DK3585892T3 - Fremgangsmåder til oprensning af messenger-rna - Google Patents
Fremgangsmåder til oprensning af messenger-rna Download PDFInfo
- Publication number
- DK3585892T3 DK3585892T3 DK18711737.9T DK18711737T DK3585892T3 DK 3585892 T3 DK3585892 T3 DK 3585892T3 DK 18711737 T DK18711737 T DK 18711737T DK 3585892 T3 DK3585892 T3 DK 3585892T3
- Authority
- DK
- Denmark
- Prior art keywords
- purification
- methods
- messenger rna
- messenger
- rna
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
- C12N15/1006—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
- C12N15/1017—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by filtration, e.g. using filters, frits, membranes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1065—Preparation or screening of tagged libraries, e.g. tagged microorganisms by STM-mutagenesis, tagged polynucleotides, gene tags
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y201/00—Transferases transferring one-carbon groups (2.1)
- C12Y201/03—Carboxy- and carbamoyltransferases (2.1.3)
- C12Y201/03003—Ornithine carbamoyltransferase (2.1.3.3)
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Computational Biology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762463981P | 2017-02-27 | 2017-02-27 | |
| PCT/US2018/019978 WO2018157141A1 (en) | 2017-02-27 | 2018-02-27 | Methods for purification of messenger rna |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3585892T3 true DK3585892T3 (da) | 2022-08-22 |
Family
ID=61683899
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK18711737.9T DK3585892T3 (da) | 2017-02-27 | 2018-02-27 | Fremgangsmåder til oprensning af messenger-rna |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US10975369B2 (da) |
| EP (2) | EP3585892B8 (da) |
| AU (1) | AU2018224318B2 (da) |
| CA (1) | CA3054323A1 (da) |
| DK (1) | DK3585892T3 (da) |
| ES (1) | ES2925083T3 (da) |
| HU (1) | HUE059594T2 (da) |
| IL (1) | IL268856B2 (da) |
| MA (1) | MA47606A (da) |
| WO (1) | WO2018157141A1 (da) |
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| DK3336082T3 (da) | 2011-06-08 | 2020-04-27 | Translate Bio Inc | Spaltelige lipider |
| DK3585892T3 (da) * | 2017-02-27 | 2022-08-22 | Translate Bio Inc | Fremgangsmåder til oprensning af messenger-rna |
| EP3668979A4 (en) | 2017-08-18 | 2021-06-02 | Modernatx, Inc. | METHOD OF HPLC ANALYSIS |
| MA50803A (fr) | 2017-11-22 | 2020-09-30 | Modernatx Inc | Polynucléotides codant pour l'ornithine transcarbamylase pour le traitement de troubles du cycle de l'urée |
| CA3097912A1 (en) * | 2018-05-15 | 2019-11-21 | Translate Bio, Inc. | Subcutaneous delivery of messenger rna |
| CN118421617A (zh) | 2018-08-24 | 2024-08-02 | 川斯勒佰尔公司 | 用于纯化信使rna的方法 |
| PT3924487T (pt) * | 2019-02-11 | 2024-05-31 | Ethris Gmbh | Purificação de arnm por filtração de fluxo tangencial |
| WO2020185811A1 (en) | 2019-03-11 | 2020-09-17 | Modernatx, Inc. | Fed-batch in vitro transcription process |
| CN115461042A (zh) | 2019-12-20 | 2022-12-09 | 翻译生物公司 | 制备负载mrna的脂质纳米颗粒的改进方法 |
| KR20220142432A (ko) | 2019-12-20 | 2022-10-21 | 트랜슬레이트 바이오 인코포레이티드 | 메신저 rna의 직장 전달 |
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| WO2021226461A1 (en) * | 2020-05-07 | 2021-11-11 | Translate Bio, Inc. | Generation of optimized nucleotide sequences |
| US20230190954A1 (en) | 2020-05-07 | 2023-06-22 | Translate Bio, Inc. | Composition and methods for treatment of primary ciliary dyskinesia |
| JP2023524767A (ja) | 2020-05-07 | 2023-06-13 | トランスレイト バイオ， インコーポレイテッド | ＳＡＲＳ－ＣｏＶ－２抗原をコードする最適化されたヌクレオチド配列 |
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| AU2021361986A1 (en) | 2020-10-12 | 2023-06-15 | Translate Bio, Inc. | Improved process of preparing mrna-loaded lipid nanoparticles |
| JP2023546175A (ja) | 2020-10-14 | 2023-11-01 | ジョージ・メイソン・リサーチ・ファウンデーション・インコーポレイテッド | 脂質ナノ粒子製造の方法及びそれに由来する組成物 |
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2018
- 2018-02-27 DK DK18711737.9T patent/DK3585892T3/da active
- 2018-02-27 CA CA3054323A patent/CA3054323A1/en active Pending
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| EP4008783A1 (en) | 2022-06-08 |
| EP3585892B1 (en) | 2022-06-01 |
| US12410422B2 (en) | 2025-09-09 |
| AU2018224318B2 (en) | 2024-06-20 |
| HUE059594T2 (hu) | 2022-11-28 |
| US20210180041A1 (en) | 2021-06-17 |
| EP3585892A1 (en) | 2020-01-01 |
| EP3585892B8 (en) | 2022-07-13 |
| IL268856A (en) | 2019-10-31 |
| IL268856B2 (en) | 2024-09-01 |
| WO2018157141A1 (en) | 2018-08-30 |
| ES2925083T3 (es) | 2022-10-13 |
| IL268856B1 (en) | 2024-05-01 |
| US20180251754A1 (en) | 2018-09-06 |
| AU2018224318A1 (en) | 2019-09-19 |
| MA47606A (fr) | 2021-04-07 |
| CA3054323A1 (en) | 2018-08-30 |
| US10975369B2 (en) | 2021-04-13 |
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