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EA201201385A1 - Новый способ синтеза ивабрадина и его фармацевтически приемлемых кислотно-аддитивных солей - Google Patents

Новый способ синтеза ивабрадина и его фармацевтически приемлемых кислотно-аддитивных солей

Info

Publication number
EA201201385A1
EA201201385A1 EA201201385A EA201201385A EA201201385A1 EA 201201385 A1 EA201201385 A1 EA 201201385A1 EA 201201385 A EA201201385 A EA 201201385A EA 201201385 A EA201201385 A EA 201201385A EA 201201385 A1 EA201201385 A1 EA 201201385A1
Authority
EA
Eurasian Patent Office
Prior art keywords
synthesis
pharmaceutically acceptable
acceptable acid
ivabradin
new method
Prior art date
Application number
EA201201385A
Other languages
English (en)
Other versions
EA026510B1 (ru
Inventor
Жан-Люк Рено
Никола Паннетье
Жан-Пьер Лекув
Люсиль Вейссе-Людо
Соллен Мулен
Original Assignee
Ле Лаборатуар Сервье
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47115640&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201201385(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ле Лаборатуар Сервье filed Critical Ле Лаборатуар Сервье
Publication of EA201201385A1 publication Critical patent/EA201201385A1/ru
Publication of EA026510B1 publication Critical patent/EA026510B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/22—Organic complexes
    • B01J31/2282—Unsaturated compounds used as ligands
    • B01J31/2295—Cyclic compounds, e.g. cyclopentadienyls
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2235/00—Indexing scheme associated with group B01J35/00, related to the analysis techniques used to determine the catalysts form or properties
    • B01J2235/05—Nuclear magnetic resonance [NMR]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Materials Engineering (AREA)
  • Inorganic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)
  • Saccharide Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Способ синтеза ивабрадина формулы (I)его фармацевтически приемлемых кислотно-аддитивных солей и его гидратов. Лекарственные средства.
EA201201385A 2011-12-20 2012-11-09 Новый способ синтеза ивабрадина и его фармацевтически приемлемых кислотно-аддитивных солей EA026510B1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1103933A FR2984319B1 (fr) 2011-12-20 2011-12-20 Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable

Publications (2)

Publication Number Publication Date
EA201201385A1 true EA201201385A1 (ru) 2013-06-28
EA026510B1 EA026510B1 (ru) 2017-04-28

Family

ID=47115640

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201201385A EA026510B1 (ru) 2011-12-20 2012-11-09 Новый способ синтеза ивабрадина и его фармацевтически приемлемых кислотно-аддитивных солей

Country Status (34)

Country Link
US (1) US8513410B2 (ru)
EP (1) EP2607353B1 (ru)
JP (1) JP5670406B2 (ru)
KR (1) KR101470879B1 (ru)
CN (1) CN103172566B (ru)
AR (1) AR088678A1 (ru)
AU (1) AU2012244188B2 (ru)
BR (1) BR102012028614A2 (ru)
CA (1) CA2795741C (ru)
CL (1) CL2012003136A1 (ru)
CY (1) CY1115682T1 (ru)
DK (1) DK2607353T3 (ru)
EA (1) EA026510B1 (ru)
ES (1) ES2525032T3 (ru)
FR (1) FR2984319B1 (ru)
GE (1) GEP20156350B (ru)
HR (1) HRP20141023T1 (ru)
JO (1) JO3031B1 (ru)
MA (1) MA34276B1 (ru)
MD (1) MD4336C1 (ru)
MX (1) MX2012012938A (ru)
MY (1) MY170662A (ru)
PE (1) PE20131097A1 (ru)
PL (1) PL2607353T3 (ru)
PT (1) PT2607353E (ru)
RS (1) RS53541B1 (ru)
SA (1) SA112330994B1 (ru)
SG (1) SG191471A1 (ru)
SI (1) SI2607353T1 (ru)
TW (1) TWI440627B (ru)
UA (1) UA111329C2 (ru)
UY (1) UY34423A (ru)
WO (1) WO2013093220A1 (ru)
ZA (1) ZA201208160B (ru)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2988720B1 (fr) * 2012-03-27 2014-03-14 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
CN105669554A (zh) * 2016-02-22 2016-06-15 徐建立 一种盐酸伊伐布雷定杂质及其制备方法和应用
FR3071833B1 (fr) * 2017-09-29 2020-01-03 Universite Paris-Sud Nouveau procede de synthese d'amines tertiaires dissymetriques

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2681862B1 (fr) * 1991-09-27 1993-11-12 Adir Cie Nouvelles (benzocycloalkyl)alkylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent.
US6225487B1 (en) * 1998-04-17 2001-05-01 Symyx Technologies, Inc. Ancillary ligands and metal complexes, catalysts and compositions using same and methods of testing
US6521793B1 (en) * 1998-10-08 2003-02-18 Symyx Technologies, Inc. Catalyst ligands, catalytic metal complexes and processes using same
FR2868777B1 (fr) * 2004-04-13 2006-05-26 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
EP1595888A1 (en) * 2004-05-11 2005-11-16 Degussa AG Cycloolefin phosphine ligands and their use in catalysis
WO2008065681A2 (en) * 2006-11-30 2008-06-05 Cadila Healthcare Limited Process for preparation of ivabradine hydrochloride
PT2471780E (pt) * 2007-05-30 2015-02-24 Ind Swift Lab Ltd Sais oxalato de ivabradina cristalinos e seus polimorfos
US7857994B2 (en) 2007-05-30 2010-12-28 GE Lighting Solutions, LLC Green emitting phosphors and blends thereof
FR2920773B1 (fr) * 2007-09-11 2009-10-23 Servier Lab Derives de 1,2,4,5-tetrahydro-3h-benzazepines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2933975B1 (fr) * 2008-07-17 2011-02-18 Servier Lab Nouveau procede de preparation de benzocyclobutenes fonctionnalises,et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable.
FR2935381B1 (fr) * 2008-08-29 2010-12-17 Servier Lab Nouveau procede de resolution des enantiomerees du (3,4-dimethoxy-bicyclo°4.2.0!octa-1,3,5-trien-7-yl)nitrile et application a la synthese de l'ivabradine
FR2940287B1 (fr) * 2008-12-24 2010-12-24 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable.
FR2941695B1 (fr) * 2009-02-04 2011-02-18 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable

Also Published As

Publication number Publication date
PE20131097A1 (es) 2013-10-12
SG191471A1 (en) 2013-07-31
CN103172566A (zh) 2013-06-26
WO2013093220A1 (fr) 2013-06-27
CN103172566B (zh) 2015-11-18
EP2607353A1 (fr) 2013-06-26
TW201326132A (zh) 2013-07-01
ZA201208160B (en) 2013-06-26
MA34276B1 (fr) 2013-06-01
GEP20156350B (en) 2015-08-25
ES2525032T3 (es) 2014-12-16
TWI440627B (zh) 2014-06-11
MD4336C1 (ru) 2015-10-31
RS53541B1 (en) 2015-02-27
UA111329C2 (uk) 2016-04-25
MX2012012938A (es) 2013-06-19
MY170662A (en) 2019-08-26
CA2795741C (fr) 2015-09-08
EP2607353B1 (fr) 2014-08-27
KR101470879B1 (ko) 2014-12-09
JP5670406B2 (ja) 2015-02-18
MD4336B1 (ru) 2015-03-31
PT2607353E (pt) 2014-10-10
PL2607353T3 (pl) 2015-01-30
US20130158256A1 (en) 2013-06-20
SI2607353T1 (sl) 2014-12-31
BR102012028614A2 (pt) 2014-12-16
FR2984319A1 (fr) 2013-06-21
HK1186733A1 (zh) 2014-03-21
AR088678A1 (es) 2014-06-25
US8513410B2 (en) 2013-08-20
HRP20141023T1 (hr) 2014-12-05
NZ603483A (en) 2014-02-28
EA026510B1 (ru) 2017-04-28
CL2012003136A1 (es) 2014-08-01
SA112330994B1 (ar) 2015-08-03
AU2012244188B2 (en) 2015-07-30
DK2607353T3 (en) 2014-12-08
FR2984319B1 (fr) 2013-12-27
UY34423A (es) 2013-07-31
AU2012244188A1 (en) 2013-07-04
JP2013129650A (ja) 2013-07-04
JO3031B1 (ar) 2016-09-05
CY1115682T1 (el) 2017-01-25
CA2795741A1 (fr) 2013-06-20
KR20130071350A (ko) 2013-06-28

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG TJ TM RU