FI105998B - Doseringsanordning för läkemedelspulver - Google Patents
Doseringsanordning för läkemedelspulver Download PDFInfo
- Publication number
- FI105998B FI105998B FI931980A FI931980A FI105998B FI 105998 B FI105998 B FI 105998B FI 931980 A FI931980 A FI 931980A FI 931980 A FI931980 A FI 931980A FI 105998 B FI105998 B FI 105998B
- Authority
- FI
- Finland
- Prior art keywords
- powder
- chamber
- air
- container
- inhalation device
- Prior art date
Links
- 239000000843 powder Substances 0.000 title claims abstract description 82
- 239000003814 drug Substances 0.000 title claims abstract description 34
- 229940079593 drug Drugs 0.000 title description 18
- 230000004888 barrier function Effects 0.000 abstract 1
- 239000003380 propellant Substances 0.000 description 7
- 238000000034 method Methods 0.000 description 5
- 239000000443 aerosol Substances 0.000 description 4
- 239000002245 particle Substances 0.000 description 4
- 238000003860 storage Methods 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 238000011109 contamination Methods 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000012856 packing Methods 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- -1 polypropylene Polymers 0.000 description 2
- VOVIALXJUBGFJZ-KWVAZRHASA-N Budesonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@H]3OC(CCC)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O VOVIALXJUBGFJZ-KWVAZRHASA-N 0.000 description 1
- 244000043261 Hevea brasiliensis Species 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 description 1
- 150000001241 acetals Chemical class 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- NDAUXUAQIAJITI-UHFFFAOYSA-N albuterol Chemical compound CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 NDAUXUAQIAJITI-UHFFFAOYSA-N 0.000 description 1
- NBMKJKDGKREAPL-DVTGEIKXSA-N beclomethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O NBMKJKDGKREAPL-DVTGEIKXSA-N 0.000 description 1
- 229940092705 beclomethasone Drugs 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 229960004436 budesonide Drugs 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 230000002301 combined effect Effects 0.000 description 1
- IMZMKUWMOSJXDT-UHFFFAOYSA-N cromoglycic acid Chemical compound O1C(C(O)=O)=CC(=O)C2=C1C=CC=C2OCC(O)COC1=CC=CC2=C1C(=O)C=C(C(O)=O)O2 IMZMKUWMOSJXDT-UHFFFAOYSA-N 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000005243 fluidization Methods 0.000 description 1
- 239000007903 gelatin capsule Substances 0.000 description 1
- 230000009931 harmful effect Effects 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229940071648 metered dose inhaler Drugs 0.000 description 1
- 229920003052 natural elastomer Polymers 0.000 description 1
- 229920001194 natural rubber Polymers 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 239000004810 polytetrafluoroethylene Substances 0.000 description 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000000284 resting effect Effects 0.000 description 1
- 229960002052 salbutamol Drugs 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 229920003051 synthetic elastomer Polymers 0.000 description 1
- 239000005061 synthetic rubber Substances 0.000 description 1
- 238000009827 uniform distribution Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0065—Inhalators with dosage or measuring devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/064—Powder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/07—General characteristics of the apparatus having air pumping means
- A61M2205/071—General characteristics of the apparatus having air pumping means hand operated
- A61M2205/073—Syringe, piston type
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Pulmonology (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Catching Or Destruction (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Percussion Or Vibration Massage (AREA)
- Massaging Devices (AREA)
- Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Nozzles (AREA)
- External Artificial Organs (AREA)
- Sampling And Sample Adjustment (AREA)
- Dental Tools And Instruments Or Auxiliary Dental Instruments (AREA)
- Encapsulation Of And Coatings For Semiconductor Or Solid State Devices (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
- Surgical Instruments (AREA)
- Telephone Function (AREA)
- Manipulator (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (14)
1. Pulverinandningsanordning, kännetecknad av att som omfattar en pulverför-rädsdel (42, 80) med förmäga att innehälla ett pulverformigt läkemedel (44, 82) och en luftvolym, en doseringskammare (48, 86), som sträcker sig frän pulverförräds- 20 delen (42, 80) för att kurnia mata firam det pulverformiga läkemedlet frän förräds-delen i separata mängder, passagemedel (3, 90) för att läta luit strömma bort frän pulverförrädsdelen (42, 80), genom eller förbi doseringskammaren (48, 86), samt medel (4, 85) för att bilda en luftoycksskillnad mellan nämnda förrädsdel (42, 80) och nämnda passagemedel (3, 90) för att bringa luft att strömma frän pulverförräds-25 delen genom eller förbi doseringskammaren (48, 86) och in i nämnda passagemedel.
2. Inandningsanordning enligt patentkrav 1, kännetecknad av att nämnda doseringskammare (48, 86) är anordnad i en dosframmatningskonstruktion, som är rörlig mellan ett laddningsläge, i vilket doseringskammaren stär i förbindelse med pulverförrädsdelen (42, 80) och ett utmatningsläge, i vilket doseringskammaren stär i 30 förbindelse med ett pulverdispergeringssystem. 12 · 106998
3. Inandningsanordning enligt patentkrav 2, kännetecknad av att dosframmat-ningskonstruktionen är ett glidbart monterat plattelement (87).
4. Pnlverinandningsanordning enligt nägot av patentkraven 1-3, kännetecknad av att den omfattar ett medel (4, 85) för att sammanpressa luften i forrädsdelen, 5 varvid luft strömmar ut i atmosfären, da tiycket mot luften i pulverforrädsdelen ökar.
5. Inandmngsanordning enligt nägot av patentkraven 1-4, kännetecknad av att forradsdelen (42, 80) omges av ett tunnväggigt i huvudsak cylindriskt element (4) och att doseringskammaren (48) är formad till ett hai avgränsat i väggen hos pulver- 10 forradsdelen (42).
6. Inandmngsanordning enligt patentkrav 5, kännetecknad av att hälet (48) är format till en cylindrisk kammare med ett djup, som i huvudsak är lika stort som cylindems diameter.
7. Inandmngsanordning enligt nägot av de foregäende patentkraven, känneteck-15 nad av att, dä doseringskammaren (48) fylls pä frän forrädsdelen (42), pulvermassan (44) passerar via det inre inloppet till doseringskammaren (48).
8. Inandmngsanordning enligt patentkrav 7, kännetecknad av att forrädsdelen (42) stär i glidande kontakt med hälet (6) i anordningen, varvid nämnda häl (6) uppvisar ett utspräng (8), anordnat i detsamma, och pulvret hälls kvar inne i 20 forrädsdelen (42) medelst utspränget. V. 9. Inandmngsanordning enligt patentkrav 7 eller 8, kännetecknad av att dose- ringskammaren (48), sä snart som den har fyllts pä med pulver (44), tillsluts för att avskilja den mätta dosen frän förrädsdelen (42), genom att bringa kammaren att röra sig förbi utspränget (8), anordnat i hälet.
10. Inandningsanordning enligt nägot av de foregäende patentkraven, känneteck nad av att en utsprutning av pulver, som doseringskammaren (48) innehäller, ästadkoms genom en luftström förbi kammaren. 1 Inandningsanordning enligt nägot av patentktaven 1-9, kännetecknad av att en utsprutning av pulver, som doseringskammaren (48) innehäller, ästadkoms genom 30 mekanisk utstötning (50) . 106998 13
12. Inandningsanordning enligt patentkrav 10, kännetecknad av att pulvret sprutas ut genom positivt eller negativt tryck, som erhälls genom luftströmning.
13. Inandningsanordning enligt patentkrav 12, kännetecknad av att ett negativt tryck erhälls genom en venturi-liknande strypning (28).
14. Inandningsanordning enligt nägot av patentkraven 1-13, kännetecknad av att doseringskammaren är skalformad. « · .
Applications Claiming Priority (16)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB909027234A GB9027234D0 (en) | 1990-12-15 | 1990-12-15 | An inhalation device |
| GB9027234 | 1990-12-15 | ||
| GB9102117 | 1991-01-31 | ||
| PCT/GB1991/002117 WO1992010229A1 (en) | 1990-12-15 | 1991-11-29 | Powdered medicament dispensing device |
| OA60224A OA10031A (en) | 1990-12-15 | 1992-06-03 | Medicament dispensing device |
| CS167892 | 1992-06-03 | ||
| OA60224 | 1992-06-03 | ||
| CS921678A CZ281662B6 (cs) | 1990-12-15 | 1992-06-03 | Inhalační přístroj na prach |
| SU5052303 | 1992-06-11 | ||
| HU9201956 | 1992-06-11 | ||
| SU925052303A RU2077893C1 (ru) | 1990-12-15 | 1992-06-11 | Ингалятор для дозированного введения лекарственного порошка при естественном вдохе |
| HU9201956A HU216770B (hu) | 1990-12-15 | 1992-06-11 | Inhalálókészülék por alakú gyógyszerkészítmények adagolására |
| RO92-0787A RO111825B1 (ro) | 1990-12-15 | 1992-06-12 | Dispozitiv pentru administrarea unor medicamente |
| RO9200787 | 1992-06-12 | ||
| KR920010412 | 1992-06-15 | ||
| KR1019920010412A KR0128232B1 (ko) | 1990-12-15 | 1992-06-15 | 약제투여장치 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI931980L FI931980L (fi) | 1993-04-30 |
| FI931980A0 FI931980A0 (fi) | 1993-04-30 |
| FI105998B true FI105998B (sv) | 2000-11-15 |
Family
ID=33304258
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI931980A FI105998B (sv) | 1990-12-15 | 1993-04-30 | Doseringsanordning för läkemedelspulver |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US5503144A (sv) |
| EP (1) | EP0561838B1 (sv) |
| JP (1) | JP2535296B2 (sv) |
| KR (1) | KR0128232B1 (sv) |
| CN (1) | CN1054304C (sv) |
| AT (1) | ATE144155T1 (sv) |
| AU (1) | AU647851B2 (sv) |
| CA (1) | CA2091366C (sv) |
| CY (1) | CY1999A (sv) |
| CZ (1) | CZ281662B6 (sv) |
| DE (1) | DE69122769T2 (sv) |
| DK (1) | DK0561838T3 (sv) |
| ES (1) | ES2092581T3 (sv) |
| FI (1) | FI105998B (sv) |
| GB (1) | GB9027234D0 (sv) |
| GR (1) | GR3021495T3 (sv) |
| HK (1) | HK48397A (sv) |
| HU (1) | HU216770B (sv) |
| IE (1) | IE76470B1 (sv) |
| IL (1) | IL100341A (sv) |
| NO (1) | NO305785B1 (sv) |
| NZ (1) | NZ240833A (sv) |
| OA (1) | OA10031A (sv) |
| PT (1) | PT99805B (sv) |
| RO (1) | RO111825B1 (sv) |
| RU (1) | RU2077893C1 (sv) |
| SG (1) | SG71676A1 (sv) |
| SK (1) | SK278819B6 (sv) |
| WO (1) | WO1992010229A1 (sv) |
| ZA (1) | ZA919521B (sv) |
Families Citing this family (119)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993000951A1 (en) * | 1991-07-02 | 1993-01-21 | Inhale, Inc. | Method and device for delivering aerosolized medicaments |
| US6029661A (en) * | 1991-08-26 | 2000-02-29 | 3M Innovative Properties Company | Powder dispenser |
| US5341801A (en) * | 1991-12-03 | 1994-08-30 | Sandoz Ltd. | Inhaler |
| US5239993A (en) * | 1992-08-26 | 1993-08-31 | Glaxo Inc. | Dosage inhalator providing optimized compound inhalation trajectory |
| IL106930A0 (en) * | 1992-09-08 | 1993-12-28 | Norton Healthcare Ltd | Medicament dispensing device |
| GB9218937D0 (en) * | 1992-09-08 | 1992-10-21 | Norton Healthcare Ltd | Medicament dispensing device |
| DK0652022T3 (da) * | 1993-05-12 | 1999-09-13 | Teijin Ltd | Indretning og fremgangsmåde til afgivelse af flere doser pulverformig medicin |
| GB9326574D0 (en) * | 1993-12-31 | 1994-03-02 | King S College London | Dry power inhalers |
| HUT75676A (en) | 1994-03-07 | 1997-05-28 | Inhale Therapeutic Syst | Methods and compositions for pulmonary delivery of insulin |
| FI942196A7 (sv) * | 1994-05-11 | 1995-11-12 | Orion Yhtymae Oy | Pulverinhalator |
| MX9707862A (es) | 1995-04-14 | 1997-11-29 | Glaxo Wellcome Inc | Inhalador de dosis medida para el propionato de fluticasona. |
| EP0820414B1 (en) * | 1995-04-14 | 2004-02-04 | SmithKline Beecham Corporation | Metered dose inhaler for beclomethasone dipropionate |
| EP0820279B1 (en) * | 1995-04-14 | 2002-07-03 | Smithkline Beecham Corporation | Metered dose inhaler for albuterol |
| TR199701169T1 (xx) | 1995-04-14 | 1998-03-21 | Glaxo Wellcome Inc. | Salmeterol i�in �l��lm�� doz inhaleri. |
| SE9502799D0 (sv) * | 1995-08-10 | 1995-08-10 | Astra Ab | Device in inhalers |
| SK287878B6 (sk) * | 1996-02-21 | 2012-02-03 | Schering Corporation | Powdered medication inhaler |
| DE19647947A1 (de) * | 1996-11-20 | 1998-05-28 | Pfeiffer Erich Gmbh & Co Kg | Austragvorrichtung für Medien |
| GB9705071D0 (en) * | 1997-03-12 | 1997-04-30 | Theobald David R | Nebuliser |
| US20030103906A1 (en) * | 1997-10-14 | 2003-06-05 | Smithkline Beecham Corporation | Metered dose inhaler having internal surfaces coated with fluorocarbon polymer |
| US6257233B1 (en) | 1998-06-04 | 2001-07-10 | Inhale Therapeutic Systems | Dry powder dispersing apparatus and methods for their use |
| JP2000217917A (ja) * | 1999-01-27 | 2000-08-08 | Unisia Jecs Corp | 吸入式投薬器 |
| US6325386B1 (en) * | 1999-03-30 | 2001-12-04 | Shimano, Inc. | Rotatable seal assembly for a bicycle hub transmission |
| FI990915A0 (sv) * | 1999-04-23 | 1999-04-23 | Orion Yhtymae Oyj | Pulverinhalator |
| WO2000074754A2 (en) | 1999-06-05 | 2000-12-14 | Innovata Biomed Limited | Delivery system |
| GB2353222B (en) * | 1999-06-23 | 2001-09-19 | Cambridge Consultants | Inhalers |
| US9006175B2 (en) | 1999-06-29 | 2015-04-14 | Mannkind Corporation | Potentiation of glucose elimination |
| US7305986B1 (en) | 1999-07-23 | 2007-12-11 | Mannkind Corporation | Unit dose capsules for use in a dry powder inhaler |
| US7464706B2 (en) | 1999-07-23 | 2008-12-16 | Mannkind Corporation | Unit dose cartridge and dry powder inhaler |
| DE19963946C2 (de) * | 1999-08-27 | 2001-07-26 | Schuckmann Alfred Von | Handbetätigter Inhalator für pulverförmige Substanzen |
| GB9920839D0 (en) | 1999-09-04 | 1999-11-10 | Innovata Biomed Ltd | Inhaler |
| AR028746A1 (es) | 2000-06-23 | 2003-05-21 | Norton Health Care Ltd | Cartucho de dosis previamente medidas para inhalador de polvo seco accionado por la respiracion, el inhalador y un metodo de provision de dosis previamente medidas de polvo seco |
| PE20020067A1 (es) | 2000-06-23 | 2002-02-05 | Norton Healthcare Ltd | Desaglomerador para inhalador de polvo seco accionado por la respiracion |
| PE20020074A1 (es) | 2000-06-23 | 2002-02-05 | Norton Healthcare Ltd | Sistema dosificador para inhalador de medicamento |
| US6357490B1 (en) * | 2000-08-22 | 2002-03-19 | Advanced Inhalation Research, Inc. | System, method and apparatus for filling containers |
| MXPA03007017A (es) * | 2001-02-06 | 2004-09-13 | Innovata Biomed Ltd | Medicamentos. |
| EG24184A (en) * | 2001-06-15 | 2008-10-08 | Otsuka Pharma Co Ltd | Dry powder inhalation system for transpulmonary |
| FI20011317A0 (sv) * | 2001-06-20 | 2001-06-20 | Orion Corp | Pulverinhalator |
| GB0128148D0 (en) * | 2001-11-23 | 2002-01-16 | Innovata Biomed Ltd | Assembly |
| KR100463978B1 (ko) * | 2002-02-07 | 2004-12-30 | 윤강준 | 의료용 오존시스템의 토출장치 |
| ES2425392T3 (es) | 2002-03-20 | 2013-10-15 | Mannkind Corporation | Cartucho para un aparato de inhalación |
| GB0207817D0 (en) * | 2002-04-04 | 2002-05-15 | Optinose As | Nasal devices |
| GB2403154B (en) * | 2002-04-04 | 2007-01-24 | Optinose As | Nasal devices |
| GB0209494D0 (en) * | 2002-04-25 | 2002-06-05 | Optinose As | Nasal devices |
| DE10233150B4 (de) | 2002-07-22 | 2013-03-07 | Alfred Von Schuckmann | Handbetätigbarer Inhalator für pulverförmige Substanzen |
| DK1658872T4 (da) | 2002-07-31 | 2019-11-11 | Chiesi Farm Spa | Pulverinhalator |
| GB0219512D0 (en) | 2002-08-21 | 2002-10-02 | Norton Healthcare Ltd | Inhalation compositions with high drug ratios |
| GB0219511D0 (en) | 2002-08-21 | 2002-10-02 | Norton Healthcare Ltd | Method of preparing dry powder inhalation compositions |
| US8273331B2 (en) | 2002-08-21 | 2012-09-25 | Norton Healthcare Ltd. | Inhalation compositions |
| US6883517B2 (en) * | 2002-09-30 | 2005-04-26 | Asaf Halamish | Downdraft nebulizer |
| GB0303870D0 (en) * | 2003-02-20 | 2003-03-26 | Norton Healthcare Ltd | Pre-metered dose magazine for breath-actuated dry powder inhaler |
| RU2324502C2 (ru) * | 2003-03-27 | 2008-05-20 | Биоактиз Лимитед | Медицинский инструмент для введения порошкообразного лекарственного препарата в полость носа |
| WO2005020963A1 (en) | 2003-09-02 | 2005-03-10 | Ivax Corporation | Process for preparing a medicament |
| RU2346705C2 (ru) * | 2003-10-09 | 2009-02-20 | Биоактиз Лимитед | Устройство для введения порошкообразного лекарства в полость носа |
| CA2562386C (en) * | 2004-04-21 | 2014-11-18 | Innovata Biomed Limited | Inhaler |
| GB0409197D0 (en) | 2004-04-24 | 2004-05-26 | Innovata Biomed Ltd | Device |
| DK1786784T3 (da) | 2004-08-20 | 2011-02-14 | Mannkind Corp | Katalyse af diketopiperazinsyntese |
| ES2543007T3 (es) | 2004-08-23 | 2015-08-13 | Mannkind Corporation | Micropartículas que comprenden sales de dicetopiperazina para la administración de fármacos |
| DE102005016102B3 (de) * | 2005-04-08 | 2006-10-26 | Altana Pharma Ag | Vorrichtung zur Dosierung und Trockenvernebelung |
| WO2007033372A2 (en) | 2005-09-14 | 2007-03-22 | Mannkind Corporation | Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents |
| DE102006022120A1 (de) * | 2006-02-20 | 2007-09-06 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Spreizspektrumverfahren zur Bestimmung von Vitalparametern |
| RU2403059C2 (ru) | 2006-02-22 | 2010-11-10 | Маннкайнд Корпорейшн | Способ улучшения фармацевтических свойств микрочастиц, содержащих дикетопиперазин и активный агент |
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- 1991-12-14 CN CN91107979A patent/CN1054304C/zh not_active Expired - Lifetime
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1992
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