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GB8827390D0 - Process for preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-pipera-zinyl)ethoxy)-acetic acid & its dihydrochloride - Google Patents

Process for preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-pipera-zinyl)ethoxy)-acetic acid & its dihydrochloride

Info

Publication number
GB8827390D0
GB8827390D0 GB888827390A GB8827390A GB8827390D0 GB 8827390 D0 GB8827390 D0 GB 8827390D0 GB 888827390 A GB888827390 A GB 888827390A GB 8827390 A GB8827390 A GB 8827390A GB 8827390 D0 GB8827390 D0 GB 8827390D0
Authority
GB
United Kingdom
Prior art keywords
zinyl
pipera
phenylmethyl
dihydrochloride
chlorophenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
GB888827390A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UCB SA
Original Assignee
UCB SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UCB SA filed Critical UCB SA
Priority to GB888827390A priority Critical patent/GB8827390D0/en
Publication of GB8827390D0 publication Critical patent/GB8827390D0/en
Priority to CA000614708A priority patent/CA1320732C/en
Priority to GR890100771A priority patent/GR1000576B/en
Priority to PT92363A priority patent/PT92363B/en
Priority to GB8926242A priority patent/GB2225320B/en
Priority to PL1989282411A priority patent/PL161374B1/en
Priority to DK198905865A priority patent/DK174289B1/en
Priority to FI895563A priority patent/FI91861C/en
Priority to AT0266489A priority patent/AT398970B/en
Priority to NO894650A priority patent/NO172287C/en
Priority to ES8903974A priority patent/ES2018967A6/en
Priority to SU894742406A priority patent/RU1838306C/en
Priority to HU896130A priority patent/HU208002B/en
Priority to KR1019890017039A priority patent/KR970009727B1/en
Priority to PH39569A priority patent/PH26334A/en
Priority to SG127/93A priority patent/SG12793G/en
Priority to HK454/93A priority patent/HK45493A/en
Priority to CY160694A priority patent/CY1696A/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
GB888827390A 1988-11-23 1988-11-23 Process for preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-pipera-zinyl)ethoxy)-acetic acid & its dihydrochloride Pending GB8827390D0 (en)

Priority Applications (18)

Application Number Priority Date Filing Date Title
GB888827390A GB8827390D0 (en) 1988-11-23 1988-11-23 Process for preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-pipera-zinyl)ethoxy)-acetic acid & its dihydrochloride
CA000614708A CA1320732C (en) 1988-11-23 1989-09-29 Process for the preparation of 2-¬2-¬4-¬(4-chlorophenyl)-phenylmethyl|-1-piperazinyl| ethyoxy|-acetic acid and its dihydrochloride
GR890100771A GR1000576B (en) 1988-11-23 1989-11-20 Method of preparing 2-[2-(4-((4-chlorophenyl)-1-piperazinyl)ethoxy) of acetic acid
PT92363A PT92363B (en) 1988-11-23 1989-11-21 PROCESS FOR THE PREPARATION OF 2- {2- (4-CHLOROPHENYL) -PHENYLMETHYL} -1-PYRAZINYL} ETOXY} ACETIC ACID AND ITS CHLORIDRATE
GB8926242A GB2225320B (en) 1988-11-23 1989-11-21 A process for the preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-acetic acid and its dihydrochloride
DK198905865A DK174289B1 (en) 1988-11-23 1989-11-22 Process for the preparation of 2- [2- [4 - [(4-chlorophenyl) phenylmethyl] -1-piperazinyl] ethoxy] acetic acid and its dihydrochloride
AT0266489A AT398970B (en) 1988-11-23 1989-11-22 METHOD FOR PRODUCING THE 2- (2- (4 - ((4-CHLOR-PHENYL) -PHENYLMETHYL) -1-PIPERAZINYL) ETHOXY) - ACETIC ACID AND ITS DICHLORHYDRATE
HU896130A HU208002B (en) 1988-11-23 1989-11-22 Process for producing 2-/2-/4-//4-chloro-phenyl/-phenyl-methyl/-1-piperazinyl/-ethoxy/- -aceticacid and dihydrochloride salt of them
FI895563A FI91861C (en) 1988-11-23 1989-11-22 Process for the preparation of 2- / 2- / 4 - [(4-chlorophenyl) phenylmethyl] -1-piperazinylethoxy / acetic acid and its dihydrochloride
PL1989282411A PL161374B1 (en) 1988-11-23 1989-11-22 Method of obtaining 2-(2-(4(/4-chlorophenyl/phenylomethyl)-1-piperazinyl)ethoxy)acetic acid and its dichydrochloride
NO894650A NO172287C (en) 1988-11-23 1989-11-22 PROCEDURE FOR THE PREPARATION OF 2- (2- (4 - ((4-CHLORPHENYL) -PHENYLMETHYL) -1-PIPERAZINYL) -ETHOXY) -ACETIC ACID AND ITS DIHYDROCHLORIDE
ES8903974A ES2018967A6 (en) 1988-11-23 1989-11-22 Process for the preparation of a 1-piperazine-ethoxyacetic acid
SU894742406A RU1838306C (en) 1988-11-23 1989-11-22 Method of synthesis of 2-[2[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-a- cetic acid or its dichlorohydrate
KR1019890017039A KR970009727B1 (en) 1988-11-23 1989-11-23 Process for the preparation of 2-(2-(-4((4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-acetic acid and tis dihyolrochloride
PH39569A PH26334A (en) 1988-11-23 1989-11-23 A process for the preparation of 2-[2-[4-[(4 chloro phenyl) phenyl methyl]-1-piperazinyl]ethoxy]-acetic and its dihydrochloride
SG127/93A SG12793G (en) 1988-11-23 1993-02-06 A process for the preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-acetic acid and its dihydrochloride
HK454/93A HK45493A (en) 1988-11-23 1993-05-13 A process for the preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-acetic acid and its dihydrochloride
CY160694A CY1696A (en) 1988-11-23 1994-01-14 Process for the preparation of 2-(2-(-4((4-chlorophenyl)phenylmethyl)- 1-piperazinyl)ethoxy)-acetic acid and its dihydrochloride

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB888827390A GB8827390D0 (en) 1988-11-23 1988-11-23 Process for preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-pipera-zinyl)ethoxy)-acetic acid & its dihydrochloride

Publications (1)

Publication Number Publication Date
GB8827390D0 true GB8827390D0 (en) 1988-12-29

Family

ID=10647346

Family Applications (2)

Application Number Title Priority Date Filing Date
GB888827390A Pending GB8827390D0 (en) 1988-11-23 1988-11-23 Process for preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-pipera-zinyl)ethoxy)-acetic acid & its dihydrochloride
GB8926242A Expired - Lifetime GB2225320B (en) 1988-11-23 1989-11-21 A process for the preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-acetic acid and its dihydrochloride

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB8926242A Expired - Lifetime GB2225320B (en) 1988-11-23 1989-11-21 A process for the preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-acetic acid and its dihydrochloride

Country Status (17)

Country Link
KR (1) KR970009727B1 (en)
AT (1) AT398970B (en)
CA (1) CA1320732C (en)
CY (1) CY1696A (en)
DK (1) DK174289B1 (en)
ES (1) ES2018967A6 (en)
FI (1) FI91861C (en)
GB (2) GB8827390D0 (en)
GR (1) GR1000576B (en)
HK (1) HK45493A (en)
HU (1) HU208002B (en)
NO (1) NO172287C (en)
PH (1) PH26334A (en)
PL (1) PL161374B1 (en)
PT (1) PT92363B (en)
RU (1) RU1838306C (en)
SG (1) SG12793G (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0663828B1 (en) * 1992-09-24 1998-09-09 Sepracor, Inc. Treating allergic rhinitis and asthma using (-) Cetirizine
DK0661975T3 (en) * 1992-09-24 1999-09-27 Sepracor Inc Transdermal treatment of hives using optically pure (+) - cetirizine
BE1010094A3 (en) 1996-04-10 1997-12-02 Ucb Sa NEW [2- (1-piperazinyl) ethoxy] SUBSTITUTED.
BE1010095A3 (en) * 1996-04-10 1997-12-02 Ucb Sa METHOD OF PREPARATION OF ACID 2- [2- [4 - [(4-Chlorophenyl) phenylmethyl] -1-PIPERAZINYL] ETHOXY] acetic acid AND ITS SALTS.
CA2180993A1 (en) * 1996-07-11 1998-01-12 Yong Tao Methods for the manufacture of cetirizine
EP0919550A1 (en) 1997-11-26 1999-06-02 Ucb, S.A. Pseudopolymorphic forms of 2-2-4-bis(4-fluorophenyl)methyl-1-piperazinyl-ethoxy acetic acid dihydrochloride
IL124195A (en) * 1998-04-23 2000-08-31 Chemagis Ltd Process for the preparation of esters of 2-¬4-¬4-chlorophenyl¾phenylmethyl¾-1-piperazinyl¬ethoxy¾acetic acid
DK176706B1 (en) * 1999-03-04 2009-03-30 Sandoz As Process for the preparation of 2- {2- [4- (diphenylmethyl) -1-piperazinyl] ethoxy} -acetic acid compounds or salts thereof
US6265579B1 (en) * 1999-10-29 2001-07-24 Salsbury Chemicals, Inc. Process for preparing piperazine-substituted aliphatic carboxylates
US6977301B1 (en) 2001-05-29 2005-12-20 Ucb, S.A. Process for preparing (S) and (R)—2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide
US7199241B1 (en) 2001-05-29 2007-04-03 Ucb, S.A. Process for preparing (S) and (R)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide
AU2003237394A1 (en) * 2002-06-05 2003-12-22 Dr. Reddy's Laboratories Limited Crystalline (2-(4-((4-chlorophenyl)-phenyl methyl)-1-piperazinyl) ethoxy) acetic acid dihydrochloride
CA2514145A1 (en) * 2003-01-23 2004-08-05 Ucb Farchim Sa Piperazine derivatives and their use as synthesis intermediates
US20060258684A1 (en) * 2003-05-21 2006-11-16 Singh Prasad S 2-[2-[4-[(4-chlorophenyl) phenylmethyl]-1-piperazinyl]ethoxy]acetic acid monohydrochloride as anti-allergenic compound and process for its production
WO2010046908A2 (en) 2008-09-17 2010-04-29 Calyx Chemicals And Pharmaceuticals Pvt. Ltd. Novel water based process for the preparation of substituted diphenylmethyl piperazines
KR101418404B1 (en) 2012-01-06 2014-07-10 한미약품 주식회사 Stable pharmaceutical formulation for oral administration comprising levocetirizine or a pharmaceutically acceptable salt thereof, and montelukast or a pharmaceutically acceptable salt thereof
KR102226833B1 (en) 2013-06-28 2021-03-12 한미약품 주식회사 Complex granule formulation having improved stability comprising levocetirizine and montelukast

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB817231A (en) * 1956-01-27 1959-07-29 Henri Morren New derivatives of n-mono-benzhydryl-piperazine and process for the preparation thereof
US3090725A (en) * 1960-02-29 1963-05-21 Burroughs Wellcome Co Phosphorylated quaternary ammonium compounds of improved oral absorption
FI75816C (en) * 1981-02-06 1988-08-08 Ucb Sa Process for the preparation of therapeutically active 2- [4- (diphenylmethyl) -1-piperazinyl] -acetic acid or its amide

Also Published As

Publication number Publication date
DK586589D0 (en) 1989-11-22
HU896130D0 (en) 1990-02-28
KR970009727B1 (en) 1997-06-17
GB2225320B (en) 1992-09-02
DK174289B1 (en) 2002-11-18
DK586589A (en) 1990-05-24
PT92363A (en) 1990-05-31
HK45493A (en) 1993-05-21
ATA266489A (en) 1994-07-15
GB8926242D0 (en) 1990-01-10
RU1838306C (en) 1993-08-30
CA1320732C (en) 1993-07-27
HUT53626A (en) 1990-11-28
AT398970B (en) 1995-02-27
CY1696A (en) 1994-01-14
GR890100771A (en) 1990-12-31
FI91861C (en) 1994-08-25
ES2018967A6 (en) 1991-05-16
PH26334A (en) 1992-04-29
GR1000576B (en) 1992-08-26
NO172287B (en) 1993-03-22
HU208002B (en) 1993-07-28
FI895563A0 (en) 1989-11-22
PT92363B (en) 1995-07-18
NO894650D0 (en) 1989-11-22
GB2225320A (en) 1990-05-30
NO894650L (en) 1990-05-25
KR900007824A (en) 1990-06-02
NO172287C (en) 1993-06-30
FI91861B (en) 1994-05-13
SG12793G (en) 1993-04-16
PL161374B1 (en) 1993-06-30

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