FR16C0026I2 - Souches de virus herpetique pour therapie genique - Google Patents
Souches de virus herpetique pour therapie geniqueInfo
- Publication number
- FR16C0026I2 FR16C0026I2 FR16C0026C FR16C0026C FR16C0026I2 FR 16C0026 I2 FR16C0026 I2 FR 16C0026I2 FR 16C0026 C FR16C0026 C FR 16C0026C FR 16C0026 C FR16C0026 C FR 16C0026C FR 16C0026 I2 FR16C0026 I2 FR 16C0026I2
- Authority
- FR
- France
- Prior art keywords
- hsv1
- strain
- hsv
- gene therapy
- virus strains
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 241000700605 Viruses Species 0.000 title 1
- 238000001415 gene therapy Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/76—Viruses; Subviral particles; Bacteriophages
- A61K35/763—Herpes virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
- C12N15/869—Herpesviral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55516—Proteins; Peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55522—Cytokines; Lymphokines; Interferons
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16021—Viruses as such, e.g. new isolates, mutants or their genomic sequences
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16033—Use of viral protein as therapeutic agent other than vaccine, e.g. apoptosis inducing or anti-inflammatory
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
- C12N2710/16632—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
- C12N2710/16641—Use of virus, viral particle or viral elements as a vector
- C12N2710/16643—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Biotechnology (AREA)
- Virology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Mycology (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Communicable Diseases (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0001475A GB0001475D0 (en) | 2000-01-21 | 2000-01-21 | Virus strains |
GB0002854A GB0002854D0 (en) | 2000-02-08 | 2000-02-08 | Virus strains |
GB0100288A GB0100288D0 (en) | 2001-01-05 | 2001-01-05 | Virus strains |
GB0100430A GB0100430D0 (en) | 2001-01-06 | 2001-01-06 | Virus strains |
PCT/GB2001/000225 WO2001053505A2 (en) | 2000-01-21 | 2001-01-22 | Herpes virus strains for gene therapy |
Publications (2)
Publication Number | Publication Date |
---|---|
FR16C0026I1 FR16C0026I1 (da) | 2016-07-22 |
FR16C0026I2 true FR16C0026I2 (fr) | 2018-04-27 |
Family
ID=27447756
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR16C0026C Active FR16C0026I2 (fr) | 2000-01-21 | 2016-06-15 | Souches de virus herpetique pour therapie genique |
Country Status (22)
Country | Link |
---|---|
US (12) | US7063835B2 (da) |
EP (4) | EP1252323B1 (da) |
JP (6) | JP4810042B2 (da) |
KR (2) | KR100802403B1 (da) |
CN (2) | CN1250732C (da) |
AT (2) | ATE312189T1 (da) |
AU (2) | AU2695101A (da) |
BE (1) | BE2016C033I2 (da) |
BR (3) | BRPI0107736B8 (da) |
CA (2) | CA2398335C (da) |
CY (2) | CY2016020I2 (da) |
DE (2) | DE60115600T2 (da) |
DK (2) | DK1252323T3 (da) |
ES (2) | ES2233600T5 (da) |
FR (1) | FR16C0026I2 (da) |
GB (2) | GB2374873C (da) |
HK (2) | HK1047451B (da) |
IL (4) | IL150677A0 (da) |
LU (2) | LU93100I2 (da) |
NL (2) | NL300820I2 (da) |
PT (1) | PT1252322E (da) |
WO (2) | WO2001053505A2 (da) |
Families Citing this family (182)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AUPQ425699A0 (en) | 1999-11-25 | 1999-12-23 | University Of Newcastle Research Associates Limited, The | A method of treating a malignancy in a subject and a pharmaceutical composition for use in same |
ES2233600T5 (es) * | 2000-01-21 | 2009-06-22 | Biovex Limited | Cepas de virus del herpes. |
AU2002306919B2 (en) | 2001-03-27 | 2007-11-22 | Tomoki Todo | Viral vectors and their use in therapeutic methods |
GB0203285D0 (en) | 2002-02-12 | 2002-03-27 | Brown Susanne M | An herpes simplex virus complex |
JP2004099584A (ja) * | 2002-05-02 | 2004-04-02 | Keio Gijuku | Hsvを用いた抗腫瘍剤 |
AU2002953436A0 (en) | 2002-12-18 | 2003-01-09 | The University Of Newcastle Research Associates Limited | A method of treating a malignancy in a subject via direct picornaviral-mediated oncolysis |
GB0317511D0 (en) * | 2003-07-25 | 2003-08-27 | Biovex Ltd | Viral vectors |
JP2007511216A (ja) * | 2003-11-17 | 2007-05-10 | クルセイド ラボラトリーズ リミテッド | 変異ウイルス |
US7897146B2 (en) | 2003-11-17 | 2011-03-01 | Crusade Laboratories Limited | Treatment using herpes simplex virus |
GB0326798D0 (en) * | 2003-11-17 | 2003-12-24 | Crusade Lab Ltd | Methods for generating mutant virus |
AU2005228788B2 (en) * | 2004-03-31 | 2010-12-02 | Tomoki Todo | Anticancer activity enhancer of viral therapy and method of cancer prevention or treatment |
JP4903689B2 (ja) * | 2004-04-08 | 2012-03-28 | サンガモ バイオサイエンシズ インコーポレイテッド | 神経障害および神経変性症状を治療するための方法と組成物 |
US9273326B2 (en) | 2004-04-30 | 2016-03-01 | The Brigham And Women's Hospital, Inc. | Tetracycline-regulated gene expression in HSV-1 vectors |
DK2002003T3 (da) * | 2005-05-27 | 2016-03-21 | Ospedale San Raffaele Srl | Genvektor omfattende miRNA |
US20080008686A1 (en) * | 2006-07-10 | 2008-01-10 | The Brigham And Women's Hospital, Inc. | Tetracycline repressor regulated oncolytic viruses |
US8450106B2 (en) * | 2007-10-17 | 2013-05-28 | The Ohio State University Research Foundation | Oncolytic virus |
US8313896B2 (en) * | 2008-04-04 | 2012-11-20 | The General Hospital Corporation | Oncolytic herpes simplex virus immunotherapy in the treatment of brain cancer |
CA2689707A1 (en) | 2009-11-16 | 2011-05-16 | Jean-Simon Diallo | Identification of the novel small molecule viral sensitizer vse1 using high-throughput screening |
PT2516629T (pt) | 2009-12-21 | 2016-07-07 | The Brigham And Women`S Hospital Inc | Vacinas de vírus herpes simplex |
CN102146418B (zh) * | 2010-02-09 | 2014-01-15 | 武汉滨会生物科技有限公司 | 重组ⅱ型单纯疱疹病毒载体及其制备方法、重组病毒、药物组合物及应用 |
WO2011101912A1 (ja) * | 2010-02-19 | 2011-08-25 | 国立大学法人東京大学 | 組み換えヘルペスウイルス及び組換えヘルペスウイルスを含む医薬組成物 |
WO2011119628A2 (en) * | 2010-03-23 | 2011-09-29 | The Regents Of The University Of California | Compositions and methods for self-adjuvanting vaccines against microbes and tumors |
WO2011119925A2 (en) * | 2010-03-25 | 2011-09-29 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Synthetic herpes simplex viruses for treatment of cancers |
WO2012106281A2 (en) | 2011-01-31 | 2012-08-09 | The General Hospital Corporation | Multimodal trail molecules and uses in cellular therapies |
RS58146B1 (sr) * | 2011-09-08 | 2019-02-28 | Univ New York | Onkolitički herpes simpleks virus i njegova terapeutska upotreba |
EP2764119A2 (en) | 2011-10-05 | 2014-08-13 | Genelux Corporation | Method for detecting replication or colonization of a biological therapeutic |
US20140087362A1 (en) | 2012-03-16 | 2014-03-27 | Aladar A. Szalay | Methods for assessing effectiveness and monitoring oncolytic virus treatment |
US20130280170A1 (en) | 2012-04-20 | 2013-10-24 | Aladar A. Szalay | Imaging methods for oncolytic virus therapy |
WO2014018113A1 (en) | 2012-07-24 | 2014-01-30 | The General Hospital Corporation | Oncolytic virus therapy for resistant tumors |
JP6457940B2 (ja) | 2012-08-30 | 2019-01-23 | アムジエン・インコーポレーテツド | 単純ヘルペスウイルスおよび免疫チェックポイント阻害薬を使用して、メラノーマを治療するための方法 |
EP2890720B1 (en) | 2012-08-30 | 2019-07-17 | The General Hospital Corporation | Compositions and methods for treating cancer |
WO2014055960A1 (en) | 2012-10-05 | 2014-04-10 | Genelux Corporation | Energy absorbing-based diagnostic and therapeutic methods employing nucleic acid molecules encoding chromophore-producing enzymes |
KR102242981B1 (ko) * | 2013-07-17 | 2021-04-22 | 유니버시티 오브 피츠버그-오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 | 효율적인 유전자 전달 적용을 위한 비독성 hsv 벡터 및 이의 생산을 위한 보완 세포 |
US10758683B2 (en) | 2013-10-24 | 2020-09-01 | Amgen Inc. | Drug delivery system with temperature-sensitive control |
KR102458637B1 (ko) | 2013-10-24 | 2022-10-24 | 암겐 인코포레이티드 | 주입기 및 조립 방법 |
AU2014338864C1 (en) | 2013-10-25 | 2020-07-16 | Akamis Bio Limited | Oncolytic adenoviruses armed with heterologous genes |
US20160303174A1 (en) | 2013-12-11 | 2016-10-20 | The General Hospital Corporation | Stem cell delivered oncolytic herpes simplex virus and methods for treating brain tumors |
US10238700B2 (en) | 2014-01-02 | 2019-03-26 | Genelux Corporation | Oncolytic virus adjunct therapy with agents that increase virus infectivity |
US10994112B2 (en) | 2014-02-05 | 2021-05-04 | Amgen Inc. | Drug delivery system with electromagnetic field generator |
MA39818A (fr) | 2014-03-30 | 2017-02-08 | Benevir Biopharm Inc | Virus oncolytiques « armés » comprenant un inhibiteur de tap exogène et leurs utilisations thérapeutiques |
KR102496507B1 (ko) | 2014-05-07 | 2023-02-03 | 암겐 인코포레이티드 | 충격 감소 요소들을 가진 자동 주사기 |
CN106663139A (zh) | 2014-06-03 | 2017-05-10 | 安姆根有限公司 | 用于远程处理由药物递送装置收集的数据的系统和方法 |
EP3943135A3 (en) | 2014-10-14 | 2022-06-29 | Amgen Inc. | Drug injection device with visual and audible indicators |
BR112017007765B1 (pt) | 2014-10-14 | 2023-10-03 | Halozyme, Inc | Composições de adenosina deaminase-2 (ada2), variantes do mesmo e métodos de usar o mesmo |
US11357916B2 (en) | 2014-12-19 | 2022-06-14 | Amgen Inc. | Drug delivery device with live button or user interface field |
JP6716566B2 (ja) | 2014-12-19 | 2020-07-01 | アムジエン・インコーポレーテツド | 近接センサ付き薬物送達装置 |
EP3250550B1 (en) | 2015-01-26 | 2023-04-05 | Ottawa Hospital Research Institute | Compositions and methods for viral sensitization |
ES2748750T3 (es) | 2015-02-17 | 2020-03-17 | Amgen Inc | Dispositivo de administración de fármacos con sujeción asistida por vacío y/o realimentación |
EP3261690B1 (en) | 2015-02-27 | 2021-12-15 | Amgen Inc. | Drug delivery device having a needle guard mechanism with a tunable threshold of resistance to needle guard movement |
GB201505860D0 (en) | 2015-04-07 | 2015-05-20 | Agalimmune Ltd | Therapeutic compositions and methods of use for treating cancer |
WO2016168601A1 (en) | 2015-04-17 | 2016-10-20 | Khalid Shah | Agents, systems and methods for treating cancer |
IL284375B (en) * | 2015-04-30 | 2022-07-01 | Psioxus Therapeutics Ltd | Replication competent oncolytic group b adenovirus |
US10967015B2 (en) | 2015-06-15 | 2021-04-06 | New York University | Method of treatment using oncolytic viruses |
WO2017039786A1 (en) | 2015-09-02 | 2017-03-09 | Amgen Inc. | Syringe assembly adapter for a syringe |
CN105219738A (zh) * | 2015-09-21 | 2016-01-06 | 北京神源德生物科技有限公司 | 重组单纯疱疹病毒及它感染和制备它的宿主细胞以及它们的应用 |
WO2017079746A2 (en) | 2015-11-07 | 2017-05-11 | Multivir Inc. | Methods and compositions comprising tumor suppressor gene therapy and immune checkpoint blockade for the treatment of cancer |
US11351308B2 (en) | 2015-12-09 | 2022-06-07 | Amgen Inc. | Auto-injector with signaling cap |
MX2018007249A (es) | 2015-12-17 | 2019-05-16 | Psioxus Therapeutics Ltd | Adenovirus del grupo b que codifica un anticuerpo contra el complejo tcr o fragmento de este. |
US11154661B2 (en) | 2016-01-06 | 2021-10-26 | Amgen Inc. | Auto-injector with signaling electronics |
MX2018008413A (es) | 2016-01-08 | 2019-02-20 | Replimune Ltd | Virus oncolitico modificado. |
CN116059379A (zh) | 2016-02-19 | 2023-05-05 | 复诺健生物科技加拿大有限公司 | 利用stat1/3抑制剂与溶瘤型疱疹病毒的组合物和方法 |
EP4035711A1 (en) | 2016-03-15 | 2022-08-03 | Amgen Inc. | Reducing probability of glass breakage in drug delivery devices |
EP4212169A1 (en) | 2016-03-25 | 2023-07-19 | PeriphaGen, Inc. | High-transducing hsv vectors |
IL262366B2 (en) | 2016-04-15 | 2024-07-01 | Alpine Immune Sciences Inc | Immunomodulatory proteins and CD80 variants and their uses |
CA3019199A1 (en) | 2016-04-15 | 2017-10-19 | Alpine Immune Sciences, Inc. | Icos ligand variant immunomodulatory proteins and uses thereof |
EP3426272A4 (en) * | 2016-04-26 | 2020-03-04 | Salk Institute for Biological Studies | ONCOLYTIC HSV-1 VIRUS THERAPIES WITH SPECIFIC KILLING OF OLD-DEPENDENT CARCINOMAS |
WO2017190112A1 (en) | 2016-04-29 | 2017-11-02 | Virogin Biotech Canada Ltd | Hsv vectors with enhanced replication in cancer cells |
US11541168B2 (en) | 2016-04-29 | 2023-01-03 | Amgen Inc. | Drug delivery device with messaging label |
US11389588B2 (en) | 2016-05-02 | 2022-07-19 | Amgen Inc. | Syringe adapter and guide for filling an on-body injector |
JP7309363B2 (ja) | 2016-05-13 | 2023-07-18 | アムジエン・インコーポレーテツド | バイアル・スリーブ組立体 |
WO2017200989A1 (en) | 2016-05-16 | 2017-11-23 | Amgen Inc. | Data encryption in medical devices with limited computational capability |
US11541176B2 (en) | 2016-06-03 | 2023-01-03 | Amgen Inc. | Impact testing apparatuses and methods for drug delivery devices |
WO2018004842A1 (en) | 2016-07-01 | 2018-01-04 | Amgen Inc. | Drug delivery device having minimized risk of component fracture upon impact events |
WO2018022945A1 (en) | 2016-07-28 | 2018-02-01 | Alpine Immune Sciences, Inc. | Cd112 variant immunomodulatory proteins and uses thereof |
CA3032120A1 (en) | 2016-07-28 | 2018-02-01 | Alpine Immune Sciences, Inc. | Cd155 variant immunomodulatory proteins and uses thereof |
US11471488B2 (en) | 2016-07-28 | 2022-10-18 | Alpine Immune Sciences, Inc. | CD155 variant immunomodulatory proteins and uses thereof |
CA3032669A1 (en) | 2016-08-01 | 2018-02-08 | William Jia | Oncolytic herpes simplex virus vectors expressing immune system-stimulatory molecules |
US20190328965A1 (en) | 2016-08-17 | 2019-10-31 | Amgen Inc. | Drug delivery device with placement detection |
GB201713765D0 (en) | 2017-08-28 | 2017-10-11 | Psioxus Therapeutics Ltd | Modified adenovirus |
CN119592523A (zh) | 2016-08-29 | 2025-03-11 | 阿卡米斯生物公司 | 携带双特异性t细胞衔接器的腺病毒 |
WO2018064762A1 (en) | 2016-10-03 | 2018-04-12 | Ottawa Hospital Research Institute | Compositions and methods for enhancing growth, spread, and oncolytic and immunotherapeutic efficacy of oncolytic rna viruses |
WO2018075447A1 (en) | 2016-10-19 | 2018-04-26 | The Trustees Of Columbia University In The City Of New York | Combination of braf inhibitor, talimogene laherparepvec, and immune checkpoint inhibitor for use in the treatment cancer (melanoma) |
EP3529361B1 (en) | 2016-10-20 | 2021-03-24 | Alpine Immune Sciences, Inc. | Secretable variant immunomodulatory proteins and engineered cell therapy |
EP3532127A1 (en) | 2016-10-25 | 2019-09-04 | Amgen Inc. | On-body injector |
CN110381997A (zh) | 2016-12-12 | 2019-10-25 | 茂体外尔公司 | 用于治疗和预防癌症和感染性疾病的包含病毒基因治疗和免疫检查点抑制剂的方法和组合物 |
US20180169271A1 (en) | 2016-12-21 | 2018-06-21 | Memgen, Llc | Armed replication-competent oncolytic adenoviruses |
US11298420B2 (en) | 2016-12-21 | 2022-04-12 | Memgen, Llc | Armed oncolytic viruses |
GB201700350D0 (en) | 2017-01-09 | 2017-02-22 | Replimune Ltd | Altered virus |
WO2018136398A1 (en) | 2017-01-17 | 2018-07-26 | Amgen Inc. | Injection devices and related methods of use and assembly |
JP2020507349A (ja) | 2017-02-09 | 2020-03-12 | インダプタ セラピューティクス インコーポレイテッド | 操作されたナチュラルキラー(nk)細胞ならびにその組成物および方法 |
WO2018151890A1 (en) | 2017-02-17 | 2018-08-23 | Amgen Inc. | Drug delivery device with sterile fluid flowpath and related method of assembly |
CA3052204A1 (en) | 2017-02-17 | 2018-08-23 | Amgen Inc. | Insertion mechanism for drug delivery device |
AU2018231107B2 (en) | 2017-03-06 | 2023-04-20 | Amgen Inc. | Drug delivery device with activation prevention feature |
AU2018230546B2 (en) | 2017-03-07 | 2024-03-21 | Amgen Inc. | Needle insertion by overpressure |
WO2018165499A1 (en) | 2017-03-09 | 2018-09-13 | Amgen Inc. | Insertion mechanism for drug delivery device |
US20200009204A1 (en) | 2017-03-15 | 2020-01-09 | Amgen Inc. | Use of oncolytic viruses, alone or in combination with a checkpoint inhibitor, for the treatment of cancer |
CA3053804A1 (en) | 2017-03-16 | 2018-09-20 | Alpine Immune Sciences, Inc. | Pd-l1 variant immunomodulatory proteins and uses thereof |
JP7386083B2 (ja) | 2017-03-16 | 2023-11-24 | アルパイン イミューン サイエンシズ インコーポレイテッド | Cd80バリアント免疫調節タンパク質及びその使用 |
US11732022B2 (en) | 2017-03-16 | 2023-08-22 | Alpine Immune Sciences, Inc. | PD-L2 variant immunomodulatory proteins and uses thereof |
EP3600491B1 (en) | 2017-03-28 | 2023-08-09 | Amgen Inc. | Plunger rod and syringe assembly system and method |
CA3057157A1 (en) | 2017-04-28 | 2018-11-01 | Merck Sharp & Dohme Corp. | Biomarkers for cancer therapeutics |
CN106974942A (zh) * | 2017-05-03 | 2017-07-25 | 武汉滨会生物科技股份有限公司 | 重组溶瘤ii型单纯疱疹病毒在制备抗淋巴瘤、食道癌、乳腺癌、胰腺癌药物中的应用 |
AU2018280054B2 (en) | 2017-06-08 | 2023-07-13 | Amgen Inc. | Syringe assembly for a drug delivery device and method of assembly |
WO2018226565A1 (en) | 2017-06-08 | 2018-12-13 | Amgen Inc. | Torque driven drug delivery device |
CN107354136A (zh) * | 2017-06-15 | 2017-11-17 | 杭州睿可特生物科技有限公司 | 重组单纯疱疹病毒及其制备方法和应用 |
CA3063920A1 (en) | 2017-06-22 | 2018-12-27 | Amgen Inc. | Device activation impact/shock reduction |
WO2018237225A1 (en) | 2017-06-23 | 2018-12-27 | Amgen Inc. | Electronic drug delivery device comprising a cap activated by a switch assembly |
WO2019014014A1 (en) | 2017-07-14 | 2019-01-17 | Amgen Inc. | NEEDLE INSERTION-RETRACTING SYSTEM HAVING DOUBLE TORSION SPRING SYSTEM |
WO2019018169A1 (en) | 2017-07-21 | 2019-01-24 | Amgen Inc. | PERMEABLE GAS SEALING ELEMENT FOR MEDICINE CONTAINER AND METHODS OF ASSEMBLY |
JP7242562B2 (ja) | 2017-07-25 | 2023-03-20 | アムジエン・インコーポレーテツド | 容器アクセスシステムを有する薬物送達デバイス及び関連する組立方法 |
EP3658203B1 (en) | 2017-07-25 | 2022-08-31 | Amgen Inc. | Drug delivery device with gear module and related method of assembly |
IL312607B1 (en) | 2017-08-03 | 2025-04-01 | Amgen Inc | Interleukin-21 Mutants and Treatment Methods |
TW201912173A (zh) | 2017-08-07 | 2019-04-01 | 美商安進公司 | 三陰性乳癌或結腸直腸癌伴隨肝轉移之治療 |
EP3664863A2 (en) | 2017-08-09 | 2020-06-17 | Amgen Inc. | Hydraulic-pneumatic pressurized chamber drug delivery system |
MA49897A (fr) | 2017-08-18 | 2020-06-24 | Amgen Inc | Injecteur sur-corps avec patch adhésif stérile |
US11103636B2 (en) | 2017-08-22 | 2021-08-31 | Amgen Inc. | Needle insertion mechanism for drug delivery device |
ES2985118T3 (es) | 2017-09-08 | 2024-11-04 | Amgen Inc | Inhibidores de KRAS G12C y métodos de uso de los mismos |
US20200308550A1 (en) | 2017-09-11 | 2020-10-01 | Imba - Institut Für Molekulare Biotechnologie Gmbh | Tumor organoid model |
ES2939292T3 (es) | 2017-10-04 | 2023-04-20 | Amgen Inc | Adaptador de flujo para dispositivo de administración de fármacos |
EP3691716B1 (en) | 2017-10-06 | 2023-11-29 | Amgen Inc. | Drug delivery device with interlock assembly and related method of assembly |
EP3694578A1 (en) | 2017-10-09 | 2020-08-19 | Amgen Inc. | Drug delivery device with drive assembly and related method of assembly |
CA3198255A1 (en) | 2017-10-10 | 2019-04-18 | Alpine Immune Sciences, Inc. | Ctla-4 variant immunomodulatory proteins and uses thereof |
BR112020007542A2 (pt) | 2017-10-18 | 2020-12-01 | Alpine Immune Sciences, Inc. | proteínas imunomoduladoras ligantes de icos variantes e composições e métodos relacionados |
US20200353022A1 (en) | 2017-10-27 | 2020-11-12 | Merck Sharp & Dohme Corp. | Compositions and methods for treating liver cancer |
US11305026B2 (en) | 2017-11-03 | 2022-04-19 | Amgen Inc. | Systems and approaches for sterilizing a drug delivery device |
EP3706830B1 (en) | 2017-11-06 | 2024-08-07 | Amgen Inc. | Drug delivery device with placement and flow sensing |
EP3707075A1 (en) | 2017-11-06 | 2020-09-16 | Amgen Inc. | Fill-finish assemblies and related methods |
CA3079665A1 (en) | 2017-11-10 | 2019-05-16 | Amgen Inc. | Plungers for drug delivery devices |
AU2018368340B2 (en) | 2017-11-16 | 2024-03-07 | Amgen Inc. | Door latch mechanism for drug delivery device |
CN111373032A (zh) | 2017-11-24 | 2020-07-03 | 渥太华医院研究所 | 用于增强干扰素敏感性病毒的生产、生长、扩散或溶瘤和免疫治疗功效的组合物和方法 |
WO2019136179A1 (en) | 2018-01-03 | 2019-07-11 | Alpine Immune Sciences, Inc. | Multi-domain immunomodulatory proteins and methods of use thereof |
CR20210319A (es) | 2018-01-12 | 2021-07-27 | Amgen Inc | ANTICUERPOS ANTI-PD-1 Y MÉTODOS DE TRATAMIENTO (Div. 2020-330) |
WO2019152821A1 (en) | 2018-02-05 | 2019-08-08 | The Brigham And Women's Hospital, Inc. | Recombinant herpes simplex virus-2 expressing glycoprotein b and d antigens |
CN112020510B (zh) | 2018-03-19 | 2024-10-11 | 茂体外尔公司 | 包含用于治疗癌症的肿瘤抑制基因疗法和cd122/cd132激动剂的方法及组合物 |
US11897924B2 (en) * | 2018-03-28 | 2024-02-13 | Bioxodes | Anticoagulant fusion proteins and uses thereof |
CN112368017A (zh) * | 2018-05-01 | 2021-02-12 | 阿尔伯特爱因斯坦医学院 | HSV-2-DELTA-gD疫苗及其生产和使用方法 |
US10835685B2 (en) | 2018-05-30 | 2020-11-17 | Amgen Inc. | Thermal spring release mechanism for a drug delivery device |
US11083840B2 (en) | 2018-06-01 | 2021-08-10 | Amgen Inc. | Modular fluid path assemblies for drug delivery devices |
CA3177467A1 (en) | 2018-06-04 | 2019-12-12 | Calidi Biotherapeutics, Inc. | Cell-based vehicles for potentiation of viral therapy |
US11505782B2 (en) | 2018-06-04 | 2022-11-22 | Calidi Biotherapeutics, Inc. | Cell-based vehicles for potentiation of viral therapy |
EP3801583A1 (en) * | 2018-06-08 | 2021-04-14 | The Board of Trustees of the University of Illinois | Recombinant herpes simplex virus for cancer immunotherapy |
WO2019241622A1 (en) * | 2018-06-15 | 2019-12-19 | Children's Hospital Medical Center | Polypeptides, nucleic acid molecules, compositions, and related methods |
US12065476B2 (en) | 2018-06-15 | 2024-08-20 | Alpine Immune Sciences, Inc. | PD-1 variant immunomodulatory proteins and uses thereof |
US12115360B2 (en) | 2018-07-24 | 2024-10-15 | Amgen Inc. | Hybrid drug delivery devices with grip portion |
US12042645B2 (en) | 2018-07-24 | 2024-07-23 | Amgen Inc. | Delivery devices for administering drugs |
US20210260279A1 (en) | 2018-07-24 | 2021-08-26 | Amgen Inc. | Hybrid drug delivery devices with optional grip portion and related method of preparation |
WO2020023451A1 (en) | 2018-07-24 | 2020-01-30 | Amgen Inc. | Delivery devices for administering drugs |
CA3103105A1 (en) | 2018-07-31 | 2020-02-06 | Amgen Inc. | Fluid path assembly for a drug delivery device |
CN109161561A (zh) * | 2018-08-09 | 2019-01-08 | 湖北科技学院 | 一种选择性杀灭前列腺癌细胞的新型溶瘤病毒及其构建方法 |
WO2020047161A2 (en) | 2018-08-28 | 2020-03-05 | Actym Therapeutics, Inc. | Engineered immunostimulatory bacterial strains and uses thereof |
US20210346601A1 (en) | 2018-09-24 | 2021-11-11 | Amgen Inc. | Interventional dosing systems and methods |
IL281469B2 (en) | 2018-09-28 | 2024-08-01 | Amgen Inc | Muscle wire escapement activation assembly for a drug delivery device |
CA3110529A1 (en) | 2018-10-02 | 2020-04-09 | Amgen Inc. | Injection systems for drug delivery with internal force transmission |
TWI824026B (zh) | 2018-10-05 | 2023-12-01 | 美商安進公司 | 具有劑量指示器之藥物遞送裝置 |
MX2021002791A (es) | 2018-10-15 | 2021-05-12 | Amgen Inc | Proceso de ensamblaje de plataforma para un dispositivo de administracion de farmacos. |
SG11202103800RA (en) | 2018-10-15 | 2021-05-28 | Amgen Inc | Drug delivery device having damping mechanism |
ES3010833T3 (en) | 2018-11-01 | 2025-04-04 | Amgen Inc | Drug delivery devices with partial drug delivery member retraction |
US20220031939A1 (en) | 2018-11-01 | 2022-02-03 | Amgen Inc. | Drug delivery devices with partial drug delivery member retraction |
TWI831847B (zh) | 2018-11-01 | 2024-02-11 | 美商安進公司 | 部分針頭縮回之藥物遞送裝置及其操作方法 |
CA3116192A1 (en) | 2018-11-06 | 2020-05-14 | Calidi Biotherapeutics, Inc. | Enhanced systems for cell-mediated oncolytic viral therapy |
CN113891934A (zh) | 2018-11-21 | 2022-01-04 | 因达普塔治疗公司 | 扩增天然杀伤(nk)细胞子集的方法以及相关组合物和方法 |
TW202038947A (zh) | 2018-11-28 | 2020-11-01 | 德商創新分子有限責任公司 | 在與溶瘤病毒之組合療法中治療癌症的解旋酶引子酶抑制劑 |
EP3887394A2 (en) | 2018-11-30 | 2021-10-06 | Alpine Immune Sciences, Inc. | Cd86 variant immunomodulatory proteins and uses thereof |
AR117547A1 (es) | 2018-12-27 | 2021-08-11 | Amgen Inc | Formulaciones de virus liofilizadas |
EP3921334A1 (en) * | 2019-02-08 | 2021-12-15 | Krystal Biotech, Inc. | Compositions and methods for delivering cftr polypeptides |
WO2020176809A1 (en) | 2019-02-27 | 2020-09-03 | Actym Therapeutics, Inc. | Immunostimulatory bacteria engineered to colonize tumors, tumor-resident immune cells, and the tumor microenvironment |
US12024709B2 (en) | 2019-02-27 | 2024-07-02 | Actym Therapeutics, Inc. | Immunostimulatory bacteria engineered to colonize tumors, tumor-resident immune cells, and the tumor microenvironment |
MX2021010458A (es) * | 2019-03-05 | 2021-09-21 | Amgen Inc | Uso de virus oncoliticos para el tratamiento del cancer. |
JP2022526094A (ja) * | 2019-03-14 | 2022-05-23 | マサチューセッツ インスティテュート オブ テクノロジー | 操作された単純ヘルペスウイルス-1(hsv-1)ベクターおよびその使用 |
TW202102543A (zh) | 2019-03-29 | 2021-01-16 | 美商安進公司 | 溶瘤病毒在癌症新輔助療法中之用途 |
MX2021012557A (es) | 2019-04-24 | 2021-11-12 | Amgen Inc | Conjuntos y metodos de verificacion de esterilizacion de jeringuillas. |
WO2021041067A2 (en) | 2019-08-23 | 2021-03-04 | Amgen Inc. | Drug delivery device with configurable needle shield engagement components and related methods |
WO2021113644A1 (en) | 2019-12-05 | 2021-06-10 | Multivir Inc. | Combinations comprising a cd8+ t cell enhancer, an immune checkpoint inhibitor and radiotherapy for targeted and abscopal effects for the treatment of cancer |
JP2023507989A (ja) * | 2019-12-20 | 2023-02-28 | クリスタル バイオテック インコーポレイテッド | 気道及び/または肺への遺伝子送達のための組成物及び方法 |
JP2023523429A (ja) | 2020-04-22 | 2023-06-05 | インダプタ セラピューティクス インコーポレイテッド | ナチュラルキラー(nk)細胞組成物およびそれを生成させるための方法 |
US20220016191A1 (en) * | 2020-07-16 | 2022-01-20 | Massachusetts Institute Of Technology | Simultaneous delivery of cancer treatment programs to tumor and immune cells |
WO2022147480A1 (en) | 2020-12-30 | 2022-07-07 | Ansun Biopharma, Inc. | Oncolytic virus encoding sialidase and multispecific immune cell engager |
EP4288140A1 (en) | 2021-02-05 | 2023-12-13 | Iovance Biotherapeutics, Inc. | Adjuvant therapy for cancer |
CN117320964A (zh) | 2021-05-21 | 2023-12-29 | 美国安进公司 | 优化药物容器的灌装方案的方法 |
TW202313982A (zh) * | 2021-08-20 | 2023-04-01 | 大陸商廣東東陽光藥業有限公司 | Hsv病毒載體及其應用 |
WO2024038857A1 (ja) | 2022-08-16 | 2024-02-22 | 具紀 藤堂 | 単純ヘルペスウイルスベクターを含む医薬組成物 |
WO2024251286A1 (zh) * | 2023-06-08 | 2024-12-12 | 上海药明生物医药有限公司 | 溶瘤性hsv-1临床分离株、定向进化株、感染性克隆及应用 |
Family Cites Families (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5163949A (en) * | 1990-03-02 | 1992-11-17 | Bonutti Peter M | Fluid operated retractors |
US6610287B1 (en) | 1990-04-16 | 2003-08-26 | The General Hospital Corporation | Transfer and expression of gene sequences into nervous system cells using herpes simplex virus mutants with deletions in genes for viral replication |
US5328688A (en) * | 1990-09-10 | 1994-07-12 | Arch Development Corporation | Recombinant herpes simplex viruses vaccines and methods |
GB9102126D0 (en) | 1991-01-31 | 1991-03-13 | Smithkline Beecham Biolog | Novel vaccine |
GB9202933D0 (en) | 1992-02-12 | 1992-03-25 | Smithkline Beecham Biolog | Vaccines |
EP0675961B1 (en) | 1992-03-31 | 2002-11-27 | Arch Development Corporation | Treatment of tumorigenic disease with a modified HSV |
GB9325496D0 (en) | 1993-12-14 | 1994-02-16 | Smithkline Beecham Biolog | Vaccines |
US5728379A (en) | 1994-06-23 | 1998-03-17 | Georgetown University | Tumor- or cell-specific herpes simplex virus replication |
US5585096A (en) * | 1994-06-23 | 1996-12-17 | Georgetown University | Replication-competent herpes simplex virus mediates destruction of neoplastic cells |
GB9423663D0 (en) * | 1994-11-23 | 1995-01-11 | Cantab Pharma Res | Viral preparations, immunogens, and vaccines |
NL9500216A (nl) * | 1995-02-06 | 1996-09-02 | Bio Pharma Sciences Bv | Farmaceutische samenstelling voor de behandeling van herpes. |
DE69636068T2 (de) * | 1995-02-21 | 2006-11-30 | Cantab Pharmaceuticals Research Ltd. | Virale zubereitungen, vektoren, immunogene und impfstoffe |
IL118942A (en) | 1995-07-27 | 2002-09-12 | American Cyanamid Co | Avirulent herpetic viruses useful as tumoricidal agents and vaccines |
US6344445B1 (en) * | 1995-10-19 | 2002-02-05 | Cantab Pharmaceutical Research Limited | Herpes virus vectors and their uses |
GB9524973D0 (en) * | 1995-12-06 | 1996-02-07 | Lynxvale Ltd | Viral vectors |
EP1314430A1 (en) | 1996-01-25 | 2003-05-28 | The University Court Of The University Of Glasgow | Treatment of non-neuronal cancer using HSV mutant |
US5824318A (en) | 1996-07-24 | 1998-10-20 | American Cyanamid Company | Avirulent herpetic viruses useful as tumoricidal agents and vaccines |
GB9615794D0 (en) * | 1996-07-26 | 1996-09-04 | Medical Res Council | Mutant herpes simplex virus strains and uses thereof |
US5876923A (en) * | 1996-07-26 | 1999-03-02 | Arch Development Corporation | Herpes simplex virus ICP4 as an inhibitor of apoptosis |
GB2322130B (en) | 1997-02-13 | 2000-12-20 | Secr Defence | A vaccine against Simian Herpes B virus |
GB9704046D0 (en) | 1997-02-27 | 1997-04-16 | Univ Leeds | Arrestable therapeutic |
US6051428A (en) * | 1997-03-21 | 2000-04-18 | Sloan-Kettering Institute For Cancer Research | Rapid production of autologous tumor vaccines |
US5998174A (en) * | 1997-05-12 | 1999-12-07 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Multigene vectors |
US6379674B1 (en) | 1997-08-12 | 2002-04-30 | Georgetown University | Use of herpes vectors for tumor therapy |
US20030044384A1 (en) * | 1997-10-09 | 2003-03-06 | Pro-Virus, Inc. | Treatment of neoplasms with viruses |
GB9801930D0 (en) | 1998-01-29 | 1998-03-25 | Univ London | Mutant herpes simplex viruses and uses thereof |
CA2323067A1 (en) | 1998-03-12 | 1999-09-16 | The Trustees Of The University Of Pennsylvania | Producer cells for replication selective viruses in the treatment of malignancy |
GB9810904D0 (en) | 1998-05-20 | 1998-07-22 | Univ London | Mutant herpes simplex viruses and uses thereof |
GB9816781D0 (en) | 1998-07-31 | 1998-09-30 | Univ London | Herpes virus vectors for dendritic cells |
US6713067B2 (en) * | 1998-07-31 | 2004-03-30 | Biovex Limited | Herpes viruses for immune modulation |
AU5467899A (en) | 1998-08-07 | 2000-02-28 | University Of Washington | Immunological herpes simplex virus antigens and methods for use thereof |
CA2356937A1 (en) | 1998-12-31 | 2000-07-13 | Richard J. Whitley | Recombinant herpes simplex virus useful for treating neoplastic disease |
US6428968B1 (en) * | 1999-03-15 | 2002-08-06 | The Trustees Of The University Of Pennsylvania | Combined therapy with a chemotherapeutic agent and an oncolytic virus for killing tumor cells in a subject |
US6764675B1 (en) * | 1999-06-08 | 2004-07-20 | The Uab Research Foundation | Herpes simplex virus expressing foreign genes and method for treating cancers therewith |
WO2000075292A1 (en) | 1999-06-08 | 2000-12-14 | Uab Research Foundation | Herpes simplex virus expressing foreign genes and method for treating cancers therewith |
IL131212A0 (en) * | 1999-08-03 | 2001-01-28 | Yissum Res Dev Co | Recombinant virus and live-virus vaccines |
GB9930419D0 (en) | 1999-12-22 | 2000-02-16 | Neurovex Ltd | Replication incompetent herpes virus vectors |
GB9930418D0 (en) | 1999-12-22 | 2000-02-16 | Neurovex Ltd | Replication incompetent herpes virus vectors |
GB0001476D0 (en) | 2000-01-21 | 2000-03-15 | Neurovex Ltd | Herpes virus strains |
ES2233600T5 (es) * | 2000-01-21 | 2009-06-22 | Biovex Limited | Cepas de virus del herpes. |
US7063851B2 (en) | 2000-04-12 | 2006-06-20 | Biovex Limited | Herpes viruses for immune modulation |
GB0317511D0 (en) * | 2003-07-25 | 2003-08-27 | Biovex Ltd | Viral vectors |
MX2018008413A (es) * | 2016-01-08 | 2019-02-20 | Replimune Ltd | Virus oncolitico modificado. |
-
2001
- 2001-01-22 ES ES01901288T patent/ES2233600T5/es not_active Expired - Lifetime
- 2001-01-22 KR KR1020027009410A patent/KR100802403B1/ko not_active Expired - Lifetime
- 2001-01-22 IL IL15067701A patent/IL150677A0/xx unknown
- 2001-01-22 AT AT01901292T patent/ATE312189T1/de active
- 2001-01-22 AT AT01901288T patent/ATE282708T1/de active
- 2001-01-22 DK DK01901292T patent/DK1252323T3/da active
- 2001-01-22 CA CA2398335A patent/CA2398335C/en not_active Expired - Lifetime
- 2001-01-22 WO PCT/GB2001/000225 patent/WO2001053505A2/en active IP Right Grant
- 2001-01-22 AU AU2695101A patent/AU2695101A/xx active Pending
- 2001-01-22 GB GB0219033A patent/GB2374873C/en not_active Expired - Lifetime
- 2001-01-22 EP EP01901292A patent/EP1252323B1/en not_active Expired - Lifetime
- 2001-01-22 BR BRPI0107736A patent/BRPI0107736B8/pt unknown
- 2001-01-22 BR BR0107736-8A patent/BR0107736A/pt not_active IP Right Cessation
- 2001-01-22 EP EP05011798A patent/EP1568779A1/en not_active Ceased
- 2001-01-22 US US10/181,692 patent/US7063835B2/en not_active Expired - Lifetime
- 2001-01-22 CA CA002398343A patent/CA2398343A1/en not_active Abandoned
- 2001-01-22 ES ES01901292T patent/ES2254359T3/es not_active Expired - Lifetime
- 2001-01-22 JP JP2001553367A patent/JP4810042B2/ja not_active Expired - Lifetime
- 2001-01-22 PT PT01901288T patent/PT1252322E/pt unknown
- 2001-01-22 DE DE60115600T patent/DE60115600T2/de not_active Expired - Lifetime
- 2001-01-22 DE DE60107203T patent/DE60107203T3/de not_active Expired - Lifetime
- 2001-01-22 EP EP09014990A patent/EP2177619A1/en not_active Withdrawn
- 2001-01-22 JP JP2001553368A patent/JP4921669B2/ja not_active Expired - Lifetime
- 2001-01-22 EP EP01901288A patent/EP1252322B2/en not_active Expired - Lifetime
- 2001-01-22 BR BRPI0107737A patent/BRPI0107737B8/pt not_active IP Right Cessation
- 2001-01-22 DK DK01901288T patent/DK1252322T4/da active
- 2001-01-22 CN CNB018067506A patent/CN1250732C/zh not_active Expired - Lifetime
- 2001-01-22 WO PCT/GB2001/000229 patent/WO2001053506A2/en active IP Right Grant
- 2001-01-22 GB GB0219030A patent/GB2375113B/en not_active Expired - Lifetime
- 2001-01-22 KR KR1020027009412A patent/KR100768408B1/ko not_active Expired - Lifetime
- 2001-01-22 US US10/181,697 patent/US7223593B2/en active Active
- 2001-01-22 AU AU2001226951A patent/AU2001226951B8/en active Active
- 2001-01-22 CN CN01806743A patent/CN1418255A/zh active Pending
- 2001-01-22 IL IL15067801A patent/IL150678A0/xx unknown
-
2002
- 2002-07-10 IL IL150677A patent/IL150677A/en active Protection Beyond IP Right Term
- 2002-07-10 IL IL150678A patent/IL150678A/en not_active IP Right Cessation
- 2002-11-28 HK HK02108579.0A patent/HK1047451B/zh unknown
- 2002-11-30 HK HK02108740.4A patent/HK1047297B/zh unknown
-
2006
- 2006-03-10 US US11/372,613 patent/US7537924B2/en not_active Expired - Lifetime
-
2007
- 2007-04-23 US US11/738,807 patent/US8277818B2/en not_active Expired - Fee Related
-
2009
- 2009-04-17 US US12/425,952 patent/US20090220460A1/en not_active Abandoned
-
2011
- 2011-10-31 JP JP2011238257A patent/JP2012072156A/ja active Pending
-
2012
- 2012-02-17 US US13/399,868 patent/US20120164108A1/en not_active Abandoned
- 2012-08-31 US US13/600,711 patent/US8680068B2/en not_active Expired - Fee Related
-
2014
- 2014-02-06 US US14/174,521 patent/US20140154215A1/en not_active Abandoned
- 2014-02-07 US US14/175,855 patent/US10301600B2/en not_active Expired - Fee Related
-
2015
- 2015-04-29 US US14/700,036 patent/US20150232812A1/en not_active Abandoned
- 2015-07-10 JP JP2015138227A patent/JP6424145B2/ja not_active Expired - Lifetime
-
2016
- 2016-06-08 LU LU93100C patent/LU93100I2/fr unknown
- 2016-06-08 LU LU93101C patent/LU93101I2/fr unknown
- 2016-06-14 NL NL300820C patent/NL300820I2/nl unknown
- 2016-06-14 BE BE2016C033C patent/BE2016C033I2/fr unknown
- 2016-06-14 NL NL300821C patent/NL300821I2/nl unknown
- 2016-06-15 CY CY2016020C patent/CY2016020I2/el unknown
- 2016-06-15 CY CY2016021C patent/CY2016021I2/el unknown
- 2016-06-15 FR FR16C0026C patent/FR16C0026I2/fr active Active
-
2017
- 2017-03-01 JP JP2017037827A patent/JP2017132779A/ja active Pending
-
2018
- 2018-11-22 JP JP2018218735A patent/JP6644378B2/ja not_active Expired - Lifetime
-
2019
- 2019-04-02 US US16/372,800 patent/US20200032218A1/en not_active Abandoned
- 2019-04-05 US US16/376,089 patent/US20200032219A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
FR16C0026I2 (fr) | Souches de virus herpetique pour therapie genique | |
BR0014408A (pt) | Antìgenos do vìrus do herpes simples imunologicamente significativos; e métodos para identificação e utilização dos mesmos | |
WO2003082200A3 (en) | Potent oncolytic herpes simplex virus for cancer therapy | |
BR9712366A (pt) | Gene de gd2 do vírus do herpes simples hsv2 isolado, plasmídeo compreendendo o mesmo, e, processos de induzir, em indivíduo, uma resposta imune contra hsv2 gd2, de tratar um indíviduo que está infectado com hsv, e, de prevenir que um indivíduo fique infectado com hsv | |
BR9912653A (pt) | Vìrus de herpes atenuado, cepa de vìrus, célula dendrìtica, processo para produzir um célula, composição farmacêutica, uso de um vìrus, e, processo para executar a terapia de gene em um paciente humano ou animal ou para tratar ou prevenir uma infecção patogênica ou câncer para tratar paciente animal | |
JP2003520044A5 (da) | ||
DK0675961T3 (da) | Behandling af tumorigen sygdom med en modificeret HSV | |
EA199800746A1 (ru) | Способ генерации противовирусного иммунного ответа у человека или животного | |
AU688101B2 (en) | Live vaccine for the treatment of tumour diseases | |
ES2141093T3 (es) | Herpesvirus equinos (ehv) que contienen adn ajeno, procedimiento para su obtencion y su empleo en vacunas. | |
BR9007741A (pt) | Protecao contra estados de choque subsequentes a lesoes por rnas de duplo filamento | |
GB2359083A (en) | Mutant herpes simplex viruses and uses thereof | |
ES2169040T3 (es) | Planta resistente a dos o mas virus y preparacion de la misma. | |
AR025203A1 (es) | Nuevos genes de mixoma para modulacion inmunitaria | |
AU6301398A (en) | Arrestable therapeutic viral agent | |
WO2003047634A3 (en) | Nucleic acids and methods for treating ebv-positive cancers |