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EA202090652A1 - T-клеточные рецепторы, рестриктированные по антигену лейкоцитов человека класса ii, против мутантного ras - Google Patents

T-клеточные рецепторы, рестриктированные по антигену лейкоцитов человека класса ii, против мутантного ras

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Publication number
EA202090652A1
EA202090652A1 EA202090652A EA202090652A EA202090652A1 EA 202090652 A1 EA202090652 A1 EA 202090652A1 EA 202090652 A EA202090652 A EA 202090652A EA 202090652 A EA202090652 A EA 202090652A EA 202090652 A1 EA202090652 A1 EA 202090652A1
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Eurasian Patent Office
Prior art keywords
class
antigen
cell receptors
human leukocytes
mutant ras
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EA202090652A
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English (en)
Inventor
Рами Йозеф
Гал Кафри
Пол Ф. Роббинс
Стивен А. Розенберг
Original Assignee
Дзе Юнайтед Стейтс Оф Америка, Эз Репрезентед Бай Дзе Секретари, Департмент Оф Хелс Энд Хьюман Сёрвисез
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Publication of EA202090652A1 publication Critical patent/EA202090652A1/ru

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Abstract

Изобретение относится к выделенному или очищенному Т-клеточному рецептору (TCR), где TCR обладает антигенной специфичностью по отношению к мутантному гомологу вирусного онкогена крысиной саркомы Кирстена (KRAS), презентируемому молекулой класса II антигена лейкоцитов человека (HLA). Изобретение также относится к соответствующим полипептидам и белкам, а также к соответствующим нуклеиновым кислотам, рекомбинантным векторам экспрессии, клеткам-хозяевам, популяциям клеток и фармацевтическим композициям. Изобретение также относится к способам обнаружения наличия рака у млекопитающего и способам лечения или предупреждения развития рака у млекопитающего.
EA202090652A 2017-09-20 2018-09-19 T-клеточные рецепторы, рестриктированные по антигену лейкоцитов человека класса ii, против мутантного ras EA202090652A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762560930P 2017-09-20 2017-09-20
PCT/US2018/051641 WO2019060349A1 (en) 2017-09-20 2018-09-19 CLASS II HLA RESTRICTED T LYMPHOCYTE RECEPTORS AGAINST KRAS MUTATED

Publications (1)

Publication Number Publication Date
EA202090652A1 true EA202090652A1 (ru) 2020-08-21

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US (3) US11306132B2 (ru)
EP (1) EP3684799A1 (ru)
JP (1) JP7256794B2 (ru)
KR (2) KR20250037592A (ru)
CN (2) CN120082603A (ru)
AR (1) AR112902A1 (ru)
AU (2) AU2018335274B2 (ru)
BR (1) BR112020005469A2 (ru)
CA (1) CA3076339A1 (ru)
CR (1) CR20240019A (ru)
EA (1) EA202090652A1 (ru)
IL (1) IL273254B2 (ru)
MA (1) MA50180A (ru)
MX (2) MX2020003117A (ru)
SG (1) SG11202002425PA (ru)
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US12533409B2 (en) 2019-01-25 2026-01-27 The Trustees Of The University Of Pennsylvania Compositions and methods for targeting mutant RAS
EP4004546A4 (en) * 2019-07-30 2024-10-09 University Health Network METHODS FOR IDENTIFYING T CELL RECEPTORS
CN112759641B (zh) * 2019-11-01 2023-01-20 香雪生命科学技术（广东）有限公司 一种识别Kras G12V的高亲和力TCR
CN115244173A (zh) 2019-12-20 2022-10-25 英研生物(英国)有限公司 用于分离肿瘤浸润淋巴细胞的装置及方法及其用途
GB2610311B (en) * 2020-02-14 2025-07-09 Us Health HLA class I-restricted T cell receptors against RAS with G12V mutation
MX2022010193A (es) * 2020-02-19 2022-11-14 Aelin Therapeutics Moleculas dirigidas a proteina ras.
BR112022016661A2 (pt) * 2020-02-26 2022-10-11 Us Health Receptores de células t restritos ao hla classe ii contra ras com mutação g12v
US20230312672A1 (en) * 2020-06-24 2023-10-05 The United States Of America,As Represented By The Secretary,Department Of Health And Human Services Hla class i-restricted t cell receptors against cd20
WO2022015694A1 (en) * 2020-07-13 2022-01-20 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Hla class ii–restricted drb t cell receptors against ras with g12d mutation
CN116348484A (zh) * 2020-07-16 2023-06-27 美国卫生和人力服务部 针对含有g12v突变的ras的hla-ii类限制性drb t细胞受体
CN112300269B (zh) * 2020-09-29 2022-12-09 中国科学院微生物研究所 Kras突变特异性t细胞受体筛选及抗肿瘤用途
WO2022072760A1 (en) * 2020-10-02 2022-04-07 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Hla class ii-restricted dq t cell receptors against ras with g13d mutation
WO2022111451A1 (zh) * 2020-11-24 2022-06-02 上海吉倍生物技术有限公司 Ras突变体表位肽及识别ras突变体的t细胞受体
US20240175047A1 (en) 2021-02-25 2024-05-30 Alaunos Therapeutics, Inc. Recombinant Vectors Comprising Polycistronic Expression Cassettes and Methods of Use Thereof
WO2023150562A1 (en) 2022-02-01 2023-08-10 Alaunos Therapeutics, Inc. Methods for activation and expansion of t cells
CN114835800B (zh) * 2022-05-27 2023-10-13 重庆医科大学 Tcr或其抗原结合片段及其应用
CN117264043B (zh) * 2022-06-14 2024-05-10 上海镔铁生物科技有限责任公司 靶向kras g12v突变多肽的t细胞受体及其用途
US20240325448A1 (en) * 2022-09-29 2024-10-03 Jerome Canady Research Institute for Advanced Biological and Technological Sciences Cold atmopsheric plasma treated pan-cancer epitope peptide within the collagen type vi a-3 (col6a3) protein as cancer vaccine

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CA2497552C (en) 2002-09-06 2014-05-27 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Immunotherapy with in vitro-selected antigen-specific lymphocytes after nonmyeloablative lymphodepleting chemotherapy
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BR112020005469A2 (pt) 2020-09-29
IL273254A (en) 2020-04-30
CA3076339A1 (en) 2019-03-28
AR112902A1 (es) 2019-12-26
TW201920251A (zh) 2019-06-01
US20220204584A1 (en) 2022-06-30
JP2020534828A (ja) 2020-12-03
US20190085046A1 (en) 2019-03-21
IL273254B2 (en) 2024-09-01
AU2018335274A1 (en) 2020-04-09
MA50180A (fr) 2021-05-26
CN111201237A (zh) 2020-05-26
EP3684799A1 (en) 2020-07-29
KR102777370B1 (ko) 2025-03-10
MX2020003117A (es) 2020-08-20
MX2024004610A (es) 2024-04-30
CR20240019A (es) 2024-02-15
JP7256794B2 (ja) 2023-04-12
US20250250318A1 (en) 2025-08-07
AU2018335274B2 (en) 2025-02-13
US12304940B2 (en) 2025-05-20
KR20250037592A (ko) 2025-03-17
SG11202002425PA (en) 2020-04-29
CN120082603A (zh) 2025-06-03
AU2025202532A1 (en) 2025-05-01
CN111201237B (zh) 2025-03-25
AU2025202532A9 (en) 2025-09-04
TWI825029B (zh) 2023-12-11
US11306132B2 (en) 2022-04-19
KR20200051804A (ko) 2020-05-13
WO2019060349A1 (en) 2019-03-28
IL273254B1 (en) 2024-05-01

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