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ES8504112A1 - Procedimiento para la obtencion de derivados de la benzamidina de actividad antimicrobiana - Google Patents

Procedimiento para la obtencion de derivados de la benzamidina de actividad antimicrobiana

Info

Publication number
ES8504112A1
ES8504112A1 ES534828A ES534828A ES8504112A1 ES 8504112 A1 ES8504112 A1 ES 8504112A1 ES 534828 A ES534828 A ES 534828A ES 534828 A ES534828 A ES 534828A ES 8504112 A1 ES8504112 A1 ES 8504112A1
Authority
ES
Spain
Prior art keywords
procedure
obtaining
antimicrobial activity
benzamidine derivatives
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES534828A
Other languages
English (en)
Other versions
ES534828A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SA
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi SA filed Critical Sanofi SA
Publication of ES8504112A1 publication Critical patent/ES8504112A1/es
Publication of ES534828A0 publication Critical patent/ES534828A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/13—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups
    • C07C205/19—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups having nitro groups bound to carbon atoms of six-membered aromatic rings and hydroxy groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/27—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups
    • C07C205/35—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C205/36—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system
    • C07C205/37—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/18—Monohydroxylic alcohols containing only six-membered aromatic rings as cyclic part
    • C07C33/20—Monohydroxylic alcohols containing only six-membered aromatic rings as cyclic part monocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Cosmetics (AREA)

Abstract

PROCEDIMIENTO DE OBTENCION DE DERIVADOS DE LA BENZAMIDINA, CON ACTIVIDAD ANTIMICROBIANA, DE FORMULA (I), DONDE A ES UNA CADENA ALQUILO, RECTA O RAMIFICADA, CON 3 A 9 ATOMOS DE CARBONO Y X ES UN ATOMO DE OXIGENO O UN ENLACE DIRECTO.SE REALIZA UNA OXIDACION CATALITICA DEL COMPUESTO DE FORMULA (II), AN/ADIENDO NITRITO SODICO EN MEDIO ACIDO, TRANSFORMANDO LOS DIAZONIOS OBTENIDOS EN BENZONITRILOS POR ACCION DEL CIANURO CUPROSO, EN EL COMPUESTO DESEADO O EN SUS SALES FARMACOLOGICAMENTE ACEPTABLES.DE LICACION COMO ANTISEPTICOS PARA USO HUMANO O EN VETERINARIA, DESINFECTANTES O CONSERVANTES.
ES534828A 1983-08-03 1984-08-02 Procedimiento para la obtencion de derivados de la benzamidina de actividad antimicrobiana Granted ES534828A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8312824A FR2550192B1 (fr) 1983-08-03 1983-08-03 Nouveaux derives de la benzamidine a activite antimicrobienne, leur procede de preparation, leur utilisation en tant que medicaments desinfectants ou conservateurs

Publications (2)

Publication Number Publication Date
ES8504112A1 true ES8504112A1 (es) 1985-04-16
ES534828A0 ES534828A0 (es) 1985-04-16

Family

ID=9291379

Family Applications (1)

Application Number Title Priority Date Filing Date
ES534828A Granted ES534828A0 (es) 1983-08-03 1984-08-02 Procedimiento para la obtencion de derivados de la benzamidina de actividad antimicrobiana

Country Status (25)

Country Link
US (1) US4720581A (es)
EP (1) EP0136195B1 (es)
JP (1) JPS6054351A (es)
KR (1) KR920000373B1 (es)
AR (1) AR242556A1 (es)
AT (1) ATE27952T1 (es)
AU (1) AU563648B2 (es)
CA (1) CA1238922A (es)
CS (1) CS246088B2 (es)
DD (1) DD220025A5 (es)
DE (1) DE3464362D1 (es)
DK (1) DK158662C (es)
ES (1) ES534828A0 (es)
FI (1) FI77020C (es)
FR (1) FR2550192B1 (es)
GR (1) GR82449B (es)
HU (1) HU192567B (es)
IL (1) IL72480A (es)
MA (1) MA20180A1 (es)
NO (1) NO157618C (es)
NZ (1) NZ209092A (es)
PT (1) PT79003B (es)
SU (1) SU1319784A3 (es)
YU (1) YU127684A (es)
ZA (1) ZA845682B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2504361Y2 (ja) * 1990-12-14 1996-07-10 大和ハウス工業株式会社 建物の配管固定構造
DE4424713A1 (de) * 1994-07-13 1996-01-18 Boehringer Ingelheim Kg Substituierte Benzamidine, ihre Herstellung und Verwendung als Arnzneistoffe
DE4447361A1 (de) * 1994-12-21 1996-06-27 Schuelke & Mayr Gmbh Biozide Alkohole, ihre Herstellung und ihre Verwendung
DE19515500A1 (de) * 1995-04-27 1996-10-31 Thomae Gmbh Dr K Substituierte Phenylamidine, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
UA63887C2 (en) * 1996-10-28 2004-02-16 Lg Chemical Ltd Selective thrombin inhibitors and a pharmaceutical composition based thereon
PT1043310E (pt) * 1997-11-20 2004-10-29 Teijin Ltd Derivados de bifenilamidina
KR20050104376A (ko) * 2003-02-19 2005-11-02 에자이 가부시키가이샤 고리형상 벤즈아미딘 유도체의 제조방법
AU2005260326B2 (en) * 2004-07-05 2008-10-23 Dong Wha Pharmaceutical Co., Ltd. An improved process for preparing N-hydroxy-4-{5- [4- (5-isopropyl-2-methyl-l, 3-thiazol-4-yl) -phenoxy] -pentoxy }-benzamidine
CN111362834B (zh) * 2020-02-26 2021-04-02 湖南大学 一种具有抗耐药性的抗菌脒类低聚物及其制作方法和用途
CN114933550B (zh) * 2021-08-02 2023-07-28 湖南大学 具有聚苯基吲哚脒类抗菌拟肽及其制作方法和用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2934438A (en) * 1958-03-20 1960-04-26 Michener Harold David Preservation process with alkyl guanidines
US3769427A (en) * 1970-10-01 1973-10-30 Armour Pharma Pharmaceutical compositions and methods of using same
IT1153988B (it) * 1981-10-05 1987-01-21 Medea Res Srl Composizioni ad attivita' antimicrobica

Also Published As

Publication number Publication date
DK362384D0 (da) 1984-07-24
DK158662B (da) 1990-07-02
KR850001730A (ko) 1985-04-01
HUT34724A (en) 1985-04-28
AU563648B2 (en) 1987-07-16
CS246088B2 (en) 1986-10-16
DK362384A (da) 1985-02-04
IL72480A (en) 1987-10-30
FI843061A7 (fi) 1985-02-04
MA20180A1 (fr) 1985-04-01
EP0136195B1 (fr) 1987-06-24
DE3464362D1 (en) 1987-07-30
ZA845682B (en) 1985-02-27
ES534828A0 (es) 1985-04-16
FI843061A0 (fi) 1984-08-02
CS584184A2 (en) 1985-12-16
DD220025A5 (de) 1985-03-20
KR920000373B1 (ko) 1992-01-13
PT79003B (fr) 1986-06-18
AR242556A1 (es) 1993-04-30
GR82449B (es) 1984-12-13
FI77020B (fi) 1988-09-30
PT79003A (fr) 1984-08-01
US4720581A (en) 1988-01-19
CA1238922A (en) 1988-07-05
FR2550192A1 (fr) 1985-02-08
FR2550192B1 (fr) 1986-04-04
NO157618B (no) 1988-01-11
JPS6054351A (ja) 1985-03-28
AU3079084A (en) 1985-02-07
YU127684A (en) 1986-12-31
ATE27952T1 (de) 1987-07-15
EP0136195A1 (fr) 1985-04-03
DK158662C (da) 1990-12-10
NO843114L (no) 1985-02-04
HU192567B (en) 1987-06-29
NZ209092A (en) 1987-03-06
IL72480A0 (en) 1984-11-30
FI77020C (fi) 1989-01-10
NO157618C (no) 1988-04-20
SU1319784A3 (ru) 1987-06-23

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