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EA201692204A1 - Композиции и способы модулирования экспрессии фактора комплемента b - Google Patents

Композиции и способы модулирования экспрессии фактора комплемента b

Info

Publication number
EA201692204A1
EA201692204A1 EA201692204A EA201692204A EA201692204A1 EA 201692204 A1 EA201692204 A1 EA 201692204A1 EA 201692204 A EA201692204 A EA 201692204A EA 201692204 A EA201692204 A EA 201692204A EA 201692204 A1 EA201692204 A1 EA 201692204A1
Authority
EA
Eurasian Patent Office
Prior art keywords
compositions
methods
factor
modulating
expression
Prior art date
Application number
EA201692204A
Other languages
English (en)
Other versions
EA036496B1 (ru
Inventor
Тража П. Пракаш
Пунит П. Сэт
Эрик Э. Свэйз
Тамар Р. Гроссмэн
Майкл Л. Маккалеб
Эндрю Т. Ватт
Сьюзан М. Фрэйер
Original Assignee
Ионис Фармасьютикалз, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ионис Фармасьютикалз, Инк. filed Critical Ионис Фармасьютикалз, Инк.
Publication of EA201692204A1 publication Critical patent/EA201692204A1/ru
Publication of EA036496B1 publication Critical patent/EA036496B1/ru

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Abstract

В вариантах реализации настоящего изобретения предложены способы, соединения и композиции для лечения, предупреждения или облегчения заболевания, связанного с дисрегуляцией альтернативного пути комплемента, посредством введения субъекту специфического ингибитора фактора комплемента В (CFB).
EA201692204A 2014-05-01 2015-05-01 Конъюгированные олигонуклеотиды для модулирования экспрессии фактора комплемента b EA036496B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461987471P 2014-05-01 2014-05-01
US201462076273P 2014-11-06 2014-11-06
PCT/US2015/028916 WO2015168635A2 (en) 2014-05-01 2015-05-01 Compositions and methods for modulating complement factor b expression

Publications (2)

Publication Number Publication Date
EA201692204A1 true EA201692204A1 (ru) 2017-04-28
EA036496B1 EA036496B1 (ru) 2020-11-17

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EA201692204A EA036496B1 (ru) 2014-05-01 2015-05-01 Конъюгированные олигонуклеотиды для модулирования экспрессии фактора комплемента b

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US (4) US10280423B2 (ru)
EP (3) EP3608406B1 (ru)
JP (2) JP6637442B2 (ru)
KR (1) KR102369736B1 (ru)
CN (2) CN106232804B (ru)
AU (1) AU2015252858C1 (ru)
BR (1) BR112016022593B1 (ru)
CA (1) CA2943894A1 (ru)
CL (2) CL2016002764A1 (ru)
CR (2) CR20160554A (ru)
DK (1) DK3137596T3 (ru)
DO (1) DOP2016000291A (ru)
EA (1) EA036496B1 (ru)
ES (2) ES2745825T3 (ru)
HR (1) HRP20191664T1 (ru)
HU (1) HUE046272T2 (ru)
IL (2) IL247883B (ru)
LT (1) LT3137596T (ru)
MX (1) MX380866B (ru)
PE (2) PE20190626A1 (ru)
PH (1) PH12016502062B1 (ru)
PL (2) PL3137596T3 (ru)
PT (1) PT3137596T (ru)
RS (1) RS59182B1 (ru)
RU (1) RU2701645C2 (ru)
SG (2) SG10201809953QA (ru)
SI (1) SI3137596T1 (ru)
UA (1) UA121656C2 (ru)
WO (1) WO2015168635A2 (ru)

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KR20230017789A (ko) * 2020-04-30 2023-02-06 알닐람 파마슈티칼스 인코포레이티드 보체 인자 B (CFB) iRNA 조성물 및 이의 사용 방법
AU2022336157A1 (en) 2021-09-02 2024-03-14 Silence Therapeutics Gmbh Nucleic acids for inhibiting expression of complement factor b (cfb) in a cell
TW202333749A (zh) * 2021-10-29 2023-09-01 美商艾拉倫製藥股份有限公司 補體因子ｂ（ｃｆｂ）ｉｒｎａ組成物及其使用方法
WO2024097861A1 (en) * 2022-11-02 2024-05-10 Ionis Pharmaceuticals, Inc. Methods for modulating complement factor b expression
WO2024137590A2 (en) * 2022-12-19 2024-06-27 Sanegene Bio Usa Inc. Small interfering rna targeting cfb and uses thereof
WO2024197017A2 (en) * 2023-03-21 2024-09-26 Arrowhead Pharmaceuticals, Inc. Rnai agents for inhibiting expression of complement factor b (cfb) pharmaceutical compositions thereof, and methods of use
TW202513799A (zh) * 2023-06-02 2025-04-01 大陸商維亞臻生物技術（蘇州）有限公司 用於免疫類疾病的雙鏈核苷酸化合物及其用途
WO2025002401A1 (zh) * 2023-06-28 2025-01-02 百奥赛图(北京)医药科技股份有限公司 一种cfb基因修饰的非人动物
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