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DK3303339T3 - Pde9-inhibitorer med imidazotriazinonskelet og imidazopyrazinonskelet til behandling af perifere sygdomme - Google Patents

Pde9-inhibitorer med imidazotriazinonskelet og imidazopyrazinonskelet til behandling af perifere sygdomme Download PDF

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Publication number
DK3303339T3
DK3303339T3 DK16734707.9T DK16734707T DK3303339T3 DK 3303339 T3 DK3303339 T3 DK 3303339T3 DK 16734707 T DK16734707 T DK 16734707T DK 3303339 T3 DK3303339 T3 DK 3303339T3
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DK
Denmark
Prior art keywords
skeleline
imidazotriazinon
imidazopyrazinon
treatment
pde9 inhibitors
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DK16734707.9T
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English (en)
Inventor
Kate Wen
Niels Svenstrup
Yazhou Wang
Original Assignee
H Lundbeck As
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Publication of DK3303339T3 publication Critical patent/DK3303339T3/da

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/02Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/08Drugs for disorders of the urinary system of the prostate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10Drugs for genital or sexual disorders; Contraceptives for impotence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK16734707.9T 2015-07-07 2016-07-06 Pde9-inhibitorer med imidazotriazinonskelet og imidazopyrazinonskelet til behandling af perifere sygdomme DK3303339T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DKPA201500393 2015-07-07
DKPA201500407 2015-07-10
DKPA201600209 2016-04-07
PCT/EP2016/065964 WO2017005786A1 (en) 2015-07-07 2016-07-06 Pde9 inhibitors with imidazo triazinone backbone and imidazo pyrazinone backbone for treatment of peripheral diseases

Publications (1)

Publication Number Publication Date
DK3303339T3 true DK3303339T3 (da) 2021-04-12

Family

ID=56345156

Family Applications (2)

Application Number Title Priority Date Filing Date
DK20217833.1T DK3865484T3 (da) 2015-07-07 2016-07-06 Pde9-hæmmer med imidazopyrazinon-rygrad til behandling af perifere sygdomme
DK16734707.9T DK3303339T3 (da) 2015-07-07 2016-07-06 Pde9-inhibitorer med imidazotriazinonskelet og imidazopyrazinonskelet til behandling af perifere sygdomme

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK20217833.1T DK3865484T3 (da) 2015-07-07 2016-07-06 Pde9-hæmmer med imidazopyrazinon-rygrad til behandling af perifere sygdomme

Country Status (21)

Country Link
US (4) US10513524B2 (da)
EP (3) EP3303339B1 (da)
CN (2) CN112010861A (da)
AU (2) AU2016289856B2 (da)
BR (1) BR112018000254A2 (da)
CA (1) CA2990521C (da)
DK (2) DK3865484T3 (da)
ES (2) ES2971969T3 (da)
FI (1) FI3865484T3 (da)
HK (1) HK1249903A1 (da)
HR (2) HRP20240082T1 (da)
HU (2) HUE065652T2 (da)
IL (2) IL280619B2 (da)
LT (1) LT3865484T (da)
MX (1) MX379456B (da)
PL (1) PL3865484T3 (da)
PT (1) PT3865484T (da)
SI (2) SI3865484T1 (da)
TN (1) TN2017000507A1 (da)
WO (1) WO2017005786A1 (da)
ZA (1) ZA201708341B (da)

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WO2018234488A1 (en) 2017-06-23 2018-12-27 Basf Se SUBSTITUTED CYCLOPROPYL DERIVATIVES
KR20210014662A (ko) 2018-05-25 2021-02-09 이마라 인크. 6-[(3S,4S)-4-메틸-1-(피리미딘-2-일메틸)피롤리딘-3-일]-3-테트라히드로피란-4-일-7H-이미다조[1,5-a]피라진-8-온의 일수화물 및 결정형
EP3843737A4 (en) * 2018-08-31 2022-06-01 Imara Inc. PDE9 INHIBITORS FOR THE TREATMENT OF SICKLE CELL DISEASE
EP3946348A4 (en) * 2019-04-05 2023-08-02 Imara Inc. PDE9 INHIBITORS FOR THE TREATMENT OF SICKLE CELL DISEASE
CN114072151A (zh) * 2019-05-07 2022-02-18 伊马拉公司 用于治疗地中海贫血的pde9抑制剂
US20240287058A1 (en) 2020-04-29 2024-08-29 Relay Therapeutics, Inc. Pi3k-alpha inhibitors and methods of use thereof
WO2022036111A1 (en) * 2020-08-13 2022-02-17 Imara Inc. Methods and compositions for treating sickle cell disease
CN112552339A (zh) * 2020-12-10 2021-03-26 安徽昊帆生物有限公司 一种o-二苯基磷酰羟胺的制备方法
AR126447A1 (es) * 2021-07-13 2023-10-11 Relay Therapeutics Inc INHIBIDORES DE PI3Ka Y MÉTODOS DE USO DE LOS MISMOS
CN115448864B (zh) * 2022-08-26 2023-12-22 上海方予健康医药科技有限公司 3-氟-3-(1-羟乙基)吡咯烷-1-羧酸叔丁酯的制备方法
WO2024151930A1 (en) * 2023-01-13 2024-07-18 Relay Therapeutics, Inc. Pi3k inhibitors and methods of making and using the same

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