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BRPI0507236A - método para o tratamento ou profilaxia de uma condição, e, composto - Google Patents

método para o tratamento ou profilaxia de uma condição, e, composto

Info

Publication number
BRPI0507236A
BRPI0507236A BRPI0507236-0A BRPI0507236A BRPI0507236A BR PI0507236 A BRPI0507236 A BR PI0507236A BR PI0507236 A BRPI0507236 A BR PI0507236A BR PI0507236 A BRPI0507236 A BR PI0507236A
Authority
BR
Brazil
Prior art keywords
conditions
compounds
present
hydrocarbon chain
treatment
Prior art date
Application number
BRPI0507236-0A
Other languages
English (en)
Inventor
Antonio Ferrante
Deborah Ann Rathjen
Original Assignee
Peplin Biolipids Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Peplin Biolipids Pty Ltd filed Critical Peplin Biolipids Pty Ltd
Publication of BRPI0507236A publication Critical patent/BRPI0507236A/pt

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    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/50Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
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    • C07C233/01Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/46Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/49Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a carbon atom of an acyclic unsaturated carbon skeleton
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    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/52Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
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    • C07C59/40Unsaturated compounds
    • C07C59/58Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/60Unsaturated compounds containing ether groups, groups, groups, or groups the non-carboxylic part of the ether being unsaturated

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Abstract

MéTODO PARA O TRATAMENTO OU PROFILAXIA DE UMA CONDIçãO, E, COMPOSTO A presente invenção se refere geralmente a compostos compreendendo uma porção de cadeia de hidrocarboneto e, mais em particular, a compostos compreendendo derivações químicas da cadeia de hidrocarboneto que são moléculas terapêuticas e profiláticas úteis. A presente invenção adicionalmente provê compostos onde a porção de cadeia de hidrocarbonetos é uma molécula carreadora para grupos, porções ou agentes funcionais. Os compostos da presente invenção são particularmente úteis no tratamento ou profilaxia de uma gama de condições incluindo cânceres, condições associadas ou relacionadas à proteína quinase c(PKC) ou NFkB, condições cardiovasculares, dor, condições inflamatórias, condições vasculares ou imunológicas tais como diabetes, condições neurológicas e infecção por uma gama de vírus ou organismos procarióticos ou eucarióticos. A presente invenção adicionalmente provê composições farmacêuticas e métodos de tratamento médico.
BRPI0507236-0A 2004-01-30 2005-01-28 método para o tratamento ou profilaxia de uma condição, e, composto BRPI0507236A (pt)

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