FI101300B1 - Menetelmä farmakologisesti aktiivisten 1,2,3,4-tetrahydrokinoliini-6-etikkahappojohdannaisten valmistamiseksi ja välituotteena käytettävät kinoliinijohdannaiset - Google Patents
Menetelmä farmakologisesti aktiivisten 1,2,3,4-tetrahydrokinoliini-6-etikkahappojohdannaisten valmistamiseksi ja välituotteena käytettävät kinoliinijohdannaisetInfo
- Publication number
- FI101300B1 FI101300B1 FI925697A FI925697A FI101300B1 FI 101300 B1 FI101300 B1 FI 101300B1 FI 925697 A FI925697 A FI 925697A FI 925697 A FI925697 A FI 925697A FI 101300 B1 FI101300 B1 FI 101300B1
- Authority
- FI
- Finland
- Prior art keywords
- substituted
- halogen
- tetrahydroquinoline
- preparation
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D215/14—Radicals substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
- C07C317/48—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/63—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C331/00—Derivatives of thiocyanic acid or of isothiocyanic acid
- C07C331/02—Thiocyanates
- C07C331/14—Thiocyanates having sulfur atoms of thiocyanate groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/36—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/40—Nitrogen atoms attached in position 8
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- External Artificial Organs (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Quinoline Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Peptides Or Proteins (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11100091 | 1991-04-16 | ||
JP11100091 | 1991-04-16 | ||
JP11673092 | 1992-04-10 | ||
JP11673092A JP3209568B2 (ja) | 1991-04-16 | 1992-04-10 | 新規環状アミノフェニル酢酸誘導体、その製造法及びそれらを有効成分とする免疫応答の修飾剤 |
PCT/JP1992/000476 WO1992018482A1 (en) | 1991-04-16 | 1992-04-15 | Novel cyclic aminophenylacetic acid derivative, production thereof, and immune response modulator containing the same as active ingredient |
JP9200476 | 1992-04-15 |
Publications (4)
Publication Number | Publication Date |
---|---|
FI925697A0 FI925697A0 (fi) | 1992-12-15 |
FI925697A FI925697A (fi) | 1992-12-15 |
FI101300B1 true FI101300B1 (fi) | 1998-05-29 |
FI101300B FI101300B (fi) | 1998-05-29 |
Family
ID=26450490
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI925697A FI101300B (fi) | 1991-04-16 | 1992-12-15 | Menetelmä farmakologisesti aktiivisten 1,2,3,4-tetrahydrokinoliini-6-e tikkahappojohdannaisten valmistamiseksi ja välituotteena käytettävät k inoliinijohdannaiset |
Country Status (19)
Country | Link |
---|---|
US (1) | US5359076A (fi) |
EP (1) | EP0538477B1 (fi) |
JP (1) | JP3209568B2 (fi) |
KR (1) | KR960007085B1 (fi) |
AT (1) | ATE226196T1 (fi) |
AU (1) | AU647612B2 (fi) |
BG (1) | BG61262B1 (fi) |
CA (1) | CA2085347C (fi) |
CZ (1) | CZ282165B6 (fi) |
DE (1) | DE69232812T2 (fi) |
DK (1) | DK0538477T3 (fi) |
ES (1) | ES2184730T3 (fi) |
FI (1) | FI101300B (fi) |
HU (2) | HU9203870D0 (fi) |
NO (1) | NO179174C (fi) |
RO (1) | RO114615B1 (fi) |
SK (1) | SK282146B6 (fi) |
TW (1) | TW203606B (fi) |
WO (1) | WO1992018482A1 (fi) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL112567A (en) * | 1994-02-10 | 2000-02-29 | Wyeth John & Brother Ltd | Substituted quinolines their preparation and pharmaceutical compositions containing them |
US6180640B1 (en) | 1998-06-25 | 2001-01-30 | Sepracor, Inc. | Di- and tetra-hydroquinoline-indole antimicrobial agents, uses and compositions related thereto |
CN102958919A (zh) * | 2010-07-02 | 2013-03-06 | 霍夫曼-拉罗奇有限公司 | 新的四氢喹啉衍生物 |
US8592594B2 (en) * | 2010-07-02 | 2013-11-26 | Hoffmann-La Roche Inc. | Tetrahydro-quinoline derivatives |
US11084787B2 (en) | 2016-02-10 | 2021-08-10 | Sumitomo Chemical Company Limited | Method for producing 1-methylpyrrolidin-3-ol |
CN116648245A (zh) | 2020-12-25 | 2023-08-25 | 东丽株式会社 | 四氢喹啉衍生物及其医药用途 |
KR20250026152A (ko) | 2022-06-24 | 2025-02-25 | 도레이 카부시키가이샤 | 근위축성 측색경화증의 치료제 또는 예방제 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2042352A1 (fr) * | 1969-04-21 | 1971-02-12 | Ciba Geigy Ag | Acides alpha-(1,2,3,4-tetrahydro-6-quinolyl)-carboxyliques et leurs derives |
CH576445A5 (fi) * | 1972-03-10 | 1976-06-15 | Ciba Geigy Ag | |
JPS5665097A (en) * | 1979-05-30 | 1981-06-02 | Lion Corp | Manufacture of fatty acid lower alcohol ester |
JPS58116466A (ja) * | 1981-12-29 | 1983-07-11 | Nippon Zoki Pharmaceut Co Ltd | 新規キノリル酢酸誘導体及び該化合物を含有する医薬組成物 |
US4956372A (en) * | 1987-10-02 | 1990-09-11 | Kyorin Pharmaceutical Co., Ltd. | Cyclic anthranilic acid derivatives and process for their preparation |
US5124325A (en) * | 1989-06-13 | 1992-06-23 | Kyorin Pharmaceutical Co., Ltd. | Therapeutic agents of metabolic bone disease |
-
1992
- 1992-04-10 JP JP11673092A patent/JP3209568B2/ja not_active Expired - Fee Related
- 1992-04-15 KR KR1019920703236A patent/KR960007085B1/ko not_active IP Right Cessation
- 1992-04-15 ES ES92908279T patent/ES2184730T3/es not_active Expired - Lifetime
- 1992-04-15 SK SK3651-92A patent/SK282146B6/sk unknown
- 1992-04-15 RO RO92-01558A patent/RO114615B1/ro unknown
- 1992-04-15 HU HU9203870A patent/HU9203870D0/hu unknown
- 1992-04-15 EP EP92908279A patent/EP0538477B1/en not_active Expired - Lifetime
- 1992-04-15 DK DK92908279T patent/DK0538477T3/da active
- 1992-04-15 WO PCT/JP1992/000476 patent/WO1992018482A1/ja active IP Right Grant
- 1992-04-15 US US07/956,012 patent/US5359076A/en not_active Expired - Lifetime
- 1992-04-15 AT AT92908279T patent/ATE226196T1/de not_active IP Right Cessation
- 1992-04-15 AU AU15549/92A patent/AU647612B2/en not_active Ceased
- 1992-04-15 CA CA002085347A patent/CA2085347C/en not_active Expired - Fee Related
- 1992-04-15 DE DE69232812T patent/DE69232812T2/de not_active Expired - Fee Related
- 1992-04-15 HU HU9203870A patent/HU222522B1/hu not_active IP Right Cessation
- 1992-04-15 CZ CS923651A patent/CZ282165B6/cs not_active IP Right Cessation
- 1992-04-25 TW TW081103268A patent/TW203606B/zh active
- 1992-12-15 NO NO924854A patent/NO179174C/no unknown
- 1992-12-15 FI FI925697A patent/FI101300B/fi active
- 1992-12-15 BG BG97173A patent/BG61262B1/bg unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR011174A1 (es) | Compuestos de pirazina, composiciones farmaceuticas que los contienen, su uso en la peparacion de medicamentos y proceso para prepararlos | |
FI904602A0 (fi) | Pyrazoloderivat, foerfarande foer deras framstaellning och dessa innehaollande farmaceutiska blandningar. | |
CA2121230A1 (en) | 1,3-dihydro-2h-imidazo(4,5-b) quinolin-2-one derivatives | |
CY1108913T1 (el) | Παραγωγα 4 (φαινυλ-πιπεραζινυλ-μεθυλ) βενζαμιδιου και η χρηση τους για τη θεραπευτικη αντιμετωπιση του πονου, του αγχους ή γαστρεντερικων διαταραχων | |
ES2054825T3 (es) | Compuestos heterociclicos terapeuticos. | |
FI884375A0 (fi) | Menetelmä terapeuttisesti käyttökelpoisten N-(1-alkyyli-3-hydroksi-4-piperidinyyli)bentsamidien valmistamiseksi | |
EP0372940A3 (en) | Anti-inflammatory 2-furanones | |
TNSN88025A1 (fr) | 4-[4-[4-[4-[[2-(2,4 - difluorophenyl)-2-(1h-azolymethyl) - 1,3 - dioxolanne -4- yl] methoxy phenyl] -1- piperazinyl] phenyl] triazolones. | |
FI101300B1 (fi) | Menetelmä farmakologisesti aktiivisten 1,2,3,4-tetrahydrokinoliini-6-etikkahappojohdannaisten valmistamiseksi ja välituotteena käytettävät kinoliinijohdannaiset | |
NO167029C (no) | Analogifremgangsmaate for fremstilling av terapeutisk aktive pyridinkarboksylsyrederivater | |
NO20020475D0 (no) | 2-aminotetralinderivater for terapi av glaukom | |
NO951812L (no) | Pyrrolderivater, deres fremstilling og anvendelse | |
ATE93847T1 (de) | Thioformamid-derivate. | |
DK38685A (da) | Oxysalicylamidoderivater og laegemiddel indeholdende saadanne | |
SE8105427L (sv) | Sett att framstella 2-metylenkinoxalin-1,4-dioxidderivat | |
FR2802926B1 (fr) | Nouveaux derives de 3-imino-1,2-dithioles, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |