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EA202091488A1 - Иммунокомпетентная клетка, которая экспрессирует молекулу клеточной поверхности, специфически распознающую человеческий мезотелин, il-7 и ccl19 - Google Patents

Иммунокомпетентная клетка, которая экспрессирует молекулу клеточной поверхности, специфически распознающую человеческий мезотелин, il-7 и ccl19

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Publication number
EA202091488A1
EA202091488A1 EA202091488A EA202091488A EA202091488A1 EA 202091488 A1 EA202091488 A1 EA 202091488A1 EA 202091488 A EA202091488 A EA 202091488A EA 202091488 A EA202091488 A EA 202091488A EA 202091488 A1 EA202091488 A1 EA 202091488A1
Authority
EA
Eurasian Patent Office
Prior art keywords
cell
surface molecule
ccl19
expresses
immunocompetent
Prior art date
Application number
EA202091488A
Other languages
English (en)
Inventor
Кодзи ТАМАДА
Юкими Сакода
Кейси Адати
Original Assignee
Нойл-Иммьюн Байотек, Инк.
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Publication date
Application filed by Нойл-Иммьюн Байотек, Инк. filed Critical Нойл-Иммьюн Байотек, Инк.
Publication of EA202091488A1 publication Critical patent/EA202091488A1/ru

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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5418—IL-7
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    • A61K40/31—Chimeric antigen receptors [CAR]
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    • A61K40/4255—Mesothelin [MSLN]
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Abstract

Целью настоящего изобретения является получение иммунокомпетентной клетки, специфичной к мезотелину. Изобретение предлагает иммунокомпетентную клетку, которая экспрессирует молекулу клеточной поверхности, специфически распознающую человеческий мезотелин, интерлейкин 7 (IL-7) и лиганд 19 хемокина (мотив C-C) (CCL19). Предпочтительно, молекула клеточной поверхности, специфически распознающая человеческий мезотелин, представляет собой химерный рецептор антигена (CAR), содержащий одноцепочечное антитело, трансмембранный участок и сигнальный участок, который индуцирует активацию иммунокомпетентной клетки; а вариабельный участок тяжелой цепи и вариабельный участок легкой цепи соединяются через пептидный линкер, последовательность которого содержит от 2 до 30 аминокислот.
EA202091488A 2017-12-24 2018-12-19 Иммунокомпетентная клетка, которая экспрессирует молекулу клеточной поверхности, специфически распознающую человеческий мезотелин, il-7 и ccl19 EA202091488A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2017247109 2017-12-24
PCT/JP2018/046888 WO2019124468A1 (ja) 2017-12-24 2018-12-19 ヒトメソセリンを特異的に認識する細胞表面分子、ｉｌ－７、及びｃｃｌ１９を発現する免疫担当細胞

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EA202091488A1 true EA202091488A1 (ru) 2020-09-23

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US (2) US20200323920A1 (ru)
EP (1) EP3730612A4 (ru)
JP (3) JP7233720B2 (ru)
KR (1) KR20200103708A (ru)
CN (1) CN111511911B (ru)
AU (1) AU2018388079B2 (ru)
BR (1) BR112020012848A2 (ru)
CA (1) CA3086658A1 (ru)
EA (1) EA202091488A1 (ru)
IL (1) IL275453B2 (ru)
MX (1) MX2020006666A (ru)
SA (1) SA520412282B1 (ru)
SG (1) SG11202005908WA (ru)
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WO (1) WO2019124468A1 (ru)

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CN113380324B (zh) * 2021-05-17 2023-06-27 西安交通大学 一种T细胞受体序列motif组合识别检测方法、存储介质及设备
AU2022318416A1 (en) * 2021-07-29 2024-01-25 Takeda Pharmaceutical Company Limited Engineered immune cell that specifically targets mesothelin and uses thereof
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US20240261406A1 (en) 2023-02-02 2024-08-08 Minerva Biotechnologies Corporation Chimeric antigen receptor compositions and methods for treating muc1* diseases

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MX2020006666A (es) 2020-08-31
CN111511911B (zh) 2023-11-03
CN111511911A (zh) 2020-08-07
BR112020012848A2 (pt) 2021-01-26
US20200323920A1 (en) 2020-10-15
IL275453B2 (en) 2024-06-01
EP3730612A1 (en) 2020-10-28
WO2019124468A1 (ja) 2019-06-27
JP2024086826A (ja) 2024-06-28
JP7475088B2 (ja) 2024-04-26
TW201930589A (zh) 2019-08-01
US20240139248A1 (en) 2024-05-02
AU2018388079B2 (en) 2024-11-14
EP3730612A4 (en) 2021-09-01
SG11202005908WA (en) 2020-07-29
KR20200103708A (ko) 2020-09-02
AU2018388079A1 (en) 2020-07-16
SA520412282B1 (ar) 2023-11-09
TWI811278B (zh) 2023-08-11
JPWO2019124468A1 (ja) 2021-01-21
JP2023053328A (ja) 2023-04-12
CA3086658A1 (en) 2019-06-27
IL275453A (en) 2020-08-31
JP7233720B2 (ja) 2023-03-07
IL275453B1 (en) 2024-02-01

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