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EA202092945A1 - Различные антигенсвязывающие домены, новые платформы и другие улучшения для клеточной терапии - Google Patents

Различные антигенсвязывающие домены, новые платформы и другие улучшения для клеточной терапии

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Publication number
EA202092945A1
EA202092945A1 EA202092945A EA202092945A EA202092945A1 EA 202092945 A1 EA202092945 A1 EA 202092945A1 EA 202092945 A EA202092945 A EA 202092945A EA 202092945 A EA202092945 A EA 202092945A EA 202092945 A1 EA202092945 A1 EA 202092945A1
Authority
EA
Eurasian Patent Office
Prior art keywords
binding domains
antigen binding
cell therapy
different antigen
new platforms
Prior art date
Application number
EA202092945A
Other languages
English (en)
Inventor
Прит М. Чаудхари
Original Assignee
Юниверсити Оф Саутерн Калифорния
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Юниверсити Оф Саутерн Калифорния filed Critical Юниверсити Оф Саутерн Калифорния
Publication of EA202092945A1 publication Critical patent/EA202092945A1/ru

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Abstract

В описании предложены различные антигенсвязывающие домены и платформы для создания обычных рецепторов химерного антигена и рецепторов химерного антигена следующего поколения для адоптивных клеточных терапий рака, инфекций, аллергических, дегенеративных и иммунных нарушений. Также представлены подходы для активации и размножения иммунных Т-клеток для адоптивной клеточной терапии рака, инфекции, аллергических, дегенеративных и иммунных нарушений.
EA202092945A 2018-06-01 2019-06-01 Различные антигенсвязывающие домены, новые платформы и другие улучшения для клеточной терапии EA202092945A1 (ru)

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Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3636761B1 (en) * 2017-06-05 2024-07-31 Mie University Antigen-binding protein recognizing mage-a4-derived peptide
MX2020004185A (es) * 2017-09-27 2021-01-08 Univ Southern California Nuevas plataformas para coestimulacion, nuevos diseños car y otras mejoras para terapia celular adoptiva.
CA3123493A1 (en) * 2018-12-21 2020-06-25 F. Hoffmann-La Roche Ag Tumor-targeted agonistic cd28 antigen binding molecules
EP3733707A1 (en) * 2019-04-30 2020-11-04 Celyad S.A. Car t-cells targeting bcma and uses thereof
EP3842461A1 (en) * 2019-12-23 2021-06-30 Albert-Ludwigs-Universität Freiburg Chimeric antigen receptors that bind to prostate specific membrane antigen
AU2021205249A1 (en) * 2020-01-08 2022-07-21 Board Of Regents, The University Of Texas System A method of engineering natural killer cells to target CD70-positive tumors
JP2023522857A (ja) * 2020-04-10 2023-06-01 ジュノー セラピューティクス インコーポレイテッド Ｂ細胞成熟抗原を標的とするキメラ抗原受容体によって操作された細胞療法に関する方法および使用
KR20230008144A (ko) * 2020-04-24 2023-01-13 메모리얼 슬로안 케터링 캔서 센터 Cd19를 표적화하는 키메라 항원 수용체 및 그의 용도
AR122014A1 (es) * 2020-05-06 2022-08-03 Crispr Therapeutics Ag Receptor de antígenos quimérico enmascarado específico para la proteína tirosina cinasa de tipo 7 (ptk7) y células inmunitarias que expresan el mismo
WO2021231237A2 (en) * 2020-05-11 2021-11-18 Augmenta Bioworks, Inc. Antibodies for sars-cov-2 and uses thereof
JP2023538526A (ja) * 2020-08-06 2023-09-08 ステレクシス セラピューティクス，エルエルシー Ｉｌ－８抗体及びその使用方法
CA3201008A1 (en) * 2020-12-02 2022-06-09 Shanghai Cellular Biopharmaceutical Group Ltd. Bcma-targeted chimeric antigen receptors
WO2022170126A2 (en) * 2021-02-05 2022-08-11 Adagio Therapeutics, Inc. Compounds specific to coronavirus s protein and uses thereof
US20240218390A1 (en) * 2021-02-26 2024-07-04 Kelonia Therapeutics, Inc. Lymphocyte targeted lentiviral vectors
CN115491358B (zh) * 2021-06-17 2024-09-06 复星凯特生物科技有限公司 一种靶向b7-h3和folr1双打靶点car t的制备及应用
AU2022358512A1 (en) * 2021-09-29 2024-04-18 Modex Therapeutics, Inc. Antigen binding polypeptides, antigen binding polypeptide complexes and methods of use thereof
IL312204A (en) 2021-10-28 2024-06-01 Lyell Immunopharma Inc Methods for culturing cells expressing ror1-binding protein
CN114106199B (zh) * 2021-11-19 2022-07-12 广州百暨基因科技有限公司 靶向adgre2的嵌合抗原受体及其应用
KR20240153603A (ko) * 2022-03-07 2024-10-23 메디뮨 엘엘씨 Ctla-4 및 pd-1 이중특이적 항체를 사용한 치료 방법
WO2023175069A1 (en) * 2022-03-16 2023-09-21 Medigene Immunotherapies Gmbh Tcr constant region pairing library for pramevld tcrs
EP4493583A1 (en) * 2022-03-16 2025-01-22 Medigene Immunotherapies GmbH Tcr constant region pairing library
GB202208119D0 (en) * 2022-06-01 2022-07-13 Univ Oslo Hf Anti-steap1 car
WO2024064952A1 (en) 2022-09-23 2024-03-28 Lyell Immunopharma, Inc. Methods for culturing nr4a-deficient cells overexpressing c-jun
WO2024064958A1 (en) 2022-09-23 2024-03-28 Lyell Immunopharma, Inc. Methods for culturing nr4a-deficient cells
WO2024077174A1 (en) 2022-10-05 2024-04-11 Lyell Immunopharma, Inc. Methods for culturing nr4a-deficient cells
WO2024136899A1 (en) * 2022-12-21 2024-06-27 Synthorx, Inc. Cancer therapy with il-2 conjugates and chimeric antigen receptor therapies
GB202301421D0 (en) * 2023-02-01 2023-03-15 Univ Oslo Hf Switch receptor for use in adoptive cell therapy
WO2024206884A1 (en) 2023-03-31 2024-10-03 AbelZeta Inc. Bispecific chimeric antigen receptors targeting cd20 and bcma
WO2024220834A1 (en) * 2023-04-19 2024-10-24 H. Lee Moffitt Cancer Center And Research Institute Inc. Car-t cells co-expressing cd40l
WO2024243093A2 (en) * 2023-05-19 2024-11-28 The Regents Of The University Of California Multispecific antibodies targeting cd3 and cd22

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9206440B2 (en) * 2009-01-23 2015-12-08 Roger Williams Hospital Viral vectors encoding multiple highly homologus non-viral polypeptides and the use of same
US9833476B2 (en) * 2011-08-31 2017-12-05 The Trustees Of Dartmouth College NKP30 receptor targeted therapeutics
US10316101B2 (en) * 2014-04-14 2019-06-11 Cellectis BCMA (CD269) specific chimeric antigen receptors for cancer immunotherapy
EP3172237A2 (en) * 2014-07-21 2017-05-31 Novartis AG Treatment of cancer using humanized anti-bcma chimeric antigen receptor
WO2016174852A1 (ja) * 2015-04-30 2016-11-03 株式会社デンソー 蒸発器
SG10201913682QA (en) * 2015-06-25 2020-03-30 Icell Gene Therapeutics Llc CHIMERIC ANTIGEN RECEPTORS (CARs), COMPOSITIONS AND METHODS OF USE THEREOF
CN107614519B (zh) * 2015-10-23 2022-08-05 优瑞科生物技术公司 抗体/t细胞受体嵌合构建体及其用途
KR102584300B1 (ko) * 2016-03-29 2023-10-05 유니버시티 오브 써던 캘리포니아 암을 표적하는 키메라 항원 수용체
CN110352068A (zh) * 2016-12-02 2019-10-18 南加利福尼亚大学 合成的免疫受体及其使用方法
KR20230153529A (ko) * 2021-02-19 2023-11-06 프리트 엠. 쇼드하리 다양한 면역세포를 위한 단일사슬 및 다중사슬 합성 항원 수용체

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