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EA200702030A1 - Производные альфа-кетоамидов в качестве ингибиторов цистеинпротеаз - Google Patents

Производные альфа-кетоамидов в качестве ингибиторов цистеинпротеаз

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Publication number
EA200702030A1
EA200702030A1 EA200702030A EA200702030A EA200702030A1 EA 200702030 A1 EA200702030 A1 EA 200702030A1 EA 200702030 A EA200702030 A EA 200702030A EA 200702030 A EA200702030 A EA 200702030A EA 200702030 A1 EA200702030 A1 EA 200702030A1
Authority
EA
Eurasian Patent Office
Prior art keywords
inhibitors
cysteinproteas
ketoamides
alpha
derivatives
Prior art date
Application number
EA200702030A
Other languages
English (en)
Other versions
EA017874B1 (ru
Inventor
Михаель Граупе
Джон О. Линк
Майкл Г. Роупл
Original Assignee
Эплера Корпорейшн
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Publication date
Application filed by Эплера Корпорейшн filed Critical Эплера Корпорейшн
Publication of EA200702030A1 publication Critical patent/EA200702030A1/ru
Publication of EA017874B1 publication Critical patent/EA017874B1/ru

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    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
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    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
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    • C07C275/06—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton
    • C07C275/16—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton being further substituted by carboxyl groups
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    • A61K31/10—Sulfides; Sulfoxides; Sulfones
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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  • Health & Medical Sciences (AREA)
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Abstract

Настоящее изобретение относится к соединениям, которые являются ингибиторами цистеинпротеаз, в частности катепсинов В, K, L, F и S и, следовательно, применимы в лечении заболеваний, опосредованных упомянутыми протеазами. Настоящее изобретение относится к фармацевтическим композициям и способам их получения.
EA200702030A 2005-03-21 2006-03-17 Производные альфа-кетоамидов в качестве ингибиторов цистеинпротеаз EA017874B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US66397005P 2005-03-21 2005-03-21
US68462305P 2005-05-24 2005-05-24
PCT/US2006/010063 WO2006102243A2 (en) 2005-03-21 2006-03-17 Alpha ketoamide compounds as cysteine protease inhibitors

Publications (2)

Publication Number Publication Date
EA200702030A1 true EA200702030A1 (ru) 2008-02-28
EA017874B1 EA017874B1 (ru) 2013-03-29

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ID=37024483

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EA200702030A EA017874B1 (ru) 2005-03-21 2006-03-17 Производные альфа-кетоамидов в качестве ингибиторов цистеинпротеаз
EA201201550A EA201201550A1 (ru) 2005-03-21 2006-03-17 Производные альфа-кетоамидов в качестве ингибиторов цистеинпротеаз

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EA201201550A EA201201550A1 (ru) 2005-03-21 2006-03-17 Производные альфа-кетоамидов в качестве ингибиторов цистеинпротеаз

Country Status (22)

Country Link
US (4) US7488848B2 (ru)
EP (2) EP2511257B1 (ru)
JP (2) JP5209466B2 (ru)
KR (1) KR101447897B1 (ru)
AU (1) AU2006227254B2 (ru)
BR (1) BRPI0609695A2 (ru)
CA (1) CA2602175C (ru)
CY (1) CY1114075T1 (ru)
DK (1) DK1865940T3 (ru)
EA (2) EA017874B1 (ru)
ES (1) ES2400582T3 (ru)
HR (1) HRP20130419T1 (ru)
IL (2) IL186102A (ru)
LV (1) LV13669B (ru)
MX (1) MX2007011617A (ru)
NO (2) NO340619B1 (ru)
NZ (1) NZ561681A (ru)
PL (1) PL1865940T3 (ru)
PT (1) PT1865940E (ru)
RS (1) RS52762B (ru)
TW (1) TWI384982B (ru)
WO (1) WO2006102243A2 (ru)

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US20070021353A1 (en) 2007-01-25
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IL221395A0 (en) 2012-09-24
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LV13669B (en) 2008-06-20
CA2602175C (en) 2012-11-27
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CA2602175A1 (en) 2006-09-28
EP1865940A4 (en) 2010-03-17
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