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ES2161217T3 - Sulfonamidas sustituidas por n-amidopiperidinilo(3/4) o n-amidino-1,4-oxazinilo(2), procedimiento para la obtencion y utilizacion como inhibidores de la trombina. - Google Patents

Sulfonamidas sustituidas por n-amidopiperidinilo(3/4) o n-amidino-1,4-oxazinilo(2), procedimiento para la obtencion y utilizacion como inhibidores de la trombina.

Info

Publication number
ES2161217T3
ES2161217T3 ES93102767T ES93102767T ES2161217T3 ES 2161217 T3 ES2161217 T3 ES 2161217T3 ES 93102767 T ES93102767 T ES 93102767T ES 93102767 T ES93102767 T ES 93102767T ES 2161217 T3 ES2161217 T3 ES 2161217T3
Authority
ES
Spain
Prior art keywords
amidopiperidinyl
sulfonamids
oxazinyl
amidino
replaced
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93102767T
Other languages
English (en)
Inventor
Jean Ackermann
David Banner
Klaus Gubernator
Kurt Hilpert
Gerard Schmid
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of ES2161217T3 publication Critical patent/ES2161217T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Peptides Or Proteins (AREA)
  • Detergent Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

LAS NUEVAS SULFONAMIDOCARBOXAMIDAS, DE FORMULA DONDE X ES UN GRUPO DE FORMULA X1 O X2, T ES CH2 O O, Y A, M, Q E Y TIENEN EL SIGNIFICADO DADO EN LA DESCRIPCION, ASI COMO SUS HIDRATOS O SOLVATOS, QUE INHIBEN LA AGREGACION PLAQUETARIA INDUCIDA POR LA TROMBINA, Y REDUCEN EL FIBRINOGENO EN EL PLASMA. SON OBTENIDOS POR LA AMIDINIZACION DE UNO DE LOS GRUPOS AMINO CICLICOS EXISTENTES, DE LA AGRUPACION X O POR LA FORMACION AMIDO C(O)N(Q).
ES93102767T 1992-03-06 1993-02-22 Sulfonamidas sustituidas por n-amidopiperidinilo(3/4) o n-amidino-1,4-oxazinilo(2), procedimiento para la obtencion y utilizacion como inhibidores de la trombina. Expired - Lifetime ES2161217T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH72892 1992-03-06
CH18093 1993-01-21

Publications (1)

Publication Number Publication Date
ES2161217T3 true ES2161217T3 (es) 2001-12-01

Family

ID=25683792

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93102767T Expired - Lifetime ES2161217T3 (es) 1992-03-06 1993-02-22 Sulfonamidas sustituidas por n-amidopiperidinilo(3/4) o n-amidino-1,4-oxazinilo(2), procedimiento para la obtencion y utilizacion como inhibidores de la trombina.

Country Status (24)

Country Link
US (4) US5405854A (es)
EP (1) EP0559046B1 (es)
JP (1) JPH0780848B2 (es)
CN (1) CN1076690A (es)
AT (1) ATE203013T1 (es)
AU (1) AU665230B2 (es)
BG (1) BG61506B1 (es)
CA (1) CA2089972C (es)
CZ (1) CZ286926B6 (es)
DE (1) DE59310186D1 (es)
DK (1) DK0559046T3 (es)
ES (1) ES2161217T3 (es)
FI (1) FI103880B1 (es)
GR (1) GR3036870T3 (es)
HU (2) HUT70156A (es)
IL (3) IL104893A0 (es)
IS (1) IS3983A (es)
MY (1) MY131303A (es)
NO (1) NO302818B1 (es)
NZ (1) NZ247014A (es)
PT (1) PT559046E (es)
RO (1) RO112863B1 (es)
RU (1) RU2133739C1 (es)
TW (1) TW223629B (es)

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Also Published As

Publication number Publication date
HU9300572D0 (en) 1993-05-28
FI930990A (fi) 1993-09-07
HUT70156A (en) 1995-09-28
RO112863B1 (ro) 1998-01-30
FI103880B (fi) 1999-10-15
AU665230B2 (en) 1995-12-21
RU2133739C1 (ru) 1999-07-27
FI930990A0 (fi) 1993-03-05
IS3983A (is) 1993-09-07
DE59310186D1 (de) 2001-08-16
CZ286926B6 (en) 2000-08-16
NZ247014A (en) 1995-11-27
TW223629B (es) 1994-05-11
CA2089972A1 (en) 1993-09-07
DK0559046T3 (da) 2001-11-05
IL120727A0 (en) 1997-08-14
BG97493A (bg) 1994-03-24
US5763604A (en) 1998-06-09
US5578594A (en) 1996-11-26
US5405854A (en) 1995-04-11
FI103880B1 (fi) 1999-10-15
AU3391693A (en) 1993-09-09
BG61506B1 (bg) 1997-10-31
CZ34693A3 (en) 1993-12-15
PT559046E (pt) 2002-01-30
IL120727A (en) 1998-08-16
NO930819D0 (no) 1993-03-05
NO930819L (no) 1993-09-07
US5677448A (en) 1997-10-14
MY131303A (en) 2007-08-30
JPH0625195A (ja) 1994-02-01
JPH0780848B2 (ja) 1995-08-30
ATE203013T1 (de) 2001-07-15
HU211252A9 (en) 1995-11-28
CN1076690A (zh) 1993-09-29
GR3036870T3 (en) 2002-01-31
CA2089972C (en) 1999-06-08
EP0559046B1 (de) 2001-07-11
EP0559046A1 (de) 1993-09-08
IL104893A0 (en) 1993-07-08
NO302818B1 (no) 1998-04-27

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