GB801894A - Urea derivatives - Google Patents
Urea derivativesInfo
- Publication number
- GB801894A GB801894A GB1417/57A GB141757A GB801894A GB 801894 A GB801894 A GB 801894A GB 1417/57 A GB1417/57 A GB 1417/57A GB 141757 A GB141757 A GB 141757A GB 801894 A GB801894 A GB 801894A
- Authority
- GB
- United Kingdom
- Prior art keywords
- prepared
- urea
- carboxyalkyl
- esters
- alkali metal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
- C07C275/06—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton
- C07C275/16—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton being further substituted by carboxyl groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The Specification describes the production of compounds of the general formula OC(NH.A.COOR)2 where A is an alkylene straight- or branched-chain radical having 3-17 carbon atoms, in which the amino group is not attached to a tertiary carbon atom, and R is hydrogen, monovalent alkali metal or an alkyl radical having 1 to 18 carbon atoms. These 1,3-di-(carboxyalkyl) ureas are prepared by the alkaline oxidation of 1,3-di-(carboxyalkyl) thioureas (prepared by the process of Specification 799,373), preferred oxidants being hydrogen peroxide and sodium hypochlorite, at or below room temperature, to give a solution of the alkali metal salt, which is acidified to precipitate the free acid. The esters are prepared by conventional esterification of the free acids. The free acids may also be prepared by heating a 1-nitroso-1,3-di-(carboxyalkyl) urea (prepared by the process of Specification 801,893) in dilute alkaline or acid solution, preferably in dilute hydrochloric acid solution. In examples the following compounds are prepared: 1,3-di-(e -carboxypentyl) urea, 1,3-di-(g -carboxypropyl) urea, and their methyl, n-butyl, n-octyl, n-decyl and myristyl di-esters.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US801894XA | 1956-02-03 | 1956-02-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB801894A true GB801894A (en) | 1958-09-24 |
Family
ID=22155816
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1417/57A Expired GB801894A (en) | 1956-02-03 | 1957-01-14 | Urea derivatives |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB801894A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3471622A (en) * | 1964-04-30 | 1969-10-07 | Inventa Ag | 1,3-bis-(epsilon-carboxyamyl) urea for the treatment of serous fluid saturation of the human brain caused by trauma |
-
1957
- 1957-01-14 GB GB1417/57A patent/GB801894A/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3471622A (en) * | 1964-04-30 | 1969-10-07 | Inventa Ag | 1,3-bis-(epsilon-carboxyamyl) urea for the treatment of serous fluid saturation of the human brain caused by trauma |
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