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MX2020006014A - Compuestos de diazaindol. - Google Patents

Compuestos de diazaindol.

Info

Publication number
MX2020006014A
MX2020006014A MX2020006014A MX2020006014A MX2020006014A MX 2020006014 A MX2020006014 A MX 2020006014A MX 2020006014 A MX2020006014 A MX 2020006014A MX 2020006014 A MX2020006014 A MX 2020006014A MX 2020006014 A MX2020006014 A MX 2020006014A
Authority
MX
Mexico
Prior art keywords
compounds
diazaindole
disclosed
toll
inhibitors
Prior art date
Application number
MX2020006014A
Other languages
English (en)
Inventor
Alaric J Dyckman
Dharmpal S Dodd
Christopher P Mussari
Sreekantha Ratna Kumar
Brian K Whiteley
Reddy Anupama Kandhi Ramachandra
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of MX2020006014A publication Critical patent/MX2020006014A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La presente invención se refiere a compuestos de Fórmula (I) (ver formula I) N-óxidos, o sales de los mismos, en donde G, A, X, Y, Z, R1, y n se definen en la presente. También se describen métodos para usar tales compuestos como inhibidores de la señalización a través del receptor similar a Toll 7, o 8, o 9, y composiciones farmacéuticas que comprenden tales compuestos. Estos compuestos son útiles en el tratamiento de enfermedades inflamatorias y autoinmunes.
MX2020006014A 2017-12-20 2018-12-18 Compuestos de diazaindol. MX2020006014A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762607941P 2017-12-20 2017-12-20
PCT/US2018/066108 WO2019126083A1 (en) 2017-12-20 2018-12-18 Diazaindole compounds

Publications (1)

Publication Number Publication Date
MX2020006014A true MX2020006014A (es) 2020-08-17

Family

ID=65003573

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020006014A MX2020006014A (es) 2017-12-20 2018-12-18 Compuestos de diazaindol.

Country Status (14)

Country Link
US (1) US11299501B2 (es)
EP (1) EP3728264B1 (es)
JP (1) JP7382938B2 (es)
KR (1) KR102722182B1 (es)
CN (1) CN111511744B (es)
AU (1) AU2018390544A1 (es)
BR (1) BR112020012002A2 (es)
CA (1) CA3085937A1 (es)
EA (1) EA202091530A1 (es)
ES (1) ES2904773T3 (es)
IL (1) IL275505A (es)
MX (1) MX2020006014A (es)
SG (1) SG11202005733QA (es)
WO (1) WO2019126083A1 (es)

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TW202440078A (zh) 2021-09-10 2024-10-16 美商基利科學股份有限公司 噻吩并吡咯化合物
IL314945A (en) * 2022-02-18 2024-10-01 Bristol Myers Squibb Co Substituted imidazopyridinyl compounds useful as inhibitors of tlr9
CN114591339B (zh) * 2022-05-10 2022-08-02 上海维申医药有限公司 一类Toll样受体抑制剂及其制备和应用

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Also Published As

Publication number Publication date
EP3728264B1 (en) 2021-12-01
KR102722182B1 (ko) 2024-10-24
EP3728264A1 (en) 2020-10-28
US20200308195A1 (en) 2020-10-01
ES2904773T3 (es) 2022-04-06
JP7382938B2 (ja) 2023-11-17
WO2019126083A1 (en) 2019-06-27
IL275505A (en) 2020-08-31
SG11202005733QA (en) 2020-07-29
CA3085937A1 (en) 2019-06-27
JP2021506941A (ja) 2021-02-22
KR20200100760A (ko) 2020-08-26
AU2018390544A1 (en) 2020-08-06
CN111511744B (zh) 2023-09-22
CN111511744A (zh) 2020-08-07
BR112020012002A2 (pt) 2020-11-17
EA202091530A1 (ru) 2020-09-14
US11299501B2 (en) 2022-04-12

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