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EA202190608A1 - Однодоменные анти-bcma антитела и их применение - Google Patents

Однодоменные анти-bcma антитела и их применение

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Publication number
EA202190608A1
EA202190608A1 EA202190608A EA202190608A EA202190608A1 EA 202190608 A1 EA202190608 A1 EA 202190608A1 EA 202190608 A EA202190608 A EA 202190608A EA 202190608 A EA202190608 A EA 202190608A EA 202190608 A1 EA202190608 A1 EA 202190608A1
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EA
Eurasian Patent Office
Prior art keywords
group
domain
antibodies
bcma antibodies
application
Prior art date
Application number
EA202190608A
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English (en)
Inventor
Цзихуай Чфан
Хунцзянь Ли
Чаолэман Бао
Цинхуа Цай
Инин Ли
Цзунпэй Сун
Ицзинь Дин
Чжибо Цай
Original Assignee
Шэньчжэнь Преджин Байофарма Ко., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Шэньчжэнь Преджин Байофарма Ко., Лтд. filed Critical Шэньчжэнь Преджин Байофарма Ко., Лтд.
Publication of EA202190608A1 publication Critical patent/EA202190608A1/ru

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K40/00—Cellular immunotherapy
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    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/4214—Receptors for cytokines
    • A61K40/4215—Receptors for tumor necrosis factors [TNF], e.g. lymphotoxin receptor [LTR], CD30
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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Abstract

Группа однодоменных анти-BCMA антител, а также гены однодоменных антител в группе, вектор, содержащий однодоменные антитела в группе, химерный антигенный рецептор и Т-клетка, модифицированная химерным антигенным рецептором, и применение однодоменных антител в группе в обнаружении и лечении. Однодоменные анти-BCMA антитела обладают высокой активностью, высокой стабильностью, высокой специфичностью и высокой способностью связывания.
EA202190608A 2018-08-24 2019-07-10 Однодоменные анти-bcma антитела и их применение EA202190608A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201810972054 2018-08-24
PCT/CN2019/095507 WO2020038147A1 (zh) 2018-08-24 2019-07-10 抗bcma的单域抗体及其应用

Publications (1)

Publication Number Publication Date
EA202190608A1 true EA202190608A1 (ru) 2021-06-01

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EA202190608A EA202190608A1 (ru) 2018-08-24 2019-07-10 Однодоменные анти-bcma антитела и их применение

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US (1) US12227581B2 (ru)
EP (1) EP3845244A4 (ru)
JP (1) JP7289562B2 (ru)
KR (1) KR20210050535A (ru)
CN (1) CN111542343B (ru)
AU (1) AU2019323389B2 (ru)
BR (1) BR112021003410A2 (ru)
CA (1) CA3110262C (ru)
EA (1) EA202190608A1 (ru)
SG (1) SG11202101675UA (ru)
WO (1) WO2020038147A1 (ru)

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CN109970855A (zh) * 2019-04-12 2019-07-05 深圳普瑞金生物药业有限公司 Il23单域抗体的vhh链、il23单域抗体、核苷酸序列及试剂盒
CN111909271B (zh) * 2020-08-12 2021-03-23 深圳市茵冠生物科技有限公司 一种基于单域抗体的bcma嵌合抗原受体及其应用
KR20230045066A (ko) * 2020-08-20 2023-04-04 치아타이 티안큉 파마수티컬 그룹 주식회사 Bcma와 결합하는 단일 가변 도메인 및 항원 결합 분자
CN112028996B (zh) * 2020-10-30 2021-01-22 南京北恒生物科技有限公司 靶向bcma的单域抗体及其用途
CN112592405B (zh) * 2020-12-08 2022-05-03 博奥信生物技术（南京）有限公司 抗人bcma纳米抗体及其制备方法和应用
CN112538115B (zh) * 2020-12-08 2022-05-03 博奥信生物技术（南京）有限公司 一种抗人bcma纳米抗体及其制备方法和应用
CA3234046A1 (en) * 2021-10-07 2023-04-13 Mehdi Arbabi-Ghahroudi Anti-bcma single domain antibodies and therapeutic constructs
CN114195896B (zh) * 2021-12-06 2022-07-05 东莞清实生物科技有限公司 一种基于单域抗体的bcma嵌合抗原受体及其应用
CN119212724A (zh) * 2022-05-09 2024-12-27 上海先博生物科技有限公司 工程化免疫效应细胞及其与CBL-b抑制剂联用的应用
CN116574194A (zh) * 2022-06-02 2023-08-11 深圳普瑞金生物药业股份有限公司 嵌合抗原受体及其用途

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CN104804092B (zh) * 2014-01-29 2018-03-27 天津胜发生物技术有限公司 一种抗b细胞生长刺激因子的纳米抗体及其用途
EP3172237A2 (en) 2014-07-21 2017-05-31 Novartis AG Treatment of cancer using humanized anti-bcma chimeric antigen receptor
RU2747457C2 (ru) * 2014-07-24 2021-05-05 Блубёрд Био, Инк. Химерные антигенные рецепторы к bcma
DK3628687T3 (da) 2014-12-12 2021-10-18 2Seventy Bio Inc Kimære bcma-antigenreceptorer
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CN105777911B (zh) * 2016-04-12 2019-07-02 上海优卡迪生物医药科技有限公司 抗bcma嵌合抗原受体、编码基因、重组表达载体及其构建方法和应用
CN105837693A (zh) * 2016-05-30 2016-08-10 李斯文 一种基于bcma的抗原嵌合受体及其制备方法和应用
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CN109694413A (zh) 2019-01-17 2019-04-30 深圳市前海精准生物科技有限公司 一种基于bmca纳米抗体序列的嵌合抗原受体及其应用

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CA3110262A1 (en) 2020-02-27
US20220251226A1 (en) 2022-08-11
US12227581B2 (en) 2025-02-18
EP3845244A1 (en) 2021-07-07
WO2020038147A1 (zh) 2020-02-27
SG11202101675UA (en) 2021-03-30
BR112021003410A2 (pt) 2021-05-18
JP2021534823A (ja) 2021-12-16
CN111542343A (zh) 2020-08-14
KR20210050535A (ko) 2021-05-07
CA3110262C (en) 2024-05-14
EP3845244A4 (en) 2022-09-07
AU2019323389B2 (en) 2024-03-21
CN111542343B (zh) 2023-08-18
JP7289562B2 (ja) 2023-06-12
AU2019323389A1 (en) 2021-04-15

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