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EA201890383A8 - Конструкции биспецифических антител, связывающиеся с мезотелином и кд3 (cd3) - Google Patents

Конструкции биспецифических антител, связывающиеся с мезотелином и кд3 (cd3)

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Publication number
EA201890383A8
EA201890383A8 EA201890383A EA201890383A EA201890383A8 EA 201890383 A8 EA201890383 A8 EA 201890383A8 EA 201890383 A EA201890383 A EA 201890383A EA 201890383 A EA201890383 A EA 201890383A EA 201890383 A8 EA201890383 A8 EA 201890383A8
Authority
EA
Eurasian Patent Office
Prior art keywords
antibody construct
mesotelin
constructions
specific antibodies
antibodies binding
Prior art date
Application number
EA201890383A
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English (en)
Other versions
EA201890383A1 (ru
Inventor
Тобиас РАУМ
Петер КУФЕР
Дорис РАУ
Йонас Анлар
Клаудиа БЛЮМЕЛЬ
Патрик ХОФФМАНН
Элизабет Нарвольд
Джули Бейлис
Маркус Мюнц
Йоханнес Брози
Маттиас Фридрих
Бенно Раттель
Памела Богнер
Андреас Вольф
Корнелиус Помпе
Original Assignee
Эмджен Рисерч (Мюник) Гмбх
Эмджен Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Эмджен Рисерч (Мюник) Гмбх, Эмджен Инк. filed Critical Эмджен Рисерч (Мюник) Гмбх
Publication of EA201890383A1 publication Critical patent/EA201890383A1/ru
Publication of EA201890383A8 publication Critical patent/EA201890383A8/ru

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622Single chain antibody (scFv)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)

Abstract

Данное изобретение относится к конструкции биспецифического антитела, содержащей первый связывающий домен, который связывается с мезотелином (MSLN) человека на поверхности клетки-мишени, и второй связывающий домен, который связывается с КД3 (CD3) человека на поверхности Т-клетки. Кроме того, в изобретении предложены полинуклеотид, кодирующий конструкцию антитела, вектор, содержащий указанный полинуклеотид, и клетка-хозяин, трансформированная или трансфектированная указанным полинуклеотидом или вектором. Дополнительно, в изобретении предложены способ получения конструкции антитела по изобретению, медицинское применение указанной конструкции антитела и набор, содержащий указанную конструкцию антитела.
EA201890383A 2015-07-31 2016-08-01 Конструкции биспецифических антител, связывающиеся с мезотелином и кд3 (cd3) EA201890383A8 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562199939P 2015-07-31 2015-07-31
US201662290861P 2016-02-03 2016-02-03
PCT/EP2016/068304 WO2017021356A1 (en) 2015-07-31 2016-08-01 Bispecific antibody constructs binding mesothelin and cd3

Publications (2)

Publication Number Publication Date
EA201890383A1 EA201890383A1 (ru) 2018-06-29
EA201890383A8 true EA201890383A8 (ru) 2019-09-30

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EA201890383A EA201890383A8 (ru) 2015-07-31 2016-08-01 Конструкции биспецифических антител, связывающиеся с мезотелином и кд3 (cd3)

Country Status (36)

Country Link
US (2) US11884720B2 (ru)
EP (2) EP4327885A3 (ru)
JP (1) JP7026610B2 (ru)
KR (1) KR20180037950A (ru)
CN (1) CN109476736B (ru)
AU (1) AU2016302575B2 (ru)
BR (1) BR112018001638A8 (ru)
CA (1) CA2991672A1 (ru)
CL (2) CL2018000268A1 (ru)
CO (1) CO2018000885A2 (ru)
DK (1) DK3328893T5 (ru)
EA (1) EA201890383A8 (ru)
ES (1) ES2964897T3 (ru)
FI (1) FI3328893T3 (ru)
HR (1) HRP20231410T1 (ru)
HU (1) HUE064248T2 (ru)
IL (1) IL256873B2 (ru)
JO (1) JO3747B1 (ru)
LT (1) LT3328893T (ru)
MD (1) MD3328893T2 (ru)
MX (1) MX2018001157A (ru)
MY (1) MY198199A (ru)
NZ (2) NZ737458A (ru)
PE (1) PE20180798A1 (ru)
PH (1) PH12018500107A1 (ru)
PL (1) PL3328893T3 (ru)
PT (1) PT3328893T (ru)
RS (1) RS64938B1 (ru)
SG (1) SG10202000828TA (ru)
SI (1) SI3328893T1 (ru)
SM (1) SMT202300446T1 (ru)
TN (1) TN2017000552A1 (ru)
TW (1) TWI796283B (ru)
UA (1) UA125580C2 (ru)
WO (1) WO2017021356A1 (ru)
ZA (1) ZA201707816B (ru)

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