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EA200801580A1 - Новые производные пирониндола и способ их получения - Google Patents

Новые производные пирониндола и способ их получения

Info

Publication number
EA200801580A1
EA200801580A1 EA200801580A EA200801580A EA200801580A1 EA 200801580 A1 EA200801580 A1 EA 200801580A1 EA 200801580 A EA200801580 A EA 200801580A EA 200801580 A EA200801580 A EA 200801580A EA 200801580 A1 EA200801580 A1 EA 200801580A1
Authority
EA
Eurasian Patent Office
Prior art keywords
derivatives
new
pirininod
production
pyrindindole
Prior art date
Application number
EA200801580A
Other languages
English (en)
Other versions
EA015605B1 (ru
Inventor
Моше Лаудон
Таль Пелег-Шульман
Original Assignee
Ньюрим Фармасьютикалз (1991) Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ньюрим Фармасьютикалз (1991) Лтд. filed Critical Ньюрим Фармасьютикалз (1991) Лтд.
Publication of EA200801580A1 publication Critical patent/EA200801580A1/ru
Publication of EA015605B1 publication Critical patent/EA015605B1/ru

Links

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
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    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Veterinary Medicine (AREA)
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  • Engineering & Computer Science (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
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  • Gynecology & Obstetrics (AREA)
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Abstract

Настоящее изобретение относится к новым производным пирониндола, фармацевтическим препаратам, содержащим их, и к применению этих соединений в изготовлении лекарственных средств для лечения или предупреждения различных заболеваний.
EA200801580A 2006-02-15 2007-02-13 Производные пирониндола, фармацевтическая композиция и способы лечения EA015605B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77332206P 2006-02-15 2006-02-15
PCT/IB2007/000330 WO2007093880A2 (en) 2006-02-15 2007-02-13 Novel pyrone-indole derivatives and process for their preparation

Publications (2)

Publication Number Publication Date
EA200801580A1 true EA200801580A1 (ru) 2009-02-27
EA015605B1 EA015605B1 (ru) 2011-10-31

Family

ID=38283075

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200801580A EA015605B1 (ru) 2006-02-15 2007-02-13 Производные пирониндола, фармацевтическая композиция и способы лечения

Country Status (22)

Country Link
US (3) US7635710B2 (ru)
EP (1) EP1991541B1 (ru)
JP (1) JP5248332B2 (ru)
KR (1) KR101207736B1 (ru)
CN (1) CN101374833B (ru)
AU (1) AU2007216226B2 (ru)
BR (1) BRPI0706992C8 (ru)
CA (1) CA2642465C (ru)
DK (1) DK1991541T3 (ru)
EA (1) EA015605B1 (ru)
ES (1) ES2428873T3 (ru)
HK (1) HK1126760A1 (ru)
IL (1) IL193236A (ru)
NO (1) NO339826B1 (ru)
NZ (1) NZ569797A (ru)
PL (1) PL1991541T3 (ru)
PT (1) PT1991541E (ru)
SI (1) SI1991541T1 (ru)
TW (1) TWI501960B (ru)
UA (1) UA104988C2 (ru)
WO (1) WO2007093880A2 (ru)
ZA (1) ZA200806799B (ru)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7576131B2 (en) 1999-06-04 2009-08-18 Metabolex, Inc. Use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes, hyperlipidemia and hyperuricemia
US6262118B1 (en) * 1999-06-04 2001-07-17 Metabolex, Inc. Use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes and hyperlipidemia
CN103319467B (zh) * 2013-06-15 2015-10-14 湖南科技大学 一种4-[5-羟基-4-吡喃酮-2-基亚甲氨基]-3-巯基-1,2,4-三唑化合物及用途
TW201617333A (zh) * 2014-01-14 2016-05-16 安斯泰來製藥股份有限公司 吲哚化合物
RU2561045C1 (ru) * 2014-07-15 2015-08-20 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Кубанский государственный университет" (ФГБОУ ВПО "КубГУ") Нейропротекторное фармакологическое средство
US9567510B2 (en) 2014-09-11 2017-02-14 Halliburton Energy Services, Inc. Cyanamide-based carbon dioxide and/or hydrogen sulfide scavengers and methods of use in subterranean operations
JP6884703B2 (ja) 2015-02-25 2021-06-09 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニアＴｈｅ Ｒｅｇｅｎｔｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃａｌｉｆｏｒｎｉａ 障害を治療するための５ｈｔ作動薬
EP3503884B1 (en) * 2016-08-23 2021-07-21 Neurim Pharmaceuticals Ltd. Pharmaceutical composition for use in treating pruritus and/or itch
AU2018309049A1 (en) 2017-08-04 2020-02-27 Ovid Therapeutics Inc. Use of gaboxadol in the treatment of diabetes and related conditions
US11666888B2 (en) 2018-02-05 2023-06-06 Bio-Rad Laboratories, Inc. Chromatography resin having an anionic exchange-hydrophobic mixed mode ligand
CN112930182A (zh) 2018-09-20 2021-06-08 奥维德医疗公司 加波沙朵用于治疗图雷特综合征、抽搐和口吃的用途
KR20210105387A (ko) 2018-12-17 2021-08-26 오비드 테라퓨틱스 인크. 비-24 시간 수면-각성 장애의 치료를 위한 가복사돌의 사용
US20230172905A1 (en) * 2020-05-11 2023-06-08 B. G. Negev Technologies And Applications Ltd., At Ben-Gurion University Compositions of tryptophol derivatives and 4-ethyl-phenol derivatives, and methods of using same
BR112023023501A2 (pt) 2021-05-11 2024-02-27 Neurim Pharmaceuticals 1991 Ltd Método para diagnóstico e tratamento de indivíduos com polimorfismos de nucleotídeos únicos no cromossomo 2, locus 2:107.510.000107.540.000
WO2024150170A1 (en) 2023-01-13 2024-07-18 Neurim Pharmaceuticals (1991) Ltd. Piromelatine for treating parasomnias associated with loss of rem sleep atonia

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA222247A (en) 1922-08-15 Hubert Rogers Reginald Pocket container for confections
IT1196849B (it) 1986-12-16 1988-11-25 Rotta Research Lab Nuovi derivati degli acidi 5 pentilammino 5 oxo pentaoico e 4 pentilammino 4 oxo butanoico ad attivita antagonista della colecistochinina e procedimento per la loro preparazione
AU8876591A (en) 1990-11-02 1992-05-26 Upjohn Company, The Indole-3-methanamines useful as anti-diabetic, anti-obesity and anti-atherosclerotic agents
US5840751A (en) * 1993-11-19 1998-11-24 Warner-Lambert Company 5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents
EP0841063A1 (en) * 1996-03-27 1998-05-13 Toray Industries, Inc. Ketone derivatives and medicinal use thereof
IL130169A (en) * 1999-05-27 2006-08-20 Neurim Pharma 1991 Indole derivatives, and pharmaceutical preparations, skin protection preparations, and cosmetics containing them
EP1324993A2 (en) * 2000-04-18 2003-07-09 Cytovia, Inc. Substituted 1,4-thiazepine and analogs as activators of caspases and inducers of apoptosis and the use thereof
PE20060303A1 (es) 2004-06-23 2006-05-19 Wyeth Corp Metabolitos de indolilalquilamina como ligandos de 5-hidroxitriptamina-6
US7834050B2 (en) * 2006-03-29 2010-11-16 Duke University Small molecule insulin mimetics absent quinones

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ZA200806799B (en) 2009-10-28
US7635710B2 (en) 2009-12-22
CN101374833B (zh) 2012-06-27
CA2642465C (en) 2012-08-07
WO2007093880A3 (en) 2007-11-01
HK1126760A1 (en) 2009-09-11
US8242163B2 (en) 2012-08-14
NO339826B1 (no) 2017-02-06
CN101374833A (zh) 2009-02-25
ES2428873T3 (es) 2013-11-12
BRPI0706992A2 (pt) 2011-04-12
JP5248332B2 (ja) 2013-07-31
AU2007216226A2 (en) 2009-05-14
US20080027121A1 (en) 2008-01-31
WO2007093880A2 (en) 2007-08-23
NO20083905L (no) 2008-09-12
IL193236A (en) 2012-08-30
TWI501960B (zh) 2015-10-01
US8569355B2 (en) 2013-10-29
TW200835690A (en) 2008-09-01
AU2007216226A1 (en) 2007-08-23
DK1991541T3 (da) 2013-10-28
NZ569797A (en) 2010-06-25
BRPI0706992C1 (pt) 2021-05-18
EA015605B1 (ru) 2011-10-31
IL193236A0 (en) 2009-02-11
BRPI0706992C8 (pt) 2021-05-25
AU2007216226B2 (en) 2011-02-24
SI1991541T1 (sl) 2014-02-28
UA104988C2 (ru) 2014-04-10
PL1991541T3 (pl) 2013-12-31
US20100048662A1 (en) 2010-02-25
EP1991541B1 (en) 2013-07-24
EP1991541A2 (en) 2008-11-19
US20120302620A1 (en) 2012-11-29
JP2009526831A (ja) 2009-07-23
KR20080094945A (ko) 2008-10-27
PT1991541E (pt) 2013-10-02
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