EA201591371A1 - Пиридиновые производные в качестве легкоразлагаемых ингибиторов rock - Google Patents
Пиридиновые производные в качестве легкоразлагаемых ингибиторов rockInfo
- Publication number
- EA201591371A1 EA201591371A1 EA201591371A EA201591371A EA201591371A1 EA 201591371 A1 EA201591371 A1 EA 201591371A1 EA 201591371 A EA201591371 A EA 201591371A EA 201591371 A EA201591371 A EA 201591371A EA 201591371 A1 EA201591371 A1 EA 201591371A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- inhibitors
- rock
- pyridine derivatives
- easily degraded
- treatment
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 7
- 239000011435 rock Substances 0.000 title abstract 3
- 150000003222 pyridines Chemical class 0.000 title 1
- 230000006806 disease prevention Effects 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 2
- 208000018522 Gastrointestinal disease Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229940043355 kinase inhibitor Drugs 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 229940126601 medicinal product Drugs 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 abstract 1
- 230000000241 respiratory effect Effects 0.000 abstract 1
- 208000023504 respiratory system disease Diseases 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
- C07D273/01—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00 having one nitrogen atom
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Neurosurgery (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Изобретение относится к новым ингибиторам киназ, а именно, к ингибиторам ROCK, к композициям, в частности, фармацевтическим препаратам, содержащим такие ингибиторы, и к применениям таких ингибиторов в лечении и профилактике заболеваний. В частности, настоящее изобретение относится к новым ингибиторам ROCK, к композициям, в частности, фармацевтическим препаратам, содержащим такие ингибиторы, и к применениям таких ингибиторов в лечении и профилактике заболеваний. В дополнение, настоящее изобретение относится к способам лечения и применению указанных соединений при изготовлении лекарственного препарата для применения в ряде терапевтических показаний, в том числе при респираторных и желудочно-кишечных заболеваниях.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13153094 | 2013-01-29 | ||
| GB201303494A GB201303494D0 (en) | 2013-02-27 | 2013-02-27 | Novel soft rock inhibitors |
| PCT/EP2014/051546 WO2014118133A1 (en) | 2013-01-29 | 2014-01-27 | Pyridine derivatives as soft rock inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201591371A1 true EA201591371A1 (ru) | 2015-12-30 |
| EA029653B1 EA029653B1 (ru) | 2018-04-30 |
Family
ID=50112877
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201591371A EA029653B1 (ru) | 2013-01-29 | 2014-01-27 | Пиридиновые производные в качестве легкоразлагаемых ингибиторов rock |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US9682963B2 (ru) |
| EP (1) | EP2951172B8 (ru) |
| KR (1) | KR102275616B1 (ru) |
| CN (1) | CN105026387B (ru) |
| AU (1) | AU2014211580B2 (ru) |
| BR (1) | BR112015018168B1 (ru) |
| CA (1) | CA2898674C (ru) |
| CY (1) | CY1119227T1 (ru) |
| DK (1) | DK2951172T3 (ru) |
| EA (1) | EA029653B1 (ru) |
| ES (1) | ES2629762T3 (ru) |
| HR (1) | HRP20170940T1 (ru) |
| HU (1) | HUE033962T2 (ru) |
| IL (1) | IL240363B (ru) |
| LT (1) | LT2951172T (ru) |
| MX (1) | MX367818B (ru) |
| NZ (1) | NZ711424A (ru) |
| PL (1) | PL2951172T3 (ru) |
| PT (1) | PT2951172T (ru) |
| RS (1) | RS56089B1 (ru) |
| SG (1) | SG11201505867PA (ru) |
| SI (1) | SI2951172T1 (ru) |
| SM (1) | SMT201700317T1 (ru) |
| WO (1) | WO2014118133A1 (ru) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JOP20190024A1 (ar) | 2016-08-26 | 2019-02-19 | Gilead Sciences Inc | مركبات بيروليزين بها استبدال واستخداماتها |
| TWI800498B (zh) | 2016-12-21 | 2023-05-01 | 義大利商吉斯藥品公司 | 作為Rho-激酶抑制劑之雙環二氫嘧啶-羧醯胺衍生物 |
| EA039783B1 (ru) | 2017-01-30 | 2022-03-14 | КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. | ПРОИЗВОДНЫЕ ТИРОЗИНАМИДА В КАЧЕСТВЕ ИНГИБИТОРОВ Rho-КИНАЗЫ |
| EP3676262A4 (en) | 2017-09-03 | 2021-03-31 | Angion Biomedica Corp. | VINYLHETEROCYCLENE AS RHO-ASSOCIATED COILED COIL KINASE (ROCK) INHIBITORS |
| EP3679039B1 (en) | 2017-09-07 | 2021-06-16 | Chiesi Farmaceutici S.p.A. | Tyrosine analogues derivatives as rho- kinase inhibitors |
| WO2019121233A1 (en) | 2017-12-18 | 2019-06-27 | Chiesi Farmaceutici S.P.A. | Oxadiazole derivatives as rho-kinase inhibitors |
| MA51285A (fr) | 2017-12-18 | 2021-04-28 | Chiesi Farm Spa | Dérivés d'azaindole comme inhibiteurs de rho-kinase |
| EP3728246B1 (en) | 2017-12-18 | 2021-09-22 | Chiesi Farmaceutici S.p.A. | Meta tyrosine derivatives as rho-kinase inhibitors |
| CN111788204B (zh) | 2018-02-26 | 2023-05-05 | 吉利德科学公司 | 作为hbv复制抑制剂的取代吡咯嗪化合物 |
| AR114926A1 (es) | 2018-06-13 | 2020-10-28 | Chiesi Farm Spa | Derivados de azaindol como inhibidores de rho-quinasa |
| TW202019923A (zh) | 2018-07-16 | 2020-06-01 | 義大利商吉斯藥品公司 | 作為Ｒｈｏ－激酶抑制劑之酪胺酸醯胺衍生物 |
| CN110917352A (zh) * | 2019-10-22 | 2020-03-27 | 天津医科大学肿瘤医院 | Rock抑制剂在肿瘤免疫治疗中的新用法 |
| UY38979A (es) | 2019-12-06 | 2021-07-30 | Vertex Pharma | Tetrahidrofuranos sustituidos como moduladores de canales de sodio |
| WO2022128851A1 (en) | 2020-12-15 | 2022-06-23 | Chiesi Farmaceutici S.P.A. | Dihydrofuropyridine derivatives as rho- kinase inhibitors |
| US20240092790A1 (en) | 2020-12-15 | 2024-03-21 | Chiesi Farmaceutici S.P.A. | Dihydrofuropyridine derivatives as rho- kinase inhibitors |
| MX2023005866A (es) | 2020-12-15 | 2023-06-05 | Chiesi Farm Spa | Derivados de dihidrofuropiridina como inhibidores de rho-cinasa. |
| EP4347031A1 (en) | 2021-06-04 | 2024-04-10 | Vertex Pharmaceuticals Incorporated | N-(hydroxyalkyl (hetero)aryl) tetrahydrofuran carboxamides as modulators of sodium channels |
| WO2023110700A1 (en) | 2021-12-13 | 2023-06-22 | Chiesi Farmaceutici S.P.A. | Dihydrofuropyridine derivatives as rho-kinase inhibitors |
| JP2024534810A (ja) * | 2022-09-08 | 2024-09-26 | レデックス・ファーマ・リミテッド | Ｒｏｃｋ阻害剤の新規な形態 |
| GB202403179D0 (en) | 2024-03-05 | 2024-04-17 | Redx Pharma Plc | Method of making kinase inhibitors |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IS2334B (is) | 1992-09-08 | 2008-02-15 | Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) | Aspartyl próteasi hemjari af nýjum flokki súlfonamíða |
| US6043358A (en) | 1995-11-01 | 2000-03-28 | Merck & Co., Inc. | Hexahydro-5-imino-1,4-heteroazepine derivatives as inhibitors of nitric oxide synthases |
| GB9718913D0 (en) | 1997-09-05 | 1997-11-12 | Glaxo Group Ltd | Substituted oxindole derivatives |
| US6369087B1 (en) | 1999-08-26 | 2002-04-09 | Robert R. Whittle | Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same |
| CN101248046A (zh) * | 2005-07-11 | 2008-08-20 | 德福根有限公司 | 作为激酶抑制剂的酰胺衍生物 |
| CA2623500A1 (en) * | 2005-10-13 | 2007-04-19 | Devgen N.V. | Kinase inhibitors |
| PL2542528T3 (pl) | 2010-03-02 | 2013-11-29 | Amakem Nv | Heterocykliczne amidy jako inhibitory ROCK |
| GB201114854D0 (en) | 2011-08-29 | 2011-10-12 | Amakem Nv | Novel rock inhibitors |
| JP2014525427A (ja) | 2011-08-31 | 2014-09-29 | アマケン エンヴェー | Ｒｏｃｋキナーゼ阻害剤としてのビフェニルカルボキサミド |
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2014
- 2014-01-27 PT PT147045322T patent/PT2951172T/pt unknown
- 2014-01-27 RS RS20170620A patent/RS56089B1/sr unknown
- 2014-01-27 SM SM20170317T patent/SMT201700317T1/it unknown
- 2014-01-27 CA CA2898674A patent/CA2898674C/en active Active
- 2014-01-27 BR BR112015018168-6A patent/BR112015018168B1/pt active IP Right Grant
- 2014-01-27 SG SG11201505867PA patent/SG11201505867PA/en unknown
- 2014-01-27 KR KR1020157023210A patent/KR102275616B1/ko active Active
- 2014-01-27 ES ES14704532.2T patent/ES2629762T3/es active Active
- 2014-01-27 CN CN201480010186.7A patent/CN105026387B/zh active Active
- 2014-01-27 HU HUE14704532A patent/HUE033962T2/en unknown
- 2014-01-27 LT LTEP14704532.2T patent/LT2951172T/lt unknown
- 2014-01-27 US US14/763,594 patent/US9682963B2/en active Active
- 2014-01-27 WO PCT/EP2014/051546 patent/WO2014118133A1/en active Application Filing
- 2014-01-27 AU AU2014211580A patent/AU2014211580B2/en active Active
- 2014-01-27 SI SI201430261T patent/SI2951172T1/sl unknown
- 2014-01-27 EP EP14704532.2A patent/EP2951172B8/en active Active
- 2014-01-27 NZ NZ711424A patent/NZ711424A/en unknown
- 2014-01-27 EA EA201591371A patent/EA029653B1/ru unknown
- 2014-01-27 MX MX2015009674A patent/MX367818B/es active IP Right Grant
- 2014-01-27 DK DK14704532.2T patent/DK2951172T3/en active
- 2014-01-27 HR HRP20170940TT patent/HRP20170940T1/hr unknown
- 2014-01-27 PL PL14704532T patent/PL2951172T3/pl unknown
-
2015
- 2015-08-04 IL IL240363A patent/IL240363B/en active IP Right Grant
-
2017
- 2017-05-15 US US15/595,219 patent/US9850234B2/en active Active
- 2017-06-28 CY CY20171100684T patent/CY1119227T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC4A | Registration of transfer of a eurasian patent by assignment |