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EA201691799A1 - Бициклические соединения в качестве ингибиторов продукции аутотаксина (atx) и лизофосфатидиловой кислоты (lpa) - Google Patents

Бициклические соединения в качестве ингибиторов продукции аутотаксина (atx) и лизофосфатидиловой кислоты (lpa)

Info

Publication number
EA201691799A1
EA201691799A1 EA201691799A EA201691799A EA201691799A1 EA 201691799 A1 EA201691799 A1 EA 201691799A1 EA 201691799 A EA201691799 A EA 201691799A EA 201691799 A EA201691799 A EA 201691799A EA 201691799 A1 EA201691799 A1 EA 201691799A1
Authority
EA
Eurasian Patent Office
Prior art keywords
inhibitors
autotaxin
atx
lpa
bicyclic compounds
Prior art date
Application number
EA201691799A
Other languages
English (en)
Other versions
EA037928B1 (ru
Inventor
Джорджо Патрик Ди
Жером Херт
Даниэль ХУНЦИКЕР
Хольгер Кюне
Патрицио Маттей
Маркус Рудольф
Original Assignee
Ф. Хоффманн-Ля Рош Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ф. Хоффманн-Ля Рош Аг filed Critical Ф. Хоффманн-Ля Рош Аг
Publication of EA201691799A1 publication Critical patent/EA201691799A1/ru
Publication of EA037928B1 publication Critical patent/EA037928B1/ru

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

В настоящем изобретении предложены новые соединения, обладающие общей формулой (I)где R, R, A, W, m, n, р и q являются такими, как здесь описано, композиции, включающие указанные соединения и способы применения указанных соединений.
EA201691799A 2014-03-26 2015-03-23 Бициклические соединения в качестве ингибиторов продукции аутотаксина (atx) и лизофосфатидиловой кислоты (lpa) EA037928B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14161760 2014-03-26
PCT/EP2015/056032 WO2015144605A1 (en) 2014-03-26 2015-03-23 Bicyclic compounds as autotaxin (atx) and lysophosphatidic acid (lpa) production inhibitors

Publications (2)

Publication Number Publication Date
EA201691799A1 true EA201691799A1 (ru) 2017-01-30
EA037928B1 EA037928B1 (ru) 2021-06-08

Family

ID=50389849

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201691799A EA037928B1 (ru) 2014-03-26 2015-03-23 Бициклические соединения в качестве ингибиторов продукции аутотаксина (atx) и лизофосфатидиловой кислоты (lpa)

Country Status (29)

Country Link
US (4) US9802944B2 (ru)
EP (2) EP3590939A1 (ru)
JP (2) JP6553637B2 (ru)
KR (1) KR20160128345A (ru)
CN (2) CN106103446B (ru)
AR (1) AR099824A1 (ru)
AU (2) AU2015238537B2 (ru)
CA (1) CA2937616A1 (ru)
CL (1) CL2016002310A1 (ru)
CR (1) CR20160419A (ru)
DK (1) DK3122750T3 (ru)
EA (1) EA037928B1 (ru)
ES (1) ES2753549T3 (ru)
HR (1) HRP20191936T1 (ru)
HU (1) HUE046820T2 (ru)
IL (1) IL246708B (ru)
LT (1) LT3122750T (ru)
MA (2) MA50635A (ru)
MX (1) MX370659B (ru)
PE (1) PE20161134A1 (ru)
PH (2) PH12016501632B1 (ru)
PL (1) PL3122750T3 (ru)
PT (1) PT3122750T (ru)
RS (1) RS59477B1 (ru)
SG (1) SG11201607839UA (ru)
SI (1) SI3122750T1 (ru)
TW (1) TWI708774B (ru)
UA (1) UA118582C2 (ru)
WO (1) WO2015144605A1 (ru)

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