Identification d'une nouvelle petite molecule sensibilisatrice virale, vse1, a l'aide du criblage a haut debit |
CN102666843B (zh) | 2009-12-21 | 2014-10-22 | 布里格海姆妇女医院公司 | 单纯疱疹病毒疫苗 |
CN102146418B (zh) * | 2010-02-09 | 2014-01-15 | 武汉滨会生物科技有限公司 | 重组ⅱ型单纯疱疹病毒载体及其制备方法、重组病毒、药物组合物及应用 |
WO2011101912A1 (fr) * | 2010-02-19 | 2011-08-25 | 国立大学法人東京大学 | Virus de l'herpès recombinant et composition pharmaceutique contenant le virus de l'herpès recombinant |
EP2550298B1 (fr) | 2010-03-23 | 2015-07-15 | The Regents of The University of California | Compositions et méthodes de préparation de vaccins auto-adjuvants contre microbes et tumeurs |
WO2011119925A2 (fr) * | 2010-03-25 | 2011-09-29 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Virus synthétiques de l'herpès simplex pour le traitement de cancers |
EP2670426B1 (fr) | 2011-01-31 | 2017-05-10 | The General Hospital Corporation | Molécules trail multimodales et leurs utilisations en thérapies cellulaires |
PT2753355T (pt) | 2011-09-08 | 2019-02-01 | Univ New York | Vírus herpes simplex oncolítico e suas utilizações terapêuticas |
WO2013052915A2 (fr) | 2011-10-05 | 2013-04-11 | Genelux Corporation | Procédé de détection de la réplication ou colonisation d'un produit thérapeutique biologique |
WO2013138522A2 (fr) | 2012-03-16 | 2013-09-19 | Genelux Corporation | Méthodes d'évaluation de l'efficacité et de la surveillance d'un traitement viral oncolytique |
US20130280170A1 (en) | 2012-04-20 | 2013-10-24 | Aladar A. Szalay | Imaging methods for oncolytic virus therapy |
EP3473708B1 (fr) | 2012-07-24 | 2021-01-27 | The General Hospital Corporation | Traitement par virus oncolytique de tumeurs résistantes |
EP2890720B1 (fr) | 2012-08-30 | 2019-07-17 | The General Hospital Corporation | Compositions et méthodes de traitement du cancer |
CN114984062A (zh) | 2012-08-30 | 2022-09-02 | 安姆根有限公司 | 使用单纯疱疹病毒和免疫检查点抑制剂治疗黑色素瘤的方法 |
WO2014055960A1 (fr) | 2012-10-05 | 2014-04-10 | Genelux Corporation | Procédés diagnostiques et thérapeutiques basés sur l'absorption d'énergie utilisant des molécules d'acide nucléique codant pour des enzymes productrices de chromophore |
EP3022307A4 (fr) * | 2013-07-17 | 2017-04-19 | University of Pittsburgh - Of the Commonwealth System of Higher Education | Vecteurs vhs non toxiques pour l'administration efficace de gènes et cellules de complémentation pour les produire |
SG11201602876WA (en) | 2013-10-24 | 2016-05-30 | Amgen Inc | Injector and method of assembly |
US10758683B2 (en) | 2013-10-24 | 2020-09-01 | Amgen Inc. | Drug delivery system with temperature-sensitive control |
CN114457044A (zh) | 2013-10-25 | 2022-05-10 | 普西奥克瑟斯医疗有限公司 | 武装有异源基因的溶瘤腺病毒 |
US20160303174A1 (en) | 2013-12-11 | 2016-10-20 | The General Hospital Corporation | Stem cell delivered oncolytic herpes simplex virus and methods for treating brain tumors |
US10238700B2 (en) | 2014-01-02 | 2019-03-26 | Genelux Corporation | Oncolytic virus adjunct therapy with agents that increase virus infectivity |
WO2015119906A1 (fr) | 2014-02-05 | 2015-08-13 | Amgen Inc. | Système d'administration de médicament doté d'un générateur de champ électromagnétique |
MA39818A (fr) | 2014-03-30 | 2017-02-08 | Benevir Biopharm Inc | Virus oncolytiques « armés » comprenant un inhibiteur de tap exogène et leurs utilisations thérapeutiques |
WO2015171777A1 (fr) | 2014-05-07 | 2015-11-12 | Amgen Inc. | Auto-injecteur comprenant des éléments de réduction de choc |
CN113990437A (zh) | 2014-06-03 | 2022-01-28 | 安姆根有限公司 | 用于远程处理由药物递送装置收集的数据的系统和方法 |
EP3206739B1 (fr) | 2014-10-14 | 2021-12-01 | Amgen Inc. | Dispositif d'injection de médicament comportant des témoins visuels et sonores |
SG11201702934TA (en) | 2014-10-14 | 2017-05-30 | Halozyme Inc | Compositions of adenosine deaminase-2 (ada2), variants thereof and methods of using same |
US10799630B2 (en) | 2014-12-19 | 2020-10-13 | Amgen Inc. | Drug delivery device with proximity sensor |
ES2785311T3 (es) | 2014-12-19 | 2020-10-06 | Amgen Inc | Dispositivo de administración de fármacos con botón móvil o campo de interfaz de usuario |
DK3250550T3 (da) | 2015-01-26 | 2023-07-17 | Ottawa Hospital Res Inst | Sammensætninger og fremgangsmåder til virussensibilisering |
MX2017010466A (es) | 2015-02-17 | 2018-06-06 | Amgen Inc | Dispositivo de administracion de farmacos con sujecion asistida de vacio y/o respuestas. |
ES2905870T3 (es) | 2015-02-27 | 2022-04-12 | Amgen Inc | Dispositivo de suministro de fármacos que tiene un mecanismo de protección de aguja con un umbral de resistencia ajustable al movimiento de la protección de aguja |
GB201505860D0 (en) | 2015-04-07 | 2015-05-20 | Agalimmune Ltd | Therapeutic compositions and methods of use for treating cancer |
EP3283529B1 (fr) | 2015-04-17 | 2023-06-07 | The General Hospital Corporation | Agents, systèmes et méthodes de traitement du cancer |
SMT202000222T1 (it) | 2015-04-30 | 2020-05-08 | Psioxus Therapeutics Ltd | Adenovirus oncolitico che codifica per una proteina b7 |
WO2016205429A1 (fr) | 2015-06-15 | 2016-12-22 | New York University | Méthode de traitement utilisant des virus oncolytiques |
WO2017039786A1 (fr) | 2015-09-02 | 2017-03-09 | Amgen Inc. | Adaptateur d'ensemble de seringue pour une seringue |
CN105219738A (zh) * | 2015-09-21 | 2016-01-06 | 北京神源德生物科技有限公司 | 重组单纯疱疹病毒及它感染和制备它的宿主细胞以及它们的应用 |
CA3004530A1 (fr) | 2015-11-07 | 2017-05-11 | Multivir Inc. | Methodes et compositions comprenant une therapie genique suppressive de tumeur et le blocage du point de controle immunitaire pour le traitement du cancer |
EP3386573B1 (fr) | 2015-12-09 | 2019-10-02 | Amgen Inc. | Auto-injecteur avec capuchon de signalisation |
US11155622B2 (en) | 2015-12-17 | 2021-10-26 | Psioxus Therapeutics Limited | Virus encoding an anti-TCR-complex antibody or fragment |
WO2017120178A1 (fr) | 2016-01-06 | 2017-07-13 | Amgen Inc. | Auto-injecteur pourvu d'une électronique de signalisation |
MX2018008413A (es) | 2016-01-08 | 2019-02-20 | Replimune Ltd | Virus oncolitico modificado. |
EP4122478A1 (fr) | 2016-02-19 | 2023-01-25 | Virogin Biotech Canada Ltd | Compositions et méthodes d'utilisation d'inhibiteurs des stat1/3 avec un virus oncolytique de l'herpès |
EP4035711A1 (fr) | 2016-03-15 | 2022-08-03 | Amgen Inc. | Réduction de la probabilité de rupture de verre dans des dispositifs d'administration de médicament |
ES2939644T3 (es) | 2016-03-25 | 2023-04-25 | Periphagen Inc | Vectores de HSV de alta transducción |
CA3019202A1 (fr) | 2016-04-15 | 2017-10-19 | Alpine Immune Sciences, Inc. | Proteines immunomodulatrices a variants de cd80 et leurs utilisations |
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IL131212A0 (en) * | 1999-08-03 | 2001-01-28 | Yissum Res Dev Co | Recombinant virus and live-virus vaccines |
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CA2398343A1 (fr) * | 2000-01-21 | 2001-07-26 | Biovex Limited | Souches virales pour le traitement oncolytique du cancer |
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2001
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2006
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2007
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2009
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2011
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2012
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2014
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