FI915779A - 3'-(2')-amino- eller tiolmodifierade nukleosider, nukleotider och oligonukleotider, till vilka kopplats ett fluorescerande faergaemne, foerfarande foer framstaellning av dessa samt anvaendning av dessa. - Google Patents

3'-(2')-amino- eller tiolmodifierade nukleosider, nukleotider och oligonukleotider, till vilka kopplats ett fluorescerande faergaemne, foerfarande foer framstaellning av dessa samt anvaendning av dessa. Download PDF

Info

Publication number: FI915779A
Authority: FI; Finland
Prior art keywords: amino; thiolmodifierade; oligonucleotider; nucleotider; nucleosider
Prior art date: 1990-12-11

Application number

FI915779A

Other languages

English (en)

Finnish (fi)

Other versions

FI915779A0 (fi

Inventor

Joachim Engels

Mathias Herrlein

Renate Konrad

Matthias Mag

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-12-11

Filing date

1991-12-09

Publication date

1992-06-12

1991-12-09 Application filed by Hoechst Ag filed Critical Hoechst Ag

1991-12-09 Publication of FI915779A0 publication Critical patent/FI915779A0/fi

1992-06-12 Publication of FI915779A publication Critical patent/FI915779A/fi

Links

101100148710 Clarkia breweri SAMT gene Proteins 0.000 title 1
108091034117 Oligonucleotide Proteins 0.000 abstract 4
238000003786 synthesis reaction Methods 0.000 abstract 3
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 abstract 2
230000015572 biosynthetic process Effects 0.000 abstract 2
239000007850 fluorescent dye Substances 0.000 abstract 2
239000002773 nucleotide Substances 0.000 abstract 2
125000003729 nucleotide group Chemical group 0.000 abstract 2
238000007796 conventional method Methods 0.000 abstract 1
238000001514 detection method Methods 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
238000002372 labelling Methods 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000002777 nucleoside Substances 0.000 abstract 1
150000003833 nucleoside derivatives Chemical class 0.000 abstract 1
125000003835 nucleoside group Chemical group 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
102000004169 proteins and genes Human genes 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1
239000000758 substrate Substances 0.000 abstract 1
125000003396 thiol group Chemical group [H]S* 0.000 abstract 1
239000001226 triphosphate Substances 0.000 abstract 1
235000011178 triphosphate Nutrition 0.000 abstract 1
125000002264 triphosphate group Chemical class [H]OP(=O)(O[H])OP(=O)(O[H])OP(=O)(O[H])O* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
General Health & Medical Sciences (AREA)
Biotechnology (AREA)
Physics & Mathematics (AREA)
Biophysics (AREA)
Analytical Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Microbiology (AREA)
Immunology (AREA)
Saccharide Compounds (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

FI915779A 1990-12-11 1991-12-09 3'-(2')-amino- eller tiolmodifierade nukleosider, nukleotider och oligonukleotider, till vilka kopplats ett fluorescerande faergaemne, foerfarande foer framstaellning av dessa samt anvaendning av dessa. FI915779A (fi)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE4039488		1990-12-11

Publications (2)

Publication Number	Publication Date
FI915779A0 FI915779A0 (fi)	1991-12-09
FI915779A true FI915779A (fi)	1992-06-12

Family

ID=6420050

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI915779A FI915779A (fi)	1990-12-11	1991-12-09	3'-(2')-amino- eller tiolmodifierade nukleosider, nukleotider och oligonukleotider, till vilka kopplats ett fluorescerande faergaemne, foerfarande foer framstaellning av dessa samt anvaendning av dessa.

Country Status (27)

Country	Link
US (3)	US5679785A (sh)
EP (1)	EP0490281B1 (sh)
JP (1)	JP3140127B2 (sh)
KR (1)	KR920012107A (sh)
AT (1)	ATE142222T1 (sh)
AU (1)	AU643856B2 (sh)
BG (1)	BG61484B1 (sh)
BR (1)	BR9105335A (sh)
CA (1)	CA2057475A1 (sh)
CS (1)	CS374391A3 (sh)
DE (1)	DE59108143D1 (sh)
DK (1)	DK0490281T3 (sh)
ES (1)	ES2093671T3 (sh)
FI (1)	FI915779A (sh)
GR (1)	GR3021041T3 (sh)
HU (1)	HUT60505A (sh)
IE (1)	IE75726B1 (sh)
IL (1)	IL100298A (sh)
MX (1)	MX9102468A (sh)
NO (1)	NO914859L (sh)
NZ (1)	NZ240900A (sh)
PL (1)	PL168874B1 (sh)
PT (1)	PT99747A (sh)
RO (1)	RO111575B1 (sh)
RU (1)	RU2073682C1 (sh)
TR (1)	TR27715A (sh)
YU (1)	YU187991A (sh)

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DE4418691A1 (de) *	1994-05-28	1996-02-22	Boehringer Mannheim Gmbh	3'-(4'-) nicht-radioaktiv markierte Nukleoside und Nukleotide mit Aminocarbonsäure-, Peptid- oder Carbonsäure-Spacer
US5962271A (en) *	1996-01-03	1999-10-05	Cloutech Laboratories, Inc.	Methods and compositions for generating full-length cDNA having arbitrary nucleotide sequence at the 3'-end
US5859233A (en) *	1996-02-21	1999-01-12	Lynx Therapeutics, Inc.	Synthons for synthesis of oligonucleotide N3-P5 phosphoramidates
US5684143A (en) *	1996-02-21	1997-11-04	Lynx Therapeutics, Inc.	Oligo-2'-fluoronucleotide N3'->P5' phosphoramidates
US6017702A (en) *	1996-12-05	2000-01-25	The Perkin-Elmer Corporation	Chain-termination type nucleic acid sequencing method including 2'-deoxyuridine-5'-triphosphate
DE19741084A1 (de) *	1997-09-18	1999-03-25	Knoell Hans Forschung Ev	Hochaffine Nukleinsäuremoleküle mit funktionellen Gruppen zur spezifischen Erkennung von Zielmolekülen, ihre Herstellung und Verwendung
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BRPI0408967B8 (pt)	2003-03-31	2021-07-27	Hoffmann La Roche	kit e métodos para detecção de um ácido nucléico de vários membros do sorogrupo do vírus da encefalite japonesa em uma amostra biológica sob condições de hibridização rigorosas
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KR101504640B1 (ko) *	2006-12-05	2015-03-20	레이저젠, 인코퍼레이티드	광절단가능 표지된 뉴클레오티드와 뉴클레오시드, 표지된 뉴클레오티드와 뉴클레오시드, 그리고 ｄｎａ 염기서열분석에서 이들의 이용 방법
AU2008283902B2 (en)	2007-08-06	2014-03-13	Orion Genomics Llc	Novel single nucleotide polymorphisms and combinations of novel and known polymorphisms for determining the allele-specific expression of the IGF2 gene
CA2639416C (en)	2007-09-11	2019-12-31	F. Hoffmann-La Roche Ag	Diagnostic test for susceptibility to b-raf kinase inhibitors
JP2010539982A (ja) *	2007-10-01	2010-12-24	アプライドバイオシステムズ，エルエルシー	チェイスライゲーション配列決定法
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CA2801468C (en)	2010-06-04	2018-09-04	Chronix Biomedical	Prostate cancer associated circulating nucleic acid biomarkers
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US20140303008A1 (en)	2011-10-21	2014-10-09	Chronix Biomedical	Colorectal cancer associated circulating nucleic acid biomarkers
ES2413566B1 (es)	2011-12-14	2014-05-20	Fundación Pública Andaluza Progreso Y Salud	Método de obtención de datos útiles para el diagnóstico y pronóstico de la hipoacusia neurosensorial.
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1991
- 1991-12-02 YU YU187991A patent/YU187991A/sh unknown
- 1991-12-04 BG BG95575A patent/BG61484B1/bg unknown
- 1991-12-06 DE DE59108143T patent/DE59108143D1/de not_active Expired - Fee Related
- 1991-12-06 DK DK91120935.1T patent/DK0490281T3/da active
- 1991-12-06 EP EP91120935A patent/EP0490281B1/de not_active Expired - Lifetime
- 1991-12-06 AT AT91120935T patent/ATE142222T1/de not_active IP Right Cessation
- 1991-12-06 ES ES91120935T patent/ES2093671T3/es not_active Expired - Lifetime
- 1991-12-09 NZ NZ24090091A patent/NZ240900A/en unknown
- 1991-12-09 IL IL100298A patent/IL100298A/xx not_active IP Right Cessation
- 1991-12-09 RO RO148926A patent/RO111575B1/ro unknown
- 1991-12-09 TR TR01195/91A patent/TR27715A/xx unknown
- 1991-12-09 FI FI915779A patent/FI915779A/fi unknown
- 1991-12-10 PT PT99747A patent/PT99747A/pt not_active Application Discontinuation
- 1991-12-10 CS CS913743A patent/CS374391A3/cs unknown
- 1991-12-10 AU AU88927/91A patent/AU643856B2/en not_active Ceased
- 1991-12-10 MX MX9102468A patent/MX9102468A/es unknown
- 1991-12-10 PL PL91292701A patent/PL168874B1/pl unknown
- 1991-12-10 CA CA002057475A patent/CA2057475A1/en not_active Abandoned
- 1991-12-10 HU HU913885A patent/HUT60505A/hu unknown
- 1991-12-10 NO NO91914859A patent/NO914859L/no unknown
- 1991-12-10 IE IE430191A patent/IE75726B1/en not_active IP Right Cessation
- 1991-12-10 RU SU915010267A patent/RU2073682C1/ru active
- 1991-12-11 BR BR919105335A patent/BR9105335A/pt unknown
- 1991-12-11 KR KR1019910022614A patent/KR920012107A/ko not_active Application Discontinuation
- 1991-12-11 JP JP03350821A patent/JP3140127B2/ja not_active Expired - Fee Related
1994
- 1994-01-18 US US08/184,759 patent/US5679785A/en not_active Expired - Fee Related
1995
- 1995-06-01 US US08/457,377 patent/US5659025A/en not_active Expired - Fee Related
- 1995-06-01 US US08/456,734 patent/US5668269A/en not_active Expired - Fee Related
1996
- 1996-09-13 GR GR960402400T patent/GR3021041T3/el unknown

Also Published As

Publication number	Publication date
GR3021041T3 (en)	1996-12-31
NZ240900A (en)	1994-07-26
US5679785A (en)	1997-10-21
US5668269A (en)	1997-09-16
IE914301A1 (en)	1992-06-17
PT99747A (pt)	1992-11-30
IL100298A0 (en)	1992-09-06
JP3140127B2 (ja)	2001-03-05
YU187991A (sh)	1994-09-09
PL168874B1 (pl)	1996-04-30
AU643856B2 (en)	1993-11-25
EP0490281B1 (de)	1996-09-04
CA2057475A1 (en)	1992-06-12
BG61484B1 (bg)	1997-09-30
FI915779A0 (fi)	1991-12-09
PL292701A1 (en)	1992-09-21
AU8892791A (en)	1992-06-18
HUT60505A (en)	1992-09-28
ES2093671T3 (es)	1997-01-01
DE59108143D1 (de)	1996-10-10
TR27715A (tr)	1995-06-22
ATE142222T1 (de)	1996-09-15
RU2073682C1 (ru)	1997-02-20
KR920012107A (ko)	1992-07-25
HU913885D0 (en)	1992-02-28
IE75726B1 (en)	1997-09-24
BG95575A (bg)	1993-12-24
BR9105335A (pt)	1992-08-25
CS374391A3 (en)	1992-06-17
RO111575B1 (ro)	1996-11-29
JPH04290896A (ja)	1992-10-15
IL100298A (en)	1997-03-18
NO914859L (no)	1992-06-12
DK0490281T3 (sh)	1997-02-10
US5659025A (en)	1997-08-19
NO914859D0 (no)	1991-12-10
EP0490281A1 (de)	1992-06-17
MX9102468A (es)	1992-06-01

Publication	Publication Date	Title
FI915779A (fi)	1992-06-12	3'-(2')-amino- eller tiolmodifierade nukleosider, nukleotider och oligonukleotider, till vilka kopplats ett fluorescerande faergaemne, foerfarande foer framstaellning av dessa samt anvaendning av dessa.
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