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EA001154B1 - (4r,5s,6s,7r)-гексагидро-1-[5-(3-аминоиндазол)метил]-3-бутил-5,6-дигидрокси-4,7-бис[фенилметил]-2н-1,3-диазепин-2-он и его применение в качестве ингибитора вич-протеазы - Google Patents

(4r,5s,6s,7r)-гексагидро-1-[5-(3-аминоиндазол)метил]-3-бутил-5,6-дигидрокси-4,7-бис[фенилметил]-2н-1,3-диазепин-2-он и его применение в качестве ингибитора вич-протеазы Download PDF

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Publication number
EA001154B1
EA001154B1 EA199900451A EA199900451A EA001154B1 EA 001154 B1 EA001154 B1 EA 001154B1 EA 199900451 A EA199900451 A EA 199900451A EA 199900451 A EA199900451 A EA 199900451A EA 001154 B1 EA001154 B1 EA 001154B1
Authority
EA
Eurasian Patent Office
Prior art keywords
compound
formula
hiv
prodrug
pharmaceutically acceptable
Prior art date
Application number
EA199900451A
Other languages
English (en)
Russian (ru)
Other versions
EA199900451A1 (ru
Inventor
Джеймс Дэвид Роджерс
Патрик Юк-Сун Лэм
Original Assignee
Дюпон Фармасьютикалз Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Дюпон Фармасьютикалз Компани filed Critical Дюпон Фармасьютикалз Компани
Publication of EA199900451A1 publication Critical patent/EA199900451A1/ru
Publication of EA001154B1 publication Critical patent/EA001154B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Chemical & Material Sciences (AREA)
  • AIDS & HIV (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
EA199900451A 1996-11-08 1997-11-04 (4r,5s,6s,7r)-гексагидро-1-[5-(3-аминоиндазол)метил]-3-бутил-5,6-дигидрокси-4,7-бис[фенилметил]-2н-1,3-диазепин-2-он и его применение в качестве ингибитора вич-протеазы EA001154B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2974696P 1996-11-08 1996-11-08
US74710396A 1996-11-08 1996-11-08
PCT/US1997/020036 WO1998020009A1 (en) 1996-11-08 1997-11-04 (4r,5s,6s,7r)-hexahydro-1- [5-(3-aminoinazole)methyl] -3-butyl-5,6-dihydroxy-4,7-bis [phaenylmethyl] -2h-1,3-diazepin-2-one, its preparation and its use as hiv protease inhibitor

Publications (2)

Publication Number Publication Date
EA199900451A1 EA199900451A1 (ru) 1999-12-29
EA001154B1 true EA001154B1 (ru) 2000-10-30

Family

ID=26705295

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199900451A EA001154B1 (ru) 1996-11-08 1997-11-04 (4r,5s,6s,7r)-гексагидро-1-[5-(3-аминоиндазол)метил]-3-бутил-5,6-дигидрокси-4,7-бис[фенилметил]-2н-1,3-диазепин-2-он и его применение в качестве ингибитора вич-протеазы

Country Status (19)

Country Link
EP (1) EP0937066A1 (no)
JP (1) JP2001503429A (no)
KR (1) KR20000053123A (no)
CN (1) CN1235601A (no)
AU (1) AU722489B2 (no)
BR (1) BR9712755A (no)
CA (1) CA2270963A1 (no)
CZ (1) CZ157499A3 (no)
EA (1) EA001154B1 (no)
EE (1) EE9900187A (no)
HU (1) HUP9904143A3 (no)
IL (1) IL129726A0 (no)
LV (1) LV12374B (no)
NO (1) NO992229L (no)
NZ (1) NZ335919A (no)
PL (1) PL333412A1 (no)
SI (1) SI9720071A (no)
SK (1) SK59599A3 (no)
WO (1) WO1998020009A1 (no)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001518094A (ja) * 1997-03-31 2001-10-09 デュポン ファーマシューティカルズ カンパニー Ｈｉｖプロテアーゼ阻害剤として有用なインダゾール−環式尿素
US6194391B1 (en) * 1998-06-24 2001-02-27 Emory University 3′-azido-2′,3′-dideoxyuridine administration to treat HIV and related test protocol
FR2810039B1 (fr) 2000-06-13 2007-05-25 Centre Nat Rech Scient Composes urees cycliques et leur procede de preparation

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5610294A (en) * 1991-10-11 1997-03-11 The Du Pont Merck Pharmaceutical Company Substituted cyclic carbonyls and derivatives thereof useful as retroviral protease inhibitors
AU2871592A (en) * 1991-10-11 1993-05-03 Du Pont Merck Pharmaceutical Company, The Cyclic ureas and analogues useful as retroviral protease inhibitiors

Also Published As

Publication number Publication date
PL333412A1 (en) 1999-12-06
KR20000053123A (ko) 2000-08-25
IL129726A0 (en) 2000-02-29
SI9720071A (sl) 1999-12-31
CN1235601A (zh) 1999-11-17
EP0937066A1 (en) 1999-08-25
WO1998020009A1 (en) 1998-05-14
BR9712755A (pt) 1999-10-19
LV12374A (lv) 1999-11-20
CA2270963A1 (en) 1998-05-14
EE9900187A (et) 1999-12-15
JP2001503429A (ja) 2001-03-13
NO992229L (no) 1999-06-07
HUP9904143A2 (hu) 2000-06-28
AU722489B2 (en) 2000-08-03
AU5103398A (en) 1998-05-29
NO992229D0 (no) 1999-05-07
HUP9904143A3 (en) 2002-11-28
NZ335919A (en) 2000-09-29
CZ157499A3 (cs) 1999-11-17
SK59599A3 (en) 1999-12-10
EA199900451A1 (ru) 1999-12-29
LV12374B (en) 2000-04-20

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

PC4A Registration of transfer of a eurasian patent by assignment
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU