FI971272A - Heikennetty rokotus- ja geenisiirtovirus, menetelmä viruksen valmista miseksi ja virusta sisältävä farmaseuttinen koostumus - Google Patents
Heikennetty rokotus- ja geenisiirtovirus, menetelmä viruksen valmista miseksi ja virusta sisältävä farmaseuttinen koostumus Download PDFInfo
- Publication number
- FI971272A FI971272A FI971272A FI971272A FI971272A FI 971272 A FI971272 A FI 971272A FI 971272 A FI971272 A FI 971272A FI 971272 A FI971272 A FI 971272A FI 971272 A FI971272 A FI 971272A
- Authority
- FI
- Finland
- Prior art keywords
- virus
- vrna
- viral
- promoter
- progeny
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16141—Use of virus, viral particle or viral elements as a vector
- C12N2760/16143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16161—Methods of inactivation or attenuation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP94115505A EP0704533A1 (en) | 1994-09-30 | 1994-09-30 | An attenuated vaccination virus, a method to make the virus and a pharmaceutical compositions comprising the virus |
| PCT/EP1995/003663 WO1996010641A1 (en) | 1994-09-30 | 1995-09-18 | An attenuated vaccination and gene-transfer virus, a method to make the virus and a pharmaceutical composition comprising the virus |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FI971272A0 FI971272A0 (fi) | 1997-03-26 |
| FI971272A true FI971272A (fi) | 1997-05-26 |
Family
ID=8216345
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI971272A FI971272A (fi) | 1994-09-30 | 1997-03-26 | Heikennetty rokotus- ja geenisiirtovirus, menetelmä viruksen valmista miseksi ja virusta sisältävä farmaseuttinen koostumus |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6524588B1 (fi) |
| EP (3) | EP0704533A1 (fi) |
| JP (1) | JP2000509962A (fi) |
| AT (1) | ATE210727T1 (fi) |
| AU (1) | AU3607695A (fi) |
| DE (1) | DE69524618T2 (fi) |
| ES (1) | ES2165434T3 (fi) |
| FI (1) | FI971272A (fi) |
| NZ (1) | NZ293600A (fi) |
| WO (1) | WO1996010641A1 (fi) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9809666D0 (en) * | 1998-05-06 | 1998-07-01 | Isis Innovation | Modified viruses |
| EP1035209A1 (en) * | 1999-03-06 | 2000-09-13 | ARTEMIS Pharmaceuticals GmbH | Stable recombinant influenza viruses free of helper viruses |
| US8715940B2 (en) | 1999-04-06 | 2014-05-06 | Wisconsin Alumni Research Foundation | Method of making recombinant influenza virus |
| EP2345716B1 (en) * | 1999-04-06 | 2015-01-14 | Wisconsin Alumni Research Foundation | Recombinant influenza viruses for vaccines and gene therapy |
| EP1201760A1 (en) * | 2000-10-30 | 2002-05-02 | ARTEMIS Pharmaceuticals GmbH | Influenza virus vector for human dendritic cells |
| US20030099670A1 (en) * | 2001-02-09 | 2003-05-29 | Gert Hobom | Influenza viruses with enhanced transcriptional and replicational capacities |
| EA200701097A1 (ru) | 2004-11-19 | 2007-10-26 | Висконсин Эламни Рисёч Фаундэйшн | Рекомбинантные векторы вируса гриппа с тандемными транскрипционными единицами |
| US20100055672A1 (en) * | 2006-05-11 | 2010-03-04 | Geneohm Sciences, Inc. | 100% sequence identity detection methods for variable genomes |
| CN101938981A (zh) * | 2008-02-08 | 2011-01-05 | 高露洁-棕榄公司 | 组合物和装置 |
| AU2009212335B2 (en) * | 2008-02-08 | 2011-12-01 | Colgate-Palmolive Company | Compositions comprising basic amino acid and soluble carbonate salt |
| AR070593A1 (es) * | 2008-02-08 | 2010-04-21 | Colgate Palmolive Co | Composiciones efervescentes |
| RU2519329C2 (ru) * | 2008-02-08 | 2014-06-10 | Колгейт-Палмолив Компани | Композиции и устройства |
| BRPI0907103A2 (pt) * | 2008-02-08 | 2016-05-03 | Colgate Palmolive Co | método para tratamento de dentes sensíveis, composição de selante dental, e, uso de um aminoácido básico em forma livre ou em forma de sal. |
| BRPI0906464A2 (pt) | 2008-02-08 | 2015-07-14 | Colgate Palmolive Co | Fio dental, embalagem para armazenar ou dispensar fio dental, e, métodos para produzir fio dental e para tratar um condição |
| US20100330002A1 (en) * | 2008-02-08 | 2010-12-30 | Colgate-Palmolive Company | Compositions and methods comprising basic amino acid peptides and proteases |
| EP2227112B1 (en) * | 2008-02-08 | 2017-01-11 | Colgate-Palmolive Company | Oral care toothbrush |
| CN101938984A (zh) * | 2008-02-08 | 2011-01-05 | 高露洁-棕榄公司 | 清洁用组合物和方法 |
| TWI451878B (zh) * | 2008-02-08 | 2014-09-11 | Colgate Palmolive Co | 呈游離或鹽類形式之l‐精胺酸及氟化物用於製造潔齒組成物之用途及潔齒組成物 |
| MX2010005007A (es) * | 2008-02-08 | 2010-05-27 | Colgate Palmolive Co | Composiciones y metodos para el tratamiento de la xerostomia. |
| US10130697B2 (en) | 2010-03-23 | 2018-11-20 | Wisconsin Alumni Research Foundation (Warf) | Vaccines comprising mutant attenuated influenza viruses |
| US9315464B1 (en) | 2013-01-31 | 2016-04-19 | Nant Holdings Ip, Llc | Small molecule inhibitors of influenza A RNA-dependent RNA polymerase |
| WO2015196150A2 (en) | 2014-06-20 | 2015-12-23 | Wisconsin Alumni Research Foundation (Warf) | Mutations that confer genetic stability to additional genes in influenza viruses |
| CN104593330A (zh) * | 2015-01-19 | 2015-05-06 | 中国科学院微生物研究所 | 含有a型流感特异性启动子的重组293t细胞及其应用 |
| US11197926B2 (en) | 2017-10-25 | 2021-12-14 | Wisconsin Alumni Research Foundation (Warf) | Recombinant influenza viruses with stabilized HA for replication in eggs |
| EP3840780A1 (en) | 2018-08-20 | 2021-06-30 | Wisconsin Alumni Research Foundation | Vectors for eliciting immune responses to non-dominant epitopes in the hemagglutinin (ha) protein |
| WO2020163804A1 (en) | 2019-02-08 | 2020-08-13 | Wisconsin Alumni Research Foundation (Warf) | Humanized cell line |
| CN114929269A (zh) | 2019-05-01 | 2022-08-19 | 威斯康星校友研究基金会(Warf) | 用于疫苗开发的改进的流感病毒复制 |
| WO2021041624A2 (en) | 2019-08-27 | 2021-03-04 | Yoshihiro Kawaoka | Recombinant influenza viruses with stabilized ha for replication in eggs |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5166057A (en) * | 1989-08-28 | 1992-11-24 | The Mount Sinai School Of Medicine Of The City University Of New York | Recombinant negative strand rna virus expression-systems |
| US5690937A (en) * | 1995-06-05 | 1997-11-25 | Aviron | Temperature sensitive clustered changed-to-alanine mutants of influenza virus PB2 gene |
-
1994
- 1994-09-30 EP EP94115505A patent/EP0704533A1/en not_active Withdrawn
-
1995
- 1995-09-18 WO PCT/EP1995/003663 patent/WO1996010641A1/en active IP Right Grant
- 1995-09-18 EP EP95933386A patent/EP0783586B1/en not_active Expired - Lifetime
- 1995-09-18 AU AU36076/95A patent/AU3607695A/en not_active Abandoned
- 1995-09-18 DE DE69524618T patent/DE69524618T2/de not_active Expired - Fee Related
- 1995-09-18 AT AT95933386T patent/ATE210727T1/de not_active IP Right Cessation
- 1995-09-18 NZ NZ293600A patent/NZ293600A/en unknown
- 1995-09-18 ES ES95933386T patent/ES2165434T3/es not_active Expired - Lifetime
- 1995-09-18 JP JP08511323A patent/JP2000509962A/ja active Pending
- 1995-09-18 EP EP00124417A patent/EP1091000A1/en not_active Withdrawn
-
1997
- 1997-03-24 US US08/809,513 patent/US6524588B1/en not_active Expired - Fee Related
- 1997-03-26 FI FI971272A patent/FI971272A/fi not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU3607695A (en) | 1996-04-26 |
| EP0704533A1 (en) | 1996-04-03 |
| JP2000509962A (ja) | 2000-08-08 |
| NZ293600A (en) | 1999-01-28 |
| EP1091000A1 (en) | 2001-04-11 |
| DE69524618D1 (de) | 2002-01-24 |
| DE69524618T2 (de) | 2002-08-14 |
| US6524588B1 (en) | 2003-02-25 |
| ATE210727T1 (de) | 2001-12-15 |
| ES2165434T3 (es) | 2002-03-16 |
| FI971272A0 (fi) | 1997-03-26 |
| WO1996010641A1 (en) | 1996-04-11 |
| EP0783586B1 (en) | 2001-12-12 |
| EP0783586A1 (en) | 1997-07-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GB | Transfer or assigment of application |
Owner name: HOBOM, GERD |
|
| MA | Patent expired |