ES268412A1 - New derivatives of heparin and processes for their preparation - Google Patents
New derivatives of heparin and processes for their preparationInfo
- Publication number
- ES268412A1 ES268412A1 ES0268412A ES268412A ES268412A1 ES 268412 A1 ES268412 A1 ES 268412A1 ES 0268412 A ES0268412 A ES 0268412A ES 268412 A ES268412 A ES 268412A ES 268412 A1 ES268412 A1 ES 268412A1
- Authority
- ES
- Spain
- Prior art keywords
- heparinamide
- produced
- salt
- alkyl
- heparin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Heparinamide or N-alkyl heparinamide as the free sulphonic acid or an alkali or quaternary ammonium salt (claimed per se) is produced by amiding a C1- 6 alkyl ester of heparin or a mixed anhydride produced by the interaction of a long-chain alkyl or aralkyl C9-27 quaternary ammonium salt of heparin and a C1- 6 alkyl chlorocarbonate. Heparinamide may be produced by reacting an alkali metal salt of the ester with ammonia in the presence of water and purified by intermediate formation of the "Hyamine 1622" salt. N-alkyl heparinamide may be similarly produced using a primary alkylamine in the presence of formamide or water. The amine may be methyl-, ethyl-, propyl-, isobutyl-, or tertbutyl-amine. Amidation may be effected at -30 to 25 DEG C. It may be 60-95% complete. N-methyl heparinamide may alternatively be produced by treating the "Hyamine 1622" salt of heparinamide with diazomethane in methyl chloride solution. In a further alternative, it may be produced by reacting the "Hyamine 1622" salt of heparin with ethyl chlorocarbonate in tetrahydrofuran containing a small amount of water and reacting the intermediate product with methylamine. Specifications 904,112, 973,894 and 973,895 are referred to.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR830651A FR1363866A (en) | 1960-06-21 | 1960-06-21 | New heparin derivatives and method of preparation |
| FR840757A FR83206E (en) | 1960-10-10 | 1960-10-10 | New heparin derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES268412A1 true ES268412A1 (en) | 1961-10-01 |
Family
ID=39273573
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES0268412A Expired ES268412A1 (en) | 1960-06-21 | 1961-06-20 | New derivatives of heparin and processes for their preparation |
Country Status (6)
| Country | Link |
|---|---|
| BE (1) | BE605170A (en) |
| CH (1) | CH400121A (en) |
| DK (2) | DK102907C (en) |
| ES (1) | ES268412A1 (en) |
| GB (1) | GB973893A (en) |
| SE (1) | SE310357B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1242203B (en) * | 1963-01-18 | 1967-06-15 | Roussel Uclaf | Process for the production of heparin derivatives |
| DE1242204B (en) * | 1963-01-21 | 1967-06-15 | Roussel Uclaf | Process for the production of heparin derivatives |
| CN112079942A (en) * | 2019-06-14 | 2020-12-15 | 苏州融析生物科技有限公司 | Methylated heparin compound and preparation and application thereof |
-
1961
- 1961-06-15 CH CH700161A patent/CH400121A/en unknown
- 1961-06-16 SE SE632661A patent/SE310357B/xx unknown
- 1961-06-19 DK DK250561A patent/DK102907C/en active
- 1961-06-19 DK DK143262A patent/DK104672C/en active
- 1961-06-20 GB GB2230761A patent/GB973893A/en not_active Expired
- 1961-06-20 BE BE605170A patent/BE605170A/en unknown
- 1961-06-20 ES ES0268412A patent/ES268412A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| SE310357B (en) | 1969-04-28 |
| DK102907C (en) | 1965-10-25 |
| GB973893A (en) | 1964-10-28 |
| CH400121A (en) | 1965-10-15 |
| DK104672C (en) | 1966-06-20 |
| BE605170A (en) | 1961-12-21 |
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