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ES8307776A1 - Un procedimiento de preparacion de nuevas 2(4-(difenilmetil)-1-piperazinil-acetamidas. - Google Patents

Un procedimiento de preparacion de nuevas 2(4-(difenilmetil)-1-piperazinil-acetamidas.

Info

Publication number
ES8307776A1
ES8307776A1 ES509358A ES509358A ES8307776A1 ES 8307776 A1 ES8307776 A1 ES 8307776A1 ES 509358 A ES509358 A ES 509358A ES 509358 A ES509358 A ES 509358A ES 8307776 A1 ES8307776 A1 ES 8307776A1
Authority
ES
Spain
Prior art keywords
diphenylmethyl
preparation
piperazinyl
amides
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES509358A
Other languages
English (en)
Other versions
ES509358A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UCB SA
Original Assignee
UCB SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UCB SA filed Critical UCB SA
Publication of ES8307776A1 publication Critical patent/ES8307776A1/es
Publication of ES509358A0 publication Critical patent/ES509358A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE 2- 4-(DIFENILMETIL)-1-PIPERAZINIL -ACETAMIDAS, DE FORMULA GENERAL (I), EN LA QUE X Y X REPRESENTAN UN ATOMO DE HIDROGENO, UN ATOMO DE HALOGENO O UN RADICAL TRIFLUOROMETILO; M ES 1 O 2; Y N ES 1 O 2, Y SUS SALES DE ADICION DE ACIDOS FARMACEUTICAMENTE ACEPTABLES. CONSISTE EN HACER REACCIONAR EN UN DISOLVENTE INERTE Y EN PRESENCIA DE UN ACEPTOR DE ACIDO, UNA 1-(DIFENILMETIL)-PIPERAZINA DE FORMULA (II), EN LA QUE X Y X TIENEN EL SIGNIFICADO YA INDICADO, CON UNA OMEGA-HALOGENOACETAMIDA, DE FORMULA (III), EN LA CUAL M Y N TIENEN LOS SIGNIFICADOS YA MENCIONADOS; Y Z REPRESENTA UN ATOMO DE HALOGENO. DE APLICACION EN FARMACIA COMO AGENTES ANTIALERGICOS, ANTIHISTAMINICOS, BRONCODILATADORES Y ANTIESPASMODICOS.
ES509358A 1981-02-06 1982-02-05 Un procedimiento de preparacion de nuevas 2(4-(difenilmetil)-1-piperazinil-acetamidas. Granted ES509358A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8103768 1981-02-06
GB8110990 1981-04-08

Publications (2)

Publication Number Publication Date
ES8307776A1 true ES8307776A1 (es) 1983-08-01
ES509358A0 ES509358A0 (es) 1983-08-01

Family

ID=26278356

Family Applications (2)

Application Number Title Priority Date Filing Date
ES509358A Granted ES509358A0 (es) 1981-02-06 1982-02-05 Un procedimiento de preparacion de nuevas 2(4-(difenilmetil)-1-piperazinil-acetamidas.
ES521548A Granted ES521548A0 (es) 1981-02-06 1983-04-15 Un procedimiento de preparacion de nuevos acidos 2-4-difenil-metil)piperazinil-aceticos.(como divisional de la patente numero 509.358)

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES521548A Granted ES521548A0 (es) 1981-02-06 1983-04-15 Un procedimiento de preparacion de nuevos acidos 2-4-difenil-metil)piperazinil-aceticos.(como divisional de la patente numero 509.358)

Country Status (24)

Country Link
US (1) US4525358A (es)
EP (1) EP0058146B1 (es)
AT (1) ATE8140T1 (es)
AU (1) AU544066B2 (es)
BA (2) BA97198B1 (es)
CA (1) CA1199918A (es)
CY (1) CY1307A (es)
DE (2) DE3260282D1 (es)
DK (2) DK154078C (es)
ES (2) ES509358A0 (es)
FI (1) FI75816C (es)
GE (1) GEP20001996B (es)
GR (1) GR75407B (es)
HK (1) HK86485A (es)
HU (1) HU184989B (es)
LU (1) LU90870I2 (es)
MY (1) MY8700279A (es)
NL (1) NL300074I2 (es)
NO (2) NO155805C (es)
NZ (1) NZ199650A (es)
PL (2) PL134903B1 (es)
PT (1) PT74390B (es)
SU (2) SU1227113A3 (es)
YU (2) YU43511B (es)

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US2630435A (en) * 1948-09-09 1953-03-03 Burroughs Wellcome Co N-benzohydryl-n-methyl piperazines and process of preparing same
US2636032A (en) * 1949-04-12 1953-04-21 Abbott Lab N, n'-disubstituted piperazines and process of preparing same
US2861072A (en) * 1952-07-19 1958-11-18 Abbott Lab Preparation of piperazine derivatives
US3244718A (en) * 1964-02-17 1966-04-05 Biel John Hans Piperazine derivatives
NL137318C (es) * 1964-06-09
FR2082168A5 (en) * 1970-03-05 1971-12-10 Aries Robert (-1-benzhydryl-4-piperazinyl)-alkoxy-alkyl esters of benzoic - or phenyl-alkanoic acids - analgesic, antipyretic, sympathomimetic,
FR2081579B1 (es) * 1970-03-18 1973-04-06 Delalande Sa
BE794804A (fr) * 1972-02-01 1973-05-16 Crc Ricerca Chim Procede de preparation de derives de piperazine, et produits obtenus

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DE3260282D1 (en) 1984-08-02
US4525358A (en) 1985-06-25
PL239687A1 (en) 1983-07-18
HK86485A (en) 1985-11-15
SU1287749A3 (ru) 1987-01-30
DK154078C (da) 1989-05-22
NZ199650A (en) 1984-07-06
BA97199B1 (bs) 1999-08-02
DK154078B (da) 1988-10-10
DK155796B (da) 1989-05-16
NL300074I2 (nl) 2002-03-01
YU23782A (en) 1985-06-30
DE10199021I1 (de) 2001-06-21
DK5388D0 (da) 1988-01-07
DE10199021I2 (de) 2002-07-04
BA97198B1 (bs) 1999-08-02
FI75816C (fi) 1988-08-08
CA1199918A (en) 1986-01-28
DK44082A (da) 1982-08-07
HU184989B (en) 1987-06-30
ES8406455A1 (es) 1984-08-01
FI75816B (fi) 1988-04-29
MY8700279A (en) 1987-12-31
NO155805C (no) 1987-06-10
ATE8140T1 (de) 1984-07-15
DK5388A (da) 1988-01-07
GR75407B (es) 1984-07-13
AU544066B2 (en) 1985-05-16
NL300074I1 (nl) 2002-02-01
DK155796C (da) 1989-10-09
LU90870I2 (en) 2002-03-01
PT74390A (fr) 1982-03-01
PT74390B (fr) 1983-07-05
CY1307A (en) 1985-12-06
ES509358A0 (es) 1983-08-01
NO2001022I2 (no) 2005-10-10
FI820318L (fi) 1982-08-07
GEP20001996B (en) 2000-02-10
ES521548A0 (es) 1984-08-01
NO155805B (no) 1987-02-23
YU43511B (en) 1989-08-31
EP0058146A1 (fr) 1982-08-18
EP0058146B1 (fr) 1984-06-27
YU223584A (en) 1985-06-30
PL234935A1 (en) 1983-05-09
AU8023182A (en) 1982-08-12
PL134969B1 (en) 1985-09-30
NO820297L (no) 1982-08-09
YU42911B (en) 1988-12-31
PL134903B1 (en) 1985-09-30
SU1227113A3 (ru) 1986-04-23

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