DK489477A - Pyrimido(6,1-a)isoquinolin-2-on-derivater og fremgangsmaade til fremstilling deraf - Google Patents

Pyrimido(6,1-a)isoquinolin-2-on-derivater og fremgangsmaade til fremstilling deraf

Info

Publication number: DK489477A
Authority: DK; Denmark
Prior art keywords: pyrimido; isoquinolin; derivatives; manufacturing
Prior art date: 1977-05-05

Application number

DK489477A

Other languages

English (en)

Other versions

DK158789C (da

DK158789B (da

Inventor

B Lal

H Darnauer

B K Bhattacharya

A N Dohadwalla

N J Souza

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1977-05-05

Filing date

1977-11-03

Publication date

1978-11-06

1977-05-05 Priority claimed from DE19772720085 external-priority patent/DE2720085A1/de

1977-11-03 Application filed by Hoechst Ag filed Critical Hoechst Ag

1978-11-06 Publication of DK489477A publication Critical patent/DK489477A/da

1990-07-16 Publication of DK158789B publication Critical patent/DK158789B/da

1990-11-26 Application granted granted Critical

1990-11-26 Publication of DK158789C publication Critical patent/DK158789C/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/650905—Six-membered rings having the nitrogen atoms in the positions 1 and 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pulmonology (AREA)
Immunology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)

DK489477A 1977-05-05 1977-11-03 Analogifremgangsmaade til fremstilling af pyrimido-(6,1-a)isoquinolin-2-imino-4-on-derivater og tilsvarende 2-thio-forbindelser til anvendelse som udgangsforbindelser ved fremgangsmaaden DK158789C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE2720085		1977-05-05
DE19772720085 DE2720085A1 (de)	1977-05-05	1977-05-05	Pyrimido(6,1-a)isochinolin-2-on- derivate

Publications (3)

Publication Number	Publication Date
DK489477A true DK489477A (da)	1978-11-06
DK158789B DK158789B (da)	1990-07-16
DK158789C DK158789C (da)	1990-11-26

Family

ID=6008073

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK489477A DK158789C (da)	1977-05-05	1977-11-03	Analogifremgangsmaade til fremstilling af pyrimido-(6,1-a)isoquinolin-2-imino-4-on-derivater og tilsvarende 2-thio-forbindelser til anvendelse som udgangsforbindelser ved fremgangsmaaden
DK267089A DK267089D0 (da)	1977-05-05	1989-06-01	Pyrimido(6,1-a)isoquinolin-2-on-derivater og fremgangsmaade til fremstilling deraf

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK267089A DK267089D0 (da)	1977-05-05	1989-06-01	Pyrimido(6,1-a)isoquinolin-2-on-derivater og fremgangsmaade til fremstilling deraf

Country Status (18)

Country	Link
US (2)	US4482556A (da)
JP (2)	JPS53137997A (da)
AT (1)	AT372383B (da)
BE (1)	BE862785A (da)
CH (2)	CH640854A5 (da)
DK (2)	DK158789C (da)
EG (1)	EG12982A (da)
ES (3)	ES464776A1 (da)
FI (1)	FI64370C (da)
FR (1)	FR2389623B1 (da)
GR (1)	GR72114B (da)
IL (1)	IL53336A (da)
IT (1)	IT1192252B (da)
NL (1)	NL185078C (da)
NO (2)	NO148032C (da)
PT (1)	PT67265B (da)
SE (2)	SE436357B (da)
ZA (1)	ZA776706B (da)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2847693A1 (de) *	1978-11-03	1980-05-22	Hoechst Ag	Verfahren zur herstellung von pyrimido-(6,1-a)-isochinolin-2-onen
FR2470130A2 (fr) *	1979-11-21	1981-05-29	Hoechst Ag	Derives de pyrimido (6,1-a) isoquinoleine-4-one, leur procede de preparation et leur application en therapeutique
DE3135831A1 (de) *	1981-09-10	1983-04-28	Hoechst Ag, 6230 Frankfurt	9,10-substituierte 2-mesitylimino-3-alkyl-3,4,6,7-tetrahydro-2h-pyrimido(6,1-a)isochinolin-4-one, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
CA1237429A (en) *	1983-05-05	1988-05-31	Frank Kienzle	Pyrimidone derivatives
DE3816995A1 (de) *	1988-05-19	1989-11-23	Hoechst Ag	Verwendung von pyrimido-(6,1-a)-isochinolin-4-on-derivaten und medizinische zubereitungen auf basis dieser verbindungen
EP0370379B1 (en) *	1988-11-19	1992-09-09	Hoechst Aktiengesellschaft	Pharmaceutical compositions comprising labdane diterpenoid derivatives and pyrimido(6,1-a) isoquinolin-4-one derivatives and their use
DK1165558T3 (da) *	1999-03-31	2004-02-09	Vernalis Ltd	Pyrimido[6,1-a]isoquinolin-4-on-derivater
EP1641766A2 (en) *	2003-07-08	2006-04-05	Smithkline Beecham Corporation	Novel chemical compounds
CN101671336B (zh)	2009-09-23	2013-11-13	辽宁利锋科技开发有限公司	芳杂环并嘧啶衍生物和类似物及其制备方法和用途
GB201613054D0 (en)	2016-07-28	2016-09-14	Verona Pharma Plc	New compound and process
PT3822272T (pt) *	2018-07-13	2025-01-22	Chia Tai Tianqing Pharmaceutical Group Co Ltd	Composto tricíclico fundido como inibidor duplo de pde3/pde4
KR20220127845A (ko) *	2020-01-15	2022-09-20	치아타이 티안큉 파마수티컬 그룹 주식회사	삼환 pde3/pde4 이중 억제제 화합물의 약학적 조성물
CA3167381A1 (en) *	2020-01-15	2021-07-22	Chia Tai Tianqing Pharmaceutical Group Co., Ltd	Crystal of pde3/pde4 dual inhibitor and use thereof
EP4332102A1 (en) *	2021-04-29	2024-03-06	Suzhou Suncadia Biopharmaceuticals Co., Ltd.	Isoquinolone compound and use thereof
GB202202297D0 (en)	2022-02-21	2022-04-06	Verona Pharma Plc	Formulation production process
WO2024088402A1 (zh) *	2022-10-28	2024-05-02	江苏恒瑞医药股份有限公司	一种异喹啉酮类化合物的晶型及其制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3021331A (en) *	1959-07-20	1962-02-13	Pfizer & Co C	Azabenzopyridocolines
US3081306A (en) *	1959-11-04	1963-03-12	Pfizer & Co C	2, 4-dioxo-3-aralkylaza-9, 10-di(lower alkoxy)-1, 2, 3, 4, 6, 7-hexahydro-11b-h-benzopyridocolines
US3297696A (en) *	1965-05-28	1967-01-10	Sandoz Ag	6-amino-8, 9-dihydro-13bh-isoquinolo-[2, 1-c] quinazolines and intermediates therefor
DE2126148A1 (en) *	1971-05-26	1972-12-07	Farbenfabriken Bayer Ag, 5090 Leverkusen	Prepn of uracil derivs - useful as plant - protection agents and their inters
DE2847693A1 (de) *	1978-11-03	1980-05-22	Hoechst Ag	Verfahren zur herstellung von pyrimido-(6,1-a)-isochinolin-2-onen
US5740368A (en) *	1995-06-30	1998-04-14	Canon Kabushiki Kaisha	Method and apparatus for providing information on a managed peripheral device to plural agents

1977
- 1977-11-02 FI FI773286A patent/FI64370C/fi not_active IP Right Cessation
- 1977-11-03 DK DK489477A patent/DK158789C/da active
- 1977-11-03 AT AT0784477A patent/AT372383B/de active
- 1977-11-04 SE SE7712513A patent/SE436357B/sv not_active IP Right Cessation
- 1977-11-08 IL IL53336A patent/IL53336A/xx unknown
- 1977-11-09 ZA ZA00776706A patent/ZA776706B/xx unknown
- 1977-11-11 PT PT67265A patent/PT67265B/pt unknown
- 1977-11-19 JP JP13845577A patent/JPS53137997A/ja active Granted
- 1977-12-02 NO NO774131A patent/NO148032C/no unknown
- 1977-12-06 ES ES464776A patent/ES464776A1/es not_active Expired
- 1977-12-10 EG EG680/77A patent/EG12982A/xx active
1978
- 1978-01-01 CH CH1331977A patent/CH640854A5/de not_active IP Right Cessation
- 1978-01-05 NL NLAANVRAGE7800149,A patent/NL185078C/xx not_active IP Right Cessation
- 1978-01-10 BE BE184225A patent/BE862785A/xx not_active IP Right Cessation
- 1978-02-02 FR FR7802935A patent/FR2389623B1/fr not_active Expired
- 1978-03-14 GR GR55702A patent/GR72114B/el unknown
- 1978-04-21 IT IT22619/78A patent/IT1192252B/it active
- 1978-08-16 ES ES472606A patent/ES472606A1/es not_active Expired
- 1978-10-19 CH CH1084178A patent/CH642949A5/de not_active IP Right Cessation
- 1978-11-13 ES ES475027A patent/ES475027A1/es not_active Expired
1980
- 1980-03-26 US US06/134,080 patent/US4482556A/en not_active Expired - Lifetime
1982
- 1982-04-19 NO NO821266A patent/NO821266L/no unknown
- 1982-11-19 SE SE8206619A patent/SE439307B/sv not_active IP Right Cessation
1984
- 1984-06-18 JP JP59123892A patent/JPS6041677A/ja active Granted
- 1984-09-19 US US06/652,005 patent/US4598148A/en not_active Expired - Lifetime
1989
- 1989-06-01 DK DK267089A patent/DK267089D0/da not_active Application Discontinuation

Also Published As

Publication number	Publication date
ZA776706B (en)	1978-08-30
FI64370B (fi)	1983-07-29
JPS6312871B2 (da)	1988-03-23
AT372383B (de)	1983-09-26
PT67265B (de)	1981-01-05
NL185078C (nl)	1990-01-16
NL185078B (nl)	1989-08-16
IT1192252B (it)	1988-03-31
JPS6225150B2 (da)	1987-06-01
EG12982A (en)	1982-03-31
JPS6041677A (ja)	1985-03-05
DK267089A (da)	1989-06-01
SE7712513L (sv)	1978-11-06
BE862785A (fr)	1978-07-10
CH642949A5 (de)	1984-05-15
CH640854A5 (de)	1984-01-31
IT7822619A0 (it)	1978-04-21
SE8206619L (sv)	1982-11-19
FI773286A (fi)	1978-11-06
NO148032B (no)	1983-04-18
SE8206619D0 (sv)	1982-11-19
IL53336A0 (en)	1978-01-31
NO774131L (no)	1978-11-07
IL53336A (en)	1984-02-29
NO821266L (no)	1978-11-07
SE439307B (sv)	1985-06-10
ES475027A1 (es)	1979-05-16
DK158789C (da)	1990-11-26
US4598148A (en)	1986-07-01
FR2389623B1 (da)	1980-10-31
GR72114B (da)	1983-09-15
PT67265A (de)	1977-12-01
ES464776A1 (es)	1979-01-01
DK158789B (da)	1990-07-16
NL7800149A (nl)	1978-11-07
SE436357B (sv)	1984-12-03
FI64370C (fi)	1983-11-10
ATA784477A (de)	1983-02-15
FR2389623A1 (da)	1978-12-01
DK267089D0 (da)	1989-06-01
JPS53137997A (en)	1978-12-01
ES472606A1 (es)	1979-02-16
NO148032C (no)	1983-07-27
US4482556A (en)	1984-11-13

Publication	Publication Date	Title
DK228878A (da)	1978-11-26	Pyrimidinderivater og fremgangsmaade til fremstilling deraf
DK556978A (da)	1979-06-16	Acylanilid og fremgangsmaade til fremstilling deraf
DK508077A (da)	1978-05-17	Hidtil ukendte spirolactoner og fremgangsmaade til fremstilling deraf
NO783307L (no)	1979-04-04	C-076 forbindelser og derivater.
DK117377A (da)	1977-09-19	Provemiddel, proveudstyr og provemetode
NO780991L (no)	1978-09-29	Roentgenopake forbindelser og fremgangsmaate for fremstilling derav
NO142844C (no)	1980-10-29	Fremgangsmaate og naalbaandvevstol for fremstilling av gurtbaand
IT7830205A0 (it)	1978-11-24	Derivati di 1,3,4,5-tetraidrobenz-indolo erelativo procedimento per fabbricarli.
DK336878A (da)	1979-01-30	Prostaglandin-12-derivater og fremgangsmaade til fremstilling heraf
DK478677A (da)	1978-04-29	Aminoglycosidderivater og fremgangsmaade til fremstilling deraf
DK489477A (da)	1978-11-06	Pyrimido(6,1-a)isoquinolin-2-on-derivater og fremgangsmaade til fremstilling deraf
DK546776A (da)	1977-06-06	Quinazolinderivater og fremgangsmade til fremstilling deraf
DK39179A (da)	1979-08-01	2h-benzofuran-3-on-derivater og fremgangsmaade til fremstilling deraf
DK421480A (da)	1981-04-13	Fremgangsmaade og anlaeg til broendlogging
DK428477A (da)	1978-03-30	1h-pyrazolo (3,4-b)pyridiner og fremgangsmaade til fremstilling deraf
DK188279A (da)	1979-11-10	Purin-derivater og fremgangsmaade til fremstilling deraf
DK307577A (da)	1978-01-15	5-aroyl-1,2-dihydro-3h-pyrrol (1,2-a) pyrrol-1-carboxylsyrederivater og fremgangsmade til fremstilling deraf
PL207947A1 (pl)	1979-10-22	Sposob wytwarzania n-amidyno-3,5-dwuamino-2-pirazynokarboksamidow,podstawionych w pozycji 6
NL7811035A (nl)	1979-05-09	Chinolylguanidinederivaten en werkwijze ter bereiding daarvan.
DK313878A (da)	1979-01-14	Indolderivater og fremgangsmaade til fremstilling deraf
DK150778A (da)	1978-10-06	Prostanderivater og fremgangsmaade til fremstilling heraf
DK297477A (da)	1978-01-03	5-o-acylerede imidazol-4-carboxamidderivater og fremgangsmade til fremstilling deraf
DK213176A (da)	1976-11-15	Antraquinon-bis-amidiner og fremgangsmade til fremstilling deraf
DK270077A (da)	1977-12-22	6,7-benzomorphanderivater og fremgangsmade til deres fremstillling
NL7707172A (nl)	1979-01-02	Trek-walswerkwijze en walsinrichting.