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DK228878A - Pyrimidinderivater og fremgangsmaade til fremstilling deraf - Google Patents

Pyrimidinderivater og fremgangsmaade til fremstilling deraf

Info

Publication number
DK228878A
DK228878A DK228878A DK228878A DK228878A DK 228878 A DK228878 A DK 228878A DK 228878 A DK228878 A DK 228878A DK 228878 A DK228878 A DK 228878A DK 228878 A DK228878 A DK 228878A
Authority
DK
Denmark
Prior art keywords
pyrimidian
derivatives
manufacturing
pyrimidian derivatives
Prior art date
Application number
DK228878A
Other languages
English (en)
Other versions
DK160279B (da
DK160279C (da
Inventor
P F Juby
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of DK228878A publication Critical patent/DK228878A/da
Publication of DK160279B publication Critical patent/DK160279B/da
Application granted granted Critical
Publication of DK160279C publication Critical patent/DK160279C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
DK228878A 1977-05-25 1978-05-23 Analogifremgangsmaade til fremstilling af 3-(1h-tetrazol-5-yl)-4h-pyrido(1,2-a)pyrimidin-4-on-derivater DK160279C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80026477 1977-05-25
US05/800,264 US4122274A (en) 1977-05-25 1977-05-25 3-Tetrazolo-5,6,7,8-substituted-pyrido[1,2-a]pyrimidin-4-ones

Publications (3)

Publication Number Publication Date
DK228878A true DK228878A (da) 1978-11-26
DK160279B DK160279B (da) 1991-02-18
DK160279C DK160279C (da) 1991-07-22

Family

ID=25177928

Family Applications (1)

Application Number Title Priority Date Filing Date
DK228878A DK160279C (da) 1977-05-25 1978-05-23 Analogifremgangsmaade til fremstilling af 3-(1h-tetrazol-5-yl)-4h-pyrido(1,2-a)pyrimidin-4-on-derivater

Country Status (26)

Country Link
US (1) US4122274A (da)
JP (1) JPS6050197B2 (da)
AT (1) AT365187B (da)
AU (1) AU521211B2 (da)
BE (1) BE867295A (da)
CA (1) CA1098520A (da)
CH (1) CH642656A5 (da)
CY (1) CY1218A (da)
DE (1) DE2822544A1 (da)
DK (1) DK160279C (da)
FI (1) FI64594C (da)
FR (1) FR2401159A1 (da)
GB (1) GB1596476A (da)
GR (1) GR71887B (da)
HK (1) HK25884A (da)
IE (1) IE46849B1 (da)
IT (1) IT1105040B (da)
KE (1) KE3357A (da)
LU (1) LU79694A1 (da)
MY (1) MY8500305A (da)
NL (1) NL190702C (da)
NO (1) NO150361C (da)
SE (1) SE437830B (da)
SG (1) SG73383G (da)
YU (2) YU42163B (da)
ZA (1) ZA782816B (da)

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HU173438B (hu) * 1975-11-27 1979-05-28 Chinoin Gyogyszer Es Vegyeszet Sposob poluchenija novykh proizvodnykh 4-okso-1,6,7,8-/tetragidro-4h-pirido/1,2/pirimidina s zaderzhivajuhhejj vozgoranie aktivnot'ju i protivosvertivajuhhem effektom
US4495189A (en) * 1975-11-27 1985-01-22 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara R.T. Condensed pyrimidines
HU180439B (en) * 1977-12-29 1983-03-28 Chinoin Gyogyszer Es Vegyeszet Process for producing 9-amino-pyrido-square bracket-1,2-a-square bracket closed-pyrimidine derivatives
US4192944A (en) * 1978-04-03 1980-03-11 Bristol-Myers Company Optionally substituted 4-oxo-4H-pyrido[1,2-a]pyrimidine-3-N-(1H-tetrazol-4-yl)carboxamides and their use as antiallergy agents
US4223031A (en) * 1978-05-05 1980-09-16 Mead Johnson & Company Azolopyrimidinones
US4491587A (en) * 1978-05-05 1985-01-01 Mead Johnson & Company Tetrazole derivatives
US4282360A (en) * 1979-10-12 1981-08-04 Hoffmann-La Roche Inc. 7-Methylthio or methylsulfinyl-5-oxo-5H-thiazolo[2,3-b]quinazoline-2-carboxylic acid
US4419357A (en) * 1982-01-18 1983-12-06 The Dow Chemical Company 3-(1H-Tetrazol-5-yl)-4(3H)-quinazolinones
US4474953A (en) * 1982-09-09 1984-10-02 Riker Laboratories, Inc. Process and intermediates for the preparation of 3(1H-tetrazol-5-yl)-4H-pyrido[1,2-a]pyrimidin-4-ones
US4476130A (en) * 1982-09-09 1984-10-09 Riker Laboratories, Inc. 3-(1H-Tetrazol-5-yl)-4H-pyrimido[2,1-b]benzoxazol-4-one compounds exhibiting anti-allergic activity
US4507477A (en) * 1982-09-09 1985-03-26 Riker Laboratories, Inc. Process for tetrazolyl-pyrimidinone derivatives
US4457932A (en) * 1983-07-22 1984-07-03 Bristol-Myers Company Anti-ulcer agents
DK169580B1 (da) * 1985-09-25 1994-12-12 Shionogi & Co 9-(substitueret thio)-4H-pyrido[1,2-a]pyrimidin-4-on-derivater, fremgangsmåde til fremstilling deraf samt farmaceutiske præparater indeholdende sådanne derivater
JPS63183581A (ja) * 1985-10-03 1988-07-28 Tokyo Tanabe Co Ltd ピリド〔１，２−ａ〕ピリミジン誘導体、その製造法及びそれを有効成分とするアレルギ−疾患治療薬
JPS62242682A (ja) * 1986-04-16 1987-10-23 Tokyo Tanabe Co Ltd 新規なピリド［１，２―ａ］ピリミジン誘導体及びその製造法
JP2504788B2 (ja) * 1987-11-10 1996-06-05 東京田辺製薬株式会社 ９−メチル−３−（１Ｈ−テトラゾ―ル−５−イル）−４Ｈ−ピリド［１，２−ａ］ピリミジン−４−オンカリウム塩の水性製剤
DE3882042T2 (de) * 1987-12-25 1993-09-30 Santen Pharma Co Ltd Antiallergische augentropfen.
CA2010336C (en) * 1989-02-27 1996-11-19 Atsunori Sano Process for producing pyrido[1,2-a]pyrimidine derivative
HU209793B (en) * 1990-09-25 1994-11-28 Chinoin Gyogyszer Es Vegyeszet Process for the production of pyrido[1,2-a]pyrimidine-derivatives and pharmaceutical compositions containing the same
CA2138957A1 (en) 1992-07-30 1994-02-17 Shigeki Omura A remedy for inflammatory intestinal diseases
US5527802A (en) * 1992-10-01 1996-06-18 Bristol-Myers Squibb Company New uses of 3-tetrazolo -5,6,7,8- substituted-pyrido (1,2-a) pyrimidin-4-ones
JPH0892093A (ja) * 1994-11-10 1996-04-09 Tokyo Tanabe Co Ltd ９−メチル−３−（１Ｈ−テトラゾール−５−イル）−４Ｈ−ピリド［１，２−ａ］ピリミジン−４−オンの水性製剤
KR100885007B1 (ko) * 2001-02-26 2009-02-20 미쓰비시 타나베 파마 코퍼레이션 신질환·신부전의 예방 또는 치료를 위한 약학 조성물
ITMI20011764A1 (it) 2001-08-10 2003-02-10 Dinamite Dipharma Spa Metodo per l'ottenimento del pemirolast ad elevata purezza
GB0316546D0 (en) * 2003-07-15 2003-08-20 Novartis Ag Process for the manufacture of organic compounds
CN101610765A (zh) * 2006-12-18 2009-12-23 卡多兹公司 用于治疗炎症的新组合物
WO2008075028A1 (en) * 2006-12-20 2008-06-26 Cardoz Ab New combination for use in the treatment of inflammatory disorders
AU2008273997A1 (en) * 2007-07-11 2009-01-15 Cardoz Ab Combination for use in the treatment of atherosclerosis comprising a mast cell inhibitor and a PPAR gamma agonist
WO2009007675A2 (en) * 2007-07-11 2009-01-15 Cardoz Ab Combination for use in the treatment of atherosclerosis comprising a mast cell inhibitor and a p2 gamma 12 antagonist
WO2009007679A2 (en) * 2007-07-11 2009-01-15 Cardoz Ab Combination for use in the treatment of atherosclerosis comprising a mast cell inhibitor and a thromboxane a2 antagonist
EP2303251B1 (en) * 2008-04-07 2012-05-16 Cardoz AB New combination for use in the treatment of inflammatory disorders
HUE032978T2 (hu) * 2009-06-16 2017-11-28 Rspr Pharma Ab Pemirolaszt kristályos formában
USD661900S1 (en) 2010-02-22 2012-06-19 Bajer Design & Marketing, Inc. Collapsible structure
CN108299314B (zh) * 2012-02-10 2024-11-26 Ptc医疗公司 用于治疗脊髓性肌萎缩的化合物
EP2819519B1 (en) 2012-03-01 2019-10-23 PTC Therapeutics, Inc. Compounds for treating spinal muscular atrophy
BR112014023483B1 (pt) 2012-03-23 2022-05-10 Ptc Therapeutics, Inc Composto e seu uso, composição farmacêutica e seu uso
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US3072485A (en) * 1960-08-24 1963-01-08 Eastman Kodak Co Optically sensitized azido polymers for photomechanical resist compositions
AT299212B (de) * 1966-11-02 1972-06-12 Chinoin Gyogyszer Es Vegyeszet Verfahren zur Herstellung von neuen Homopyrimidazol-Derivaten sowie von deren Salzen
US3960847A (en) * 1972-04-17 1976-06-01 E. R. Squibb & Sons, Inc. 9-Substituted-4-oxopyrido(1,2-α)pyrimidine-3-carboxylic acids and derivatives thereof
US3929787A (en) * 1974-04-22 1975-12-30 Squibb & Sons Inc 6,7,8,9-Tetrahydro-pyrido(1,2-a)pyrimidin-4-ones
US3960863A (en) * 1974-06-25 1976-06-01 Sankyo Company Limited Pyrido[1,2-a]pyrimidinone derivatives
US4017625A (en) * 1975-08-01 1977-04-12 Pfizer Inc. Anti-allergic N-(5-tetrazolyl)-1-oxo-1H-6-alkoxypyrimido-[1,2-a]quinoline-2-carboxamides and intermediates therefor
US4012387A (en) * 1975-09-18 1977-03-15 Warner-Lambert Company Benzo-[g]pyrido[2,1-b]quinazolinones

Also Published As

Publication number Publication date
HK25884A (en) 1984-03-30
YU123678A (en) 1983-02-28
YU233082A (en) 1988-08-31
NO150361C (no) 1984-10-03
GR71887B (da) 1983-08-04
ATA373278A (de) 1981-05-15
AU521211B2 (en) 1982-03-25
CA1098520A (en) 1981-03-31
KE3357A (en) 1984-02-03
CH642656A5 (de) 1984-04-30
SE437830B (sv) 1985-03-18
SG73383G (en) 1984-08-03
LU79694A1 (fr) 1979-02-02
JPS5436294A (en) 1979-03-16
AU3631978A (en) 1979-11-29
FI781614A (fi) 1978-11-26
US4122274A (en) 1978-10-24
NL190702B (nl) 1994-02-01
DE2822544C2 (da) 1988-10-27
SE7805954L (sv) 1978-11-26
IT7849523A0 (it) 1978-05-24
BE867295A (fr) 1978-11-20
IE46849B1 (en) 1983-10-05
DK160279B (da) 1991-02-18
FR2401159B1 (da) 1983-05-20
FI64594B (fi) 1983-08-31
NO781786L (no) 1978-11-28
JPS6050197B2 (ja) 1985-11-07
YU42163B (en) 1988-06-30
NL190702C (nl) 1994-07-01
DE2822544A1 (de) 1978-12-07
FR2401159A1 (fr) 1979-03-23
MY8500305A (en) 1985-12-31
GB1596476A (en) 1981-08-26
AT365187B (de) 1981-12-28
DK160279C (da) 1991-07-22
IT1105040B (it) 1985-10-28
ZA782816B (en) 1979-05-30
YU44212B (en) 1990-04-30
CY1218A (en) 1984-04-06
IE781036L (en) 1978-11-25
NO150361B (no) 1984-06-25
NL7805534A (nl) 1978-11-28
FI64594C (fi) 1983-12-12

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