[go: up one dir, main page]

DK3185876T3 - Sammensætninger og fremgangsmåder til behandling af neurologiske lidelser - Google Patents

Sammensætninger og fremgangsmåder til behandling af neurologiske lidelser Download PDF

Info

Publication number
DK3185876T3
DK3185876T3 DK15835807.7T DK15835807T DK3185876T3 DK 3185876 T3 DK3185876 T3 DK 3185876T3 DK 15835807 T DK15835807 T DK 15835807T DK 3185876 T3 DK3185876 T3 DK 3185876T3
Authority
DK
Denmark
Prior art keywords
compositions
treatment
methods
neurological disorders
neurological
Prior art date
Application number
DK15835807.7T
Other languages
English (en)
Inventor
Richard Rox Anderson
William A Farinelli
Emilia Javorsky
Lilit Garibyan
Original Assignee
Massachusetts Gen Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Gen Hospital filed Critical Massachusetts Gen Hospital
Application granted granted Critical
Publication of DK3185876T3 publication Critical patent/DK3185876T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/718—Starch or degraded starch, e.g. amylose, amylopectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/765—Polymers containing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/02—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00434—Neural system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/02—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
    • A61B2018/0293—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques using an instrument interstitially inserted into the body, e.g. needle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F2007/0059—Heating or cooling appliances for medical or therapeutic treatment of the human body with an open fluid circuit
    • A61F2007/0063—Heating or cooling appliances for medical or therapeutic treatment of the human body with an open fluid circuit for cooling
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Emergency Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Biochemistry (AREA)
  • Anesthesiology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
DK15835807.7T 2014-08-28 2015-08-27 Sammensætninger og fremgangsmåder til behandling af neurologiske lidelser DK3185876T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201462042979P 2014-08-28 2014-08-28
US201562121329P 2015-02-26 2015-02-26
US201562121472P 2015-02-26 2015-02-26
PCT/US2015/047292 WO2016033380A1 (en) 2014-08-28 2015-08-27 Compositions and methods for treatment of neurological disorders

Publications (1)

Publication Number Publication Date
DK3185876T3 true DK3185876T3 (da) 2022-10-31

Family

ID=55400611

Family Applications (2)

Application Number Title Priority Date Filing Date
DK15836780.5T DK3185854T3 (da) 2014-08-28 2015-08-27 Injicerbare opslæmninger og fremgangsmåder til fremstilling og anvendelse af disse
DK15835807.7T DK3185876T3 (da) 2014-08-28 2015-08-27 Sammensætninger og fremgangsmåder til behandling af neurologiske lidelser

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK15836780.5T DK3185854T3 (da) 2014-08-28 2015-08-27 Injicerbare opslæmninger og fremgangsmåder til fremstilling og anvendelse af disse

Country Status (16)

Country Link
US (7) US20170274011A1 (da)
EP (4) EP3988105A1 (da)
JP (7) JP6707525B2 (da)
KR (2) KR20170044199A (da)
CN (4) CN113813222A (da)
AU (4) AU2015308790B2 (da)
BR (2) BR112017003111B1 (da)
CA (2) CA2958769A1 (da)
DK (2) DK3185854T3 (da)
ES (1) ES2898097T3 (da)
MX (3) MX383790B (da)
PL (1) PL3185854T3 (da)
PT (1) PT3185854T (da)
SG (4) SG11201701504WA (da)
WO (2) WO2016033384A1 (da)
ZA (3) ZA201701048B (da)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10028753B2 (en) 2008-09-26 2018-07-24 Relievant Medsystems, Inc. Spine treatment kits
JP5688022B2 (ja) 2008-09-26 2015-03-25 リリーバント メドシステムズ、インコーポレイテッド 骨の内部を通って器具を誘導するためのシステムおよび方法
US9980765B2 (en) 2010-02-15 2018-05-29 The General Hospital Corporation Methods and devices for selective disruption of visceral fat by controlled cooling
BR112013011944B1 (pt) 2010-11-16 2022-02-22 TVA Medical, Inc Sistema para formação de uma fistula
CA2825624C (en) 2011-01-27 2020-01-14 Osa Holdings, Inc. Apparatus and methods for treatment of obstructive sleep apnea utilizing cryolysis of adipose tissues
WO2013101772A1 (en) 2011-12-30 2013-07-04 Relievant Medsystems, Inc. Systems and methods for treating back pain
US10588691B2 (en) 2012-09-12 2020-03-17 Relievant Medsystems, Inc. Radiofrequency ablation of tissue within a vertebral body
CA2887557C (en) 2012-10-11 2022-05-17 Tva Medical, Inc. Devices and methods for fistula formation
JP6195625B2 (ja) 2012-11-05 2017-09-13 リリーバント メドシステムズ、インコーポレイテッド 骨を通して湾曲経路を作り、骨内で神経を調節するシステム及び方法
US10821217B2 (en) 2013-03-14 2020-11-03 Tva Medical, Inc. Fistula formation devices and methods therefor
US9724151B2 (en) 2013-08-08 2017-08-08 Relievant Medsystems, Inc. Modulating nerves within bone using bone fasteners
CN111167008A (zh) 2013-12-05 2020-05-19 免疫系统公司 利用射频电学膜击穿（rf-emb）的癌症免疫疗法
US10695534B2 (en) 2014-03-14 2020-06-30 Tva Medical, Inc. Fistula formation devices and methods therefor
US10646666B2 (en) 2014-08-27 2020-05-12 Tva Medical, Inc. Cryolipolysis devices and methods therefor
US11504322B2 (en) 2014-08-28 2022-11-22 The General Hospital Corporation Injectable slurries and methods of manufacturing the same
US11471401B2 (en) 2014-08-28 2022-10-18 The General Hospital Corporation Injectable slurries and methods of manufacturing the same
CN113813222A (zh) 2014-08-28 2021-12-21 通用医疗公司 治疗神经疾病的组合物和方法
EP3200736B8 (en) 2014-10-01 2020-06-17 CryOSA, Inc. Apparatus for treatment of obstructive sleep apnea utilizing cryolysis of adipose tissues
US10603040B1 (en) 2015-02-09 2020-03-31 Tva Medical, Inc. Methods for treating hypertension and reducing blood pressure with formation of fistula
US11161156B2 (en) * 2015-10-27 2021-11-02 Hamilton Sundstrand Corporation Powder monitoring
TWI834598B (zh) 2016-01-15 2024-03-11 美商Ｒｆｅｍｂ控股有限公司 癌症之免疫治療
EP3402432B1 (en) 2016-01-15 2023-05-31 TVA Medical, Inc. Devices for forming a fistula
WO2017124060A1 (en) 2016-01-15 2017-07-20 Tva Medical, Inc. Systems and methods for adhering vessels
ES2974309T3 (es) 2016-01-15 2024-06-26 Tva Medical Inc Dispositivos para hacer avanzar un hilo
US10874422B2 (en) 2016-01-15 2020-12-29 Tva Medical, Inc. Systems and methods for increasing blood flow
MX2018010220A (es) 2016-02-26 2018-11-29 Massachusetts Gen Hospital Sistemas y metodos de produccion y suministro de suspension medica helada.
EP3515322B1 (en) 2016-09-25 2022-04-20 TVA Medical, Inc. Vascular stent devices
CN110392561B (zh) 2016-11-02 2021-10-01 米拉基创新智库有限公司 用于料浆生成的装置和方法
US11324673B2 (en) * 2016-11-18 2022-05-10 Miraki Innovation Think Tank Llc Cosmetic appearance of skin
BR112019018191A2 (pt) * 2017-03-01 2020-06-23 Miraki Innovation Think Tank Llc Crioterapias
CA3059294A1 (en) * 2017-04-05 2018-10-11 Miraki Innovation Think Tank Llc Point of delivery cold slurry generation
KR102589816B1 (ko) 2017-04-05 2023-10-16 미라키 이노베이션 씽크 탱크 엘엘씨 저온 슬러리 격납
US10500342B2 (en) 2017-08-21 2019-12-10 Miraki Innovation Think Tank Llc Cold slurry syringe
AU2018384077B2 (en) * 2017-12-11 2024-08-22 Saban Ventures Pty Limited Suspension cleaning
KR20210071009A (ko) * 2018-10-04 2021-06-15 미라키 이노베이션 씽크 탱크 엘엘씨 슬러리 및 용액 조성물
EP3860548A4 (en) * 2018-10-04 2022-06-01 Miraki Innovation Think Tank, LLC METHODS OF TREATMENT OF SUBCUTANEOUS FAT LAYERS
JP2022502211A (ja) * 2018-10-10 2022-01-11 ミラキ イノベーション シンク タンク エルエルシー スラリーを生成するシステム及び方法
US20210346192A1 (en) * 2018-10-10 2021-11-11 Miraki Innovation Think Tank Llc Systems and methods of generating cold slurry for injection
AU2019359364A1 (en) * 2018-10-12 2021-05-20 Miraki Innovation Think Tank Llc Cold solution for fat reduction
CN109800472B (zh) * 2018-12-26 2022-09-27 哈尔滨工程大学 一种冰桨接触过程中桨叶表面瞬时冰载压力分布计算方法
US11576812B2 (en) 2019-04-25 2023-02-14 Carlos Wambier Methods for reducing body fat in a subject
JP2022542571A (ja) * 2019-07-24 2022-10-05 ザ ジェネラル ホスピタル コーポレイション カプセル化により異なる凝固点を有する物質を作製する方法
EP4501263A3 (en) 2019-09-12 2025-03-19 Relievant Medsystems, Inc. Systems and methods for tissue modulation
JP2022549499A (ja) 2019-09-26 2022-11-25 ミラキ イノベーション シンク タンク エルエルシー 小型の体内で制御可能な医療機器
JP2023508941A (ja) * 2019-12-24 2023-03-06 ミラキ イノベーション シンク タンク エルエルシー 実質的に固体の溶液、実質的に固体の溶液を生成するシステム及び方法、並びにそれを投与する方法
WO2021133720A1 (en) * 2019-12-26 2021-07-01 Miraki Innovative Think Tank Llc Treatment of obstructive sleep apnea
US20230028322A1 (en) * 2019-12-31 2023-01-26 Miraki Innovation Think Tank Llc Cold solution for inducing therapeutic hypothermia
JP2023511404A (ja) * 2020-01-23 2023-03-17 ザ ジェネラル ホスピタル コーポレイション 神経系への増強された薬物送達の方法
CN115884791A (zh) * 2020-03-27 2023-03-31 视酷医疗有限公司 使用医用冰浆来减轻眼表不适的症状的方法
AU2021305336B2 (en) 2020-07-10 2025-02-06 C° Change Surgical Llc Injectable slush feed supply
WO2022011115A1 (en) 2020-07-10 2022-01-13 Relievant Medsystems, Inc. Vertebral denervation in conjunction with vertebral fusion
WO2022016015A1 (en) * 2020-07-15 2022-01-20 Lyotip, Inc. Formulations for tetracaine and lidocaine
US20220071900A1 (en) * 2020-09-08 2022-03-10 Brixton Biosciences, Inc. Systems and methods for preparing and transporting an injectable slurry
US12426594B2 (en) 2020-09-24 2025-09-30 Everest Medical Innovation GmbH Cryoprotective compositions and methods for protection of a surgical site during cryosurgery
US12453805B2 (en) 2020-09-24 2025-10-28 Everest Medical Innovation GmbH Cryoprotective compositions, surgical kits, and methods for protection of a surgical site during cryosurgery
US12082876B1 (en) 2020-09-28 2024-09-10 Relievant Medsystems, Inc. Introducer drill
JP2024505335A (ja) 2020-12-22 2024-02-06 リリーバント メドシステムズ、インコーポレイテッド 脊椎神経調節の候補の予測
JP2024513688A (ja) 2021-03-12 2024-03-27 アンバー セラピューティクス リミテッド 失禁制御のためのデバイス、システム、および方法
US11241330B1 (en) 2021-04-02 2022-02-08 Brixton Biosciences, Inc. Apparatus for creation of injectable slurry
US11490925B1 (en) 2021-06-09 2022-11-08 Mohammed A. Alsufyani Combination ultrasound transducer and fat injecting cannula
JP2024522208A (ja) * 2021-06-11 2024-06-11 ブリクストン バイオサイエンシズ インコーポレイテッド リポソームエマルジョンを使用してスラリーを作製する方法
JP2024539656A (ja) * 2021-10-14 2024-10-29 ザ ジェネラル ホスピタル コーポレイション 閉塞性睡眠時無呼吸の処置のための組成物および方法
US12433668B1 (en) 2021-11-08 2025-10-07 Relievant Medsystems, Inc. Impedance stoppage mitigation during radiofrequency tissue ablation procedures
JP2025502801A (ja) 2021-12-30 2025-01-28 クライオサ， インク． 閉塞性睡眠時無呼吸の治療のためのシステム及び方法
CA3251622A1 (en) 2022-02-07 2023-08-10 Martin J. MOSKOVITZ Cryosurgical devices and materials and their method of use
WO2024238743A1 (en) * 2023-05-17 2024-11-21 Edwards Lifesciences Corporation Systems for epicardial tissue distension solutions

Family Cites Families (137)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1256372A (en) 1985-04-11 1989-06-27 Koichiro Miyazima Process for producing liposome composition
US5143063A (en) 1988-02-09 1992-09-01 Fellner Donald G Method of removing adipose tissue from the body
JP2512095B2 (ja) * 1988-08-12 1996-07-03 株式会社日立製作所 冷熱発生方法
WO1990003795A1 (en) 1988-10-05 1990-04-19 Vestar, Inc. Method of making liposomes with improved stability during drying
US5005364A (en) 1990-02-07 1991-04-09 Nelson William R Apparatus for and method of making and delivering slush ice
CA2112109A1 (en) * 1991-07-05 1993-01-21 Arne Berg Improvements in or relating to contrast agents
US5507790A (en) 1994-03-21 1996-04-16 Weiss; William V. Method of non-invasive reduction of human site-specific subcutaneous fat tissue deposits by accelerated lipolysis metabolism
US5769879A (en) 1995-06-07 1998-06-23 Medical Contouring Corporation Microwave applicator and method of operation
US6126657A (en) 1996-02-23 2000-10-03 Somnus Medical Technologies, Inc. Apparatus for treatment of air way obstructions
US6464697B1 (en) 1998-02-19 2002-10-15 Curon Medical, Inc. Stomach and adjoining tissue regions in the esophagus
US6467953B1 (en) 1999-03-30 2002-10-22 Medical Solutions, Inc. Method and apparatus for monitoring temperature of intravenously delivered fluids and other medical items
US7892229B2 (en) 2003-01-18 2011-02-22 Tsunami Medtech, Llc Medical instruments and techniques for treating pulmonary disorders
US6126684A (en) 1998-04-21 2000-10-03 The Regents Of The University Of California Indwelling heat exchange catheter and method of using same
US6546932B1 (en) 1999-04-05 2003-04-15 Cryocath Technologies Inc. Cryogenic method and apparatus for promoting angiogenesis
JP3111219B1 (ja) * 1999-05-25 2000-11-20 工業技術院長 ポリビニルアルコールを利用した冷熱輸送方法及び装置
CA2379366A1 (en) 1999-07-16 2001-01-25 Alza Corporation A liposome composition having resistance to freeze/thaw damage
US6596333B1 (en) 1999-07-21 2003-07-22 Nestec S.A. Process for producing aerated frozen products
US6244052B1 (en) * 1999-08-02 2001-06-12 The University Of Chicago Method and apparatus for producing phase change ice particulate perfluorocarbon slurries
US6413444B1 (en) 1999-08-02 2002-07-02 The University Of Chicago Methods and apparatus for producing phase change ice particulate saline slurries
US7422601B2 (en) * 1999-08-02 2008-09-09 University Of Chicago Office Of Technology Transfer Method for inducing hypothermia
US6962601B2 (en) 1999-08-02 2005-11-08 University Of Chicago Office Of Technology Transfer Method for inducing hypothermia
US6495164B1 (en) 2000-05-25 2002-12-17 Alkermes Controlled Therapeutics, Inc. I Preparation of injectable suspensions having improved injectability
US7306591B2 (en) 2000-10-02 2007-12-11 Novasys Medical, Inc. Apparatus and methods for treating female urinary incontinence
US7255865B2 (en) * 2000-12-05 2007-08-14 Allergan, Inc. Methods of administering botulinum toxin
US7897141B2 (en) 2002-04-01 2011-03-01 Drexel University Echogenic polymer microcapsules and nanocapsules and methods for production and use thereof
US20030032996A1 (en) * 2001-08-08 2003-02-13 Hallman Arlan Jay Cryogenic massage tube and compress
US6709431B2 (en) 2001-12-18 2004-03-23 Scimed Life Systems, Inc. Cryo-temperature monitoring
WO2003072108A1 (en) * 2002-02-26 2003-09-04 Astrazeneca Ab Novel crystalline forms of the anti-cancer compound zd1839
US8840608B2 (en) 2002-03-15 2014-09-23 The General Hospital Corporation Methods and devices for selective disruption of fatty tissue by controlled cooling
SI3173042T1 (sl) 2002-03-15 2022-05-31 The General Hospital Corporation Postopek in naprave za selektivno razbitje maščobnega tkiva z nadzorovanim hlajenjem
US6858025B2 (en) 2002-08-06 2005-02-22 Medically Advanced Designs, Llc Cryo-surgical apparatus and method of use
US7211104B2 (en) 2002-10-08 2007-05-01 Vital Wear, Inc. Contrast therapy system and method
US7083612B2 (en) 2003-01-15 2006-08-01 Cryodynamics, Llc Cryotherapy system
US20040258760A1 (en) 2003-03-20 2004-12-23 Wheatley Margaret A. Isolated nanocapsule populations and surfactant-stabilized microcapsules and nanocapsules for diagnostic imaging and drug delivery and methods for their production
US7344530B2 (en) 2003-03-26 2008-03-18 Regents Of The University Of Minnesota Thermal surgical procedures and compositions
US20060161232A1 (en) 2005-01-18 2006-07-20 Kasza, Oras and Son to The University of Chicago Phase-change particulate ice slurry coolant medical delivery tubing and insertion devices
US7850683B2 (en) 2005-05-20 2010-12-14 Myoscience, Inc. Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat)
US7713266B2 (en) 2005-05-20 2010-05-11 Myoscience, Inc. Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat)
US20090326621A1 (en) 2005-05-24 2009-12-31 Rizk El-Galley Surgical delivery devices and methods
US7389653B2 (en) * 2005-09-15 2008-06-24 The University Of Chicago Medical ice slurry production device
US20070093697A1 (en) 2005-10-21 2007-04-26 Theranova, Llc Method and apparatus for detection of right to left shunting in the cardiopulmonary vasculature
US7854754B2 (en) 2006-02-22 2010-12-21 Zeltiq Aesthetics, Inc. Cooling device for removing heat from subcutaneous lipid-rich cells
GB0615287D0 (en) 2006-08-01 2006-09-06 Ares Trading Sa Integral membrane protein
US8192474B2 (en) 2006-09-26 2012-06-05 Zeltiq Aesthetics, Inc. Tissue treatment methods
US20090118722A1 (en) 2006-10-31 2009-05-07 Ebbers Edward A Method and apparatus for cooling subcutaneous lipid-rich cells or tissue
US9254162B2 (en) 2006-12-21 2016-02-09 Myoscience, Inc. Dermal and transdermal cryogenic microprobe systems
US20080247957A1 (en) 2007-02-16 2008-10-09 Drexel University Advanced drug delivery strategy and platform for minimally-invasive treatment of liver cancer
US20080300571A1 (en) 2007-05-30 2008-12-04 Lepivert Patrick Process and device for selectively treating interstitial tissue
US20090028797A1 (en) 2007-06-14 2009-01-29 Drexel University Novel polymeric ultrasound contrast agent and methods of making thereof
AU2008275158A1 (en) 2007-07-09 2009-01-15 Velomedix, Inc Hypothermia devices and methods
US8523927B2 (en) 2007-07-13 2013-09-03 Zeltiq Aesthetics, Inc. System for treating lipid-rich regions
US9540649B2 (en) 2007-10-12 2017-01-10 The Provost, Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin Method for opening tight junctions
US8298216B2 (en) 2007-11-14 2012-10-30 Myoscience, Inc. Pain management using cryogenic remodeling
WO2009102367A2 (en) 2007-11-19 2009-08-20 The Regents Of The University Of Colorado Tight junction protein modulators and uses thereof
US20090234325A1 (en) 2008-03-17 2009-09-17 Allan Rozenberg Methods and devices for non-invasive cerebral and systemic cooling
AU2009251688A1 (en) 2008-04-01 2009-12-03 The General Hospital Corporation Method and apparatus for cooling biological tissue
US8505315B2 (en) * 2008-04-15 2013-08-13 Uchicago Argonne, Llc Enhanced integrated operation blender based sterile medical ice slurry production device
US7874167B2 (en) 2008-06-06 2011-01-25 C Change Surgical Llc Method and apparatus for producing slush for surgical use
WO2010017556A1 (en) 2008-08-08 2010-02-11 Palomar Medical Technologies, Inc Method and apparatus for fractional deformation and treatment of cutaneous and subcutaneous tissue
US8518031B2 (en) * 2008-10-31 2013-08-27 The Invention Science Fund I, Llc Systems, devices and methods for making or administering frozen particles
US9060931B2 (en) 2008-10-31 2015-06-23 The Invention Science Fund I, Llc Compositions and methods for delivery of frozen particle adhesives
US8603073B2 (en) 2008-12-17 2013-12-10 Zeltiq Aesthetics, Inc. Systems and methods with interrupt/resume capabilities for treating subcutaneous lipid-rich cells
WO2010083281A1 (en) 2009-01-15 2010-07-22 Boston Scientific Scimed, Inc. Controlling depth of cryoablation
US8608696B1 (en) 2009-02-24 2013-12-17 North Carolina State University Rapid fluid cooling devices and methods for cooling fluids
US20110009748A1 (en) 2009-06-11 2011-01-13 Galil Medical Ltd. Transperineal prostate biopsy system and methods
US20130011332A1 (en) 2009-09-15 2013-01-10 Searete Llc, Frozen Compositions and Methods for Piercing a Substrate
US20140200511A1 (en) * 2009-10-30 2014-07-17 Searete Llc Systems, devices, and methods for making or administering frozen particles
US9980765B2 (en) * 2010-02-15 2018-05-29 The General Hospital Corporation Methods and devices for selective disruption of visceral fat by controlled cooling
AU2011293227A1 (en) 2010-08-26 2013-02-07 Cryomedix, Llc Cryoablation balloon catheter and related method
US9095320B2 (en) 2010-09-27 2015-08-04 CyroMedix, LLC Cryo-induced renal neuromodulation devices and methods
US20120136344A1 (en) 2010-10-26 2012-05-31 Medtronic Ardian Luxembourg S.A.R.L. Neuromodulation cryotherapeutic devices and associated systems and methods
US9060754B2 (en) 2010-10-26 2015-06-23 Medtronic Ardian Luxembourg S.A.R.L. Neuromodulation cryotherapeutic devices and associated systems and methods
WO2012082798A2 (en) 2010-12-13 2012-06-21 Palmer Iii Francis R Method for reducing hyperdynamic facial wrinkles
GB2485864B (en) 2011-07-14 2013-05-29 Ide Technologies Ltd Vacuum ice maker (vim) with an integrated water vapor depostion process
ES2976564T3 (es) 2011-02-01 2024-08-05 Channel Medsystems Inc Aparato para el tratamiento criogénico de una cavidad o luz del cuerpo
CN103747754B (zh) 2011-06-14 2016-07-06 艾琳医药股份有限公司 用于治疗鼻气道的装置
EP2561886A1 (en) 2011-08-23 2013-02-27 Forschungsverbund Berlin e.V. Peptide adjuvant for improved peripheral analgesia
KR102284689B1 (ko) 2011-10-21 2021-08-02 셀라토 파마슈티칼즈, 인코포레이티드 동결건조된 리포좀
KR102359731B1 (ko) 2011-11-16 2022-02-08 더 제너럴 하스피탈 코포레이션 피부 조직의 극저온 처리를 위한 방법 및 장치
US9241753B2 (en) 2012-01-13 2016-01-26 Myoscience, Inc. Skin protection for subdermal cryogenic remodeling for cosmetic and other treatments
EP2854681A4 (en) 2012-06-01 2016-02-17 Cibiem Inc PERCUTANEOUS METHODS AND DEVICES FOR CAROTIDE BODY ABLATION
JP6168644B2 (ja) 2012-07-12 2017-07-26 国立大学法人弘前大学 氷スラリー製造装置および氷スラリー製造方法
US9844460B2 (en) 2013-03-14 2017-12-19 Zeltiq Aesthetics, Inc. Treatment systems with fluid mixing systems and fluid-cooled applicators and methods of using the same
US9610112B2 (en) 2013-03-15 2017-04-04 Myoscience, Inc. Cryogenic enhancement of joint function, alleviation of joint stiffness and/or alleviation of pain associated with osteoarthritis
US9033966B2 (en) 2013-03-15 2015-05-19 Warsaw Orthopedic, Inc. Nerve and soft tissue ablation device
US9023022B2 (en) 2013-03-15 2015-05-05 Warsaw Orthopedic, Inc. Nerve and soft tissue ablation device having release instrument
US9023023B2 (en) 2013-03-15 2015-05-05 Warsaw Orthopedic, Inc. Nerve and soft tissue ablation device
US9295512B2 (en) 2013-03-15 2016-03-29 Myoscience, Inc. Methods and devices for pain management
US9131975B2 (en) 2013-03-15 2015-09-15 Warsaw Orthopedic, Inc. Nerve and soft tissue ablation device
WO2014146126A1 (en) 2013-03-15 2014-09-18 Myoscience, Inc. Cryogenic blunt dissection methods and devices
CN105792875B (zh) 2013-08-05 2019-05-31 吴粤 一个制备和输送用于低温疗法的无气泡医用冰浆的方法和仪器
US9687288B2 (en) 2013-09-30 2017-06-27 Arrinex, Inc. Apparatus and methods for treating rhinitis
US10660688B2 (en) 2014-05-12 2020-05-26 Gary Kalser Cryotherapy device with cryoprotection and methods for performing cryotherapy with cryoprotection
US9763743B2 (en) 2014-07-25 2017-09-19 Arrinex, Inc. Apparatus and method for treating rhinitis
US10646666B2 (en) 2014-08-27 2020-05-12 Tva Medical, Inc. Cryolipolysis devices and methods therefor
US11504322B2 (en) 2014-08-28 2022-11-22 The General Hospital Corporation Injectable slurries and methods of manufacturing the same
US11471401B2 (en) 2014-08-28 2022-10-18 The General Hospital Corporation Injectable slurries and methods of manufacturing the same
CN113813222A (zh) 2014-08-28 2021-12-21 通用医疗公司 治疗神经疾病的组合物和方法
US9549843B2 (en) 2014-11-30 2017-01-24 C° Change Surgical Llc Production of well-mixed surgical slush
CN204468406U (zh) 2015-02-05 2015-07-15 张淑华 一种新型便携式冷敷装置
WO2016145452A1 (en) 2015-03-12 2016-09-15 Myoscience, Inc. Methods and systems for preventing neuroma formations
US20160317346A1 (en) 2015-04-28 2016-11-03 Zeltiq Aesthetics, Inc. Systems and methods for monitoring cooling of skin and tissue to identify freeze events
HK1259174A1 (zh) 2016-01-07 2019-11-29 Zeltiq Aesthetics, Inc. 组织冷却过程中涂敷器与皮肤之间的温度依赖性粘附力
MX2018010220A (es) 2016-02-26 2018-11-29 Massachusetts Gen Hospital Sistemas y metodos de produccion y suministro de suspension medica helada.
CN105640642B (zh) 2016-04-07 2018-01-12 上海导向医疗系统有限公司 带扩张球囊的内冷却微波消融针
US11382790B2 (en) 2016-05-10 2022-07-12 Zeltiq Aesthetics, Inc. Skin freezing systems for treating acne and skin conditions
DE102016115387B3 (de) 2016-08-18 2018-02-01 Cardiolectra GmbH Medizinisches Gerät zur Denervierung renaler perivaskulärer Nerven
EP3506846A4 (en) 2016-08-30 2021-01-06 The General Hospital Corporation Cryotherapy and cryoablation systems and methods for treatment of tissue
CN110392561B (zh) 2016-11-02 2021-10-01 米拉基创新智库有限公司 用于料浆生成的装置和方法
KR101905830B1 (ko) 2016-11-15 2018-10-08 울산과학기술원 국부 냉각 마취 장치, 국부 냉각 마취 장치의 제어 방법 및 국부 냉각 마취 장치의 냉각 온도 조절기
US11324673B2 (en) 2016-11-18 2022-05-10 Miraki Innovation Think Tank Llc Cosmetic appearance of skin
ES2994230T3 (en) 2017-02-04 2025-01-20 Vessi Medical Ltd Cryotherapy device flow control
US9980076B1 (en) 2017-02-21 2018-05-22 At&T Intellectual Property I, L.P. Audio adjustment and profile system
BR112019018191A2 (pt) 2017-03-01 2020-06-23 Miraki Innovation Think Tank Llc Crioterapias
US20180271767A1 (en) 2017-03-21 2018-09-27 Zeltiq Aesthetics, Inc. Use of saccharides for cryoprotection and related technology
KR102589816B1 (ko) 2017-04-05 2023-10-16 미라키 이노베이션 씽크 탱크 엘엘씨 저온 슬러리 격납
CA3059294A1 (en) 2017-04-05 2018-10-11 Miraki Innovation Think Tank Llc Point of delivery cold slurry generation
US10500342B2 (en) 2017-08-21 2019-12-10 Miraki Innovation Think Tank Llc Cold slurry syringe
US11523855B2 (en) 2018-09-28 2022-12-13 Team Neuro LLC Spinal pain management system and method
KR20210071009A (ko) 2018-10-04 2021-06-15 미라키 이노베이션 씽크 탱크 엘엘씨 슬러리 및 용액 조성물
EP3860548A4 (en) 2018-10-04 2022-06-01 Miraki Innovation Think Tank, LLC METHODS OF TREATMENT OF SUBCUTANEOUS FAT LAYERS
JP2022502211A (ja) 2018-10-10 2022-01-11 ミラキ イノベーション シンク タンク エルエルシー スラリーを生成するシステム及び方法
US20210346192A1 (en) 2018-10-10 2021-11-11 Miraki Innovation Think Tank Llc Systems and methods of generating cold slurry for injection
AU2019359364A1 (en) 2018-10-12 2021-05-20 Miraki Innovation Think Tank Llc Cold solution for fat reduction
JP2022542571A (ja) 2019-07-24 2022-10-05 ザ ジェネラル ホスピタル コーポレイション カプセル化により異なる凝固点を有する物質を作製する方法
US12121281B2 (en) 2019-08-07 2024-10-22 Christopher M. Shaari Systems and methods for cryogenic treatment of headache
EP4031042A1 (en) 2019-09-17 2022-07-27 Arrinex, Inc. Apparatus and methods for improved nasal cavity treatments
JP2023508941A (ja) 2019-12-24 2023-03-06 ミラキ イノベーション シンク タンク エルエルシー 実質的に固体の溶液、実質的に固体の溶液を生成するシステム及び方法、並びにそれを投与する方法
WO2021133720A1 (en) 2019-12-26 2021-07-01 Miraki Innovative Think Tank Llc Treatment of obstructive sleep apnea
JP2023511404A (ja) 2020-01-23 2023-03-17 ザ ジェネラル ホスピタル コーポレイション 神経系への増強された薬物送達の方法
EP4081144A4 (en) 2020-02-19 2024-01-17 CryOSA, Inc. Systems and methods for treatment of obstructive sleep apnea
CN115884791A (zh) 2020-03-27 2023-03-31 视酷医疗有限公司 使用医用冰浆来减轻眼表不适的症状的方法
US20210330927A1 (en) 2020-04-27 2021-10-28 Black Cat Medical Llc Method of performing cryoneurolysis
US20220071900A1 (en) 2020-09-08 2022-03-10 Brixton Biosciences, Inc. Systems and methods for preparing and transporting an injectable slurry
US12453805B2 (en) 2020-09-24 2025-10-28 Everest Medical Innovation GmbH Cryoprotective compositions, surgical kits, and methods for protection of a surgical site during cryosurgery
US12426594B2 (en) 2020-09-24 2025-09-30 Everest Medical Innovation GmbH Cryoprotective compositions and methods for protection of a surgical site during cryosurgery
US20220409428A1 (en) 2021-06-23 2022-12-29 Black Cat Medical Llc Method of performing cryoneurolysis

Also Published As

Publication number Publication date
BR112017003143A2 (pt) 2017-11-28
CA2958769A1 (en) 2016-03-03
JP2020143113A (ja) 2020-09-10
SG10201913572TA (en) 2020-03-30
CN117064838A (zh) 2023-11-17
ZA201701080B (en) 2019-05-29
JP2021152055A (ja) 2021-09-30
EP3988105A1 (en) 2022-04-27
BR112017003111A2 (pt) 2017-12-05
SG10201913564WA (en) 2020-03-30
JP2025142046A (ja) 2025-09-29
US20170274078A1 (en) 2017-09-28
SG11201701505RA (en) 2017-03-30
US11964017B2 (en) 2024-04-23
EP3185876A1 (en) 2017-07-05
CA2958768C (en) 2023-08-29
SG11201701504WA (en) 2017-03-30
AU2023214304B2 (en) 2025-11-13
JP6858698B2 (ja) 2021-04-21
US20170274011A1 (en) 2017-09-28
PT3185854T (pt) 2021-12-03
AU2015308794A1 (en) 2017-03-02
MX2017002274A (es) 2017-05-22
BR112017003143B1 (pt) 2023-12-05
WO2016033384A1 (en) 2016-03-03
ZA201701048B (en) 2023-12-20
JP7714596B2 (ja) 2025-07-29
BR112017003111B1 (pt) 2021-10-13
AU2021200481A1 (en) 2021-02-25
US11938188B2 (en) 2024-03-26
JP2021098748A (ja) 2021-07-01
JP2017526684A (ja) 2017-09-14
JP6903792B2 (ja) 2021-07-14
MX2017002271A (es) 2017-05-22
WO2016033380A1 (en) 2016-03-03
CN106794138B (zh) 2021-10-01
EP3185854A4 (en) 2018-07-25
US20250073336A1 (en) 2025-03-06
US20210244817A1 (en) 2021-08-12
MX383790B (es) 2025-03-11
JP2017529336A (ja) 2017-10-05
CN106794138A (zh) 2017-05-31
DK3185854T3 (da) 2021-12-20
EP4176885A1 (en) 2023-05-10
AU2015308790A1 (en) 2017-03-02
ES2898097T3 (es) 2022-03-03
PL3185854T3 (pl) 2022-01-31
KR102507789B1 (ko) 2023-03-07
EP3185854A1 (en) 2017-07-05
AU2023214304A1 (en) 2023-08-31
CA2958768A1 (en) 2016-03-03
CN113813222A (zh) 2021-12-21
KR20170045330A (ko) 2017-04-26
EP3185854B1 (en) 2021-10-06
US11826427B2 (en) 2023-11-28
CN107106481A (zh) 2017-08-29
JP2023060133A (ja) 2023-04-27
KR20170044199A (ko) 2017-04-24
US20240042034A1 (en) 2024-02-08
EP3185876A4 (en) 2018-04-18
AU2015308790B2 (en) 2020-12-03
JP6707525B2 (ja) 2020-06-10
AU2021200481B2 (en) 2023-05-11
MX2021007621A (es) 2021-08-11
JP7201727B2 (ja) 2023-01-10
JP7240447B2 (ja) 2023-03-15
ZA201901279B (en) 2021-08-25
US20250018042A1 (en) 2025-01-16
EP3185876B1 (en) 2022-08-10
US20210236639A1 (en) 2021-08-05

Similar Documents

Publication Publication Date Title
DK3185876T3 (da) Sammensætninger og fremgangsmåder til behandling af neurologiske lidelser
IL289423A (en) Compounds and methods for treating neurological and cardiovascular conditions
DK3102673T3 (da) Fremgangsmåder og sammensætninger til behandling af beta-talassæmi
DK3570844T3 (da) Azolopyrimidin til behandlingen af kræftrelaterede lidelser
DK3224269T3 (da) Sammensætninger og fremgangsmåder til behandling af cns-forstyrrelser
DK3206493T3 (da) Sammensætninger og fremgangsmåder til behandling af cns-forstyrrelser
DK3212226T3 (da) Sammensætninger og anvendelsesfremgangsmåder til behandling af metaboliske lidelser
DK3119797T3 (da) Raav-baserede sammensætninger og fremgangsmåder til behandling af amyotrofisk lateralsklerose
DK3102213T3 (da) Farmaceutiske sammensætninger til behandlingen af inflammatoriske lidelser
DK3119397T3 (da) Heterocykliske forbindelser til anvendelse i behandling af PI3K-gamma-medierede lidelser
LT3250210T (lt) Kompozicijos ir būdai, skirti gydyti cns sutrikimus
DK3240612T3 (da) Fremgangsmåder til behandling af nethindesygdomme
DK3481846T3 (da) 11-substituerede 24-hydroxysteroler til anvendelse til behandling af nmda-relaterede tilstande
DK3362066T3 (da) Kombinationsterapi til behandling af maligniteter
DK3189074T3 (da) Sammensætninger og metoder til behandling og forebyggelse af inflammation
DK3081263T3 (da) Sammensætninger og redskaber til behandling af glaukom
DK3157534T3 (da) Acetylcholinesterasehæmmere til behandling af dermatologiske tilstande
DK3209696T3 (da) Fremgangsmåder og sammensætninger til diagnosticering og behandling af glioblastom
DK3104852T3 (da) Sammensætninger og fremgangsmåde til behandling af aldring og aldersbetingede sygdomme og symptomer
DK3142664T3 (da) Sammensætninger og fremgangsmåder til behandling og diagnosticering af øjensygdomme
DK3110446T3 (da) Fremgangsmåder og sammensætninger til behandling af Siglec-8-associerede sygdomme
DK3192524T3 (da) Hgf præparat egnet til behandling af neurologiske lidelser
DK3522873T3 (da) Sammensætninger og fremgangsmåder til behandlingen af xerostomi
DK3157522T3 (da) Muskarin-antagonister og kombinationer deraf til behandlingen af luftvejssygdomme i heste
DK3200828T3 (da) Intranasale sammensætninger til behandling af neurologiske og neurodegenerative sygdomme og forstyrrelser