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EA200100554A1 - Замещенные пиразолы как ингибиторы p38 киназы - Google Patents

Замещенные пиразолы как ингибиторы p38 киназы

Info

Publication number
EA200100554A1
EA200100554A1 EA200100554A EA200100554A EA200100554A1 EA 200100554 A1 EA200100554 A1 EA 200100554A1 EA 200100554 A EA200100554 A EA 200100554A EA 200100554 A EA200100554 A EA 200100554A EA 200100554 A1 EA200100554 A1 EA 200100554A1
Authority
EA
Eurasian Patent Office
Prior art keywords
kinase
inhibitors
substituted pyrazoles
class
correspond
Prior art date
Application number
EA200100554A
Other languages
English (en)
Other versions
EA005205B1 (ru
Inventor
Ашок Анантанараян
Майкл Клэр
Пол В. Коллинз
Джойс З. Крич
Раджеш Деврадж
Даньел Л. Флинн
Лифенг Дженг
Меттью Дж. Грането
Кэтлин Е. Хано
Гуннар Дж. Хэнсон
Сьюзен Дж. Хартманн
Майкл Хепперле
Хе Хуан
Иш К. Ханна
Фрэнсис Дж. Козик
Шуюан Лиао
Сьюзен Мец
Ричард А. Партис
Тао Д. Перри
Шашидхар Н. Рао
Шон Радж Селнесс
Майкл С. Саут
Майкл А. Стили
Джон Джеффри Талли
Майкл Л. Васкес
Ричард М. Уэйер
Ксянгдонг Ксу
И Ю
Original Assignee
Дж.Д.Сирл Энд Ко.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Дж.Д.Сирл Энд Ко. filed Critical Дж.Д.Сирл Энд Ко.
Publication of EA200100554A1 publication Critical patent/EA200100554A1/ru
Publication of EA005205B1 publication Critical patent/EA005205B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Описан класс производных пиразола для использования при лечении расстройств, опосредованных p38 киназой. Соединения, представляющие особый интерес, определены формулой (1), где R, R, Rи Rсоответствуют приведенному описанию.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200100554A 1998-11-20 1999-11-17 ЗАМЕЩЕННЫЕ ПИРАЗОЛЫ КАК ИНГИБИТОРЫ р38 КИНАЗЫ EA005205B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/196,623 US6514977B1 (en) 1997-05-22 1998-11-20 Substituted pyrazoles as p38 kinase inhibitors
PCT/US1999/026007 WO2000031063A1 (en) 1998-11-20 1999-11-17 SUBSTITUTED PYRAZOLES AS p38 KINASE INHIBITORS

Publications (2)

Publication Number Publication Date
EA200100554A1 true EA200100554A1 (ru) 2001-12-24
EA005205B1 EA005205B1 (ru) 2004-12-30

Family

ID=22726159

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200100554A EA005205B1 (ru) 1998-11-20 1999-11-17 ЗАМЕЩЕННЫЕ ПИРАЗОЛЫ КАК ИНГИБИТОРЫ р38 КИНАЗЫ

Country Status (35)

Country Link
US (5) US6514977B1 (ru)
EP (2) EP1144403B1 (ru)
JP (1) JP2002530397A (ru)
KR (1) KR20030002291A (ru)
CN (1) CN1342157A (ru)
AP (1) AP2001002172A0 (ru)
AR (1) AR035836A1 (ru)
AT (2) ATE373649T1 (ru)
AU (1) AU774262B2 (ru)
BG (1) BG105620A (ru)
BR (1) BR9915420A (ru)
CA (1) CA2351725A1 (ru)
CZ (1) CZ20011714A3 (ru)
DE (2) DE69920966T2 (ru)
DK (2) DK1144403T3 (ru)
EA (1) EA005205B1 (ru)
EE (1) EE200100268A (ru)
ES (2) ES2229809T3 (ru)
GE (1) GEP20053421B (ru)
HK (1) HK1040705B (ru)
HR (1) HRP20010363A2 (ru)
HU (1) HUP0200130A2 (ru)
ID (1) ID29993A (ru)
IL (1) IL143120A0 (ru)
IS (1) IS5938A (ru)
NO (1) NO20012456L (ru)
NZ (1) NZ512344A (ru)
OA (1) OA11914A (ru)
PL (1) PL353853A1 (ru)
PT (2) PT1144403E (ru)
SK (1) SK6862001A3 (ru)
TR (1) TR200102001T2 (ru)
WO (1) WO2000031063A1 (ru)
YU (1) YU35601A (ru)
ZA (1) ZA200103882B (ru)

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IL143120A0 (en) 2002-04-21
ATE373649T1 (de) 2007-10-15
NZ512344A (en) 2003-11-28
AP2001002172A0 (en) 2001-06-30
SK6862001A3 (en) 2002-06-04
US7153959B2 (en) 2006-12-26
PT1500657E (pt) 2007-12-05
DK1500657T3 (da) 2008-01-02
ATE278685T1 (de) 2004-10-15
OA11914A (en) 2006-04-11
US6423713B1 (en) 2002-07-23
EP1144403B1 (en) 2004-10-06
WO2000031063A1 (en) 2000-06-02
AR035836A1 (es) 2004-07-21
US6525059B1 (en) 2003-02-25
DE69920966T2 (de) 2006-03-09
KR20030002291A (ko) 2003-01-08
US20040176433A1 (en) 2004-09-09
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ID29993A (id) 2001-10-25
NO20012456L (no) 2001-07-19
US6617324B1 (en) 2003-09-09
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HK1040705A1 (en) 2002-06-21
EP1500657A1 (en) 2005-01-26
CA2351725A1 (en) 2000-06-02
BR9915420A (pt) 2002-01-22
PL353853A1 (en) 2003-12-01
PT1144403E (pt) 2005-01-31
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CZ20011714A3 (cs) 2001-12-12
AU774262B2 (en) 2004-06-24

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