EA200101134A1 - Одно- и двузамещенные 3-пропил-гамма-аминомасляные кислоты - Google Patents
Одно- и двузамещенные 3-пропил-гамма-аминомасляные кислотыInfo
- Publication number
- EA200101134A1 EA200101134A1 EA200101134A EA200101134A EA200101134A1 EA 200101134 A1 EA200101134 A1 EA 200101134A1 EA 200101134 A EA200101134 A EA 200101134A EA 200101134 A EA200101134 A EA 200101134A EA 200101134 A1 EA200101134 A1 EA 200101134A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- disorders
- gamma
- propyl
- diplomed
- amino
- Prior art date
Links
- 239000002253 acid Substances 0.000 title abstract 2
- 150000007513 acids Chemical class 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000035475 disorder Diseases 0.000 abstract 2
- 208000002551 irritable bowel syndrome Diseases 0.000 abstract 2
- -1 3-propyl Chemical class 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 208000012895 Gastric disease Diseases 0.000 abstract 1
- 208000006083 Hypokinesia Diseases 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 206010003246 arthritis Diseases 0.000 abstract 1
- 208000002173 dizziness Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 206010015037 epilepsy Diseases 0.000 abstract 1
- 230000003483 hypokinetic effect Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 230000002981 neuropathic effect Effects 0.000 abstract 1
- 208000019116 sleep disease Diseases 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A61P25/10—Antiepileptics; Anticonvulsants for petit-mal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
- C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/20—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/30—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and unsaturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/32—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Настоящее изобретение представляет собой ряд новых одно- и двузамещенных 3-пропил-гамма-аминомасляных кислот формулы (I). Эти соединения являются полезными в качестве терапевтических агентов при лечении эпилепсии, приступов головокружения, гипокинезии, черепных расстройств, нейродегенеративных расстройств, депрессии, тревоги, паники, боли, невропатологических расстройств, артрита, нарушений сна, синдрома раздраженного кишечника (СРК) и желудочного нарушения. Способы получения этих соединений и полезных промежуточных соединений также входят в данное изобретение.Отчет о международном поиске был опубликован 2001.04.12.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13848599P | 1999-06-10 | 1999-06-10 | |
| PCT/US2000/015070 WO2000076958A2 (en) | 1999-06-10 | 2000-05-31 | Mono- and disubstituted 3-propyl gamma-aminobutyric acids |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA200101134A1 true EA200101134A1 (ru) | 2002-06-27 |
| EA004398B1 EA004398B1 (ru) | 2004-04-29 |
Family
ID=22482232
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200101134A EA004398B1 (ru) | 1999-06-10 | 2000-05-31 | Одно- и двузамещенные 3-пропил-гамма-аминомасляные кислоты |
Country Status (43)
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7164034B2 (en) | 1999-06-10 | 2007-01-16 | Pfizer Inc. | Alpha2delta ligands for fibromyalgia and other disorders |
| US6620829B2 (en) * | 2000-10-17 | 2003-09-16 | Warner-Lambert Company | Method of treating noninflammatory cartilage damage |
| US8048917B2 (en) | 2005-04-06 | 2011-11-01 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| KR20070108282A (ko) * | 2001-06-11 | 2007-11-08 | 제노포트 인코포레이티드 | 감소된 독성을 가진 ｇａｂａ 유사체 프로드러그의 구강투여용 투여 형태물 |
| ITMI20011308A1 (it) | 2001-06-21 | 2002-12-21 | Nicox Sa | Farmaci per il dolore cronico |
| MXPA04004105A (es) | 2002-01-31 | 2004-11-29 | Warner Lambert Co | Metodo de tratamiento de tinnitus. |
| NI200300043A (es) * | 2002-03-28 | 2003-11-05 | Warner Lambert Co | AMINOACIDOS CON AFINIDAD POR LA PROTEINA a2DELTA. |
| US20030225149A1 (en) * | 2002-04-30 | 2003-12-04 | Blazecka Peter G. | Process for preparing highly functionalized gamma-butyrolactams and gamma-amino acids |
| US7071339B2 (en) | 2002-08-29 | 2006-07-04 | Warner Lambert Company Llc | Process for preparing functionalized γ-butyrolactones from mucohalic acid |
| CA2451267A1 (en) | 2002-12-13 | 2004-06-13 | Warner-Lambert Company Llc | Pharmaceutical uses for alpha2delta ligands |
| AU2003303040B2 (en) | 2002-12-13 | 2009-04-23 | Warner-Lambert Company Llc | Pregabalin derivatives for the treatment of fibromyalgia and other disorders |
| ATE465725T1 (de) | 2002-12-13 | 2010-05-15 | Warner Lambert Co | Alpha-2-delta-ligand zur behandlung vonsymptomen der unteren harnwege |
| WO2004054565A1 (en) * | 2002-12-13 | 2004-07-01 | Warner-Lambert Company Llc | Pregabalin and derivates thereof for the treatment of fibromyalgia and other related disorders |
| ITMI20022658A1 (it) | 2002-12-17 | 2004-06-18 | Nicox Sa | Farmaci per il dolore cronico. |
| EP1680125A1 (en) * | 2003-07-02 | 2006-07-19 | Warner-Lambert Company LLC | Combination of an allosteric inhibitor of matrix metalloproteinase-13 and a ligand to an alpha-2-delta receptor |
| WO2005025675A1 (en) | 2003-09-12 | 2005-03-24 | Pfizer Limited | Combinations comprising alpha-2-delta ligands and serotonin / noradrenaline re-uptake inhibitors |
| MXPA06003396A (es) | 2003-09-25 | 2006-06-08 | Warner Lambert Co | Profarmacos de aminoacidos con afinidad por la proteina a 2d. |
| JP4001349B2 (ja) * | 2003-09-25 | 2007-10-31 | ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー | α２δ−タンパク質に親和性を有するアミノ酸 |
| WO2006043171A2 (en) * | 2004-10-23 | 2006-04-27 | Warner-Lambert Company Llc | Methods of using alpha2delta-1 selective compounds |
| CN101263113B (zh) * | 2005-09-15 | 2012-06-13 | Ucb医药有限公司 | 4-取代的-吡咯烷-2-酮及其用途 |
| US20070141684A1 (en) * | 2005-12-21 | 2007-06-21 | Pfizer Inc | Preparation of gamma-amino acids having affinity for the alpha-2-delta protein |
| AR061728A1 (es) * | 2006-06-30 | 2008-09-17 | Pfizer Prod Inc | Composicion para tratamiento usando compuestos selectivos alfa-2-delta-1 |
| ATE511860T1 (de) | 2006-12-22 | 2011-06-15 | Recordati Ireland Ltd | Kombinationstherapie für erkrankungen der unteren harnwege mit 2 liganden und nsar |
| WO2009136375A1 (en) * | 2008-05-08 | 2009-11-12 | Pfizer Inc | Treatment of interstitial cystitis |
| ES2758554T3 (es) | 2009-12-08 | 2020-05-05 | Univ Case Western Reserve | Aminoácidos gama para tratamiento de trastornos oculares |
| CN101914031B (zh) * | 2010-07-30 | 2013-08-28 | 中国广州分析测试中心 | 普瑞巴林衍生物及其应用 |
| SG11201803099SA (en) * | 2015-10-23 | 2018-05-30 | Navitor Pharm Inc | Modulators of sestrin-gator2 interaction and uses thereof |
| JP7644002B2 (ja) | 2018-10-24 | 2025-03-11 | ナビター ファーマシューティカルズ， インコーポレイテッド | 多形化合物およびその使用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2460891C2 (de) * | 1974-12-21 | 1982-09-23 | Gödecke AG, 1000 Berlin | 1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
| US4087544A (en) * | 1974-12-21 | 1978-05-02 | Warner-Lambert Company | Treatment of cranial dysfunctions using novel cyclic amino acids |
| AU9137091A (en) * | 1990-11-27 | 1992-06-25 | Northwestern University | Gaba and l-glutamic acid analogs for antiseizure treatment |
| US6197819B1 (en) * | 1990-11-27 | 2001-03-06 | Northwestern University | Gamma amino butyric acid analogs and optical isomers |
| HU222776B1 (hu) * | 1992-05-20 | 2003-10-28 | Northwestern University | (S)-(+)-4-amino-3-(2-metil-propil)-butánsav előállításának új hexánsav- és butándisav-származék köztitermékei és ezek előállítása |
| US5637767A (en) * | 1995-06-07 | 1997-06-10 | Warner-Lambert Company | Method of making (S)-3-(aminomethyl)-5-methylhexanoic acid |
| ES2200184T7 (es) * | 1996-07-24 | 2015-02-10 | Warner-Lambert Company Llc | Isobutilgaba y sus derivados para el tratamiento del dolor |
| CA2263663C (en) * | 1996-10-23 | 2006-05-30 | Justin Stephen Bryans | Substituted gamma aminobutyric acids as pharmaceutical agents |
| NZ503651A (en) * | 1997-10-27 | 2002-09-27 | Warner Lambert Co | Cyclic amino acids and derivatives thereof useful as pharmaceutical agents |
-
2000
- 2000-05-31 OA OA1200100326A patent/OA11962A/en unknown
- 2000-05-31 AP APAP/P/2002/002388A patent/AP1397A/en active
- 2000-05-31 HK HK02107862.8A patent/HK1046401B/zh not_active IP Right Cessation
- 2000-05-31 IL IL14696900A patent/IL146969A0/xx active IP Right Grant
- 2000-05-31 SK SK1764-2001A patent/SK287247B6/sk not_active IP Right Cessation
- 2000-05-31 EE EEP200100672A patent/EE200100672A/xx unknown
- 2000-05-31 CN CNB00808730XA patent/CN1196671C/zh not_active Expired - Fee Related
- 2000-05-31 BR BR0011727-7A patent/BR0011727A/pt not_active IP Right Cessation
- 2000-05-31 CN CNB2005100037011A patent/CN1310872C/zh not_active Expired - Fee Related
- 2000-05-31 CZ CZ20080760A patent/CZ301608B6/cs not_active IP Right Cessation
- 2000-05-31 PT PT00938022T patent/PT1192125E/pt unknown
- 2000-05-31 HR HR20020025A patent/HRP20020025A2/hr not_active Application Discontinuation
- 2000-05-31 SK SK5045-2009A patent/SK287399B6/sk not_active IP Right Cessation
- 2000-05-31 DZ DZ003253A patent/DZ3253A1/fr active
- 2000-05-31 ES ES00938022T patent/ES2317839T3/es not_active Expired - Lifetime
- 2000-05-31 AT AT00938022T patent/ATE419231T1/de not_active IP Right Cessation
- 2000-05-31 KR KR1020017015841A patent/KR100694735B1/ko not_active Expired - Fee Related
- 2000-05-31 AU AU53119/00A patent/AU776723C/en not_active Ceased
- 2000-05-31 GE GE4667A patent/GEP20074142B/en unknown
- 2000-05-31 HU HU0201601A patent/HUP0201601A3/hu unknown
- 2000-05-31 SI SI200031015T patent/SI1192125T1/sl unknown
- 2000-05-31 UA UA2001128283A patent/UA72519C2/uk unknown
- 2000-05-31 JP JP2001503818A patent/JP3904452B2/ja not_active Expired - Fee Related
- 2000-05-31 CZ CZ20014285A patent/CZ300834B6/cs not_active IP Right Cessation
- 2000-05-31 WO PCT/US2000/015070 patent/WO2000076958A2/en active Application Filing
- 2000-05-31 CA CA2374755A patent/CA2374755C/en not_active Expired - Fee Related
- 2000-05-31 MX MXPA01012319A patent/MXPA01012319A/es active IP Right Grant
- 2000-05-31 ME MEP-448/08A patent/MEP44808A/xx unknown
- 2000-05-31 CA CA2689997A patent/CA2689997A1/en not_active Abandoned
- 2000-05-31 DE DE60041256T patent/DE60041256D1/de not_active Expired - Lifetime
- 2000-05-31 RS RSP-2009/0257A patent/RS20090257A/sr unknown
- 2000-05-31 DK DK00938022T patent/DK1192125T3/da active
- 2000-05-31 TR TR2001/03587T patent/TR200103587T2/xx unknown
- 2000-05-31 EA EA200101134A patent/EA004398B1/ru not_active IP Right Cessation
- 2000-05-31 NZ NZ515668A patent/NZ515668A/xx not_active IP Right Cessation
- 2000-05-31 RS YUP-870/01A patent/RS50352B/sr unknown
- 2000-05-31 EP EP00938022A patent/EP1192125B9/en not_active Expired - Lifetime
- 2000-06-07 AR ARP000102808A patent/AR033335A1/es active IP Right Grant
- 2000-06-09 CO CO00043067A patent/CO5200791A1/es not_active Application Discontinuation
- 2000-06-09 PE PE2000000577A patent/PE20010285A1/es not_active Application Discontinuation
-
2001
- 2001-11-26 ZA ZA200109711A patent/ZA200109711B/en unknown
- 2001-11-28 IS IS6181A patent/IS6181A/is unknown
- 2001-12-05 NO NO20015949A patent/NO327746B1/no not_active IP Right Cessation
- 2001-12-06 IL IL146969A patent/IL146969A/en not_active IP Right Cessation
- 2001-12-06 CU CU20010291A patent/CU23101A3/es not_active IP Right Cessation
- 2001-12-07 CR CR6529A patent/CR6529A/es not_active Application Discontinuation
-
2002
- 2002-01-02 MA MA26462A patent/MA26804A1/fr unknown
- 2002-01-09 BG BG106292A patent/BG65561B1/bg unknown
-
2009
- 2009-02-26 CY CY20091100228T patent/CY1108827T1/el unknown
- 2009-03-13 NO NO20091094A patent/NO20091094L/no not_active Application Discontinuation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EA200101134A1 (ru) | Одно- и двузамещенные 3-пропил-гамма-аминомасляные кислоты | |
| MX9806069A (es) | Novedosos amino acidos ciclicos substituidos como agentes farmaceuticos. | |
| IL135314A0 (en) | Novel amines as pharmaceutical agents | |
| EA200200293A1 (ru) | Бициклические аминокислоты в качестве фармацевтических агентов | |
| NZ503651A (en) | Cyclic amino acids and derivatives thereof useful as pharmaceutical agents | |
| BR9810841A (pt) | Inibidores de metaloprotease alicìclicos | |
| EA200300952A1 (ru) | Конденсированные бициклические или трициклические аминокислоты | |
| EA199900669A1 (ru) | Промежуточные соединения для получения замещенных n-[аминоиминометил или аминометил)фенил]пропиламидов | |
| EA200200716A1 (ru) | Арилконденсированные азаполициклические соединения | |
| RU93049265A (ru) | Производные декагидроизохинолинов, способ получения, фармацевтическая композиция | |
| NO983612D0 (no) | Nye cykliske aminosyrer som farmasöytiske midler | |
| DK1187832T3 (da) | Aminoheterocycler, som er anvendelige som farmaceutiske midler | |
| NO20014241D0 (no) | C16-umettede FP-selektive prostaglandinanaloger | |
| YU41602A (sh) | Postupak za stereoselektivnu sintezu cikličnih aminokiselina | |
| BR0011039A (pt) | Análogos de gaba substituìdos com 3-heteroarilalquila | |
| DE60108130D1 (de) | Pharmazeutische zusammensetzungen zur behandlung von neurologischen krankheiten | |
| EA200500382A1 (ru) | Соединения тиазола для лечения нейродегенеративных расстройств | |
| CA2245647A1 (en) | Novel bridged cyclic amino acids as pharmaceutical agents | |
| ECSP003815A (es) | Metodo novedoso para la sintesis estereoselectiva de aminoacidos ciclicos |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| TC4A | Change in name of a patent proprietor in a eurasian patent |
Designated state(s): BY |
|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM RU |