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PE20120205A1 - Combinaciones antitumorales que contienen anticuerpos que reconocen especificamente cd38 y citarabina - Google Patents

Combinaciones antitumorales que contienen anticuerpos que reconocen especificamente cd38 y citarabina

Info

Publication number
PE20120205A1
PE20120205A1 PE2011001097A PE2011001097A PE20120205A1 PE 20120205 A1 PE20120205 A1 PE 20120205A1 PE 2011001097 A PE2011001097 A PE 2011001097A PE 2011001097 A PE2011001097 A PE 2011001097A PE 20120205 A1 PE20120205 A1 PE 20120205A1
Authority
PE
Peru
Prior art keywords
citarabin
specifically recognize
containing antibodies
combinations containing
tumor
Prior art date
Application number
PE2011001097A
Other languages
English (en)
Inventor
Pascale Lejeune
Patricia Vrignaud
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40627502&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20120205(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of PE20120205A1 publication Critical patent/PE20120205A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)

Abstract

REFERIDA A UNA COMBINACION FARMACEUTICA QUE COMPRENDE: A) UN ANTICUERPO HUMANIZADO QUE RECONOCE LA CD38 QUE COMPRENDE UNA CADENA PESADA CON UNA SECUENCIA DE AMINOACIDOS REPRESENTADA POR SEC ID NO: 66 Y UNA CADENA LIGERA SELECCIONADA DE SEQ ID NO: 62 Y 64 Y; B) CITARABINA. DICHA COMPOSICION ES UTIL EN EL TRATAMIENTO DE CANCER
PE2011001097A 2008-11-28 2009-11-27 Combinaciones antitumorales que contienen anticuerpos que reconocen especificamente cd38 y citarabina PE20120205A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP08291118A EP2191842A1 (en) 2008-11-28 2008-11-28 Antitumor combinations containing antibodies recognizing specifically CD38 and cytarabine

Publications (1)

Publication Number Publication Date
PE20120205A1 true PE20120205A1 (es) 2012-03-03

Family

ID=40627502

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2011001097A PE20120205A1 (es) 2008-11-28 2009-11-27 Combinaciones antitumorales que contienen anticuerpos que reconocen especificamente cd38 y citarabina

Country Status (39)

Country Link
US (1) US20120093806A1 (es)
EP (2) EP2191842A1 (es)
JP (2) JP2012510463A (es)
KR (1) KR101715958B1 (es)
CN (2) CN107096022A (es)
AR (1) AR073425A1 (es)
AU (1) AU2009321251B2 (es)
BR (1) BRPI0921858B1 (es)
CA (1) CA2745005C (es)
CL (1) CL2011001232A1 (es)
CO (1) CO6440556A2 (es)
CR (1) CR20110282A (es)
DK (1) DK2370096T5 (es)
EA (1) EA027070B1 (es)
EC (1) ECSP11011071A (es)
ES (1) ES2638926T3 (es)
HN (1) HN2011001423A (es)
HR (1) HRP20171301T1 (es)
HU (1) HUE035910T2 (es)
IL (2) IL213115A (es)
LT (1) LT2370096T (es)
MA (1) MA32899B1 (es)
MX (1) MX344973B (es)
NI (1) NI201100107A (es)
NZ (1) NZ593085A (es)
PA (1) PA8849901A1 (es)
PE (1) PE20120205A1 (es)
PL (1) PL2370096T3 (es)
PT (1) PT2370096T (es)
RS (1) RS56248B1 (es)
SG (1) SG171821A1 (es)
SI (1) SI2370096T1 (es)
SM (1) SMT201700403T1 (es)
TN (1) TN2011000242A1 (es)
TW (1) TWI436770B (es)
UA (1) UA104160C2 (es)
UY (1) UY32266A (es)
WO (1) WO2010061359A1 (es)
ZA (1) ZA201104064B (es)

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UA112170C2 (uk) * 2010-12-10 2016-08-10 Санофі Протипухлинна комбінація, що містить антитіло, яке специфічно розпізнає cd38, і бортезоміб
JOP20210044A1 (ar) 2010-12-30 2017-06-16 Takeda Pharmaceuticals Co الأجسام المضادة لـ cd38
NZ706147A (en) 2012-09-25 2018-10-26 Morphosys Ag Anti-cd38 antibody and melphalan for the treatment of multiple myeloma
IL292978A (en) * 2013-03-13 2022-07-01 Univ California Compositions comprising anti-cd38 antibodies and carfilzomib
SG11201603088RA (en) 2013-10-31 2016-05-30 Sanofi Sa Specific anti-cd38 antibodies for treating human cancers
US9732154B2 (en) 2014-02-28 2017-08-15 Janssen Biotech, Inc. Anti-CD38 antibodies for treatment of acute lymphoblastic leukemia
US9603927B2 (en) 2014-02-28 2017-03-28 Janssen Biotech, Inc. Combination therapies with anti-CD38 antibodies
EP3191187B1 (en) 2014-09-09 2021-07-28 Janssen Biotech, Inc. Combination therapies with anti-cd38 antibodies
TWI721959B (zh) 2014-12-04 2021-03-21 美商健生生物科技公司 治療急性骨髓性白血病之抗ｃｄ３８抗體
UA124143C2 (uk) 2015-05-20 2021-07-28 Янссен Байотек, Інк. Антитіла до cd38 для лікування амілоїдозу, викликаного відкладеннями легких ланцюгів імуноглобулінів, і інших cd38-позитивних злоякісних гематологічних новоутворень
KR102601550B1 (ko) 2015-06-22 2023-11-10 얀센 바이오테크 인코포레이티드 항-cd38 항체 및 서바이빈 억제제를 사용한 헴 악성종양에 대한 병용 요법
US20170044265A1 (en) 2015-06-24 2017-02-16 Janssen Biotech, Inc. Immune Modulation and Treatment of Solid Tumors with Antibodies that Specifically Bind CD38
CA2998611A1 (en) * 2015-09-14 2017-03-23 Leukemia Therapeutics, LLC Identification of novel diagnostics and therapeutics by modulating rhoh
MY202415A (en) 2015-11-03 2024-04-27 Janssen Biotech Inc Subcutaneous formulations of anti-cd38 antibodies and their uses
US10781261B2 (en) 2015-11-03 2020-09-22 Janssen Biotech, Inc. Subcutaneous formulations of anti-CD38 antibodies and their uses
WO2019035938A1 (en) 2017-08-16 2019-02-21 Elstar Therapeutics, Inc. MULTISPECIFIC MOLECULES BINDING TO BCMA AND USES THEREOF
CA3079242A1 (en) 2017-10-31 2019-05-09 Janssen Biotech, Inc. Methods of treating high risk multiple myeloma
CN113574071B (zh) 2019-03-15 2025-03-25 莫佛塞斯公司 用于治疗自身抗体介导的自身免疫疾病的抗-cd38抗体及其药物组合物
US11655302B2 (en) 2019-06-10 2023-05-23 Sanofi Anti-CD38 antibodies and formulations
CN112876563B (zh) * 2019-11-29 2022-08-16 康诺亚生物医药科技（成都）有限公司 药物组合物及其制备方法和应用
JP2023505217A (ja) 2019-12-05 2023-02-08 サノフィ－アベンティス・ユー・エス・エルエルシー 皮下投与のための抗ｃｄ３８抗体の製剤
MX2023008187A (es) 2021-01-14 2023-07-18 Morphosys Ag Anticuerpos anti-cd38 y sus usos.
TW202302642A (zh) 2021-03-01 2023-01-16 德商莫菲西斯公司 用於治療抗體介導移植物排斥用途之抗ｃｄ３８抗體
CN113278075B (zh) * 2021-06-18 2021-12-14 芜湖森爱驰生物科技有限公司 一种炎症检测试剂盒
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Also Published As

Publication number Publication date
TW201023863A (en) 2010-07-01
EA027070B1 (ru) 2017-06-30
PL2370096T3 (pl) 2017-10-31
LT2370096T (lt) 2017-09-25
BRPI0921858A2 (pt) 2018-10-09
IL213118A0 (en) 2011-07-31
HRP20171301T1 (hr) 2017-10-20
CA2745005C (en) 2020-08-11
CN107096022A (zh) 2017-08-29
CL2011001232A1 (es) 2012-02-10
MX344973B (es) 2017-01-12
EP2370096A1 (en) 2011-10-05
UA104160C2 (uk) 2014-01-10
KR101715958B1 (ko) 2017-03-14
TWI436770B (zh) 2014-05-11
NI201100107A (es) 2011-09-26
AR073425A1 (es) 2010-11-03
CO6440556A2 (es) 2012-05-15
CA2745005A1 (en) 2010-06-03
US20120093806A1 (en) 2012-04-19
EP2370096B1 (en) 2017-05-31
BRPI0921858B1 (pt) 2022-11-16
UY32266A (es) 2010-06-30
CN102264386A (zh) 2011-11-30
TN2011000242A1 (en) 2012-12-17
IL213118A (en) 2017-08-31
AU2009321251B2 (en) 2016-06-09
ES2638926T3 (es) 2017-10-24
HN2011001423A (es) 2014-01-13
NZ593085A (en) 2012-12-21
WO2010061359A1 (en) 2010-06-03
JP2015205893A (ja) 2015-11-19
JP2012510463A (ja) 2012-05-10
DK2370096T5 (en) 2017-09-18
DK2370096T3 (en) 2017-07-17
EP2191842A1 (en) 2010-06-02
MA32899B1 (fr) 2011-12-01
RS56248B1 (sr) 2017-11-30
ECSP11011071A (es) 2011-07-29
AU2009321251A1 (en) 2010-06-03
SG171821A1 (en) 2011-07-28
PT2370096T (pt) 2017-09-08
SI2370096T1 (sl) 2017-10-30
EA201100868A1 (ru) 2011-10-31
IL213115A (en) 2017-08-31
CR20110282A (es) 2011-09-20
HUE035910T2 (en) 2018-05-28
PA8849901A1 (es) 2010-07-27
ZA201104064B (en) 2012-09-26
KR20110096551A (ko) 2011-08-30
IL213115A0 (en) 2011-07-31
MX2011005666A (es) 2011-09-30
SMT201700403T1 (it) 2017-11-15
JP6072854B2 (ja) 2017-02-01

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