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EA201791754A1 - АНТИТЕЛА, СОДЕРЖАЩИЕ ЗАВИСЯЩИЙ ОТ КОНЦЕНТРАЦИИ ИОНОВ АНТИГЕНСВЯЗЫВАЮЩИЙ ДОМЕН, ВАРИАНТЫ Fc-ОБЛАСТИ, IL-8-СВЯЗЫВАЮЩИЕ АНТИТЕЛА И ИХ ПРИМЕНЕНИЯ - Google Patents

АНТИТЕЛА, СОДЕРЖАЩИЕ ЗАВИСЯЩИЙ ОТ КОНЦЕНТРАЦИИ ИОНОВ АНТИГЕНСВЯЗЫВАЮЩИЙ ДОМЕН, ВАРИАНТЫ Fc-ОБЛАСТИ, IL-8-СВЯЗЫВАЮЩИЕ АНТИТЕЛА И ИХ ПРИМЕНЕНИЯ

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Publication number
EA201791754A1
EA201791754A1 EA201791754A EA201791754A EA201791754A1 EA 201791754 A1 EA201791754 A1 EA 201791754A1 EA 201791754 A EA201791754 A EA 201791754A EA 201791754 A EA201791754 A EA 201791754A EA 201791754 A1 EA201791754 A1 EA 201791754A1
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Eurasian Patent Office
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antibodies
ions
concentration
applications
binding domain
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EA201791754A
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English (en)
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Томоюки Игава
Ацухико Маэда
Кента Харая
Тацухико Татибана
Юки Иваянаги
Юдзи Хори
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Чугаи Сейяку Кабусики Кайся
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Publication of EA201791754A1 publication Critical patent/EA201791754A1/ru

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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
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    • C07K16/244—Interleukins [IL]
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Abstract

В качестве одного объекта изобретения, не ограничивающего его объем, в заявке описаны дополнительно улучшенные молекулы антител, которые могут связываться с антигенами в зависимости от концентрации ионов. В качестве альтернативного объекта изобретения, не ограничивающего его объем, в заявке описаны безопасные и более предпочтительные варианты Fc-области, обладающие пониженной способностью связываться с ранее присутствующим ADA. В качестве альтернативного объекта изобретения, не ограничивающего его объем, в заявке описаны новые антитела к IL-8, обладающие преимуществом в качестве фармацевтических агентов.
EA201791754A 2015-02-05 2016-02-04 АНТИТЕЛА, СОДЕРЖАЩИЕ ЗАВИСЯЩИЙ ОТ КОНЦЕНТРАЦИИ ИОНОВ АНТИГЕНСВЯЗЫВАЮЩИЙ ДОМЕН, ВАРИАНТЫ Fc-ОБЛАСТИ, IL-8-СВЯЗЫВАЮЩИЕ АНТИТЕЛА И ИХ ПРИМЕНЕНИЯ EA201791754A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2015021371 2015-02-05
JP2015185254 2015-09-18
PCT/JP2016/000577 WO2016125495A1 (en) 2015-02-05 2016-02-04 Antibodies comprising an ion concentration dependent antigen-binding domain, fc region variants, il-8-binding antibodies, and uses therof

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EA201791754A1 true EA201791754A1 (ru) 2019-01-31

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US (4) US9969800B2 (ru)
EP (2) EP3253778A1 (ru)
JP (4) JP2018510842A (ru)
KR (3) KR20240090831A (ru)
CN (3) CN114773470A (ru)
AU (4) AU2016216079A1 (ru)
CA (1) CA2974547A1 (ru)
EA (1) EA201791754A1 (ru)
MX (3) MX2017008978A (ru)
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