[go: up one dir, main page]

FI925697A - Nya cykliska aminofenylaettiksyraderivat, foerfarande foer deras framstaellning och en immunsvarmodulator innehaollande dem saosom effektiv ingrediens - Google Patents

Nya cykliska aminofenylaettiksyraderivat, foerfarande foer deras framstaellning och en immunsvarmodulator innehaollande dem saosom effektiv ingrediens Download PDF

Info

Publication number
FI925697A
FI925697A FI925697A FI925697A FI925697A FI 925697 A FI925697 A FI 925697A FI 925697 A FI925697 A FI 925697A FI 925697 A FI925697 A FI 925697A FI 925697 A FI925697 A FI 925697A
Authority
FI
Finland
Prior art keywords
substituted
immunsvarmodulator
cycliska
aminophenylethetyraderivat
ingrediens
Prior art date
Application number
FI925697A
Other languages
English (en)
Other versions
FI101300B1 (fi
FI925697A0 (fi
FI101300B (fi
Inventor
Yasushi Kohno
Katsuya Awano
Takayoshi Ishizaki
Eisuke Kojima
Shinji Kudoh
Yasuhiko Sakoe
Koji Saito
Original Assignee
Kyorin Seiyaku Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyorin Seiyaku Kk filed Critical Kyorin Seiyaku Kk
Publication of FI925697A0 publication Critical patent/FI925697A0/fi
Publication of FI925697A publication Critical patent/FI925697A/fi
Application granted granted Critical
Publication of FI101300B1 publication Critical patent/FI101300B1/fi
Publication of FI101300B publication Critical patent/FI101300B/fi

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D215/14Radicals substituted by oxygen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/21Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00Sulfones; Sulfoxides
    • C07C317/44Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C07C317/48Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/62Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/63Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C331/00Derivatives of thiocyanic acid or of isothiocyanic acid
    • C07C331/02Thiocyanates
    • C07C331/14Thiocyanates having sulfur atoms of thiocyanate groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18Halogen atoms or nitro radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/36Sulfur atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38Nitrogen atoms
    • C07D215/40Nitrogen atoms attached in position 8
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/0803Compounds with Si-C or Si-Si linkages
    • C07F7/081Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • External Artificial Organs (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Peptides Or Proteins (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
FI925697A 1991-04-16 1992-12-15 Menetelmä farmakologisesti aktiivisten 1,2,3,4-tetrahydrokinoliini-6-e tikkahappojohdannaisten valmistamiseksi ja välituotteena käytettävät k inoliinijohdannaiset FI101300B (fi)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP11100091 1991-04-16
JP11100091 1991-04-16
JP11673092 1992-04-10
JP11673092A JP3209568B2 (ja) 1991-04-16 1992-04-10 新規環状アミノフェニル酢酸誘導体、その製造法及びそれらを有効成分とする免疫応答の修飾剤
PCT/JP1992/000476 WO1992018482A1 (en) 1991-04-16 1992-04-15 Novel cyclic aminophenylacetic acid derivative, production thereof, and immune response modulator containing the same as active ingredient
JP9200476 1992-04-15

Publications (4)

Publication Number Publication Date
FI925697A0 FI925697A0 (fi) 1992-12-15
FI925697A true FI925697A (fi) 1992-12-15
FI101300B1 FI101300B1 (fi) 1998-05-29
FI101300B FI101300B (fi) 1998-05-29

Family

ID=26450490

Family Applications (1)

Application Number Title Priority Date Filing Date
FI925697A FI101300B (fi) 1991-04-16 1992-12-15 Menetelmä farmakologisesti aktiivisten 1,2,3,4-tetrahydrokinoliini-6-e tikkahappojohdannaisten valmistamiseksi ja välituotteena käytettävät k inoliinijohdannaiset

Country Status (19)

Country Link
US (1) US5359076A (fi)
EP (1) EP0538477B1 (fi)
JP (1) JP3209568B2 (fi)
KR (1) KR960007085B1 (fi)
AT (1) ATE226196T1 (fi)
AU (1) AU647612B2 (fi)
BG (1) BG61262B1 (fi)
CA (1) CA2085347C (fi)
CZ (1) CZ282165B6 (fi)
DE (1) DE69232812T2 (fi)
DK (1) DK0538477T3 (fi)
ES (1) ES2184730T3 (fi)
FI (1) FI101300B (fi)
HU (2) HU9203870D0 (fi)
NO (1) NO179174C (fi)
RO (1) RO114615B1 (fi)
SK (1) SK282146B6 (fi)
TW (1) TW203606B (fi)
WO (1) WO1992018482A1 (fi)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL112567A (en) * 1994-02-10 2000-02-29 Wyeth John & Brother Ltd Substituted quinolines their preparation and pharmaceutical compositions containing them
US6180640B1 (en) 1998-06-25 2001-01-30 Sepracor, Inc. Di- and tetra-hydroquinoline-indole antimicrobial agents, uses and compositions related thereto
CN102958919A (zh) * 2010-07-02 2013-03-06 霍夫曼-拉罗奇有限公司 新的四氢喹啉衍生物
US8592594B2 (en) * 2010-07-02 2013-11-26 Hoffmann-La Roche Inc. Tetrahydro-quinoline derivatives
US11084787B2 (en) 2016-02-10 2021-08-10 Sumitomo Chemical Company Limited Method for producing 1-methylpyrrolidin-3-ol
CN116648245A (zh) 2020-12-25 2023-08-25 东丽株式会社 四氢喹啉衍生物及其医药用途
KR20250026152A (ko) 2022-06-24 2025-02-25 도레이 카부시키가이샤 근위축성 측색경화증의 치료제 또는 예방제

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2042352A1 (fr) * 1969-04-21 1971-02-12 Ciba Geigy Ag Acides alpha-(1,2,3,4-tetrahydro-6-quinolyl)-carboxyliques et leurs derives
CH576445A5 (fi) * 1972-03-10 1976-06-15 Ciba Geigy Ag
JPS5665097A (en) * 1979-05-30 1981-06-02 Lion Corp Manufacture of fatty acid lower alcohol ester
JPS58116466A (ja) * 1981-12-29 1983-07-11 Nippon Zoki Pharmaceut Co Ltd 新規キノリル酢酸誘導体及び該化合物を含有する医薬組成物
US4956372A (en) * 1987-10-02 1990-09-11 Kyorin Pharmaceutical Co., Ltd. Cyclic anthranilic acid derivatives and process for their preparation
US5124325A (en) * 1989-06-13 1992-06-23 Kyorin Pharmaceutical Co., Ltd. Therapeutic agents of metabolic bone disease

Also Published As

Publication number Publication date
CZ282165B6 (cs) 1997-05-14
SK282146B6 (sk) 2001-11-06
NO179174B (no) 1996-05-13
DE69232812T2 (de) 2003-08-07
FI101300B1 (fi) 1998-05-29
TW203606B (fi) 1993-04-11
RO114615B1 (ro) 1999-06-30
DE69232812D1 (de) 2002-11-21
FI925697A0 (fi) 1992-12-15
HUT68184A (en) 1995-05-29
EP0538477A4 (en) 1993-02-12
NO924854D0 (no) 1992-12-15
SK365192A3 (en) 2000-11-07
HU222522B1 (hu) 2003-08-28
AU647612B2 (en) 1994-03-24
AU1554992A (en) 1992-11-17
HU9203870D0 (en) 1993-03-29
EP0538477A1 (en) 1993-04-28
CA2085347C (en) 2003-08-19
DK0538477T3 (da) 2002-11-11
CA2085347A1 (en) 1992-10-17
FI101300B (fi) 1998-05-29
KR930700449A (ko) 1993-03-15
EP0538477B1 (en) 2002-10-16
KR960007085B1 (ko) 1996-05-27
NO924854L (no) 1993-02-16
NO179174C (no) 1996-08-21
JP3209568B2 (ja) 2001-09-17
JPH05125052A (ja) 1993-05-21
WO1992018482A1 (en) 1992-10-29
ATE226196T1 (de) 2002-11-15
US5359076A (en) 1994-10-25
BG61262B1 (en) 1997-04-30
CZ365192A3 (en) 1993-08-11
BG97173A (bg) 1993-12-24
ES2184730T3 (es) 2003-04-16

Similar Documents

Publication Publication Date Title
AR011174A1 (es) Compuestos de pirazina, composiciones farmaceuticas que los contienen, su uso en la peparacion de medicamentos y proceso para prepararlos
DK0539204T3 (da) Antivirale 4-substituerede-deoxy-2,3-didehydroderivater af alfa-D-neuraminsyre
CY1108913T1 (el) Παραγωγα 4 (φαινυλ-πιπεραζινυλ-μεθυλ) βενζαμιδιου και η χρηση τους για τη θεραπευτικη αντιμετωπιση του πονου, του αγχους ή γαστρεντερικων διαταραχων
FI884879A0 (fi) Terapeutiskt anvaendbara heterocykliska foereningar.
FI904602A0 (fi) Pyrazoloderivat, foerfarande foer deras framstaellning och dessa innehaollande farmaceutiska blandningar.
FR2645537B1 (fr) Nouveaux sulfonamides derives d'acides benzocycliques ou benzoheterocycliques, leur preparation et leur application en therapeutique
FI925697A0 (fi) Nya cykliska aminofenylaettiksyraderivat, foerfarande foer deras framstaellning och en immunsvarmodulator innehaollande dem saosom effektiv ingrediens
NO922133L (no) Substituerte diaminoftalimider og analoger
ATE111082T1 (de) 3-sulfonylamino-2-(1h)-chinolinone und deren 7- azaderivate als anregende aminosäuren antagonisten.
DE60002733D1 (de) Diester prodrugs von decahydroischinoline-3-carbonsäure
DK26689A (da) Pyridinderivater
FI924848A (fi) Triazaspirodekanon-metylkromaner
ES8105748A1 (es) Procedimiento para preparar derivados de pirimidina
DE69007029D1 (de) Arzneimittelzubereitungen.
DE3887102D1 (de) Substituierte Derivate von 20,21-Dinoreburnamenin, Verfahren zur Herstellung und so hergestellte Zwischenprodukte, ihre Verwendung als Arzneimittel und diese enthaltende pharmazeutische Zusammenstellungen.
FR2674246B1 (fr) Nouveaux derives de l'acide alpha-methylene 5-thiazolacetique, leur procede de preparation et les intermediaires de ce procede, leur application a titre de fongicides et les compositions les renfermant.
SE8000699L (sv) Nya kinazolinderivat jemte sett for deras framstellning och farmaceutiska beredningar innehallande dem
ATE125793T1 (de) Substituierte alkensäure und ihre derivate.
FR2802926B1 (fr) Nouveaux derives de 3-imino-1,2-dithioles, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
DK0537729T3 (da) Farmaceutiske præparater indeholdende triazolderivater til rektal indgivelse
DK1490391T3 (da) 11beta-langkædet substituerede 19-nor-17alfa-pregna-1,3,5(10)-trien-17beta-oler med en 21,2alfa-lactonring