DK2445911T3 - 5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-ylcarboxamider som jak-inhibitorer - Google Patents
5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-ylcarboxamider som jak-inhibitorer Download PDFInfo
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- DK2445911T3 DK2445911T3 DK10724881.7T DK10724881T DK2445911T3 DK 2445911 T3 DK2445911 T3 DK 2445911T3 DK 10724881 T DK10724881 T DK 10724881T DK 2445911 T3 DK2445911 T3 DK 2445911T3
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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- A61P19/00—Drugs for skeletal disorders
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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- Organic Chemistry (AREA)
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- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
- Vascular Medicine (AREA)
- Obesity (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Claims (15)
1. Forbindelse med formel I:
eller et farmaceutisk acceptabelt salt deraf.
2. Farmaceutisk sammensætning, der omfatter et farmaceutisk acceptabelt bæremateriale og en farmaceutisk effektiv mængde af en forbindelse ifølge krav 1.
3. Farmaceutisk sammensætning ifølge krav 2, der omfatter et yderligere terapeutisk middel.
4. Anvendelse af en forbindelse ifølge krav 1 til fremstilling af et medikament.
5. Forbindelse ifølge krav 1 eller farmaceutisk sammensætning ifølge krav 2 til anvendelse som et medikament.
6. Forbindelse ifølge krav 1 til anvendelse til behandling, forebyggelse eller profylakse af inflammationstilstande, autoimmunsygdomme, proliferative sygdomme, transplantatafstødning, sygdomme, der inddrager nedsat bruskomsætning, medfødte bruskmisdannelser, Castlemans sygdom, multipelt myelom, psoriasis, Kaposis sarkom og/eller mesangial proliferativ glomerulonefritis.
7. Forbindelse til anvendelse ifølge krav 6, hvor inflammationstilstanden er udvalgt blandt rheumatoid arthritis, osteoarthritis, allergisk luftvejssygdom og inflammatoriske tarmsygdomme.
8. Forbindelse til anvendelse ifølge krav 6 eller 7, hvor inflammationstilstanden er rheumatoid arthritis.
9. Forbindelse til anvendelse ifølge krav 6, hvor inflammationstilstanden er inflammatorisk tarmsygdom.
10. Forbindelse til anvendelse ifølge krav 6, hvor inflammationstilstanden er colitis og/eller Crohns sygdom.
11. Forbindelse til anvendelse ifølge krav 6, hvor sygdommen, der inddrager nedsat bruskomsætning, er udvalgt blandt ankyloserende spondylitis og psoriasisarthritis.
12. Forbindelse til anvendelse ifølge krav 6, hvor autoimmunsygdommen er atopisk dermatitis.
13. Forbindelse til anvendelse ifølge krav 6, hvor transplantatafstødningssygdommen er graft-versus-host-sygdom.
14. Forbindelse til anvendelse ifølge krav 6, hvor forbindelsen ifølge krav 1 administreres i kombination med et yderligere terapeutisk middel.
15. Forbindelse til anvendelse ifølge krav 9, hvor det yderligere terapeutiske middel er et middel til behandling og/eller forebyggelse af arthritis, inflammatoriske tarmsygdomme, autoimmunsygdomme eller transplantatafstødning.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22068809P | 2009-06-26 | 2009-06-26 | |
| PCT/EP2010/059064 WO2010149769A1 (en) | 2009-06-26 | 2010-06-25 | 5-phenyl-[1,2,4 ]triazolo[1,5-a]pyridin-2-yl carboxamides as jak inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2445911T3 true DK2445911T3 (da) | 2017-06-06 |
Family
ID=42562363
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK17152084.4T DK3178819T3 (en) | 2009-06-26 | 2010-06-25 | 5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl-carboxamider som jak-inhibitorer |
| DK10724881.7T DK2445911T3 (da) | 2009-06-26 | 2010-06-25 | 5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-ylcarboxamider som jak-inhibitorer |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK17152084.4T DK3178819T3 (en) | 2009-06-26 | 2010-06-25 | 5-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl-carboxamider som jak-inhibitorer |
Country Status (44)
Families Citing this family (83)
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| CN105218539B (zh) * | 2015-09-18 | 2017-07-25 | 上海宣创生物科技有限公司 | 一种环丙烷甲酰胺衍生物b晶型及其制备方法 |
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