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ECSP066741A - - Google Patents

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Publication number
ECSP066741A
ECSP066741A EC2006006741A ECSP066741A ECSP066741A EC SP066741 A ECSP066741 A EC SP066741A EC 2006006741 A EC2006006741 A EC 2006006741A EC SP066741 A ECSP066741 A EC SP066741A EC SP066741 A ECSP066741 A EC SP066741A
Authority
EC
Ecuador
Prior art keywords
antibodies
madcam
relates
human anti
nucleic acid
Prior art date
Application number
EC2006006741A
Other languages
English (en)
Inventor
Nicholas Pullen
Elizabeth Molloy
Sirid Aimee Kellermann
Larry L Green
Frendscho Haah
Original Assignee
Pfizer
Amgen Fremont Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34794356&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP066741(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer, Amgen Fremont Inc filed Critical Pfizer
Publication of ECSP066741A publication Critical patent/ECSP066741A/es

Links

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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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Abstract

. ] La presente invención se refiere a anticuerpos que incluyen anticuerpos humanos y porciones que ligan antígeno de los mismos que se ligan específicamente a MAdCAM, preferentemente a MAdCAM humano y que funcionan para inhibir MAdCAM. La invención también se refiere a anticuerpos anti-MAdCAM humanos y porciones que ligan antígeno de los mismos. La invención también se refiere a anticuerpos que son quiméricos, biespecíficos, derivatizados, anticuerpos de cadena simple o porciones de proteínas de fusión. La invención también se refiere a inmunoglobulinas aisladas de cadena pesada y liviana derivadas de anticuerpos anti-MAdCAM humanos y a moléculas de ácido nucleico que codifican tales inmunoglobulinas. La presente invención también se refiere a métodos para fabricar anticuerpos anti-MAdCAM humanos, a composiciones que comprenden estos anticuerpos y a métodos para usar los anticuerpos y composiciones para diagnóstico y tratamiento. La invención también provee métodos de terapia con genes que usan moléculas de ácido nucleico que codifican la cadena pesada y/o liviana de moléculas de inmunoglobulina que comprenden los anticuerpos anti-MAdCAM humanos. La invención también se refiere a animales o plantas transgénicos que comprenden moléculas de ácido nucleico de la invención.
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