DK2280696T3 - Modulatorer af prostacyclin (PG12)-receptoren til anvendelse til behandling af lidelser relateret til denne - Google Patents
Modulatorer af prostacyclin (PG12)-receptoren til anvendelse til behandling af lidelser relateret til denneInfo
- Publication number
- DK2280696T3 DK2280696T3 DK09721284.9T DK09721284T DK2280696T3 DK 2280696 T3 DK2280696 T3 DK 2280696T3 DK 09721284 T DK09721284 T DK 09721284T DK 2280696 T3 DK2280696 T3 DK 2280696T3
- Authority
- DK
- Denmark
- Prior art keywords
- prostacyclin
- modulators
- receptor
- treatment
- disorders related
- Prior art date
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- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
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US20945309P | 2009-03-06 | 2009-03-06 | |
PCT/US2009/001688 WO2009117095A1 (en) | 2008-03-18 | 2009-03-17 | Modulators of the prostacyclin (pgi2) receptor useful for the treatment of disorders related thereto |
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EP (3) | EP2857015B1 (da) |
JP (7) | JP5536752B2 (da) |
KR (13) | KR20200129175A (da) |
CN (4) | CN110003123B (da) |
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CA (1) | CA2728756C (da) |
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EA (1) | EA019882B1 (da) |
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CN103274926B (zh) | 2007-12-17 | 2016-08-10 | 联合治疗公司 | 一种制备Remodulin中的活性成分曲前列素的改良方法 |
KR20200129175A (ko) | 2008-03-18 | 2020-11-17 | 아레나 파마슈티칼스, 인크. | 프로스타시클린 (pgi2) 수용체와 관련된 장애의 치료에 유용한 상기 수용체의 조절제 |
US20110224262A1 (en) | 2008-11-26 | 2011-09-15 | Arena Pharmaceuticals, Inc. | Pyrazolyl substituted carbonic acid derivatives as modulators of the prostacyclin (pgi2) receptor useful for the treatment of disorders related thereto |
DK2370413T3 (da) | 2008-12-08 | 2015-11-02 | Arena Pharm Inc | Modulatorer af prostacyclin(PG12)-receptoren, hvilke kan anvendes til behandling af lidelser relateret til denne |
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CN103476762B (zh) | 2011-03-02 | 2015-04-22 | 联合治疗公司 | 用于生产曲前列环素的中间体的合成 |
BR112016028255A2 (pt) | 2014-06-06 | 2017-08-22 | Flexus Biosciences Inc | agentes imunorreguladores |
KR101890080B1 (ko) | 2014-10-20 | 2018-09-20 | 유나이티드 쎄러퓨틱스 코포레이션 | 프로스타시클린 유도체 제조를 위한 중간체의 합성 |
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