DK2285808T3 - Spiroindolderivater til behandling af parasitsygdomme - Google Patents

Spiroindolderivater til behandling af parasitsygdomme

Info

Publication number: DK2285808T3
Authority: DK; Denmark
Prior art keywords: treatment; parasitic diseases; spiroindole; derivatives; spiroindole derivatives
Prior art date: 2008-04-29

Application number

DK09737965.5T

Other languages

English (en)

Inventor

Shi Hua Ang

Philipp Krastel

Seh Yong Leong

Liying Jocelyn Tan

Wei Lin Josephine Wong

Bryan Ks Yeung

Bin Zou

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-04-29

Filing date

2009-04-01

Publication date

2014-02-03

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40613087&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2285808(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2009-04-01 Application filed by Novartis Ag filed Critical Novartis Ag

2014-02-03 Application granted granted Critical

2014-02-03 Publication of DK2285808T3 publication Critical patent/DK2285808T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/20—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/20—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Tropical Medicine & Parasitology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

DK09737965.5T 2008-04-29 2009-04-01 Spiroindolderivater til behandling af parasitsygdomme DK2285808T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP08155342		2008-04-29
EP09151117		2009-01-22
PCT/EP2009/053902 WO2009132921A1 (en)	2008-04-29	2009-04-01	Spiro-indole derivatives for the treatment of parasitic diseases

Publications (1)

Publication Number	Publication Date
DK2285808T3 true DK2285808T3 (da)	2014-02-03

Family

ID=40613087

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK09737965.5T DK2285808T3 (da)	2008-04-29	2009-04-01	Spiroindolderivater til behandling af parasitsygdomme

Country Status (30)

Country	Link
US (2)	US8053442B2 (da)
EP (2)	EP2285808B1 (da)
JP (2)	JP5438098B2 (da)
KR (1)	KR101390081B1 (da)
CN (1)	CN102015711B (da)
AR (1)	AR071222A1 (da)
AU (1)	AU2009242279B2 (da)
BR (1)	BRPI0911577B8 (da)
CA (1)	CA2719365C (da)
CL (1)	CL2009001007A1 (da)
CO (1)	CO6300940A2 (da)
CY (1)	CY1114874T1 (da)
DK (1)	DK2285808T3 (da)
EA (1)	EA019601B1 (da)
EC (2)	ECSP10010646A (da)
ES (1)	ES2447590T3 (da)
HR (1)	HRP20140151T1 (da)
IL (1)	IL208357A (da)
JO (1)	JO2904B1 (da)
MA (1)	MA32316B1 (da)
MX (1)	MX2010011868A (da)
MY (2)	MY152021A (da)
NZ (1)	NZ588217A (da)
PE (1)	PE20091787A1 (da)
PL (1)	PL2285808T3 (da)
PT (1)	PT2285808E (da)
SI (1)	SI2285808T1 (da)
TW (1)	TWI442921B (da)
WO (1)	WO2009132921A1 (da)
ZA (1)	ZA201006752B (da)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN102015711B (zh) *	2008-04-29	2013-05-01	诺瓦提斯公司	用于治疗寄生虫病的螺-吲哚衍生物
CN102584835B (zh) *	2011-01-17	2014-08-27	苏州大学	一种含吲哚结构的螺杂环化合物及其制备方法
JP6117906B2 (ja) *	2012-03-23	2017-04-19	ノバルティスアーゲー	スピロインドロンおよびこれらの中間体を調製するための化学プロセス
DK2828385T3 (da)	2012-03-23	2018-03-12	Codexis Inc	Biokatalysatorer og fremgangsmåder til syntetisering af derivater og tryptamin og tryptaminanaloger
CN104185634B (zh) *	2012-03-23	2017-05-03	诺华股份有限公司	制备螺旋吲哚酮和其中间体的化学工艺
EP3068793B1 (en)	2013-11-13	2021-02-17	Codexis, Inc.	Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
SG10202012428PA (en)	2014-11-25	2021-01-28	Codexis Inc	Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
IL311006A (en)	2014-12-18	2024-04-01	Hoffmann La Roche	Tetrahydro-pyrido[3, 4-b]indole estrogen receptor modulators and their uses
JP6625649B2 (ja) *	2015-01-23	2019-12-25	グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅＩｎｔｅｌｌｅｃｔｕａｌＰｒｏｐｅｒｔｙＤｅｖｅｌｏｐｍｅｎｔＬｉｍｉｔｅｄ	ピラゾロ［３，４−ｄ］ピリミジン誘導体およびリーシュマニア症の処置のためのその使用
WO2016147205A1 (en) *	2015-03-13	2016-09-22	Council Of Scientific & Industrial Research	Novel substituted 3-spirophosphoryl pyrazole-2-oxindoles as anti-infectives and process for the synthesis thereof
US11174267B2 (en)	2015-06-12	2021-11-16	The Regents Of The University Of California	Spiroindolinones and therapeutic uses thereof
JP2017024992A (ja) *	2015-07-15	2017-02-02	公益財団法人微生物化学研究会	化合物の製造方法
IL319761A (en)	2018-06-21	2025-05-01	Hoffmann La Roche	Solid forms of 3-((R3,R1)-1-(6,2-difluoro-4-((1-(3-fluoropropyl)azetidin-3-yl)amino)phenyl)-3-methyl-9,4,3,1-tetrahydro-H2-pyrido[4,3-B]indol-2-yl]2,2-difluoropropan-1-ol and processes for preparing fused tricyclic compounds containing a substituted phenyl or pyridinyl residue, including methods for using them
CN110590795B (zh) *	2019-10-10	2021-01-22	贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室)	一类多并杂环螺羟吲哚类化合物的合成方法
US20230132973A1 (en) *	2020-03-17	2023-05-04	The University Of Buea	DIHYDRO-SPIRO[INDOLINE-3:1'-iSOQUINOLIN]-2-ONES AS ANTIMALARIAL AGENTS
CN116273188B (zh) *	2023-03-01	2024-06-25	岭南师范学院	一种负载金属的多孔有机框架材料在催化Pictet-Spengler反应中的应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2663935A1 (fr) *	1990-06-27	1992-01-03	Adir	Nouveaux 1,2,3,4,5,6-hexahydroazepino [4,5-b] indoles et 1,2,3,4-tetrahydrobethacarbolines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
NZ509324A (en) *	1998-07-14	2003-07-25	Bayer Ag	Antiparasitic artemisinin derivatives (endoperoxides)
SI1144411T1 (en)	1998-12-19	2005-10-31	Janssen Pharmaceutica N.V.	Antihistaminic spiro compounds
US20050101623A1 (en)	2003-07-23	2005-05-12	Pharmacia Corporation	Beta-carboline compounds and analogues thereof as mitogen-activated protein kinase-activated protein kinase-2 inhibitors
AR053710A1 (es)	2005-04-11	2007-05-16	Xenon Pharmaceuticals Inc	Compuestos espiroheterociclicos y sus usos como agentes terapeuticos
ES2344131T3 (es)	2006-12-07	2010-08-18	F. Hoffmann-La Roche Ag	Derivados de espiro-piperidina como antagonistas del receptor v1a.
CA2709784A1 (en) *	2007-12-21	2009-07-09	University Of Rochester	Method for altering the lifespan of eukaryotic organisms
JP5512545B2 (ja)	2008-01-09	2014-06-04	アレイバイオファーマ、インコーポレイテッド	Ａｋｔタンパク質キナーゼ阻害剤としてのピリミジルシクロペンタン類
CN102015711B (zh) *	2008-04-29	2013-05-01	诺瓦提斯公司	用于治疗寄生虫病的螺-吲哚衍生物

2009
- 2009-04-01 CN CN2009801149364A patent/CN102015711B/zh active Active
- 2009-04-01 MY MYPI20104473 patent/MY152021A/en unknown
- 2009-04-01 NZ NZ588217A patent/NZ588217A/xx unknown
- 2009-04-01 EP EP09737965.5A patent/EP2285808B1/en active Active
- 2009-04-01 MX MX2010011868A patent/MX2010011868A/es active IP Right Grant
- 2009-04-01 PT PT97379655T patent/PT2285808E/pt unknown
- 2009-04-01 DK DK09737965.5T patent/DK2285808T3/da active
- 2009-04-01 EP EP13185962.1A patent/EP2722333A1/en not_active Withdrawn
- 2009-04-01 SI SI200930847T patent/SI2285808T1/sl unknown
- 2009-04-01 AU AU2009242279A patent/AU2009242279B2/en active Active
- 2009-04-01 KR KR1020107026548A patent/KR101390081B1/ko active Active
- 2009-04-01 BR BRPI0911577A patent/BRPI0911577B8/pt active IP Right Grant
- 2009-04-01 ES ES09737965.5T patent/ES2447590T3/es active Active
- 2009-04-01 PL PL09737965T patent/PL2285808T3/pl unknown
- 2009-04-01 WO PCT/EP2009/053902 patent/WO2009132921A1/en not_active Ceased
- 2009-04-01 MY MYPI2013001071A patent/MY156601A/en unknown
- 2009-04-01 HR HRP20140151AT patent/HRP20140151T1/hr unknown
- 2009-04-01 EA EA201001689A patent/EA019601B1/ru not_active IP Right Cessation
- 2009-04-01 JP JP2011506638A patent/JP5438098B2/ja active Active
- 2009-04-01 CA CA2719365A patent/CA2719365C/en active Active
- 2009-04-27 AR ARP090101487A patent/AR071222A1/es active IP Right Grant
- 2009-04-27 US US12/430,625 patent/US8053442B2/en active Active
- 2009-04-28 CL CL2009001007A patent/CL2009001007A1/es unknown
- 2009-04-28 PE PE2009000577A patent/PE20091787A1/es active IP Right Grant
- 2009-04-28 JO JO2009149A patent/JO2904B1/en active
- 2009-04-28 TW TW098114086A patent/TWI442921B/zh active
2010
- 2010-09-21 ZA ZA2010/06752A patent/ZA201006752B/en unknown
- 2010-09-21 IL IL208357A patent/IL208357A/en active IP Right Grant
- 2010-11-19 MA MA33365A patent/MA32316B1/fr unknown
- 2010-11-25 CO CO10148514A patent/CO6300940A2/es active IP Right Grant
- 2010-11-29 EC EC2010010646A patent/ECSP10010646A/es unknown
2011
- 2011-07-19 US US13/186,035 patent/US8399453B2/en active Active
2013
- 2013-12-12 JP JP2013257004A patent/JP2014065729A/ja active Pending
2014
- 2014-02-20 CY CY20141100135T patent/CY1114874T1/el unknown
2017
- 2017-10-13 EC ECIEPI201768127A patent/ECSP17068127A/es unknown

Also Published As

Publication number	Publication date
BRPI0911577A8 (pt)	2018-03-06
EP2722333A1 (en)	2014-04-23
CN102015711A (zh)	2011-04-13
ES2447590T3 (es)	2014-03-12
MY152021A (en)	2014-08-15
EA201001689A1 (ru)	2011-08-30
US8399453B2 (en)	2013-03-19
KR101390081B1 (ko)	2014-04-29
BRPI0911577A2 (pt)	2016-01-05
AR071222A1 (es)	2010-06-02
TW200948357A (en)	2009-12-01
CN102015711B (zh)	2013-05-01
CA2719365A1 (en)	2009-11-05
PL2285808T3 (pl)	2014-04-30
MX2010011868A (es)	2010-11-26
WO2009132921A1 (en)	2009-11-05
AU2009242279B2 (en)	2012-08-30
KR20100135320A (ko)	2010-12-24
PT2285808E (pt)	2014-02-24
NZ588217A (en)	2012-10-26
PE20091787A1 (es)	2009-12-14
US20090275560A1 (en)	2009-11-05
HK1149935A1 (en)	2011-10-21
JP5438098B2 (ja)	2014-03-12
MY156601A (en)	2016-03-15
MA32316B1 (fr)	2011-05-02
US20110275613A1 (en)	2011-11-10
BRPI0911577B1 (pt)	2021-02-23
HRP20140151T1 (hr)	2014-03-28
ECSP10010646A (es)	2010-12-30
IL208357A0 (en)	2010-12-30
JO2904B1 (en)	2015-09-15
JP2011518852A (ja)	2011-06-30
EA019601B1 (ru)	2014-04-30
ECSP17068127A (es)	2017-10-31
TWI442921B (zh)	2014-07-01
EP2285808A1 (en)	2011-02-23
CO6300940A2 (es)	2011-07-21
CA2719365C (en)	2017-03-07
AU2009242279A1 (en)	2009-11-05
ZA201006752B (en)	2011-05-25
BRPI0911577B8 (pt)	2021-05-25
IL208357A (en)	2014-11-30
US8053442B2 (en)	2011-11-08
EP2285808B1 (en)	2013-11-20
JP2014065729A (ja)	2014-04-17
SI2285808T1 (sl)	2014-03-31
CY1114874T1 (el)	2016-12-14
CL2009001007A1 (es)	2010-06-11

Publication	Publication Date	Title
DK2285808T3 (da)	2014-02-03	Spiroindolderivater til behandling af parasitsygdomme
DK3456707T3 (da)	2020-07-20	4-(p-quinonyl)-2-hydroxybutanamidderivater til behandling af mitokondriesygdomme
LTC2137143I2 (lt)	2023-10-10	Pleuromutilino dariniai, skirti mikrobų sukeltų ligų gydymui
DK2504005T3 (da)	2014-01-13	Anvendelse af 1,3-diphenylprop-2-en-1-on-derivater til behandling af lever-sygdomme
DK1874781T3 (da)	2009-11-02	Dihydrothienopyrimidiner til behandling af inflammatoriske sygdomme
SMAP200900085A (it)	2010-01-19	3-imidazolil-indoli per il trattamento di malattieproliferative
DK3289876T3 (da)	2022-10-10	Forbindelser til behandling af cancer
DK2300443T3 (da)	2013-02-18	Triazolderivater, der er anvendelige til behandling af sygdomme
DK2474321T3 (da)	2019-06-03	Sammensætninger til behandling af collagenmedierede sygdomme
DK3192520T3 (da)	2019-05-27	Terapeutiske midler til reducering af niveauerne af parathyreoideahormon
DK2056842T3 (da)	2013-01-14	Modificeret galactosylceramid til behandling af cancerøse sygdomme
PL3354276T3 (pl)	2020-09-21	Kompozycje do leczenia zapalenia przewodu pokarmowego
DK2381965T3 (da)	2020-07-27	Modulation af præ-mrna under anvendelse af splejsningsmodulerende oligonukleotider som terapeutiske midler til behandling af sygdom
EP2334277A4 (en)	2016-01-06	CRUTCH
DK2440230T3 (da)	2021-01-18	Behandlingsregimener til behandling af neurologisk sygdom
DK2451482T3 (da)	2019-07-22	Kombinationsterapi til behandlingen af diabetes
DK2627345T3 (da)	2014-09-01	Formuleringer til behandling af sygdomme i de øvre luftveje
DK2117565T3 (da)	2012-11-19	Anvendelse af chitosaner til behandlingen af negleinflammatoriske sygdomme
DK2099446T3 (da)	2013-02-11	Fremgangsmåde til behandling af inflammatorisk tarmsygdom
BRPI0917210A2 (pt)	2015-11-10	exoterma controlada de formulações de cianocrilato
DK2022504T3 (da)	2013-02-11	Salve til behandling af hæmorider
DK2296651T3 (da)	2012-09-24	5-hydroxymethyl-oxazolidin-2-on-derivater til behandling af bakterielle intestinale sygdomme
DK2285416T3 (da)	2012-09-10	Konjugat til behandlingen af mesotheliom
DK2109449T3 (da)	2011-09-12	Lægemiddel til behandling af endometriose
DK2455064T3 (da)	2021-02-22	Indretning til behandling af periodontal sygdom